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  1. Article ; Online: Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis.

    Lloyd, Sarah M / He, Yupeng

    Cells

    2024  Volume 13, Issue 5

    Abstract: The extracellular matrix (ECM) provides structural support for tissues and regulatory signals for resident cells. ECM requires a careful balance between protein accumulation and degradation for homeostasis. Disruption of this balance can lead to ... ...

    Abstract The extracellular matrix (ECM) provides structural support for tissues and regulatory signals for resident cells. ECM requires a careful balance between protein accumulation and degradation for homeostasis. Disruption of this balance can lead to pathological processes such as fibrosis in organs across the body. Post-translational crosslinking modifications to ECM proteins such as collagens alter ECM structure and function. Dysregulation of crosslinking enzymes as well as changes in crosslinking composition are prevalent in fibrosis. Because of the crucial roles these ECM crosslinking pathways play in disease, the enzymes that govern crosslinking events are being explored as therapeutic targets for fibrosis. Here, we review in depth the molecular mechanisms underlying ECM crosslinking, how ECM crosslinking contributes to fibrosis, and the therapeutic strategies being explored to target ECM crosslinking in fibrosis to restore normal tissue structure and function.
    MeSH term(s) Humans ; Extracellular Matrix/metabolism ; Fibrosis ; Collagen/metabolism ; Extracellular Matrix Proteins/metabolism
    Chemical Substances Collagen (9007-34-5) ; Extracellular Matrix Proteins
    Language English
    Publishing date 2024-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13050438
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  2. Article ; Online: Cold induction of nuclear FRIGIDA condensation in Arabidopsis.

    Zhang, Zhicheng / Luo, Xiao / Yang, Yupeng / He, Yuehui

    Nature

    2023  Volume 619, Issue 7969, Page(s) E27–E32

    MeSH term(s) Arabidopsis/genetics
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06189-z
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Can feature structure improve model's precision? A novel prediction method using artificial image and image identification.

    He, Yupeng / Sun, Qiwen / Matsunaga, Masaaki / Ota, Atsuhiko

    JAMIA open

    2024  Volume 7, Issue 1, Page(s) ooae012

    Abstract: Objectives: This study aimed to develop an approach to enhance the model precision by artificial images.: Materials and methods: Given an epidemiological study designed to predict : Results: We randomly selected 10 000 artificial sample sets to ... ...

    Abstract Objectives: This study aimed to develop an approach to enhance the model precision by artificial images.
    Materials and methods: Given an epidemiological study designed to predict
    Results: We randomly selected 10 000 artificial sample sets to train the model. Models' performance (area under the receiver operating characteristic curve values) depicted a bell-shaped distribution.
    Conclusion: The model construction strategy developed in the research has potential to capture feature order related information and enhance model predictability.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2531
    ISSN (online) 2574-2531
    DOI 10.1093/jamiaopen/ooae012
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  4. Article ; Online: Efficacy of Biportal Endoscopic Decompression for Lumbar Spinal Stenosis: A Meta-Analysis With Single-Arm Analysis and Comparative Analysis With Microscopic Decompression and Uniportal Endoscopic Decompression.

    Lv, Shuangwen / Lv, Haiwen / He, Yupeng / Xia, Xiansheng

    Operative neurosurgery (Hagerstown, Md.)

    2024  

    Abstract: Background and objective: Biportal endoscopic decompression is a minimally invasive surgical technique for lumbar spinal stenosis (LSS). This meta-analysis aimed to evaluate the efficacy and safety of biportal endoscopic decompression through both a ... ...

    Abstract Background and objective: Biportal endoscopic decompression is a minimally invasive surgical technique for lumbar spinal stenosis (LSS). This meta-analysis aimed to evaluate the efficacy and safety of biportal endoscopic decompression through both a single-arm analysis and a comparative analysis.
    Methods: A comprehensive literature search was conducted to identify eligible studies reporting the outcomes of biportal endoscopic decompression for LSS. Single-arm analysis and comparisons with microscopic and uniportal endoscopic decompression were performed. Evaluated outcomes included visual analog scale (VAS) scores for back pain and leg pain, Oswestry Disability Index (ODI) scores, operation time, estimated blood loss, duration of hospital stay, and adverse events.
    Results: Single-arm analysis demonstrated significant improvements in VAS back pain, VAS leg pain, and ODI scores after biportal endoscopic decompression at postoperative 1-day to 36-month follow-up (all P < .001), compared with preoperative levels. The pooled mean single-level operation time was 71.44 min, and the pooled mean hospital stay was 3.63 days. The overall adverse event rate was 4.0%, with dural tear being the most common complication (3.0%). Compared with microscopic decompression, biportal endoscopic decompression showed significantly lower VAS back pain at 1-month (P < .001) and 6-month (P < .001) follow-up; lower VAS leg pain at 1-month (P = .045) follow-up; lower ODI scores at 3-month (P < .001), 12-month (P = .017), and >12-month (P = .007) follow-up; lower estimated blood loss (P = .003); and shorter hospital stay (P < .001). Adverse event rates did not differ between the techniques. No significant differences were observed between biportal endoscopic and uniportal endoscopic decompression groups for most efficacy and safety outcomes.
    Conclusion: Biportal endoscopic decompression emerges as a safe and effective alternative for LSS, presenting potential advantages over the microscopic technique and comparable efficacy with the uniportal endoscopic technique.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000001097
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424 -ON-: Show issues Location:
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  5. Article ; Online: Reactive transport model of uranium by CO

    Zhang, Haitao / Zhang, Tong / He, Yupeng

    Environmental science and pollution research international

    2023  Volume 30, Issue 24, Page(s) 65976–65989

    Abstract: Uranium is an important strategic resource, and its safe and efficient development and utilization are of great significance to ensuring a nation's energy supply and strategic security. Sandstone-type uranium ore is commonly mined by ... ...

    Abstract Uranium is an important strategic resource, and its safe and efficient development and utilization are of great significance to ensuring a nation's energy supply and strategic security. Sandstone-type uranium ore is commonly mined by CO
    MeSH term(s) Uranium/analysis ; Carbon Dioxide/analysis ; Groundwater ; Water Pollutants, Radioactive/analysis ; Environmental Restoration and Remediation
    Chemical Substances Uranium (4OC371KSTK) ; Carbon Dioxide (142M471B3J) ; Water Pollutants, Radioactive
    Language English
    Publishing date 2023-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-27200-0
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    Z 5915: Show issues

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  6. Article ; Online: Effects and possible mechanisms of dexmedetomidine on post-operative cognitive dysfunction.

    He, Huijuan / Zhu, Manhua / Lyu, Yupeng / Yuan, Yuan / Qi, Yong

    Chinese medical journal

    2023  Volume 136, Issue 19, Page(s) 2392–2394

    MeSH term(s) Humans ; Dexmedetomidine/therapeutic use ; Hypnotics and Sedatives ; Cognitive Dysfunction/drug therapy
    Chemical Substances Dexmedetomidine (67VB76HONO) ; Hypnotics and Sedatives
    Language English
    Publishing date 2023-10-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002372
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    Zs.B 1207: Show issues Location:
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  7. Article ; Online: Meta-analysis of the influence of tracheal intubation with cuff and without cuff on the incidence of total wound complications in ICU intubation patients.

    Jiang, Bingyu / Wang, Yupeng / He, Xiaoyan / Zhang, Lele / Fu, Shangpeng

    International wound journal

    2024  Volume 21, Issue 3, Page(s) e14741

    Abstract: At present, it is still controversial whether patients in intensive care unit (ICU) use tracheal intubation with or without cuff. This paper evaluates the effect of tracheal intubation with and without cuff on overall complication rate of patients with ... ...

    Abstract At present, it is still controversial whether patients in intensive care unit (ICU) use tracheal intubation with or without cuff. This paper evaluates the effect of tracheal intubation with and without cuff on overall complication rate of patients with intubation in ICU. The database of PubMed, Embase, Conchrane Library and Web of Science was searched by computer, and the clinical research on intubation with and without cuff in ICU was collected. The time range was from the database establishment to November 2023. Literature was independently screened, information was extracted, and quality was assessed by two researchers. Finally, there were nine studies included, with 11 068 patients (7391 in cuff group and 3677 in non-cuff group). The results showed that the overall complication rate of cuff group was significantly lower than that of non-cuff group, and that of cuff group (RR = 0.53, p < 0.01). In addition, compared with the non-cuff group, the cuff group had a lower number of tracheal intubation changes [RR = 0.05, p < 0.01] and a lower incidence of aspiration pneumonia (RR = 0.45, p = 0.01). Compared with the non-cuff group, the cuff group had a higher incidence of oral mucosal ulcers and pharyngitis (RR = 1.99, p = 0.04), while the cuff group had a lower incidence of laryngeal edema (RR = 0.39, p < 0.01). In ICU intubation patients, the use of cuffs reduces overall complication rate in comparison to patients without cuffs. Therefore, patients with intubation in ICU can recommend tracheal intubation with cuff.
    MeSH term(s) Humans ; Incidence ; Intubation, Intratracheal/adverse effects ; Critical Care ; Intensive Care Units
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14741
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    Zs.A 6006: Show issues Location:
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  8. Article: Potato glycoside alkaloids exhibit antifungal activity by regulating the tricarboxylic acid cycle pathway of

    Zhang, Chongqing / Chen, Wei / Wang, Bin / Wang, Yupeng / Li, Nan / Li, Ruiyun / Yan, Yuke / Sun, Yuyan / He, Jing

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1390269

    Abstract: ... Fusarium ... ...

    Abstract Fusarium solani
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1390269
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  9. Article ; Online: Nano-Zero-Valent Zinc-Modified Municipal Sludge Biochar for Phosphorus Removal

    Yupeng Zhang / Wenbo Zhang / Hong Zhang / Dandan He

    Molecules, Vol 28, Iss 3231, p

    2023  Volume 3231

    Abstract: Municipal sludge biochar (MSBC) can be used to absorb phosphorus in water for waste treatment. Nano-zero-valent zinc (nZVZ) was uniformly attached to MSBC to obtain a highly efficient phosphorus-absorbing composite material, nZVZ–MSBC. Characterization ... ...

    Abstract Municipal sludge biochar (MSBC) can be used to absorb phosphorus in water for waste treatment. Nano-zero-valent zinc (nZVZ) was uniformly attached to MSBC to obtain a highly efficient phosphorus-absorbing composite material, nZVZ–MSBC. Characterization by FTIR, XPS, XRD, and BET showed that nZVZ was uniformly dispersed on the surface of the MSBC. Zinc loading was able to greatly improve the adsorption performance of MSBC for phosphorus. Adsorption experiments illustrated that the adsorption process conformed to the Langmuir model, and the maximum adsorption amount was 186.5 mg/g, which is much higher than that for other municipal sludge biochars. The adsorption process reached 80% of the maximum adsorption capacity at 90 min, and this gradually stabilized after 240 min; adsorption equilibrium was reached within 24 h. The optimum pH for adsorption was 5. The main adsorption mechanism was chemical adsorption, but physical adsorption, external diffusion, internal diffusion, and surface adsorption also played roles. The potential for application as an efficient adsorbent of phosphorus from water was confirmed. In addition, a novel strategy for municipal sludge disposal and resource utilization is provided.
    Keywords nano-zero-valent zinc ; phosphorus ; chemical adsorption ; physical adsorption ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Nano-Zero-Valent Zinc-Modified Municipal Sludge Biochar for Phosphorus Removal.

    Zhang, Yupeng / Zhang, Wenbo / Zhang, Hong / He, Dandan

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: Municipal sludge biochar (MSBC) can be used to absorb phosphorus in water for waste treatment. Nano-zero-valent zinc (nZVZ) was uniformly attached to MSBC to obtain a highly efficient phosphorus-absorbing composite material, nZVZ-MSBC. Characterization ... ...

    Abstract Municipal sludge biochar (MSBC) can be used to absorb phosphorus in water for waste treatment. Nano-zero-valent zinc (nZVZ) was uniformly attached to MSBC to obtain a highly efficient phosphorus-absorbing composite material, nZVZ-MSBC. Characterization by FTIR, XPS, XRD, and BET showed that nZVZ was uniformly dispersed on the surface of the MSBC. Zinc loading was able to greatly improve the adsorption performance of MSBC for phosphorus. Adsorption experiments illustrated that the adsorption process conformed to the Langmuir model, and the maximum adsorption amount was 186.5 mg/g, which is much higher than that for other municipal sludge biochars. The adsorption process reached 80% of the maximum adsorption capacity at 90 min, and this gradually stabilized after 240 min; adsorption equilibrium was reached within 24 h. The optimum pH for adsorption was 5. The main adsorption mechanism was chemical adsorption, but physical adsorption, external diffusion, internal diffusion, and surface adsorption also played roles. The potential for application as an efficient adsorbent of phosphorus from water was confirmed. In addition, a novel strategy for municipal sludge disposal and resource utilization is provided.
    MeSH term(s) Sewage/chemistry ; Phosphorus ; Zinc ; Water Pollutants, Chemical/chemistry ; Charcoal/chemistry ; Adsorption ; Acids ; Water ; Kinetics
    Chemical Substances Sewage ; biochar ; Phosphorus (27YLU75U4W) ; Zinc (J41CSQ7QDS) ; Water Pollutants, Chemical ; Charcoal (16291-96-6) ; Acids ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28073231
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    Zs.MO 81: Show issues

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