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Article ; Online: Reply to Arnaldo Stanzione, Massimo Imbriaco, and Renato Cuocolo's Letter to the Editor re: Marloes van der Leest, Bas Israël, Eric Bastiaan Cornel, et al. High Diagnostic Performance of Short Magnetic Resonance Imaging Protocols for Prostate Cancer Detection in Biopsy-naïve Men: The Next Step in Magnetic Resonance Imaging Accessibility. Eur Urol 2019;76:574-81. Are We Meeting Our Standards? Stringent Prostate Imaging Reporting and Data System Acquisition Requirements Might be Limiting Prostate Accessibility.

Leest, Marloes van der / Israël, Bas / Engels, Rianne R M / Barentsz, Jelle O

2019 Volume 77, Issue 3, Page(s) e58–e59

MeSH term(s)	Biopsy ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms
Language	English
Publishing date	2019-12-06
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2019.11.016
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Response to Liu and Zhou.

Song, Minkyo / Engels, Eric A

The American journal of gastroenterology

2022 Volume 117, Issue 9, Page(s) 1539

Language	English
Publishing date	2022-08-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000001857
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Ui V Zs.36: Show issues

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Article ; Online: Epidemiologic perspectives on immunosuppressed populations and the immunosurveillance and immunocontainment of cancer.

Engels, Eric A

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2019 Volume 19, Issue 12, Page(s) 3223–3232

Abstract: The advent in the last several years of effective immunotherapy for cancer has renewed interest in the role of the immune system in controlling cancer. The idea that the immune system can help control cancer has a long history. Solid organ transplant ... ...

Abstract	The advent in the last several years of effective immunotherapy for cancer has renewed interest in the role of the immune system in controlling cancer. The idea that the immune system can help control cancer has a long history. Solid organ transplant recipients (SOTRs) as well as human immunodeficiency virus (HIV)-infected people are affected by cell-mediated immune dysfunction. Epidemiologic studies of these populations reveal a pattern characterized by a strongly increased incidence of virus-related cancers (eg, Kaposi sarcoma, non-Hodgkin lymphoma, and anogenital cancers). In addition, recent epidemiologic studies have evaluated cancer-specific mortality among SOTRs and HIV-infected people following a cancer diagnosis. For a wider range of cancers-not limited to those caused by viruses, and including melanoma and cancers of the colorectum, lung, and breast- these immunosuppressed cancer patients have higher cancer-specific mortality than other cancer patients. This latter group of cancers somewhat mirrors those for which immunotherapy with checkpoint inhibitors is approved. These epidemiologic observations suggest that there are 2 distinct immune selection processes in humans: immunosurveillance directed against premalignant cells before cancer diagnosis (most relevant for preventing virus-related cancers), and "immunocontainment" directed against established cancers. These processes thus appear relevant for different groups of malignancies and may have different mechanisms.
MeSH term(s)	HIV/immunology ; HIV/isolation & purification ; HIV Infections/complications ; HIV Infections/virology ; Humans ; Immunocompromised Host/immunology ; Immunosuppression Therapy/statistics & numerical data ; Incidence ; Monitoring, Immunologic ; Neoplasms/epidemiology ; Neoplasms/etiology ; Neoplasms/pathology ; Organ Transplantation/adverse effects ; Prognosis ; Risk Factors ; Transplant Recipients
Language	English
Publishing date	2019-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.15495
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Zs.A 5542: Show issues

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Article ; Online: White Blood Cell Count, Neutrophil-to-Lymphocyte Ratio, and Incident Cancer in the UK Biobank.

Song, Minkyo / Graubard, Barry I / Loftfield, Erikka / Rabkin, Charles S / Engels, Eric A

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2024

Abstract: Background: The peripheral white blood cell (WBC) and neutrophil-to-lymphocyte ratio (NLR) reflect levels of inflammation and adaptive immunity. They are associated with cancer prognosis, but their associations with cancer incidence are not established.! ...

Abstract	Background: The peripheral white blood cell (WBC) and neutrophil-to-lymphocyte ratio (NLR) reflect levels of inflammation and adaptive immunity. They are associated with cancer prognosis, but their associations with cancer incidence are not established. Methods: We evaluated 443,540 cancer-free adults in the UK Biobank with data on total WBC and its subsets, follow-up starting one year after baseline. Cox regression was used to estimate hazard ratios (HRs) per quartile of WBC or NLR for incidence of 73 cancer types. Results: 22,747 incident cancers were diagnosed during a median of 6.9 years of follow-up. WBC was associated with risk of cancer overall (HR 1.05, 95%CI 1.03-1.06), chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL: 2.79, 2.45-3.18), lung cancer (1.14, 1.08-1.20), and breast cancer (1.05-1.02-1.08). NLR was positively associated with cancer overall (HR 1.03, 95%CI 1.02-1.04, per quartile) and kidney cancer (1.16, 1.07-1.25), and inversely with CLL/SLL (0.38, 0.33-0.42). Conclusions: High WBC or NLR may reflect excessive inflammatory status, promoting development of some cancers. Conversely, low NLR indicates a relative rise in lymphocytes, which could reflect an increase in circulating premalignant cells before CLL/SLL diagnosis. Peripheral WBC and NLR, in combination with other clinical information or biomarkers, may be useful tools for cancer risk stratification. Impact: Elevated levels of white blood cells or an increased neutrophil-to-lymphocyte ratio may indicate an overly active inflammatory response, potentially contributing to the eventual onset of certain types of cancer.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-23-1145
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Zs.A 3693: Show issues

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Article ; Online: Balancing uncertain risks in candidates for solid organ transplantation with a history of malignancy: Who is safe to transplant?

Hart, Allyson / Engels, Eric A

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2020 Volume 21, Issue 2, Page(s) 447–448

MeSH term(s)	Consensus ; Expert Testimony ; Humans ; Neoplasms ; Organ Transplantation/adverse effects ; Waiting Lists
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16366
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Zs.A 5542: Show issues

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Article ; Online: Immune-related conditions and cancer-specific mortality among older adults with cancer in the United States.

Wang, Jeanny H / Derkach, Andriy / Pfeiffer, Ruth M / Engels, Eric A

International journal of cancer

2022 Volume 151, Issue 8, Page(s) 1216–1227

Abstract: Immunity may play a role in preventing cancer progression. We studied associations of immune-related conditions with cancer-specific mortality among older adults in the United States. We evaluated 1 229 443 patients diagnosed with 20 common cancer types ( ...

Abstract	Immunity may play a role in preventing cancer progression. We studied associations of immune-related conditions with cancer-specific mortality among older adults in the United States. We evaluated 1 229 443 patients diagnosed with 20 common cancer types (age 67-99, years 1993-2013) using Surveillance Epidemiology and End Results-Medicare data. With Medicare claims, we ascertained immune-related medical conditions diagnosed before cancer diagnosis (4 immunosuppressive conditions [n = 3380 affected cases], 32 autoimmune conditions [n = 155 766], 3 allergic conditions [n = 101 366]). For each cancer site, we estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for cancer-specific mortality associated with each condition, applying a Bonferroni cutoff for significance (P < 5.1 × 10
MeSH term(s)	Aged ; Aged, 80 and over ; Autoimmune Diseases/epidemiology ; Bayes Theorem ; Case-Control Studies ; Humans ; Hypersensitivity/complications ; Hypersensitivity/epidemiology ; Male ; Medicare ; Neoplasms ; SEER Program ; United States/epidemiology
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Intramural
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34140
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: Reply to: Decreased incidence of Kaposi sarcoma after kidney transplant in Italy and role of mTOR-inhibitors: 1997-2016.

Cahoon, Elizabeth K / Engels, Eric A

International journal of cancer

2019 Volume 145, Issue 2, Page(s) 599

MeSH term(s)	Humans ; Incidence ; Italy ; Kidney Transplantation ; Sarcoma, Kaposi ; TOR Serine-Threonine Kinases ; United States
Chemical Substances	MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2019-01-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.32096
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: Autoimmune disease and the risk of anal cancer in the US population aged 66 years and over.

Song, Minkyo / Engels, Eric A / Clarke, Megan A / Kreimer, Aimée R / Shiels, Meredith S

Journal of the National Cancer Institute

2023 Volume 116, Issue 2, Page(s) 309–315

Abstract: Background: In the United States, anal squamous cell carcinoma rates have increased rapidly, particularly among women 50 or older than 66 years of age. As immunosuppression is associated with increased risk, autoimmune conditions may be associated with ... ...

Abstract	Background: In the United States, anal squamous cell carcinoma rates have increased rapidly, particularly among women 50 or older than 66 years of age. As immunosuppression is associated with increased risk, autoimmune conditions may be associated with greater risk of anal squamous cell carcinoma. Methods: We conducted a population-based, case-control study using Surveillance, Epidemiology, and End Results-Medicare data (2000-2017). Anal squamous cell carcinoma cases (n = 4505) were matched to 200 000 cancer-free controls. Using multivariable logistic regression, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between 47 autoimmune conditions diagnosed before selection, identified using Medicare claims, and anal squamous cell carcinoma. The Bonferroni threshold was used to correct for multiple comparisons. Population attributable fractions were calculated for conditions nominally associated with anal squamous cell carcinoma. Results: In total, 18% of anal squamous cell carcinoma cases and 15% of cancer-free controls had a diagnosed autoimmune condition. Any autoimmune condition was associated with an increased risk of anal squamous cell carcinoma (OR = 1.11, 95% CI = 1.02 to 1.21; population attributable fraction = 1.8%). Anal squamous cell carcinoma was associated with systemic lupus erythematosus (OR = 1.79, 95% CI = 1.32 to 2.42; population attributable fraction = 0.4%) and nominally associated (P < .05) with sarcoidosis (OR = 2.09, 95% CI = 1.30 to 3.37; population-attributable fraction = 0.2%) and psoriasis (OR = 1.28, 95% CI = 1.06 to 1.56; population attributable fraction = 0.5%). Stratified by sex, only women showed statistically significant associations for systemic lupus erythematosus (OR = 1.97, 95% CI = 1.46 to 2.68). Statistically significant interaction was observed by sex for psoriasis (men vs women: OR = 1.68 [95% CI = 1.03 to 4.28] vs OR = 1.12 [95% CI = 0.88 to 1.43]) and polymyalgia rheumatica (OR = 0.33 [95% CI = 0.12 to 0.89] vs OR = 0.99 [95% CI = 0.75 to 1.30]). Conclusion: Systemic lupus erythematosus, sarcoidosis, and psoriasis were associated with a moderately increased risk of anal squamous cell carcinoma. Given these conditions' rarity and moderate associations with anal squamous cell carcinoma, autoimmune diseases cannot explain the rising trend in this disease.
MeSH term(s)	Male ; Humans ; Aged ; Female ; United States/epidemiology ; Case-Control Studies ; Medicare ; Autoimmune Diseases/complications ; Autoimmune Diseases/epidemiology ; Lupus Erythematosus, Systemic/complications ; Sarcoidosis/complications ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/etiology ; Anus Neoplasms/epidemiology ; Psoriasis/complications
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djad187
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Uh III Zs.131: Show issues

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Article ; Online: Brief Report: The Virome of Bladder Tumors Arising in People Living With HIV.

Starrett, Gabriel J / Foster, Haidn / Sigel, Keith / Liu, Yuxin / Engels, Eric A

Journal of acquired immune deficiency syndromes (1999)

2023 Volume 94, Issue 4, Page(s) 337–340

Abstract: Background: People living with HIV (PLWH) have elevated risk for developing virus-related cancers. Bladder cancer risk is not increased in PLWH but is elevated among immunosuppressed solid organ transplant recipients (SOTRs). BK polyomavirus and, to a ... ...

Abstract	Background: People living with HIV (PLWH) have elevated risk for developing virus-related cancers. Bladder cancer risk is not increased in PLWH but is elevated among immunosuppressed solid organ transplant recipients (SOTRs). BK polyomavirus and, to a lesser extent, other viruses have been detected in bladder cancers from SOTRs. Objective: To characterize the virome of bladder tumors in PLWH. Design: Retrospective case series. Methods: We sequenced DNA and RNA from archived formalin-fixed bladder tumors from PLWH. Nonhuman reads were assembled and matched to a database of known viruses. Results: Fifteen bladder tumors from PLWH (13 carcinomas, 2 benign tumors) were evaluated. Fourteen tumors were in men, and the median age at diagnosis was 59 years (median CD4 count 460 cells/mm3). All but 1 tumor yielded both sufficient DNA and RNA. One bladder cancer, arising in a 52-year-old man with a CD4 count of 271 cells/mm3, manifested diverse Alphatorquevirus DNA and RNA sequences. A second cancer arising in a 58-year-old male former smoker (CD4 count of 227 cells/mm3) also showed Alphatorquevirus and Gammatorquevirus DNA sequences. Neither tumor exhibited viral integration. Conclusions: Alphatorqueviruses and Gammatorqueviruses are anelloviruses, which have also been detected in bladder cancers from SOTRs, but anelloviruses are common infections, and detection may simply reflect increased abundance in the setting of immunosuppression. The lack of detection of BK polyomavirus among bladder tumors from PLWH parallels the lower level of bladder cancer risk seen in PLWH compared with SOTRs, indirectly supporting a role for BK polyomavirus in causing the excess risk in SOTRs.
MeSH term(s)	Humans ; Male ; Middle Aged ; BK Virus/genetics ; DNA ; HIV Infections ; Retrospective Studies ; RNA ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/pathology ; Virome ; Female
Chemical Substances	DNA (9007-49-2) ; RNA (63231-63-0)
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003283
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Zs.A 2442: Show issues

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Article ; Online: Erratum to: Deaths Attributable to Cancer in the US Human Immunodeficiency Virus Population During 2001-2015.

Horner, Marie-Josèphe / Shiels, Meredith S / Pfeiffer, Ruth M / Engels, Eric A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2021 Volume 74, Issue 2, Page(s) 373

Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab805
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Zs.MO 480: Show issues

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