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  1. Article ; Online: Autosomal dominant chronic tubulointerstitial nephropathy: do not forget amyloidosis.

    Bridoux, Frank / Nasr, Samih H

    Kidney international

    2024  Volume 105, Issue 4, Page(s) 666–669

    Abstract: Amyloidosis is a rare cause of inherited kidney disease, with most variants responsible for prominent glomerular involvement. In this issue, Kmochová et al. reported the first description of autosomal dominant medullary amyloidosis due to apolipoprotein ... ...

    Abstract Amyloidosis is a rare cause of inherited kidney disease, with most variants responsible for prominent glomerular involvement. In this issue, Kmochová et al. reported the first description of autosomal dominant medullary amyloidosis due to apolipoprotein A4 variants, resulting in slowly progressive chronic kidney disease with minimal proteinuria. Combining next-generation sequencing with histopathological studies incorporating Congo red staining and mass spectrometry should be considered in the diagnostic workup of hereditary tubulointerstitial disorders not identified after routine genetic testing.
    MeSH term(s) Humans ; Nephritis, Interstitial/diagnosis ; Nephritis, Interstitial/genetics ; Nephritis, Interstitial/complications ; Amyloidosis/diagnosis ; Amyloidosis/genetics ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/genetics ; Genetic Testing
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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  2. Article ; Online: 2024 Update on Classification, Etiology, and Typing of Renal Amyloidosis.

    Leung, Nelson / Nasr, Samih H

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2024  

    Abstract: Amyloidosis is a protein folding disease that causes organ injuries and even death. In humans, 42 proteins are now known to cause amyloidosis. Some proteins become amyloidogenic as a result of a pathogenic variant as seen in hereditary amyloidoses. In ... ...

    Abstract Amyloidosis is a protein folding disease that causes organ injuries and even death. In humans, 42 proteins are now known to cause amyloidosis. Some proteins become amyloidogenic as a result of a pathogenic variant as seen in hereditary amyloidoses. In acquired forms of amyloidosis, the proteins form amyloid in their wild-type state. Four types (serum amyloid A (AA), transthyretin (ATTR), apolipoprotein AIV (ApoAIV), and beta-2-macroglobulin (AB2m)) of amyloid can occur either as acquired or as a mutant. Iatrogenic amyloid from injected protein medications have also been reported and AIL1RAP (anakinra) has been recently found to involve the kidney. Finally, the mechanism of how leukocyte cell derived chemotaxin-2 (ALECT2) forms amyloid remains unknown. This paper will review amyloids that involve the kidney and how they are typed.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2024.01.530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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  3. Article ; Online: Posaconazole-induced podocyte phospholipidosis.

    Gilani, Sarwat / Nasr, Samih H / Sethi, Sanjeev

    Kidney international

    2022  Volume 101, Issue 3, Page(s) 654

    MeSH term(s) Humans ; Lipidoses/chemically induced ; Podocytes ; Triazoles/adverse effects
    Chemical Substances Triazoles ; posaconazole (6TK1G07BHZ)
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  4. Article ; Online: Novel approaches beyond standard immunofluorescence for kidney biopsies.

    Santoriello, Dominick / Nasr, Samih H

    Current opinion in nephrology and hypertension

    2022  Volume 31, Issue 3, Page(s) 221–227

    Abstract: Purpose of review: Immunofluorescence on frozen tissue (IF-F) utilizing antibodies against immunoglobulin (Ig) heavy and light chains (IgA, IgG and IgM, kappa and lambda) and components of classical and alternative complement pathways (C1q, C3c and C4) ... ...

    Abstract Purpose of review: Immunofluorescence on frozen tissue (IF-F) utilizing antibodies against immunoglobulin (Ig) heavy and light chains (IgA, IgG and IgM, kappa and lambda) and components of classical and alternative complement pathways (C1q, C3c and C4) is the standard of renal pathology. However, conventional IF-F has limitations, particularly in nephropathies associated with organized and/or monoclonal Ig deposits. This review will discuss new applications of established methods beyond conventional IF-F and recent novel immunohistochemical methods.
    Recent findings: The combined application of paraffin immunofluorescence (IF-P) and IgG subtype staining excluded monotypic deposits in 62-66% of DNA J homolog subfamily B member 9-associated fibrillary glomerulonephritis (FGN) with apparent monotypic deposits by IF-F, whereas IF-P unmasks IgG deposits in a subset of cases of immunotactoid glomerulopathy. A novel IF technique targeting epitopes at the junction of the Ig heavy and light chains was introduced and unmasked polytypic deposits in a subset of glomerulonephritis with apparent monotypic deposits on IF-F. A recent study described the successful application of co-detection by indexing (CODEX) multiplexed IF to visualize more than a dozen target antigens within a single kidney tissue section. Finally, immunohistochemical protocols for detection of the novel antigens in membranous nephropathy have already entered the clinical practice of renal pathology.
    Summary: Novel ancillary techniques in renal pathology have the potential to significantly enhance our ability to evaluate renal biopsies.
    MeSH term(s) Biopsy ; Female ; Fluorescent Antibody Technique ; Glomerulonephritis ; Humans ; Immunoglobulin G/metabolism ; Kidney/metabolism ; Male ; Staining and Labeling
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  5. Article ; Online: COVID-19-Associated Collapsing Glomerulopathy: An Emerging Entity.

    Nasr, Samih H / Kopp, Jeffrey B

    Kidney international reports

    2020  Volume 5, Issue 6, Page(s) 759–761

    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.04.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Atypical Antiglomerular Basement Membrane Nephritis Following Immune Checkpoint Inhibitor.

    Javaugue, Vincent / Watson, Myra J / Fervenza, Fernando C / Nasr, Samih H

    Kidney international reports

    2022  Volume 7, Issue 8, Page(s) 1913–1916

    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.04.089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Light chain crystalline podocytopathy.

    Nasr, Samih H / Conley, James / Said, Samar M

    Kidney international

    2021  Volume 100, Issue 3, Page(s) 713

    MeSH term(s) Heterocyclic Compounds ; Humans ; Kidney Diseases ; Podocytes
    Chemical Substances Heterocyclic Compounds
    Language English
    Publishing date 2021-08-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.02.031
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  8. Article ; Online: Monoclonal Gammopathy of Renal Significance.

    Leung, Nelson / Bridoux, Frank / Nasr, Samih H

    The New England journal of medicine

    2021  Volume 384, Issue 20, Page(s) 1931–1941

    MeSH term(s) Humans ; Kidney/pathology ; Kidney/physiopathology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Paraproteinemias/complications ; Paraproteinemias/diagnosis ; Paraproteinemias/pathology ; Paraproteinemias/therapy
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1810907
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    Ua VI Zs.34: Show issues Location:
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  9. Article ; Online: A Pregnant Woman With New-Onset Hypertension and Acute Kidney Injury.

    Miao, Jing / Nasr, Samih H / Zand, Ladan / Kattah, Andrea G

    Kidney international reports

    2021  Volume 7, Issue 4, Page(s) 924–929

    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.12.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Monoclonal Immunoglobulin Crystalline Membranous Nephropathy.

    Mignano, Salvatore E / Pascal, Virginie / Odioemene, Nnaemezie E / Forehand, William / Javaugue, Vincent / Said, Samar M / Sethi, Sanjeev / Sirac, Christophe / Nasr, Samih H

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2024  

    Abstract: Monoclonal immunoglobulin (MIg) crystalline nephropathies are rare lesions resulting from precipitation of MIgs in the kidney as intracellular or extracellular crystals. We describe a patient with multiple myeloma (IgGλ) and diabetes who presented with ... ...

    Abstract Monoclonal immunoglobulin (MIg) crystalline nephropathies are rare lesions resulting from precipitation of MIgs in the kidney as intracellular or extracellular crystals. We describe a patient with multiple myeloma (IgGλ) and diabetes who presented with nephrotic range proteinuria. Kidney biopsy revealed membranous nephropathy superimposed on diabetic glomerulosclerosis. Glomeruli were negative for PLA2R, THSD7A, and NELL-1. Ultrastructurally, the subepithelial deposits were composed of crystals (ranging from rhomboid to rod to needle shaped), which failed to stain for immunoglobulins by routine immunofluorescence but stained for IgG+λ by paraffin immunofluorescence after pronase digestion. RNA-based immunoglobulin repertoire sequencing performed on bone marrow aspirate identified an IgGλ (γ1) clone, which was highly atypical, combining an extensively mutated (23.6%) Ig heavy chain derived from the IGHV1-24 with low pI and unusual mutations and a light chain derived from an extremely rare germline gene (IGLV10-54). This report expands the pathologic spectrum of MIg crystalline nephropathies by describing a unique case of crystalline nephropathy with IgGλ deposits manifesting as membranous nephropathy.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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