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  1. Article: Plasma-derived immune-related factors as biomarkers of osimertinib resistance in EGFR-mutant non-small cell lung cancer patients.

    Hydbring, Per

    Translational lung cancer research

    2023  Volume 12, Issue 3, Page(s) 405–407

    Language English
    Publishing date 2023-03-17
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-117
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  2. Article: Targeting gene fusions in non-small cell lung cancer-a ceaseless success story?

    Hydbring, Per

    Translational lung cancer research

    2023  Volume 12, Issue 7, Page(s) 1358–1360

    Language English
    Publishing date 2023-06-14
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-284
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  3. Article: Complex glandular pattern as an independent predictor of survival probability in lung adenocarcinoma.

    Hydbring, Per

    Translational lung cancer research

    2022  Volume 11, Issue 9, Page(s) 1739–1741

    Language English
    Publishing date 2022-08-04
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-22-513
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  4. Article ; Online: Concepts and Design of Introducing Synthetic MicroRNAs into Mammalian Cells.

    Hydbring, Per

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2445, Page(s) 171–182

    Abstract: MicroRNAs are pleiotropic gene modulators affecting numerous cellular processes in development and disease. Due to their small size, microRNAs can easily be synthesized for the purpose of mechanistic or therapeutic studies in biological processes, ... ...

    Abstract MicroRNAs are pleiotropic gene modulators affecting numerous cellular processes in development and disease. Due to their small size, microRNAs can easily be synthesized for the purpose of mechanistic or therapeutic studies in biological processes, including autophagy. Depending on the biological question posed, approaches of modulating microRNAs involve either microRNA mimic or inhibitory nucleic acid molecules. This protocol outlines the detailed methodological steps to introduce synthetic microRNA drugs into target cells in vitro and in vivo and how to monitor their function. In addition, it provides insights on how to control the adverse effects when ectopically expressing synthetic microRNA mimic molecules.
    MeSH term(s) Animals ; Autophagy ; Mammals/genetics ; MicroRNAs/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2071-7_11
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  5. Article ; Online: Editorial: Immune-mediated damage to the heart and lungs in autoimmune diseases.

    Wei, Lingling / Hydbring, Per / Long, Li

    Frontiers in immunology

    2024  Volume 15, Page(s) 1407748

    MeSH term(s) Humans ; Autoimmune Diseases/immunology ; Autoimmune Diseases/etiology ; Animals ; Lung/immunology ; Lung/pathology ; Lung Diseases/immunology ; Lung Diseases/etiology ; Heart Diseases/immunology ; Heart Diseases/etiology ; Myocardium/immunology ; Myocardium/pathology ; Myocardium/metabolism
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1407748
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  6. Article ; Online: Construction of a Full-Length 3'UTR Reporter System for Identification of Cell-Cycle Regulating MicroRNAs.

    Kaźmierczak, Dominika / Hydbring, Per

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2329, Page(s) 81–94

    Abstract: Three prime untranslated region (3'UTR) reporter constructs are widely used by the scientific community to functionally link microRNAs (miRNAs) to suppression of mRNA expression. However, full-length 3'UTR vectors are rarely employed due to labor- ... ...

    Abstract Three prime untranslated region (3'UTR) reporter constructs are widely used by the scientific community to functionally link microRNAs (miRNAs) to suppression of mRNA expression. However, full-length 3'UTR vectors are rarely employed due to labor-intensive cloning work. Instead, 3'UTR fragments containing putative miRNA binding sites are commonly utilized to mechanistically validate miRNAs. Assaying truncated 3'UTRs may falsely validate miRNAs due to altered positioning of binding sites in respect to 3'UTR length and RNA secondary structure. Here we present a detailed protocol for the construction of full-length 3'UTR luciferase reporter constructs that was used to unveil miRNAs regulating multiple cell-cycle factors.
    MeSH term(s) 3' Untranslated Regions ; Binding Sites ; Cell Cycle ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/genetics ; Cell Line ; Genes, Reporter ; Humans ; Luciferases/genetics ; MicroRNAs/analysis ; RNA, Messenger/chemistry ; RNA, Messenger/genetics
    Chemical Substances 3' Untranslated Regions ; Cell Cycle Proteins ; MicroRNAs ; RNA, Messenger ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1538-6_7
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  7. Article: Development and validation of a dynamic survival nomogram for metastatic non-small cell lung cancer based on the SEER database and an external validation cohort.

    Wang, Qing / Wang, Yansu / Wang, Xinyu / Nakamura, Yusuke / Hydbring, Per / Yamauchi, Yoshikane / Zhao, Xiaojing / Cao, Min

    Translational lung cancer research

    2022  Volume 11, Issue 8, Page(s) 1678–1691

    Abstract: Background: Limited efficacy and poor prognosis are common in patients with metastatic non-small cell lung cancer (NSCLC). An accurate and useful nomogram helps the clinician predict the prognosis of the patients. However, there has been no previous ... ...

    Abstract Background: Limited efficacy and poor prognosis are common in patients with metastatic non-small cell lung cancer (NSCLC). An accurate and useful nomogram helps the clinician predict the prognosis of the patients. However, there has been no previous report on the nomogram specially for predicting the overall survival (OS) of metastatic NSCLC patients.
    Methods: A total of 18,343 patients diagnosed with metastatic NSCLC in the Surveillance, Epidemiology, and End Results (SEER) database were included and divided into the training cohort (n=12,840) and the internal validation cohort (n=5,503), and 242 patients in Renji Hospital were additionally enrolled as the external validation cohort. Demographical, clinical, and OS data were collected. A Cox proportional hazards regression model was used to develop a nomogram based on the training cohort. To validate the nomogram, we applied C-indexes, calibration curves, receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and a Kaplan-Meier survival curve.
    Results: The multivariate Cox regression model found that there were a total of 16 independent risk factors for OS of the patients (all 16 factors showed P<0.001), which were integrated into the nomogram with a C-index of 0.702 [95% confidence interval (CI): 0.684-0.720]. The nomogram also exhibited good prognostic value in the internal validation cohort (C-index =0.699, 95% CI: 0.673-0.725) and external validation cohort (C-index =0.695, 95% CI: 0.653-0.737). The ROC and Kaplan-Meier survival curve analyses demonstrated a high discriminative ability. High-risk patients had significantly less favorable OS than low-risk patients in the SEER population and external validation cohort (both P<0.001). The DCA analysis showed that the nomogram provided better prognosis prediction than the tumor-node-metastasis (TNM) staging system.
    Conclusions: We constructed and validated a dynamic nomogram with 16 variables based on a large-scale population of SEER database to predict the prognosis of metastatic NSCLC patients. The nomogram is expected to provide higher predictive ability and accuracy than the TNM staging system.
    Language English
    Publishing date 2022-10-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-22-544
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  8. Article: MYC Modulation around the CDK2/p27/SKP2 Axis.

    Hydbring, Per / Castell, Alina / Larsson, Lars-Gunnar

    Genes

    2017  Volume 8, Issue 7

    Abstract: MYC is a pleiotropic transcription factor that controls a number of fundamental cellular processes required for the proliferation and survival of normal and malignant cells, including the cell cycle. MYC interacts with several central cell cycle ... ...

    Abstract MYC is a pleiotropic transcription factor that controls a number of fundamental cellular processes required for the proliferation and survival of normal and malignant cells, including the cell cycle. MYC interacts with several central cell cycle regulators that control the balance between cell cycle progression and temporary or permanent cell cycle arrest (cellular senescence). Among these are the cyclin E/A/cyclin-dependent kinase 2 (CDK2) complexes, the CDK inhibitor p27
    Language English
    Publishing date 2017-06-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes8070174
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  9. Article ; Online: Cerebrospinal fluid as a liquid biopsy for molecular characterization of brain metastasis in patients with non-small cell lung cancer.

    Tsakonas, Georgios / Tadigotla, Vasisht / Chakrabortty, Sudipto K / Stragliotto, Giuseppe / Chan, Dalin / Lewensohn, Rolf / Yu, Wei / Skog, Johan K / Hydbring, Per / Ekman, Simon

    Lung cancer (Amsterdam, Netherlands)

    2023  Volume 182, Page(s) 107292

    Abstract: Objectives: Non-small cell lung cancer (NSCLC) with brain metastases (BM) is a challenging clinical issue with poor prognosis. No data exist regarding extensive genetic analysis of cerebrospinal fluid (CSF) and its correlation to associated tumor ... ...

    Abstract Objectives: Non-small cell lung cancer (NSCLC) with brain metastases (BM) is a challenging clinical issue with poor prognosis. No data exist regarding extensive genetic analysis of cerebrospinal fluid (CSF) and its correlation to associated tumor compartments.
    Materials and methods: We designed a study across multiple NSCLC patients with matched material from four compartments; primary tumor, BM, plasma and CSF. We performed enrichment-based targeted next-generation sequencing analysis of ctDNA and exosomal RNA in CSF and plasma and compared the outcome with the solid tumor compartments.
    Results: An average of 105 million reads per sample was generated with fractions of mapped reads exceeding 99% in all samples and with a mean coverage above 10,000x. We observed a high degree of overlap in variants between primary lung tumor and BM. Variants specific for the BM/CSF compartment included in-frame deletions in AR, FGF10 and TSC1 and missense mutations in HNF1a, CD79B, BCL2, MYC, TSC2, TET2, NRG1, MSH3, NOTCH3, VHL and EGFR.
    Conclusion: Our approach of combining ctDNA and exosomal RNA analyses in CSF presents a potential surrogate for BM biopsy. The specific variants that were only observed in the CNS compartments could serve as targets for individually tailored therapies in NSCLC patients with BM.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Mutation/genetics ; Liquid Biopsy ; Brain Neoplasms/genetics
    Language English
    Publishing date 2023-07-03
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2023.107292
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  10. Article: Clinical applications of microRNAs.

    Hydbring, Per / Badalian-Very, Gayane

    F1000Research

    2013  Volume 2, Page(s) 136

    Abstract: MicroRNAs represent a class of small RNAs derived from polymerase II controlled transcriptional regions. The primary transcript forms one or several bulging double stranded hairpins which are processed by Drosha and Dicer into hetero-duplexes. The ... ...

    Abstract MicroRNAs represent a class of small RNAs derived from polymerase II controlled transcriptional regions. The primary transcript forms one or several bulging double stranded hairpins which are processed by Drosha and Dicer into hetero-duplexes. The targeting microRNA strand of the duplex is incorporated into the RNA Induced Silencing Complex from where it silences up to hundreds of mRNA transcript by inducing mRNA degradation or blocking protein translation. Apart from involvement in a variety of biological processes, microRNAs were early recognized for their potential in disease diagnostics and therapeutics. Due to their stability, microRNAs could be used as biomarkers. Currently, there are microRNA panels helping physicians determining the origins of cancer in disseminated tumors. The development of microRNA therapeutics has proved more challenging mainly due to delivery issues. However, one drug is already in clinical trials and several more await entering clinical phases. This review summarizes what has been recognized pre-clinically and clinically on diagnostic microRNAs. In addition, it highlights individual microRNA drugs in running platforms driven by four leading microRNA-therapeutic companies.
    Language English
    Publishing date 2013-06-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.2-136.v3
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