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  1. Article ; Online: Cerebroventricular clozapine would be a viable treatment modality for clozapine-dependent schizophrenia patients with neutropenia.

    Alisky, Joseph Martin

    Medical hypotheses

    2012  Volume 79, Issue 4, Page(s) 497–499

    Abstract: The atypical antipsychotic clozapine is very effective for treatment of schizophrenia, but it causes agranulocytosis requiring drug cessation in up to 2% of cases. There has been some success rechallenging with clozapine at a later date or giving ... ...

    Abstract The atypical antipsychotic clozapine is very effective for treatment of schizophrenia, but it causes agranulocytosis requiring drug cessation in up to 2% of cases. There has been some success rechallenging with clozapine at a later date or giving granulocyte colony stimulating factor or lithium while continuing clozapine. However, there are still some patients for whom these strategies do not work yet who cannot be controlled on other medications. This paper proposes that for such individuals, cerebroventricular administration of clozapine via Ommaya catheters could allow continued use of clozapine therapy. Direct infusion into cerebrospinal fluid means far smaller amounts of drug would be needed for efficacy, and clozapine concentrates in the central nervous system where it would not be exposed to bone marrow stem cells to cause agranulocytosis. This treatment paradigm would also provide a means for court-ordered clozapine therapy and a possible delivery system for future therapeutics based on trophic factors such as brain-derived neurotrophic factor.
    MeSH term(s) Animals ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/cerebrospinal fluid ; Clozapine/administration & dosage ; Clozapine/adverse effects ; Clozapine/cerebrospinal fluid ; Humans ; Infusions, Intraventricular ; Models, Biological ; Neutropenia/etiology ; Neutropenia/prevention & control ; Schizophrenia/complications ; Schizophrenia/drug therapy
    Chemical Substances Antipsychotic Agents ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2012-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2012.06.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  2. Article ; Online: Direct renal artery injection of cyclophosphamide and corticosteroids could offer a better means for treating transplant rejection and vasculitis.

    Alisky, Joseph Martin

    Medical hypotheses

    2011  Volume 76, Issue 1, Page(s) 149–150

    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Animals ; Cyclophosphamide/administration & dosage ; Dogs ; Graft Rejection/prevention & control ; Immunosuppressive Agents/administration & dosage ; Injections, Intra-Arterial ; Renal Artery ; Vasculitis/prevention & control
    Chemical Substances Adrenal Cortex Hormones ; Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2010.10.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  3. Article ; Online: Some patients with advanced malignancies also have reversible catatonia or limbic encephalitis

    Joseph Martin Alisky

    International Journal of Cancer Therapy and Oncology, Vol 3, Iss

    2015  Volume 4

    Abstract: Two potentially treatable disorders, paraneoplastic catatonia and paraneoplastic limbic encephalitis, may be hidden within the presentation of end stage cancer patients, because catatonia and limbic encephalitis usually feature severely altered mental ... ...

    Abstract Two potentially treatable disorders, paraneoplastic catatonia and paraneoplastic limbic encephalitis, may be hidden within the presentation of end stage cancer patients, because catatonia and limbic encephalitis usually feature severely altered mental status, confusion, anorexia, and minimal responsiveness that are also common with people dying of cancer. If catatonia and limbic encephalitis are correctly diagnosed and treated, there should be definite and dramatic improvement that would translate into better quality of life and perhaps even resumption of cancer therapy. This editorial reviews basic features of catatonia and limbic encephalitis, and then presents a strategy to systematically screen for these in end stage cancer patients who are about to enter hospice. A protocol is outlined that could be adapted for clinical practice or for designing clinical studies.
    Keywords Catatonia ; Limbic Encephalitis ; Anti NMDA-receptor Encephalitis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher IJCTO
    Document type Article ; Online
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  4. Article: Minimally-responsive head injury survivors may have chronic catatonia reversed years after an accident.

    Alisky, Joseph Martin

    Singapore medical journal

    2009  Volume 50, Issue 11, Page(s) 1117–1118

    MeSH term(s) Accidents ; Benzodiazepines/administration & dosage ; Brain Injuries/therapy ; Craniocerebral Trauma/therapy ; Electroconvulsive Therapy/methods ; Fructose/administration & dosage ; Fructose/analogs & derivatives ; Humans ; Male ; Memantine/administration & dosage ; Middle Aged ; Pilot Projects ; Pyridines/administration & dosage ; Valproic Acid/administration & dosage
    Chemical Substances Pyridines ; topiramate (0H73WJJ391) ; Benzodiazepines (12794-10-4) ; Fructose (30237-26-4) ; Valproic Acid (614OI1Z5WI) ; zolpidem (7K383OQI23) ; Memantine (W8O17SJF3T)
    Language English
    Publishing date 2009-11
    Publishing country Singapore
    Document type Letter
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 589: Show issues Location:
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  5. Article ; Online: Pregnancy outcomes for women with epilepsy and bipolar disorder could be improved with intraventricular or intrathecal medication administration.

    Alisky, Joseph Martin

    Medical hypotheses

    2009  Volume 73, Issue 6, Page(s) 1073–1074

    MeSH term(s) Anticonvulsants/administration & dosage ; Antipsychotic Agents/administration & dosage ; Bipolar Disorder/complications ; Bipolar Disorder/drug therapy ; Bipolar Disorder/physiopathology ; Drug Administration Routes ; Epilepsy/complications ; Epilepsy/drug therapy ; Epilepsy/physiopathology ; Female ; Humans ; Injections, Spinal ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Complications/physiopathology ; Pregnancy Outcome
    Chemical Substances Anticonvulsants ; Antipsychotic Agents
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2009.05.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  6. Article ; Online: Splenic artery infusion of IL-2 might allow treatment of melanoma and renal cell cancer with less side effects and greater efficacy

    Joseph Martin Alisky

    International Journal of Cancer Therapy and Oncology, Vol 2, Iss

    2014  Volume 1

    Abstract: ... excluded from IL-2 by medical comorbidities. --- Cite this article as : Alisky JM. Splenic artery infusion ...

    Abstract Treatment of stave IV renal cell cancer and melanoma with intravenous interleukin-2 (IL-2) is often limited by side effects, and only a minority of patients obtain sustained remissions. This editorial proposes that infusing IL-2 into the splenic artery will allow much stronger immune activation without systemic side effects, achieving a superior clinical response and enabling treatment of patients currently excluded from IL-2 by medical comorbidities. --- Cite this article as : Alisky JM. Splenic artery infusion of IL-2 might allow treatment of melanoma and renal cell cancer with less side effects and greater efficacy. Int J Cancer Ther Oncol 2014; 2 (1):020115. DOI: http://dx.doi.org/10.14319/ijcto.0201.15
    Keywords Interleukin-2 ; Cytokines ; Treatment Protocols ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2014-02-01T00:00:00Z
    Publisher IJCTO
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Intrathecal corticosteroids might slow Alzheimer's disease progression.

    Alisky, Joseph Martin

    Neuropsychiatric disease and treatment

    2009  Volume 4, Issue 5, Page(s) 831–833

    Abstract: Anti-inflammatory drugs for treatment and prevention of Alzheimer's disease have to date proved disappointing, including a large study of low-dose prednisone, but higher dose steroids significantly reduced amyloid secretion in a small series of ... ...

    Abstract Anti-inflammatory drugs for treatment and prevention of Alzheimer's disease have to date proved disappointing, including a large study of low-dose prednisone, but higher dose steroids significantly reduced amyloid secretion in a small series of nondemented patients. In addition, there is a case report of a patient with amyloid angiopathy who had complete remission from two doses of dexamethasone, and very high dose steroids are already used for systemic amyloidosis. This paper presents the hypothesis that pulse-dosed intrathecal methylprednisolone or dexamethasone will produce detectable slowing of Alzheimer's progression, additive to that obtained with cholinesterase inhibitors and memantine. A protocol based on treatment regimens for multiple sclerosis and central nervous system lupus is outlined, to serve as a basis for formulating clinical trials. Ultimately intrathecal corticosteroids might become part of a multi-agent regimen for Alzheimer's disease and also have application for other neurodegenerative disorders.
    Language English
    Publishing date 2009-02-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/ndt.s3685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6068: Show issues Location:
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  8. Article: La inmovilidad en pacientes con demencia avanzada pudiese ser una forma de catatonia reversible por lorazepam.

    Alisky, Joseph Martin

    Revista medica de Chile

    2008  Volume 136, Issue 10, Page(s) 1359–1360

    Title translation Immobility in patients with advanced dementia may actually be a form of a Lorazepam-reversible catatonia.
    MeSH term(s) Catatonia/drug therapy ; Dementia/complications ; Dementia/drug therapy ; GABA Modulators/therapeutic use ; Humans ; Lorazepam/therapeutic use
    Chemical Substances GABA Modulators ; Lorazepam (O26FZP769L)
    Language Spanish
    Publishing date 2008-10
    Publishing country Chile
    Document type Letter
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI /S0034-98872008001000021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 402: Show issues Location:
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  9. Article ; Online: Do not overlook polymyalgia rheumatica as a cause for immobility in poorly communicating dementia patients.

    Alisky, Joseph Martin

    Southern medical journal

    2008  Volume 101, Issue 12, Page(s) 1277–1278

    MeSH term(s) Accidental Falls ; Aged ; Alzheimer Disease/diagnosis ; Anti-Inflammatory Agents/therapeutic use ; Communication Disorders/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Hypokinesia/etiology ; Polymyalgia Rheumatica/diagnosis ; Polymyalgia Rheumatica/drug therapy ; Prednisone/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2008-12
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.1097/SMJ.0b013e3181819f48
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 336: Show issues

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  10. Article: Giant cell arteritis dementia and other steroid-responsive dementia syndromes are a unique opportunity for clinicians and researchers.

    Alisky, Joseph Martin

    Singapore medical journal

    2008  Volume 49, Issue 3, Page(s) 268–270

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Dementia/etiology ; Dementia/physiopathology ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/drug therapy ; Giant Cell Arteritis/physiopathology ; Humans
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2008-03
    Publishing country Singapore
    Document type Letter
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 589: Show issues Location:
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