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Book: L-Asparaginase

Gökbuget, Nicola / Attarbaschi, Andishe

akute lymphatische Leukämie (ALL) bei Erwachsenen

(Drug report ; 11. Jahrgang, Heft 6 (April 2017))

2017

Author's details	Autor: Dr. med. Nikola Gökbuget, Dr. med. Andishe Attarbaschi
Series title	Drug report ; 11. Jahrgang, Heft 6 (April 2017)
Collection
Language	German
Size	11 Seiten, Illustrationen, 28 cm
Publisher	Thieme
Publishing place	Stuttgart
Publishing country	Germany
Document type	Book
HBZ-ID	HT019371963
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Diagnosis and management of rare paediatric Non-Hodgkin lymphoma.

Xavier, Ana C / Suzuki, Ritsuro / Attarbaschi, Andishe

Best practice & research. Clinical haematology

2023 Volume 36, Issue 1, Page(s) 101440

Abstract: Mature B-cell lymphomas, (B- or T-cell) lymphoblastic lymphomas (LBL), and anaplastic large cell lymphoma (ALCL) correspond to about 90% of all non-Hodgkin lymphoma (NHL) cases occurring in children and adolescents. The remaining 10% encompass a complex ... ...

Abstract	Mature B-cell lymphomas, (B- or T-cell) lymphoblastic lymphomas (LBL), and anaplastic large cell lymphoma (ALCL) correspond to about 90% of all non-Hodgkin lymphoma (NHL) cases occurring in children and adolescents. The remaining 10% encompass a complex group of entities characterized by low/very low incidences, paucity of knowledge in terms of underlying biology in comparison to their adult counterparts, and consequent lack of standardization of care, information on clinical therapeutic efficacy and long-term survival. At the Seventh International Symposium on Childhood, Adolescent and Young Adult NHL, organized on October 20-23, 2022, in New York City, New York, US, we had the opportunity to discuss clinical, pathogenetic, diagnostic, and treatment aspects of certain subtypes of rare B- or T-cell NHL and they will be the topic of this review.
MeSH term(s)	Child ; Adolescent ; Young Adult ; Humans ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, B-Cell/therapy ; Treatment Outcome
Language	English
Publishing date	2023-01-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2048027-1
ISSN	1532-1924 ; 1521-6926
ISSN (online)	1532-1924
ISSN	1521-6926
DOI	10.1016/j.beha.2023.101440
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Article ; Online: 18

Kroeze, Emma / Padilla, Laura Arias / Burkhardt, Birgit / Attarbaschi, Andishe / von Mersi, Hannah / Kebudi, Rejin / Nievelstein, Rutger A J / Tolboom, Nelleke / Hagleitner, Melanie M / Kuiper, Roland P / Beishuizen, Auke / Loeffen, Jan L C

Pediatric blood & cancer

2023 Volume 70, Issue 11, Page(s) e30642

Abstract: ... ...

Abstract	18
MeSH term(s)	Humans ; Child ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnostic imaging ; Retrospective Studies ; Diagnostic Imaging
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30642
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Article ; Online: Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group.

Luedersen, Jette / Stadt, Udo Zur / Richter, Julia / Oschlies, Ilske / Klapper, Wolfram / Rosenwald, Andreas / Kalinova, Marketa / Simonitsch-Klupp, Ingrid / Siebert, Reiner / Zimmermann, Martin / Qi, Minyue / Nakel, Jacqueline / Scheinemann, Katrin / Knörr, Fabian / Attarbaschi, Andishe / Kabickova, Edita / Woessmann, Wilhelm / Damm-Welk, Christine

British journal of haematology

2024

Abstract: Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive ...

Abstract	Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1::ALK was detected in 13 cases. Among the 28 patients with a non-NPM1::ALK-fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATIC::ALK-positive ALCL relapsed, none of nine with TPM3::ALK. Variant ALK-partners are rare and potentially associated with different prognoses.
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.19308
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Article ; Online: Vemurafenib acts as a molecular on-off switch governing systemic inflammation in Langerhans cell histiocytosis.

Eder, Sebastian K / Schwentner, Raphaela / Ben Soussia, Philipp / Abagnale, Giulio / Attarbaschi, Andishe / Minkov, Milen / Halbritter, Florian / Hutter, Caroline

Blood advances

2022 Volume 6, Issue 3, Page(s) 970–975

Abstract: Langerhans cell histiocytosis (LCH) is a neoplasm marked by the accumulation of CD1A+CD207+ cells. It is most commonly driven by a somatic, activating mutation in the BRAF serine-threonine kinase (BRAFV600E). Multisystem disease with risk-organ ... ...

Abstract	Langerhans cell histiocytosis (LCH) is a neoplasm marked by the accumulation of CD1A+CD207+ cells. It is most commonly driven by a somatic, activating mutation in the BRAF serine-threonine kinase (BRAFV600E). Multisystem disease with risk-organ involvement requires myelotoxic chemotherapy, making BRAF-inhibitors an attractive treatment option. Here, we present a comprehensive analysis of the course of an LCH patient treated with the combination of vemurafenib and salvage chemotherapy who achieved sustained clinical and molecular remission. We show that there is no relationship between peripheral blood BRAFV600E levels and clinical presentation during treatment with vemurafenib, but that vemurafenib leads to a fast, efficient, but reversible inhibition of clinical manifestations of systemic inflammation. In line, serum levels of inflammatory cytokines exactly mirror vemurafenib administration. Genotyping analysis identified the BRAFV600E mutation in multiple hematopoietic cell types, including NK cells and granulocytes. Single-cell transcriptome analyses of peripheral blood and bone marrow cells at time of diagnosis and during treatment indicate that RAF-inhibition abrogates the expression of inflammatory cytokines previously implicated in LCH such as IL1B and CXCL8. Together, our data suggest that while the CD1A+CD207+ histiocytes are the hallmark of LCH, other BRAF-mutated cell populations may contribute significantly to morbidity in patients with multisystem LCH.
MeSH term(s)	Cytokines ; Histiocytosis, Langerhans-Cell/complications ; Histiocytosis, Langerhans-Cell/drug therapy ; Histiocytosis, Langerhans-Cell/genetics ; Humans ; Inflammation/drug therapy ; Proto-Oncogene Proteins B-raf/genetics ; Vemurafenib/therapeutic use
Chemical Substances	Cytokines ; Vemurafenib (207SMY3FQT) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021005442
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Article ; Online: Optical Genome Mapping Identifies Novel Recurrent Structural Alterations in Childhood

Brandes, Danielle / Yasin, Layal / Nebral, Karin / Ebler, Jana / Schinnerl, Dagmar / Picard, Daniel / Bergmann, Anke K / Alam, Jubayer / Köhrer, Stefan / Haas, Oskar A / Attarbaschi, Andishe / Marschall, Tobias / Stanulla, Martin / Borkhardt, Arndt / Brozou, Triantafyllia / Fischer, Ute / Wagener, Rabea

HemaSphere

2023 Volume 7, Issue 8, Page(s) e925

Abstract: The mutational landscape of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the most common pediatric cancer, is not fully described partially because commonly applied short-read next generation sequencing has a limited ability to identify ... ...

Abstract	The mutational landscape of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the most common pediatric cancer, is not fully described partially because commonly applied short-read next generation sequencing has a limited ability to identify structural variations. By combining comprehensive analysis of structural variants (SVs), single-nucleotide variants (SNVs), and small insertions-deletions, new subtype-defining and therapeutic targets may be detected. We analyzed the landscape of somatic alterations in 60 pediatric patients diagnosed with the most common BCP-ALL subtypes,
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000925
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Article ; Online: Hypersensitivity Reactions to Native

HemaSphere

2023 Volume 7, Issue 6, Page(s) e888

Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000888
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Article ; Online: Large B-cell lymphoma-IRF4+ in children and young people: time to reduce chemotherapy in a rare malignant mature B-cell neoplasm?

Huibers, Minke / Abla, Oussama / Andrés, Mara / Balagué, Olga / Beishuizen, Auke / Carraro, Elisa / Chiang, Alan / Csóka, Monika / David, Bianca-Andreea / de Ville de Goyet, Maëlle / Gilad, Gil / Hori, Daiki / Kotecha, Rishi S / Kabickova, Edita / Klapper, Wolfram / Miakova, Natasha / Minard-Colin, Veronique / Nakazawa, Atsuko / Pillon, Marta /

Rigaud, Charlotte / Salaverria, Itziar / Tölle, Ida / Verdú-Amorós, Jaime / von Mersi, Hannah / Wössmann, Wilhelm / Burkhardt, Birgit / Attarbaschi, Andishe

Blood advances

2024 Volume 8, Issue 6, Page(s) 1509–1514

MeSH term(s)	Child ; Humans ; Adolescent ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023012109
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Article ; Online: Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study.

Bone marrow transplantation

2024 Volume 59, Issue 5, Page(s) 604–614

Abstract: Peripheral T-cell lymphomas (PTCL) other than anaplastic large-cell lymphoma are rare in children, and the role of hematopoietic stem cell transplantation (HSCT) has not been clarified yet. In a retrospective analysis of registry-data of the European ... ...

Abstract	Peripheral T-cell lymphomas (PTCL) other than anaplastic large-cell lymphoma are rare in children, and the role of hematopoietic stem cell transplantation (HSCT) has not been clarified yet. In a retrospective analysis of registry-data of the European Society for Blood and Marrow Transplantation we analyzed 55 patients aged < 18 years who received allogeneic (N = 46) or autologous (N = 9) HSCT for PTCL. Median age at HSCT was 13.9 years; 33 patients (60%) were in first remission, and 6 (19%) in progression at HSCT. Conditioning was myeloablative in 87% of the allogeneic HSCTs and in 27 (58.7%) based on total body irradiation. After allogeneic HSCT the 5-year overall- and progression-free survival was 58.9% (95% CI 42.7-71.9) and 52.6% (95% CI 36.8-66.1), respectively. 5-year relapse incidence was 27.6% (95% CI 15.1-41.6), the non-relapse mortality rate was 19.8% (95% CI 9.7-32.6). Five of the six patients with progression at HSCT died. Seven of nine patients after autologous HSCT were alive and disease-free at last follow-up. Our data suggest a role of allogeneic HSCT in consolidation-treatment of patients with high-risk disease, who reach at least partial remission after primary- or relapse-therapy, whereas patients with therapy-refractory or progressive disease prior to transplantation do not profit from HSCT.
MeSH term(s)	Humans ; Hematopoietic Stem Cell Transplantation/methods ; Child ; Adolescent ; Male ; Female ; Lymphoma, T-Cell, Peripheral/therapy ; Lymphoma, T-Cell, Peripheral/mortality ; Child, Preschool ; Retrospective Studies ; Infant ; Transplantation Conditioning/methods ; Disease-Free Survival ; Survival Rate
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/s41409-024-02226-1
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Article ; Online: Pulmonary lesions in early response assessment in pediatric Hodgkin lymphoma: prevalence and possible implications for initial staging.

Stoevesandt, Dietrich / Ludwig, Christiane / Mauz-Körholz, Christine / Körholz, Dieter / Hasenclever, Dirk / McCarten, Kathleen / Flerlage, Jamie E / Kurch, Lars / Wohlgemuth, Walter A / Landman-Parker, Judith / Wallace, William H / Fosså, Alexander / Vordermark, Dirk / Karlén, Jonas / Cepelová, Michaela / Klekawka, Tomasz / Attarbaschi, Andishe / Hraskova, Andrea / Uyttebroeck, Anne /

Beishuizen, Auke / Dieckmann, Karin / Leblanc, Thierry / Daw, Stephen / Steglich, Jonas

Pediatric radiology

2024 Volume 54, Issue 5, Page(s) 725–736

Abstract: Background: Disseminated pulmonary involvement in pediatric Hodgkin lymphoma (pHL) is indicative of Ann Arbor stage IV disease. During staging, it is necessary to assess for coexistence of non-malignant lung lesions due to infection representing ... ...

Abstract	Background: Disseminated pulmonary involvement in pediatric Hodgkin lymphoma (pHL) is indicative of Ann Arbor stage IV disease. During staging, it is necessary to assess for coexistence of non-malignant lung lesions due to infection representing background noise to avoid erroneously upstaging with therapy intensification. Objective: This study attempts to describe new lung lesions detected on interim staging computed tomography (CT) scans after two cycles of vincristine, etoposide, prednisolone, doxorubicin in a prospective clinical trial. Based on the hypothesis that these new lung lesions are not part of the underlying malignancy but are epiphenomena, the aim is to analyze their size, number, and pattern to help distinguish true lung metastases from benign lung lesions on initial staging. Materials and methods: A retrospective analysis of the EuroNet-PHL-C1 trial re-evaluated the staging and interim lung CT scans of 1,300 pediatric patients with HL. Newly developed lung lesions during chemotherapy were classified according to the current Fleischner glossary of terms for thoracic imaging. Patients with new lung lesions found at early response assessment (ERA) were additionally assessed and compared to response seen in hilar and mediastinal lymph nodes. Results: Of 1,300 patients at ERA, 119 (9.2%) had new pulmonary lesions not originally detectable at diagnosis. The phenomenon occurred regardless of initial lung involvement or whether a patient relapsed. In the latter group, new lung lesions on ERA regressed by the time of relapse staging. New lung lesions on ERA in patients without relapse were detected in 102 (7.8%) patients. Pulmonary nodules were recorded in 72 (5.5%) patients, the majority (97%) being<10 mm. Consolidations, ground-glass opacities, and parenchymal bands were less common. Conclusion: New nodules on interim staging are common, mostly measure less than 10 mm in diameter and usually require no further action because they are most likely non-malignant. Since it must be assumed that benign and malignant lung lesions coexist on initial staging, this benign background noise needs to be distinguished from lung metastases to avoid upstaging to stage IV disease. Raising the cut-off size for lung nodules to ≥ 10 mm might achieve the reduction of overtreatment but needs to be further evaluated with survival data. In contrast to the staging criteria of EuroNet-PHL-C1 and C2, our data suggest that the number of lesions present at initial staging may be less important.
MeSH term(s)	Humans ; Male ; Female ; Hodgkin Disease/diagnostic imaging ; Hodgkin Disease/pathology ; Hodgkin Disease/drug therapy ; Child ; Neoplasm Staging ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Adolescent ; Tomography, X-Ray Computed/methods ; Retrospective Studies ; Prevalence ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Prospective Studies ; Child, Preschool ; Doxorubicin/therapeutic use ; Etoposide/therapeutic use ; Etoposide/administration & dosage ; Vincristine/therapeutic use
Chemical Substances	Doxorubicin (80168379AG) ; Etoposide (6PLQ3CP4P3) ; Vincristine (5J49Q6B70F)
Language	English
Publishing date	2024-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-024-05859-y
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