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Article ; Online: Mutations in

Essadik, Insaf / Boucher, Charlie / Bobée, Cécilia / Cabet, Éva / Gautier, Valérie / Lalucque, Hervé / Silar, Philippe / Chapeland-Leclerc, Florence / Ruprich-Robert, Gwenaël

Journal of fungi (Basel, Switzerland)

2024 Volume 10, Issue 1

Abstract: ... The ... ...

Abstract	The ascomycete
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof10010079
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Article ; Online: Prediction and experimental evidence of different growth phases of the Podospora anserina hyphal network.

Ledoux, Clara / Chapeland-Leclerc, Florence / Ruprich-Robert, Gwenaël / Bobée, Cécilia / Lalanne, Christophe / Herbert, Éric / David, Pascal

Scientific reports

2023 Volume 13, Issue 1, Page(s) 8501

Abstract: Under ideal conditions, the growth of the mycelial network of a filamentous fungus is monotonous, showing an ever increasing complexity with time. The components of the network growth are very simple and based on two mechanisms: the elongation of each ... ...

Abstract	Under ideal conditions, the growth of the mycelial network of a filamentous fungus is monotonous, showing an ever increasing complexity with time. The components of the network growth are very simple and based on two mechanisms: the elongation of each hypha, and their multiplication by successive branching. These two mechanisms are sufficient to produce a complex network, and could be localized only at the tips of hyphae. However, branching can be of two types, apical or lateral, depending on its location on the hyphae, therefore imposing the redistribution of the necessary material in the whole mycelium. From an evolutionary point of view, maintaining different branching processes, with additional energy needs for structure and metabolism, is intriguing. We propose in this work to discuss the advantages of each branching type using a new observable for the network growth, allowing us to compare growth configurations. For this purpose, we build on experimental observations of the Podospora anserina mycelium growth, enabling us to feed and constrain a lattice-free modeling of this network based on a binary tree. First, we report the set of statistics related to the branches of P. anserina that we have implemented into the model. Then, we build the density observable, allowing us to discuss the succession of growth phases. We predict that density over time is not monotonic, but shows a decay growth phase, clearly separated from an other one by a stationary phase. The time of appearance of this stable region appears to be driven solely by the growth rate. Finally, we show that density is an appropriate observable to differentiate growth stress.
MeSH term(s)	Hyphae ; Podospora ; Mycelium ; Fungi/metabolism ; Fungal Proteins/metabolism
Chemical Substances	Fungal Proteins
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-35327-w
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Article ; Online: Characterization of spatio-temporal dynamics of the constrained network of the filamentous fungus Podospora anserina using a geomatics-based approach.

Ledoux, Clara / Bobée, Cécilia / Cabet, Éva / David, Pascal / Filaine, Frédéric / Hachimi, Sabrina / Lalanne, Christophe / Ruprich-Robert, Gwenaël / Herbert, Éric / Chapeland-Leclerc, Florence

PloS one

2024 Volume 19, Issue 2, Page(s) e0297816

Abstract: In their natural environment, fungi are subjected to a wide variety of environmental stresses which they must cope with by constantly adapting the architecture of their growing network. In this work, our objective was to finely characterize the thallus ... ...

Abstract	In their natural environment, fungi are subjected to a wide variety of environmental stresses which they must cope with by constantly adapting the architecture of their growing network. In this work, our objective was to finely characterize the thallus development of the filamentous fungus Podospora anserina subjected to different constraints that are simple to implement in vitro and that can be considered as relevant environmental stresses, such as a nutrient-poor environment or non-optimal temperatures. At the Petri dish scale, the observations showed that the fungal thallus is differentially affected (thallus diameter, mycelium aspect) according to the stresses but these observations remain qualitative. At the hyphal scale, we showed that the extraction of the usual quantities (i.e. apex, node, length) does not allow to distinguish the different thallus under stress, these quantities being globally affected by the application of a stress in comparison with a thallus having grown under optimal conditions. Thanks to an original geomatics-based approach based on the use of automatized Geographic Information System (GIS) tools, we were able to produce maps and metrics characterizing the growth dynamics of the networks and then to highlight some very different dynamics of network densification according to the applied stresses. The fungal thallus is then considered as a map and we are no longer interested in the quantity of material (hyphae) produced but in the empty spaces between the hyphae, the intra-thallus surfaces. This study contributes to a better understanding of how filamentous fungi adapt the growth and densification of their network to potentially adverse environmental changes.
MeSH term(s)	Podospora ; Fungi ; Hyphae ; Mycelium ; Stress, Physiological ; Fungal Proteins
Chemical Substances	Fungal Proteins
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297816
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Article ; Online: Prediction and experimental evidence of different growth phases of the Podospora anserina hyphal network

Clara Ledoux / Florence Chapeland-Leclerc / Gwenaël Ruprich-Robert / Cécilia Bobée / Christophe Lalanne / Éric Herbert / Pascal David

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Under ideal conditions, the growth of the mycelial network of a filamentous fungus is monotonous, showing an ever increasing complexity with time. The components of the network growth are very simple and based on two mechanisms: the elongation ... ...

Abstract	Abstract Under ideal conditions, the growth of the mycelial network of a filamentous fungus is monotonous, showing an ever increasing complexity with time. The components of the network growth are very simple and based on two mechanisms: the elongation of each hypha, and their multiplication by successive branching. These two mechanisms are sufficient to produce a complex network, and could be localized only at the tips of hyphae. However, branching can be of two types, apical or lateral, depending on its location on the hyphae, therefore imposing the redistribution of the necessary material in the whole mycelium. From an evolutionary point of view, maintaining different branching processes, with additional energy needs for structure and metabolism, is intriguing. We propose in this work to discuss the advantages of each branching type using a new observable for the network growth, allowing us to compare growth configurations. For this purpose, we build on experimental observations of the Podospora anserina mycelium growth, enabling us to feed and constrain a lattice-free modeling of this network based on a binary tree. First, we report the set of statistics related to the branches of P. anserina that we have implemented into the model. Then, we build the density observable, allowing us to discuss the succession of growth phases. We predict that density over time is not monotonic, but shows a decay growth phase, clearly separated from an other one by a stationary phase. The time of appearance of this stable region appears to be driven solely by the growth rate. Finally, we show that density is an appropriate observable to differentiate growth stress.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Complementary Strategies to Unlock Biosynthesis Gene Clusters Encoding Secondary Metabolites in the Filamentous Fungus

Shen, Ling / Roullier, Catherine / Porée, François-Hugues / Gaslonde, Thomas / Riffault-Valois, Ludivine / Grovel, Olivier / Ruprich-Robert, Gwenaël / Chapeland-Leclerc, Florence

Journal of fungi (Basel, Switzerland)

2022 Volume 9, Issue 1

Abstract: The coprophilous ... ...

Abstract	The coprophilous ascomycete
Language	English
Publishing date	2022-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof9010009
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Article ; Online: Prediction and experimental evidence of the optimisation of the angular branching process in the thallus growth of Podospora anserina.

Ledoux, Clara / Chapeland-Leclerc, Florence / Ruprich-Robert, Gwenaël / Bobée, Cécilia / Lalanne, Christophe / Herbert, Éric / David, Pascal

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12351

Abstract: Based upon apical growth and hyphal branching, the two main processes that drive the growth pattern of a fungal network, we propose here a two-dimensions simulation based on a binary-tree modelling allowing us to extract the main characteristics of a ... ...

Abstract	Based upon apical growth and hyphal branching, the two main processes that drive the growth pattern of a fungal network, we propose here a two-dimensions simulation based on a binary-tree modelling allowing us to extract the main characteristics of a generic thallus growth. In particular, we showed that, in a homogeneous environment, the fungal growth can be optimized for exploration and exploitation of its surroundings with a specific angular distribution of apical branching. Two complementary methods of extracting angle values have been used to confront the result of the simulation with experimental data obtained from the thallus growth of the saprophytic filamentous fungus Podospora anserina. Finally, we propose here a validated model that, while being computationally low-cost, is powerful enough to test quickly multiple conditions and constraints. It will allow in future works to deepen the characterization of the growth dynamic of fungal network, in addition to laboratory experiments, that could be sometimes expensive, tedious or of limited scope.
MeSH term(s)	Fungal Proteins ; Fungi ; Hyphae ; Podospora
Chemical Substances	Fungal Proteins
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16245-9
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Article ; Online: Functional Characterization of the GATA-Type Transcription Factor PaNsdD in the Filamentous Fungus Podospora anserina and Its Interplay with the Sterigmatocystin Pathway.

Shen, Ling / Gaslonde, Thomas / Roullier, Catherine / Wang, Huijuan / Bodin, Jennifer / Porée, François-Hugues / Ruprich-Robert, Gwenaël / Chapeland-Leclerc, Florence

Applied and environmental microbiology

2022 Volume 88, Issue 6, Page(s) e0237821

Abstract: The model ascomycete Podospora anserina, distinguished by its strict sexual development, is a prolific but yet unexploited reservoir of natural products. The GATA-type transcription factor NsdD has been characterized by the role in balancing asexual and ... ...

Abstract	The model ascomycete Podospora anserina, distinguished by its strict sexual development, is a prolific but yet unexploited reservoir of natural products. The GATA-type transcription factor NsdD has been characterized by the role in balancing asexual and sexual reproduction and governing secondary metabolism in filamentous fungi. In the present study, we functionally investigated the NsdD ortholog PaNsdD in P. anserina. Compared to the wild-type strain, vegetative growth, ageing processes, sexual reproduction, stress tolerance, and interspecific confrontations in the mutant were drastically impaired, owing to the loss of function of PaNsdD. In addition, the production of 3-acetyl-4-methylpyrrole, a new metabolite identified in P. anserina in this study, was significantly inhibited in the
MeSH term(s)	Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Fungi/metabolism ; GATA Transcription Factors/metabolism ; Podospora/genetics ; Podospora/metabolism ; Sterigmatocystin/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Fungal Proteins ; GATA Transcription Factors ; Transcription Factors ; Sterigmatocystin (10048-13-2)
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.02378-21
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Article ; Online: Involvement of VIVID in white light-responsive pigmentation, sexual development and sterigmatocystin biosynthesis in the filamentous fungus Podospora anserina.

Shen, Ling / Chapeland-Leclerc, Florence / Ruprich-Robert, Gwenaël / Chen, Qiyi / Chen, Siyu / Adnan, Muhammad / Wang, Jiangxin / Liu, Gang / Xie, Ning

Environmental microbiology

2022 Volume 24, Issue 7, Page(s) 2907–2923

Abstract: Light serves as a source of information and regulates diverse physiological processes in living organisms. Fungi perceive and respond to light through a complex photosensory system. Fungi have evolved the desensitization mechanism to adapt to the ... ...

Abstract	Light serves as a source of information and regulates diverse physiological processes in living organisms. Fungi perceive and respond to light through a complex photosensory system. Fungi have evolved the desensitization mechanism to adapt to the changing light signal in a natural environment. White light exerts multiple essential impacts on the model filamentous fungus Podospora anserina. However, the light sensing and response in this species has not been investigated. In this study, we demonstrated that the loss of function of the light desensitization protein VIVID (VVD) in P. anserina triggered exacerbated light responses and therefore led to drastic morphological and physiological changes. The white light-sensitive mutant Δvvd showed growth reduction, spermatia overproduction, enhanced hyphae pigmentation and reduced oxidative stress tolerance. We observed the decreased expression level of sterigmatocystin gene cluster by transcriptome analysis and finally detected the reduced production of sterigmatocystin in Δvvd in response to white light. Our data indicate that VVD acts as a repressor of white collar complex. This study exhibits a vital role of VVD in governing white light-responsive gene expression and secondary metabolite production and contributes to a better understanding of the photoreceptor VVD in P. anserina.
MeSH term(s)	Fungal Proteins/metabolism ; Fungi/metabolism ; Pigmentation/genetics ; Podospora/genetics ; Sexual Development ; Sterigmatocystin
Chemical Substances	Fungal Proteins ; Sterigmatocystin (10048-13-2)
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/1462-2920.15978
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Article: Role of Fungal Infections in Carcinogenesis and Cancer Development: A Literature Review.

Hosseini, Kamran / Ahangari, Hossein / Chapeland-Leclerc, Florence / Ruprich-Robert, Gwenael / Tarhriz, Vahideh / Dilmaghani, Azita

Advanced pharmaceutical bulletin

2021 Volume 12, Issue 4, Page(s) 747–756

Abstract: Cancer is a serious debilitating disease and one of the most common causes of death. In recent decades the high risk of various cancers enforced scientists to discover novel prevention and treatment methods to diminish the mortality of this terrifying ... ...

Abstract	Cancer is a serious debilitating disease and one of the most common causes of death. In recent decades the high risk of various cancers enforced scientists to discover novel prevention and treatment methods to diminish the mortality of this terrifying disease. Accordingly, its prevention can be possible in near future. Based on epidemiological evidence, there is a clear link between pathogenic fungal infections and cancer development. This association is often seen in people with weakened immune systems such as the elderly and people with acquired immunodeficiency (AIDS). Carcinoma in these people is first seen chronically and then acutely. Although the different genetic and environmental risk factors are involved in carcinogenesis, one of the most important risk factors is fungal species and infections associating with cancers etiology. Now it is known that microbial infection is responsible for initiating 2.2 million new cancer cases. In this way, many recent studies have focused on investigating the role and mechanism of fungal infections in diverse cancers occurrence. This review provides a comprehensive framework of the latest clinical findings and the association of fungal infections with versatile cancers including esophageal, gastric, colorectal, lung, cervical, skin, and ovarian cancer.
Language	English
Publishing date	2021-09-29
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2022.076
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Article ; Online: Antimicrobial activity of Bacillus sp. isolated strains of wild honey.

Hallaj-Nezhadi, Somayeh / Hamdipour, Rasoul / Shahrvirani, Mohamad / Zare Tin, Roya / Chapeland-Leclerc, Florence / Ruprich-Robert, Gwenael / Esnaashari, Solmaz / Elyasi Far, Babak / Dilmaghani, Azita

BMC complementary medicine and therapies

2022 Volume 22, Issue 1, Page(s) 78

Abstract: Background: Multi-drug resistant bacteria hazards to the health of humans could be an agent in the destruction of human generation. Natural products of Bacillus species are the main source to access progressive antibiotics that can be a good candidate ... ...

Abstract	Background: Multi-drug resistant bacteria hazards to the health of humans could be an agent in the destruction of human generation. Natural products of Bacillus species are the main source to access progressive antibiotics that can be a good candidate for the discovery of novel antibiotics. Wild honey as a valuable food has been used in medicine with antimicrobial effects. Objective: Bacillus strains isolated from wild honey were evaluated for the potential antimicrobial activity against human and plant bacterial and fungal pathogens. Methods: Three bacterial isolates were identified as strain Khuz-1 (98.27% similarity with Bacillus safensis subsp. Safensis strain FO-36b Results: The results indicated that B. rugosus strain Khuz-2 inhibited the growth of phytopathogenic and human fungal more effective than other ones. It seems that the strain Khuz-2 has a suitable antimicrobial and antifungal potential as a good candidate for further pharmaceutical research. Conclusion: Based on the results of GC-MS, Pyrrolo [1,2-a] pyrazine-1,4-dion, hexahydro-3-(2-methylpropyle) (PPDHM) was the major compound for all strains which have a various pharmacological effect. Isolation and identification of beneficial bacteria from natural sources can play an important role in future pharmaceutical and industrial applications.
MeSH term(s)	Anti-Infective Agents/pharmacology ; Bacillus/genetics ; Fungi ; Honey ; Humans ; RNA, Ribosomal, 16S
Chemical Substances	Anti-Infective Agents ; RNA, Ribosomal, 16S
Language	English
Publishing date	2022-03-19
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-022-03551-y
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