Article ; Online: Diversity, localization, and (patho)physiology of mature lymphocyte populations in the bone marrow.
2021 Volume 137, Issue 22, Page(s) 3015–3026
Abstract: The bone marrow (BM) is responsible for generating and maintaining lifelong output of blood and immune cells. In addition to its key hematopoietic function, the BM acts as an important lymphoid organ, hosting a large variety of mature lymphocyte ... ...
| Abstract | The bone marrow (BM) is responsible for generating and maintaining lifelong output of blood and immune cells. In addition to its key hematopoietic function, the BM acts as an important lymphoid organ, hosting a large variety of mature lymphocyte populations, including B cells, T cells, natural killer T cells, and innate lymphoid cells. Many of these cell types are thought to visit the BM only transiently, but for others, like plasma cells and memory T cells, the BM provides supportive niches that promote their long-term survival. Interestingly, accumulating evidence points toward an important role for mature lymphocytes in the regulation of hematopoietic stem cells (HSCs) and hematopoiesis in health and disease. In this review, we describe the diversity, migration, localization, and function of mature lymphocyte populations in murine and human BM, focusing on their role in immunity and hematopoiesis. We also address how various BM lymphocyte subsets contribute to the development of aplastic anemia and immune thrombocytopenia, illustrating the complexity of these BM disorders and the underlying similarities and differences in their disease pathophysiology. Finally, we summarize the interactions between mature lymphocytes and BM resident cells in HSC transplantation and graft-versus-host disease. A better understanding of the mechanisms by which mature lymphocyte populations regulate BM function will likely improve future therapies for patients with benign and malignant hematologic disorders. |
|---|---|
| MeSH term(s) | Allografts ; Animals ; Bone Marrow Cells/immunology ; Bone Marrow Cells/pathology ; Cell Movement/immunology ; Graft vs Host Disease/immunology ; Graft vs Host Disease/pathology ; Graft vs Host Disease/physiopathology ; Graft vs Host Disease/therapy ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/pathology ; Hematologic Neoplasms/physiopathology ; Hematologic Neoplasms/therapy ; Hematopoiesis/immunology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/pathology ; Humans ; Immunity, Innate ; Lymphocytes/immunology ; Lymphocytes/pathology ; Mice ; Thrombocytopenia/immunology ; Thrombocytopenia/pathology ; Thrombocytopenia/physiopathology ; Thrombocytopenia/therapy |
| Language | English |
| Publishing date | 2021-03-08 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 80069-7 |
| ISSN | 1528-0020 ; 0006-4971 |
| ISSN (online) | 1528-0020 |
| ISSN | 0006-4971 |
| DOI | 10.1182/blood.2020007592 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uh III Zs.140: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 364: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.