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Article ; Online: Yu-Ping-Feng-San alleviates inflammation in atopic dermatitis mice by TLR4/MyD88/NF-κB pathway.

Nie, Jing / Jiang, Xiaoyuan / Wang, Guomi / Xu, Yanan / Pan, Rui / Yu, Wantao / Li, Yuanwen / Wang, Jingxiao

2024 Volume 329, Page(s) 118092

Abstract: Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula ...

Abstract	Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula that has therapeutic effects on allergic diseases such as allergic rhinitis and asthma. However, its potential efficacy and mechanism in the treatment of atopic dermatitis (AD) has not been extensively illustrated. Aim of the study: The purpose of this study was to investigate the efficacy and possible mechanisms of YPF in AD pathogenesis. Methods: Network pharmacology and GEO data mining were adopted to firstly identify the potential mechanisms of YPF on AD. Then DNCB induced-AD murine model was established to test the efficacy of YPF and verify its effects on inflammatory cytokines and NF-κB pathway. In addition, molecular docking was performed to detect the binding affinity of YPF's active components with NF-κB pathway related molecules. Results: Network pharmacology and human data mining suggested that YPF may act on the NF-κB pathway in AD pathogenesis. With DNCB mice model, we found that YPF significantly improved AD symptoms, reduced SCORAD scores, and alleviated skin tissue inflammation in mice. At the same time, the expression of inflammatory cytokines, TNF-α, sPLA2-IIA and IL-6, was down-regulated. Moreover, YPF suppressed TLR4/MyD88/NF-κB pathway in situ in a dose-dependent manner. Molecular docking further confirmed that seven compounds in YPF had exceptional binding properties with TNF-α, IL-6 and TLR4. Conclusion: YPF may help the recovery of AD by inhibiting the TLR4/MyD88/NF-κB pathway, which provides novel insights for the treatment of AD by YPF.
Language	English
Publishing date	2024-04-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118092
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Article: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise

Wang, Di / Li, Quan / Pan, Chun-Shui / Yan, Li / Sun, Kai / Wang, Xiao-Yi / Anwaier, Gulinigaer / Liao, Qian-Zan / Xie, Ting-Ting / Fan, Jing-Yu / Huo, Xin-Mei / Wang, Yuan / Han, Jing-Yan

Frontiers in pharmacology

2022 Volume 13, Page(s) 891802

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.891802
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Article ; Online: Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise via Regulation of Cytoskeleton

Di Wang / Quan Li / Chun-Shui Pan / Li Yan / Kai Sun / Xiao-Yi Wang / Gulinigaer Anwaier / Qian-Zan Liao / Ting-Ting Xie / Jing-Yu Fan / Xin-Mei Huo / Yuan Wang / Jing-Yan Han

Frontiers in Pharmacology, Vol

2022 Volume 13

Abstract: Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used ...

Abstract	Background: Yu-ping-feng powder (YPF) is a compound traditional Chinese medicine extensively used in China for respiratory diseases. However, the role of YPF in alveolar-capillary barrier dysfunction remains unknown. This study aimed to explore the effect and potential mechanism of YPF on alveolar-capillary barrier injury induced by exhausted exercise.Methods: Male Sprague–Dawley rats were used to establish an exhausted-exercise model by using a motorized rodent treadmill. YPF at doses of 2.18 g/kg was administrated by gavage before exercise training for 10 consecutive days. Food intake-weight/body weight, blood gas analysis, lung water percent content, BALF protein concentration, morphological observation, quantitative proteomics, real-time PCR, and Western blot were performed. A rat pulmonary microvascular endothelial cell line (PMVEC) subjected to hypoxia was applied for assessing the related mechanism.Results: YPF attenuated the decrease of food intake weight/body weight, improved lung swelling and hemorrhage, alleviated the increase of lung water percent content and BALF protein concentration, and inhibited the impairment of lung morphology. In addition, YPF increased the expression of claudin 3, claudin 18, occludin, VE-cadherin, and β-catenin, attenuated the epithelial and endothelial hyperpermeability in vivo and/or in vitro, and the stress fiber formation in PMVECs after hypoxia. Quantitative proteomics discovered that the effect of YPF implicated the Siah2-ubiquitin-proteasomal pathway, Gng12-PAK1-MLCK, and RhoA/ROCK, which was further confirmed by Western blot. Data are available via ProteomeXchange with identifier PXD032737.Conclusion: YPF ameliorated alveolar-capillary barrier injury induced by exhausted exercise, which is accounted for at least partly by the regulation of cytoskeleton.
Keywords	traditional Chinese medicine ; lung injury ; proteomics ; cell junctions ; stress fiber ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical profiling and mechanistic studies of Zhi-Shang-Feng granules against influenza virus by high-performance liquid chromatography coupled with Q exactive focus hybrid quadrupole orbitrap high-resolution mass spectrometry in combination with network pharmacology analysis.

Xie, Yuan-Yuan / Luo, Jia-Yi / Hu, Hong / Pan, Juan / Jiang, Meng / Wang, Shu-Mei

Journal of separation science

2023 Volume 46, Issue 20, Page(s) e2200839

Abstract: Zhi-Shang-Feng Granules are used in the clinical treatment of influenza to relieve headaches ... responsible for therapeutic effects of Zhi-Shang-Feng g ranules against influenza virus, an analytical method ... high resolution mass spectrometry was developed and the chemical profile of Zhi-Shang-Feng granules was ...

Abstract	Zhi-Shang-Feng Granules are used in the clinical treatment of influenza to relieve headaches, chills and fever, bronchitis, nasal congestion, neuralgia and other symptoms. To decipher the components responsible for therapeutic effects of Zhi-Shang-Feng g ranules against influenza virus, an analytical method based on high-performance liquid chromatography coupled with Q exactive focus hybrid quadrupole orbitrap high resolution mass spectrometry was developed and the chemical profile of Zhi-Shang-Feng granules was characterized. Then, the identified components were used to conduct network pharmacological analysis and determine the potential mechanism of Zhi-Shang-Feng Granules. As a result, 177 compounds were putatively identified through comprehensive analysis by liquid chromatography coupled with high-resolution mass spectrometry, of which 23 compounds were unambiguously confirmed with reference standards. Components in Zhi-Shang-Feng Granules were found to specifically act on different enzymes, G-protein-coupled receptors, ion channels and transporters in the immune, endocrine, nervous, and circulatory systems. The potential mechanism was related to several biological processes, including cell growth and death, pattern recognition receptor signalling, signalling by interleukins, and lipid metabolism. The combination of chemical profile characterization and network construction provided useful insight into the overall chemical composition of Zhi-Shang-Feng granules and revealed their potential anti-infection, anti-inflammatory and immunoregulatory mechanisms against influenza virus infected disease.
MeSH term(s)	Chromatography, High Pressure Liquid ; Network Pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Mass Spectrometry/methods ; Orthomyxoviridae
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-08-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202200839
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Article ; Online: Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei.

Su, Chen / Fan, Depeng / Pan, Luqing / Lu, Yusong / Wang, Yuxuan / Zhang, Mengyu

Fish & shellfish immunology

2020 Volume 105, Page(s) 104–116

Abstract: A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides ...

Abstract	A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides (YPS) containing Astragalus polysaccharides (APS), Atractylodes macrocephala polysaccharides (AMP) and Saposhnikoviae polysaccharides (SPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei. Seven hundred and twenty shrimp (3.04 ± 0.33 g) were fed the following diets: Control, YPS1 (0.13% APS + 0.0325% AMP + 0.0325% SPS), YPS2 (0.13% APS + 0.0325% AMP + 0.065% SPS) and YPS3 (0.13% APS + 0.0325% AMP+0.0975% SPS). After 14 and 28 days of feeding, the immune responses of hemocytes and intestine were measured. Intestinal microbiota and growth performance were measured after 28 days of feeding, after that, a 7-day challenge test against Vibrio harveyi was conducted. A significant (P < 0.05) increase of the total haemocyte count (THC), phagocytic activity, antibacterial activity and phenoloxidase (PO) activity was observed in shrimp fed YPS diets compared to the control. Also, dietary YPS supplementation particularly YPS3 group significantly increased the expressions of immune-related genes in the hemocytes and intestine. Regarding the intestinal microbiota, the microbial diversity and richness decreased and functional genes associated with short-chain fatty acids metabolism increased in YPS groups. After Vibrio harveyi challenge, the cumulative mortality in YPS groups was significantly lower than that of the control. Besides, dietary YPS had no significant effect on growth performance of shrimp (P > 0.05). The present results suggested that YPS could be considered as potential prebiotics for aquaculture farmed shrimp.
MeSH term(s)	Animals ; Gastrointestinal Microbiome/drug effects ; Hemocytes/immunology ; Immunity, Innate/drug effects ; Intestines/immunology ; Penaeidae/growth & development ; Penaeidae/immunology ; Penaeidae/microbiology ; Polysaccharides/administration & dosage ; Random Allocation ; Vibrio/physiology
Chemical Substances	Polysaccharides
Keywords	covid19
Language	English
Publishing date	2020-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2020.07.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo.

Fan, Wentao / Zheng, Pimiao / Wang, Yang / Hao, Pan / Liu, Jianzhu / Zhao, Xiaona

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2017 Volume 93, Page(s) 146–155

Abstract: As a traditional Chinese multiherbal formula, Yu-Ping-Feng (YPF) is frequently used to treat cold ...

Abstract	As a traditional Chinese multiherbal formula, Yu-Ping-Feng (YPF) is frequently used to treat cold, flu and inflammation-associated diseases. We aimed to evaluate the immunostimulatory effects of polysaccharide isolated from YPF (YPF-PS) in vitro and in vivo. In in vitro experiment, macrophage cell proliferation, phagocytosis rate, cytokine and costimulatory molecule release, T lymphocyte proliferation, cell cycle distribution, CD4
Language	English
Publishing date	2017-09
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2017.05.138
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Ud II Zs.198: Show issues

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Article ; Online: Feng-liao-chang-wei-kang is synergistic with 5-fluorouracil in inhibiting proliferation of colorectal cancer

Pan-Li Ni / Shu-Hong Tian / Zhao-Xin Yang / Jun-Qing Zhang / Fan Yang / Li-Fan Zhong / Lian-Fang Gan / Mian-Qing Huang / Ling Huang

Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 14, Pp 41-

2019 Volume 53

Abstract: Objective: To explore the effect of Feng-liao-chang-wei-kang (FLCWK) on acute and chronic ...

Abstract	Objective: To explore the effect of Feng-liao-chang-wei-kang (FLCWK) on acute and chronic gastroenteritis, synergistic effect on the growth inhibitory effect with 5-fluorouracil (5-FU) on colorectal cancer and its underlying mechanisms. Methods: In the in vitro study, HT-29 cells were divided into 5-FU alone, FLCWK alone and coadministration groups. The MTT assay was used to analyze the proliferation of HT-29 cells at 24 h. Flow cytometry was used to observe the apoptosis, cycle of colorectal cancer HT-29 cells at 24 h. In the in vivo experiment, The subcutaneous transplantation tumor model of colorectal cancer HT-29-Luc was established with nude mice. All mice were randomly divided into 5-FU alone, FLCWK alone and coadministration groups according to body weight. During administration, the Interactive Video Information System small animal live imaging system was used to monitor the growth of subcutaneous transplantation in nude mice. The model of colitis-associated colorectal cancer (CACC) was established with BALB/c mice. BALB/c mice were randomly divided into the normal control group, the model control group, and the FLCWK group. At the end of the administration, the pathological status was detected by HE staining. Cell apoptosis of tumor tissue tumor and colon tissues were observed by TUNEL staining and TUNEL green fluorescence. The protein expression of Caspase 3, p-STAT3, Bcl-2, Bax and P-gp in tumor tissues tumor and colon tissues were tested by using immunohistochemical assay. Results: FLCWK and 5-FU coadministration suppressed HT-29 cell viability and induced S phase arrest and apoptosis compared to treatment with 5-FU alone. Furthermore, compared to treatment with 5-FU alone, coadministration of FLCWK and 5-FU obviously reduced tumor volume and weight and induced apoptosis through decreasing p-STAT3 and P-gp and increasing Caspase 3 protein expression in a murine xenograft tumor model. Moreover, the result revealed decreased number and size of tumors following FLCWK protective administration, downregulated p-STAT3 and Bcl-2 levels and upregulated Bax and Caspase 3 expression in mice with CACC. Conclusions: FLCWK has synergistic effects with 5-FU on colorectal cancer by suppressing the STAT3 pathway and downregulating P-gp expression. Furthermore, FLCWK administration suppresses CACC tumorigenesis by inhibiting the STAT3 pathway.
Keywords	colorectal cancer ; flcwk ; 5-fluorouracil ; synergistic effect ; colitis-associated colorectal cancer ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei

Su, Chen / Fan, Depeng / Pan, Luqing / Lu, Yusong / Wang, Yuxuan / Zhang, Mengyu

Fish & shellfish immunology. 2020 Oct., v. 105

2020

Abstract: A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides ...

Abstract	A 28-day feeding trial was conducted to investigate the effects of Yu-Ping-Feng polysaccharides (YPS) containing Astragalus polysaccharides (APS), Atractylodes macrocephala polysaccharides (AMP) and Saposhnikoviae polysaccharides (SPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei. Seven hundred and twenty shrimp (3.04 ± 0.33 g) were fed the following diets: Control, YPS1 (0.13% APS + 0.0325% AMP + 0.0325% SPS), YPS2 (0.13% APS + 0.0325% AMP + 0.065% SPS) and YPS3 (0.13% APS + 0.0325% AMP+0.0975% SPS). After 14 and 28 days of feeding, the immune responses of hemocytes and intestine were measured. Intestinal microbiota and growth performance were measured after 28 days of feeding, after that, a 7-day challenge test against Vibrio harveyi was conducted. A significant (P < 0.05) increase of the total haemocyte count (THC), phagocytic activity, antibacterial activity and phenoloxidase (PO) activity was observed in shrimp fed YPS diets compared to the control. Also, dietary YPS supplementation particularly YPS3 group significantly increased the expressions of immune-related genes in the hemocytes and intestine. Regarding the intestinal microbiota, the microbial diversity and richness decreased and functional genes associated with short-chain fatty acids metabolism increased in YPS groups. After Vibrio harveyi challenge, the cumulative mortality in YPS groups was significantly lower than that of the control. Besides, dietary YPS had no significant effect on growth performance of shrimp (P > 0.05). The present results suggested that YPS could be considered as potential prebiotics for aquaculture farmed shrimp.
Keywords	Astragalus ; Atractylodes macrocephala ; Litopenaeus vannamei ; Vibrio harveyi ; antibacterial properties ; aquaculture ; disease resistance ; fish ; growth performance ; hemocytes ; immune response ; intestinal microorganisms ; intestines ; monophenol monooxygenase ; mortality ; phagocytosis ; polysaccharides ; prebiotics ; shellfish ; shrimp
Language	English
Dates of publication	2020-10
Size	p. 104-116.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2020.07.003
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online ; E-Book: Multi-modal EEG monitoring of severely neurologically ill patients

Wang, Xuefeng / Li, Feng / Pan, Suyue

2022

Title variant	Multi-modal EEG-monitoring of severely neurologically ill patients ; Multi modal EEG monitoring of severely neurologically ill patients
Author's details	Xuefeng Wang, Feng Li, Suyue Pan editors
Keywords	Neurology
Subject code	616.8
Language	English
Size	1 Online-Ressource (xiii, 360 Seiten), Illustrationen, Diagramme
Publisher	Springer
Publishing place	Singapore
Publishing country	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021142413
ISBN	978-981-16-4493-1 ; 9789811644924 ; 9789811644948 ; 9789811644955 ; 981-16-4493-4 ; 9811644926 ; 9811644942 ; 9811644950
DOI	10.1007/978-981-16-4493-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Thesis: Enhancement of irreversible electroporation by transarterial injection of lidocaine as a cell sensitizer

Pan, Feng / Sommer, Christof-Matthias

an experimental in vivo liver study

2019

Institution	Universität Heidelberg
Author's details	vorgelegt von Feng Pan ; Doktorvater: Priv.-Doz. Dr. med. Christof-Matthias Sommer
Language	English
Size	VI, 61 Seiten, Illustrationen, Diagramme
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
Note	Text auf Englisch, Zusammenfassung auf Englisch und Deutsch
HBZ-ID	HT021379315
Database	Catalogue ZB MED Medicine, Health

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