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  1. Article ; Online: Durability of antimicrobial activity of antibiotic-impregnated external ventricular drains: a prospective study-authors' response.

    Mounier, Roman / Lebeaux, David

    The Journal of antimicrobial chemotherapy

    2020  Volume 75, Issue 6, Page(s) 1662–1663

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cerebrospinal Fluid Shunts ; Drainage ; Prospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-02-23
    Publishing country England
    Document type Letter
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa059
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  2. Article ; Online: No evidence of clinical benefits of early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: Comment on "Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France".

    Lebeaux, David / Revest, Matthieu

    Travel medicine and infectious disease

    2020  Volume 36, Page(s) 101819

    MeSH term(s) Azithromycin ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; France ; Humans ; Hydroxychloroquine ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6236: Show issues Location:
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  3. Article ; Online: Durability of antimicrobial activity of antibiotic-impregnated external ventricular drains: a prospective study-authors' response.

    Mounier, Roman / Lebeaux, David

    The Journal of antimicrobial chemotherapy

    2019  Volume 75, Issue 3, Page(s) 779–780

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cerebrospinal Fluid Shunts ; Drainage ; Prospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-11-18
    Publishing country England
    Document type Letter
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkz486
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    Zs.A 1197: Show issues Location:
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  4. Article ; Online: Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study.

    Lombès, Amélie / Fernandez-Gerlinger, Marie-Paule / Khalifé, Marc / Kassis-Chikhani, Najiby / Jomli, Amira / Mainardi, Jean-Luc / Lebeaux, David / Dubert, Marie

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 62

    Abstract: Background: Post-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without ... ...

    Abstract Background: Post-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without spinal implants is not well documented.
    Methods: This single center retrospective 7-year observational study described and compared the outcome (treatment failure or mortality rate one year after diagnosis) of 20 patients with staphylococcal-implant-free pSSI treated with single or combination antibiotics.
    Results: Median duration of treatment was 40 days (IQR 38-42), with 6 days (IQR 5-7) on intravenous antibiotics and 34 days (IQR 30-36) on oral therapy. Four patients (20%) underwent new surgical debridement, all due to surgical failure, and 1 patient died within the first year without significant differences between both treatment group.
    Conclusion: This study raises the possibility of single antibiotic therapy for patients with implant-free post-surgical spinal infections due to Staphylococcus spp.
    MeSH term(s) Humans ; Retrospective Studies ; Postoperative Complications ; Staphylococcal Infections/drug therapy ; Staphylococcus ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-08977-y
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  5. Article ; Online: Management dilemmas in Nocardia brain infection.

    Lebeaux, David / Coussement, Julien / Bodilsen, Jacob / Tattevin, Pierre

    Current opinion in infectious diseases

    2021  Volume 34, Issue 6, Page(s) 611–618

    Abstract: Purpose of review: Brain nocardiosis is a rare but severe infection mostly occurring among immunocompromised patients. In this review, we present recent data on this infection and address some of the common clinical dilemmas encountered in patients with ...

    Abstract Purpose of review: Brain nocardiosis is a rare but severe infection mostly occurring among immunocompromised patients. In this review, we present recent data on this infection and address some of the common clinical dilemmas encountered in patients with brain nocardiosis.
    Recent findings: Strategies used to approach a patient with suspected brain nocardiosis include the 'conservative strategy' (without early neurosurgery) and the 'neurosurgical strategy' (with early aspiration or excision of brain abscess[es]). The advantages and disadvantages of both strategies are summarised. Our opinion is that the use of the 'conservative strategy' should be limited to well-selected patients presenting with an easily accessible extra-neurological lesion(s) and have brain abscesses at low risk of treatment failure. In terms of antimicrobial therapy, we summarise the data supporting the use of a multidrug regimen in patients with brain nocardiosis.Last, we list possible reasons for treatment failure in patients with brain nocardiosis and suggest interventions to overcome them.
    Summary: Literature is scarce regarding brain nocardiosis, as a consequence of the rarity of this disease. A multidisciplinary and individualised management is required to optimise the outcome of patients with brain nocardiosis.
    MeSH term(s) Brain ; Brain Abscess/drug therapy ; Humans ; Immunocompromised Host ; Nocardia ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2462: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: No evidence of clinical benefits of early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: Comment on "Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France"

    Lebeaux, David / Revest, Matthieu

    Travel Med Infect Dis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #626469
    Database COVID19

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  7. Article ; Online: No evidence of clinical benefits of early treatment of COVID-19 patients with hydroxychloroquine and azithromycin

    Lebeaux, David / Revest, Matthieu

    Travel Medicine and Infectious Disease

    2020  Volume 36, Page(s) 101819

    Keywords Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101819
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 6236: Show issues Location:
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  8. Article ; Online: Targeted SARS-CoV-2 treatment is associated with decreased mortality in immunocompromised patients with COVID-19.

    Lafont, Emmanuel / Pere, Hélène / Lebeaux, David / Cheminet, Geoffrey / Thervet, Eric / Guillemain, Romain / Flahault, Adrien

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 10, Page(s) 2688–2692

    Abstract: Background: Little is known about targeted (antiviral or monoclonal antibody) anti-SARS-CoV-2 treatment in immunocompromised patients with COVID-19.: Objectives: To assess the real-life efficacy and tolerance of targeted treatment of COVID-19 in ... ...

    Abstract Background: Little is known about targeted (antiviral or monoclonal antibody) anti-SARS-CoV-2 treatment in immunocompromised patients with COVID-19.
    Objectives: To assess the real-life efficacy and tolerance of targeted treatment of COVID-19 in immunocompromised patients.
    Patients and methods: Single-centre retrospective case series of immunocompromised patients with COVID-19 between December 2021 and March 2022. We recorded all cases of COVID-19 among immunocompromised patients treatment between 20 December 2021 and 15 March 2022. Choice of treatment was left to the physician's decision, according to internal treatment protocol, treatment availability and circulating variants. Main outcome was death from COVID-19 after no treatment or targeted treatment.
    Results: Sixty-seven immunocompromised patients [38 male; median (IQR) age, 53 (43-63) years], with a median (IQR) follow-up of 60 (47-80) days. Ten patients did not receive any targeted treatment. Targeted treatment consisted of IV curative remdesivir (n = 22), sotrovimab (n = 16), tixagevimab/cilgavimab (n = 13) and casirivimab/imdevimab (n = 1). Ten patients (15%) presented severe COVID-19 and 2 (3%) died from Omicron COVID-19. Comparing patients who received targeted anti-SARS-CoV-2 treatment and no prophylaxis, (n = 42; 81%) with those who did not (n = 10; 19%), death rate was significantly lower in treated patients [n = 0 (0%) versus n = 2 (20%); P = 0.034]. No severe adverse events were reported among treated patients. Among 15 patients who received tixagevimab/cilgavimab as pre-exposure prophylaxis, 6 received an additional curative treatment and none died from COVID-19.
    Conclusions: Our results suggest that targeted COVID-19 treatment, including direct antivirals or monoclonal antibodies, is safe and efficient and could be proposed in high-risk immunocompromised patients.
    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antiviral Agents ; tixagevimab ; cilgavimab (1KUR4BN70F) ; sotrovimab (1MTK0BPN8V) ; imdevimab (2Z3DQD2JHM) ; casirivimab (J0FI6WE1QN)
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac253
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    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 124: Show issues

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  9. Article ; Online: Infectious native aortic aneurysm with negative blood cultures: do not forget the pneumococcal urinary antigen test!

    Dubert, Marie / Derycke, Lucie / Bidaud, Anne-Laure / Gibault, Laure / Le Pendu, Claire / Pogdlajen, Isabelle / Lebeaux, David

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2023  Volume 131, Issue 3, Page(s) 125–127

    Abstract: Infectious native aortic aneurysm (INAA) are rare but life-threatening infections. Early microbiological identification is crucial to initiate adequate therapy and decrease the peri-operative risk, but can be challenging when blood cultures remain ... ...

    Abstract Infectious native aortic aneurysm (INAA) are rare but life-threatening infections. Early microbiological identification is crucial to initiate adequate therapy and decrease the peri-operative risk, but can be challenging when blood cultures remain negative. We describe two cases of pneumococcal INAA with negative blood cultures, diagnosed in the with the pneumococcal urinary antigen test.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Blood Culture ; Streptococcus pneumoniae ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/surgery ; Aortic Aneurysm/drug therapy ; Communicable Diseases/drug therapy ; Antigens, Bacterial/urine
    Chemical Substances Anti-Bacterial Agents ; Antigens, Bacterial
    Language English
    Publishing date 2023-01-26
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13287
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    Ud II Zs.73: Show issues Location:
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  10. Article ; Online: Frequency and factors associated with infusion-related local complications of vancomycin on peripheral venous catheters.

    Ammar, Helmi / Rolland, Simon / Jouffroy, Romain / Dubert, Marie / Le Beller, Christine / Podglajen, Isabelle / Lillo-Lelouet, Agnès / Lebeaux, David / Bensaid, Samuel

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 4, Page(s) 1050–1054

    Abstract: Background: Vancomycin is a reference antibiotic against methicillin-resistant staphylococci. Its administration is associated with infusion-related local complications (IRLC). To reduce this risk, it has been proposed to increase vancomycin dilution in ...

    Abstract Background: Vancomycin is a reference antibiotic against methicillin-resistant staphylococci. Its administration is associated with infusion-related local complications (IRLC). To reduce this risk, it has been proposed to increase vancomycin dilution in the IV bag and to perform continuous infusion using the volumetric pump. The aim of our study was to assess the safety of peripheral infusion of vancomycin with the volumetric pump.
    Objectives: To compare the frequency of IRLC between patients receiving vancomycin and those receiving β-lactam (BL) antibiotics. Our secondary objective was to assess factors associated with the occurrence of IRLC.
    Patients and methods: We conducted a prospective observational study in a French tertiary hospital. Between February 2021 and November 2021, we included all patients receiving continuous infusions of vancomycin or BL through a peripherally inserted venous catheter (PIVC). The primary endpoint was the occurrence of IRLC on Day 1 (D1).
    Results: We included 168 patients (56 vancomycin, 112 BL). At D1, 14 patients (25%) presented IRLC in the vancomycin group versus 11 patients (10%) in the BL group (P = 0.01). There was significantly more IRLC in the group receiving vancomycin at an infused concentration above 5 mg/mL than those receiving BL (8/15, 53.3% versus 11/112, 10%, respectively, P < 0.01). However, no significant difference was observed between patients receiving infused vancomycin concentration ≤5 mg/mL and patients receiving BL (P = 0.4).
    Conclusion: Our data support safe administration of vancomycin if infused at a concentration under 5 mg/mL, through the volumetric pump on PIVC.
    MeSH term(s) Humans ; Vancomycin/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Infusions, Intravenous ; Staphylococcus ; Catheters
    Chemical Substances Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad044
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