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Article ; Online: A Narrative Review of the Clinical Trials in Sleep-Related Breathing Disorders from 2022 to Present.

Pıhtılı, Aylin / Gündüz Gürkan, Canan / Habeşoğlu, Mehmet Ali / Öztürk, Önder / Özsancak Uğurlu, Aylin / Taşbakan, Mehmet Sezai / Peker, Yüksel / Sleep Related Breathing Disorders Working Group, On Behalf Of The Turkish Thoracic Society

Thoracic research and practice

2023

Abstract: Sleep-related breathing disorders (SRBD) comprise obstructive sleep apnea (OSA), central sleep apnea (CSA), obesity-hypoventilation syndrome (OHS), as well as isolated sleep-related hypoxemia (ISRH), according to the recent International Classification ... ...

Abstract	Sleep-related breathing disorders (SRBD) comprise obstructive sleep apnea (OSA), central sleep apnea (CSA), obesity-hypoventilation syndrome (OHS), as well as isolated sleep-related hypoxemia (ISRH), according to the recent International Classification of Sleep Disorders 3. During the last decades, there have been cumulative research reports indicating an association between the SRBD and increased cardiometabolic illness and death, as well as decreased quality of life. Notwithstanding, the results have been inconclusive, and the evidence level was not high regarding the effect of treatment for the SRBD on adverse outcomes. In the current work, we aim to give a comprehensive review of the clinical trials published from January 2022 to August 31, 2023. We highlight the heterogeneity of cardiometabolic disorders among adults with SRBD and particularly emphasize OSA management, drug therapy for OSA, positive airway pressure (PAP) therapy and cardiovascular outcomes, other effects of PAP in pregnancy and neurocognitive function, as well as the effects of surgical treatment and oral appliances. We also underline future directions in OSA management, telemonitoring, and druginduced sleep endoscopy in managing the SRBD, especially OSA. We ascertain that more studies are needed within the CSA, OHS, and ISRH research fields.
Language	English
Publishing date	2023-11-28
Publishing country	Turkey
Document type	Journal Article
ISSN	2979-9139
ISSN (online)	2979-9139
DOI	10.5152/ThoracResPract.2023.23104
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Article: Results of Polysomnographies and Treatment Strategies in Elderly Patients with Symptoms of Obstructive Sleep Apnea Syndrome.

Balcan, Baran / Uğurlu, Aylin Özsancak

Turkish thoracic journal

2017 Volume 18, Issue 4, Page(s) 108–113

Abstract: Objectives: In this study, we evaluated data regarding the management of geriatric patients with symptoms of obstructive sleep apnea syndrome (age, >65 years) who were admitted to our sleep clinic.: Material and methods: Symptoms and sleep data of ... ...

Abstract	Objectives: In this study, we evaluated data regarding the management of geriatric patients with symptoms of obstructive sleep apnea syndrome (age, >65 years) who were admitted to our sleep clinic. Material and methods: Symptoms and sleep data of the patients were retrospectively evaluated, and the patients were reevaluated after treatment. Results: A total of 85 patients with a median age of 69 years were included. Snoring and fatigue were the most common symptoms. Cardiovascular diseases were the most frequently listed comorbidity. The median Epworth sleepiness scale was 10, and based on Berlin sleep questionnaire findings, 63.5% of the participants were in the high-risk group. Eighty-seven percent were diagnosed with obstructive sleep apnea (2/3 of them were positional), and moderate-to-severe obstructive sleep apnea was observed more in women than in men. Only one patient was diagnosed with central sleep apnea. There were positive and linear correlations between increased age and the apnea-hypopnea index, arousal index, Epworth sleepiness scale, and being in a high-risk group according to the Berlin sleep scale; however, there was no correlation between increased age and the number of hypopnea and apnea events. There were also positive and linear correlations between the apnea-hypopnea index and the Epworth sleepiness scale, being in a high-risk group according to the Berlin sleep questionnaire, an increased number of known medical conditions, and increased body mass index. We were able to contact 72 of the 85 patients via phone calls. Patients who adjusted to treatment had positive feedbacks. Conclusion: Sleep disorders are observed more in the elderly, and an increasing age is an independent factor for sleep disorders. Besides the usual signs and symptoms of sleep disorders, it should be considered in elderly who have cognitive dysfunction and dementia.
Language	English
Publishing date	2017-07-21
Publishing country	Turkey
Document type	Journal Article
ISSN	2148-7197
ISSN	2148-7197
DOI	10.5152/TurkThoracJ.2017.17019
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Article: Altered pulmonary functions due to biomass smoke in a rural population of Turkish women: a descriptive study.

Balcan, Baran / Akan, Selçuk / Özsancak Uğurlu, Aylin / Ceyhan, Berrin

Tuberkuloz ve toraks

2018 Volume 66, Issue 2, Page(s) 122–129

Abstract: Introduction: Wood or other organic sources of fuel are used as source of energy for heating or cooking particularly in developing countries. The aim of the current study was to evaluate the association between biomass exposure time and parameters of ... ...

Title translation	Kırsal alanda yaşayan kadınlarda biyomas dumanına bağlı solunum fonksiyon kapasitesinde bozulma.
Abstract	Introduction: Wood or other organic sources of fuel are used as source of energy for heating or cooking particularly in developing countries. The aim of the current study was to evaluate the association between biomass exposure time and parameters of pulmonary function tests. Materials and methods: Four hundred twenty-four consecutive women who lived and exposed to biomass smoke in a small province in Eastern Turkey were involved. This study was performed with women who had come to pulmonology out-patient clinic with symptom of dyspnea. Result: The independent variables assessed in the study patients were age, BMI, starting age of cooking, hours per day and weeks per month spent cooking, and cooking years; the dependent variables were PFT parameters. Ninety-two (21.6%) patients had an obstructive PFT pattern. Sixty-seven (73%) of these patients were classified as GOLD 2 and 25 (27%) patients were classified as GOLD 3. Seventy-five (17.6 %) of the patients had restrictive lung disease; 54 (72%) of these patients were found to have a mild and 21 (27%) had a moderate restrictive pattern. Increased number of years in cooking and to start cooking at younger ages were a risk factors for the development of obstructive and restrictive disease. There was a statistically significant and negative correlation between increased number of years and the value of FEV Conclusions: Cumulative biomass exposure time is associated with impairment in PFT parameters; results in both obstructive and restrictive lung disease. Biomass exposure is a public health problem and pre-cautions should be taken in order to prevent impaired pulmonary functions.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Air Pollution, Indoor/adverse effects ; Biomass ; Cooking ; Female ; Humans ; Incidence ; Lung/physiopathology ; Lung Diseases/epidemiology ; Lung Diseases/physiopathology ; Middle Aged ; Respiratory Function Tests ; Risk Factors ; Rural Population ; Smoke/adverse effects ; Turkey/epidemiology ; Wood ; Young Adult
Chemical Substances	Smoke
Language	English
Publishing date	2018-07-06
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2468802-2
ISSN	0494-1373
ISSN	0494-1373
DOI	10.5578/tt.54027
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Article ; Online: Home Noninvasive Ventilation to Reduce Readmissions for Chronic Obstructive Pulmonary Disease.

Hill, Nicholas S / Ugurlu, Aylin Ozsancak

JAMA

2017 Volume 317, Issue 21, Page(s) 2167–2169

MeSH term(s)	Humans ; Noninvasive Ventilation ; Patient Readmission ; Pulmonary Disease, Chronic Obstructive ; Respiration, Artificial ; Respiratory Insufficiency
Language	English
Publishing date	2017--06
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2017.5226
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Ua VI Zs.88: Show issues

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Article ; Online: Epidemiology of NIV for Acute Respiratory Failure in COPD Patients: Results from the International Surveys vs. the "Real World".

Ozsancak Ugurlu, Aylin / Habesoglu, Mehmet Ali

COPD

2017 Volume 14, Issue 4, Page(s) 429–438

Abstract: Non-invasive ventilation (NIV) has been recommended as the first-line ventilation modality for acute respiratory failure (ARF) due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) based on strong evidence. However, everyday ... ...

Abstract	Non-invasive ventilation (NIV) has been recommended as the first-line ventilation modality for acute respiratory failure (ARF) due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) based on strong evidence. However, everyday clinical practice may differ from findings of multiple randomized controlled trials. Physicians and respiratory therapists involved in NIV management have been queried about its utilization and effectiveness. In addition to these estimates, cohort studies and analysis of large inpatient dataset of patients with AECOPD and ARF managed with NIV have been extensively published over the last two decades. This review summarizes the perception of medical staff vs. the "real life" data about NIV use for ARF in AECOPD patients.
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2171107-0
ISSN	1541-2563 ; 1541-2555
ISSN (online)	1541-2563
ISSN	1541-2555
DOI	10.1080/15412555.2017.1336527
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Zs.A 5990: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Combined catheter thrombus fragmentation and percutaneous thrombectomy in a patient with massive pulmonary emboli and acute cerebral infarct.

Özsancak Uğurlu, Aylin / Çınar, Özlem / Caymaz, İsmail / Çevik, Halime / Gümüş, Burçak

Anatolian journal of cardiology

2015 Volume 15, Issue 1, Page(s) 72–74

MeSH term(s)	Catheterization/instrumentation ; Cerebral Infarction/complications ; Cerebral Infarction/diagnosis ; Cerebral Infarction/therapy ; Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/therapy ; Thrombectomy/instrumentation ; Thrombolytic Therapy ; Tomography, X-Ray Computed
Language	English
Publishing date	2015-01
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ISSN	2149-2271
ISSN (online)	2149-2271
DOI	10.5152/akd.2014.5765
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Article ; Online: Cardiotoxicity following cyclophosphamidetherapy: a case report.

Atalay, Figen / Gulmez, Oyku / Ozsancak Ugurlu, Aylin

Journal of medical case reports

2014 Volume 8, Page(s) 252

Abstract: Introduction: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced ...

Abstract	Introduction: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. Case presentation: A 66-year-old Caucasian woman with a mediastinal mass diagnosed with Burkitt lymphoma underwent chemotherapy with rituximab-hyperfractionated-cyclophosphamide-vincristine-doxorubicin-dexamethasone. On the seventh day of chemotherapy, she developed dyspnea. An electrocardiogram demonstrated low voltage in the limb and precordial leads. It also showed diffusely increased myocardial echogenicity, mild pericardial and pleural effusion, generally impaired biventricular systolic functions with a left ventricular ejection fraction of 31%, and right ventricular mid-apical akinesia, even though she had normal biventricular functions before chemotherapy. Cyclophosphamide-induced cardiotoxicity was suspected and she was given treatment for congestive heart failure. Her dyspnea decreased and she was discharged on the tenth day with a left ventricular ejection fraction of 37% and normal right ventricular function. After 1 month, echocardiography showed normal biventricular functions with a left ventricular ejection fraction of 60%. Conclusions: Drug-induced cardiotoxicity, therefore, should be taken into consideration when using cyclophosphamide therapy, especially when anthracyclines are co-administered. Close communication between hematologists and cardiologists is required.
MeSH term(s)	Aged ; Antineoplastic Agents, Alkylating/toxicity ; Burkitt Lymphoma/drug therapy ; Cardiotoxicity/diagnosis ; Cardiotoxicity/etiology ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/therapeutic use ; Cyclophosphamide/toxicity ; Echocardiography ; Female ; Heart Failure/chemically induced ; Humans ; Pericardial Effusion/chemically induced ; Pleural Effusion/chemically induced ; Stroke Volume/drug effects ; Ventricular Dysfunction/chemically induced ; Ventricular Dysfunction/diagnosis
Chemical Substances	Antineoplastic Agents, Alkylating ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2014-07-14
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/1752-1947-8-252
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Article ; Online: Effects of Noninvasive Versus Invasive Mechanical Ventilation on Sleep in the Intensive Care Unit – A Pilot Study

Aylin Ozsancak Ugurlu / Karthik Jothianandan / Carolyn M. D'Ambrosio / Samy Sidhom / Eric Garpestad / Nicholas S. Hill

European Medical Journal Respiratory, Vol 8, Iss 1, Pp 127-

2020 Volume 136

Abstract: Rationale: Use of noninvasive ventilation (NIV) has increased in intensive care units, but sleep during NIV has received little attention. The authors surmised that due to frequent air leaks and mask discomfort, patients receiving NIV would manifest ... ...

Abstract	Rationale: Use of noninvasive ventilation (NIV) has increased in intensive care units, but sleep during NIV has received little attention. The authors surmised that due to frequent air leaks and mask discomfort, patients receiving NIV would manifest poorer sleep quality than those receiving invasive mechanical ventilation (INV). Methods: A prospective observational study on patients receiving NIV or INV for respiratory failure in a medical intensive care unit or coronary care unit. Patients were monitored by polysomnography for 24 hours with simultaneous collection of data on ventilator and environmental parameters. Results: Eight subjects in each group were studied. Mean total sleep time was 7.29 +1.78 hours (range: 0.57–13.82) in the NIV versus 11.74 +0.65 hours (8.95–15.19) in the INV group (p=0.034). Sleep efficiency was lower in NIV than INV group (30.4% versus 53.3%, respectively; p=0.013). The NIV group had lighter sleep than the INV group (mean % of Stage 1: 36.9% versus 17.2% of total sleep time, respectively; p=0.000), whereas no significant differences were found for other stages. Median total arousal and awakening indexes were higher in the NIV group (16.8/hour versus 4.4/hour and 5.3/hour versus 2.1/hour, respectively; p=0.005), as well as spontaneous arousals and awakenings (p=0.006 and p=0.005, respectively). Sedation was provided mostly by intermittent bolus in the NIV group whereas often by infusion in the INV group. Conclusion: Compared to INV, NIV in critically ill patients was associated with poorer quality and quantity of sleep. Future studies should determine whether adjustments in ventilator settings, mask type or fit, or use of sedation/analgaesia can improve sleep in patients receiving NIV.
Keywords	intensive care unit (icu) ; invasive mechanical ventilation (inv) ; noninvasive ventilation (niv) ; polysomnography (psg) ; Medicine ; R ; Diseases of the respiratory system ; RC705-779
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	European Medical Journal
Document type	Article ; Online
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Article ; Online: ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure.

The European respiratory journal

2022 Volume 59, Issue 4

Abstract: Background: High-flow nasal cannula (HFNC) has become a frequently used noninvasive form of respiratory support in acute settings; however, evidence supporting its use has only recently emerged. These guidelines provide evidence-based recommendations ... ...

Abstract	Background: High-flow nasal cannula (HFNC) has become a frequently used noninvasive form of respiratory support in acute settings; however, evidence supporting its use has only recently emerged. These guidelines provide evidence-based recommendations for the use of HFNC alongside other noninvasive forms of respiratory support in adults with acute respiratory failure (ARF). Materials and methodology: The European Respiratory Society task force panel included expert clinicians and methodologists in pulmonology and intensive care medicine. The task force used the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) methods to summarise evidence and develop clinical recommendations for the use of HFNC alongside conventional oxygen therapy (COT) and noninvasive ventilation (NIV) for the management of adults in acute settings with ARF. Results: The task force developed eight conditional recommendations, suggesting the use of 1) HFNC over COT in hypoxaemic ARF; 2) HFNC over NIV in hypoxaemic ARF; 3) HFNC over COT during breaks from NIV; 4) either HFNC or COT in post-operative patients at low risk of pulmonary complications; 5) either HFNC or NIV in post-operative patients at high risk of pulmonary complications; 6) HFNC over COT in nonsurgical patients at low risk of extubation failure; 7) NIV over HFNC for patients at high risk of extubation failure unless there are relative or absolute contraindications to NIV; and 8) trialling NIV prior to use of HFNC in patients with COPD and hypercapnic ARF. Conclusions: HFNC is a valuable intervention in adults with ARF. These conditional recommendations can assist clinicians in choosing the most appropriate form of noninvasive respiratory support to provide to patients in different acute settings.
MeSH term(s)	Adult ; Cannula ; Humans ; Noninvasive Ventilation/methods ; Oxygen ; Oxygen Inhalation Therapy/methods ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-04-14
Publishing country	England
Document type	Journal Article ; Practice Guideline
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.01574-2021
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Timing of noninvasive ventilation failure: causes, risk factors, and potential remedies.

Ozyilmaz, Ezgi / Ugurlu, Aylin Ozsancak / Nava, Stefano

BMC pulmonary medicine

2014 Volume 14, Page(s) 19

Abstract: Background: Identifying the predictors of noninvasive ventilation (NIV) failure has attracted significant interest because of the strong link between failure and poor outcomes. However, very little attention has been paid to the timing of the failure. ... ...

Abstract	Background: Identifying the predictors of noninvasive ventilation (NIV) failure has attracted significant interest because of the strong link between failure and poor outcomes. However, very little attention has been paid to the timing of the failure. This narrative review focuses on the causes of NIV failure and risk factors and potential remedies for NIV failure, based on the timing factor. Results: The possible causes of immediate failure (within minutes to <1 h) are a weak cough reflex, excessive secretions, hypercapnic encephalopathy, intolerance, agitation, and patient-ventilator asynchrony. The major potential interventions include chest physiotherapeutic techniques, early fiberoptic bronchoscopy, changing ventilator settings, and judicious sedation. The risk factors for early failure (within 1 to 48 h) may differ for hypercapnic and hypoxemic respiratory failure. However, most cases of early failure are due to poor arterial blood gas (ABGs) and an inability to promptly correct them, increased severity of illness, and the persistence of a high respiratory rate. Despite a satisfactory initial response, late failure (48 h after NIV) can occur and may be related to sleep disturbance. Conclusions: Every clinician dealing with NIV should be aware of these risk factors and the predicted parameters of NIV failure that may change during the application of NIV. Close monitoring is required to detect early and late signs of deterioration, thereby preventing unavoidable delays in intubation.
MeSH term(s)	Humans ; Noninvasive Ventilation ; Pulmonary Disease, Chronic Obstructive/therapy ; Risk Factors ; Time Factors ; Treatment Failure
Language	English
Publishing date	2014-02-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/1471-2466-14-19
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