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Book: F.P.A. a fábrica leccionada

Alho, Albérico Afonso Costa

aventuras dos tecnocatólicos no Ministério das Corpora-cões

2008

Institution	Portugal / Ministério das Corporações e Segurança Social
Author's details	Albérico Afonso Costa Alho
Language	Portuguese
Size	414 S, graph. Darst, 23 cm
Publisher	Profedi-cões
Publishing place	Porto
Document type	Book
Note	FPA, Forma-cão Profissional Acelerada ; On the job training in Portugal in the 1960's
ISBN	9789728562557 ; 9728562551
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Paralympic Versus Olympic Canoe Sprint: Comprehension of the Development Trajectory of the Kayak 200 Meters.

Ribeiro Neto, Frederico / Dos Santos, Luiz Gustavo Teixeira Fabrício / Castelli Correia de Campos, Luis Felipe / Winckler, Ciro / Gomes Costa, Rodrigo Rodrigues

Perceptual and motor skills

2024 , Page(s) 315125241247859

Abstract: ... in specific sports classes (KL3-M, K1-M, and K1-F; KL: Kayak Level, M: male, F: female), with a poor positive ...

Abstract	Improvements in race times for male and female Para canoe athletes across different sports classes have led to a reduction in relative differences between classes over time. However, there is a lack of research examining the comparative developmental trajectories between high-performance Paralympic (PCS) and Olympic (OCS) canoe sprint. In this study, we compared the developmental trajectories of 200-meter kayak performances among PCS and OCS athletes. In total, we analyzed 628 race results obtained from public online databases, for nine competitions between 2015 and 2023. Race times were reduced over the years except in specific sports classes (KL3-M, K1-M, and K1-F; KL: Kayak Level, M: male, F: female), with a poor positive correlation (r = 0.17 to 0.33) between time and the years. For the remaining sports classes, these correlations ranged from poor to fair (r = -0.58 to -0.13). OCS K1 athletes outperformed their Paralympic counterparts. Among Paralympic classes, KL1 had slower times than KL2 and KL3 (
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	204507-2
ISSN	1558-688X ; 0031-5125
ISSN (online)	1558-688X
ISSN	0031-5125
DOI	10.1177/00315125241247859
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1088: Show issues

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Article ; Online: Short-term outcomes of laparoscopic extended hepatectomy versus major hepatectomy: a single-center experience.

Costa, Adriano C / Mazzotta, Alessandro / Santa-Cruz, Fernando / Coelho, Fabricio F / Tribillon, Ecoline / Gayet, Brice / Herman, Paulo / Soubrane, Olivier

HPB : the official journal of the International Hepato Pancreato Biliary Association

2024

Abstract: Introduction: Laparoscopic major hepatectomy (LMH) remains restricted to a few specialized centers and poses a challenge to surgeons performing laparoscopic resections. Laparoscopic extended resections are even more complex and rarely conducted.: ... ...

Abstract	Introduction: Laparoscopic major hepatectomy (LMH) remains restricted to a few specialized centers and poses a challenge to surgeons performing laparoscopic resections. Laparoscopic extended resections are even more complex and rarely conducted. Methods: From a single-institution database, we compared the short-term outcomes of patients who underwent major and extended laparoscopic resections, stratifying the entire retrospective cohort into four groups: right hepatectomy, left hepatectomy, right extended hepatectomy, and left extended hepatectomy. Patient demographics, tumor characteristics, operative variables, and especially postoperative outcomes were evaluated. Results: 250 patients underwent major and extended laparoscopic liver resections, including 160 right, 31 right extended, 36 left, and 23 left extended laparoscopic hepatectomies. The most common indication for resection was colorectal liver metastases (64%). Laparoscopic extended hepatectomy (LEH) showed significantly longer operative time, more blood loss, need for Pringle maneuver, conversion to open surgery, higher rates of liver failure, postoperative ascites, and intra-abdominal hemorrhage, R1 margins and length of stay when compared with the LMH group. Mortality rates were similar between groups. Multivariate analysis revealed intraoperative blood transfusion (OR = 5.1[CI-95%: 1.15-6.79]; p = 0.02) as an independent predictor for major complications. Conclusions: LEH showed to be feasible, however with higher blood loss and significantly associated to major complications.
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2024.02.017
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Article ; Online: Biochemical characterization and analysis of gene expression of an α-mannosidase secreted by Paracoccidioides brasiliensis.

Corrêa, Priscila C / Fernandes, Fabrício F / Costa, Marcelo V / Landgraf, Taise N / Panunto-Castelo, Ademilson

Medical mycology

2022 Volume 60, Issue 2

Abstract: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the Paracoccidioides genus, being endemic in Latin America and with the highest number of cases in Brazil. Paracoccidioides spp. release a wide range of molecules, such as enzymes, ... ...

Abstract	Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the Paracoccidioides genus, being endemic in Latin America and with the highest number of cases in Brazil. Paracoccidioides spp. release a wide range of molecules, such as enzymes, which may be important for PCM establishment. Here, we identified the 85- and 90-kDa proteins from the supernatants of P. brasiliensis cultures as being an α-mannosidase. Because the expected mass of this α-mannosidase is 124.2-kDa, we suggest that the proteins were cleavage products. Indeed, we found an α-mannosidase activity in the culture supernatants among the excreted/secreted antigens (ESAg). Moreover, we determined that the enzyme activity was optimal in buffer at pH 5.6, at the temperature of 45ºC, and with a concentration of 3 mM of the substrate p-NP-α-D-Man. Remarkably, we showed that the gene expression of this α-mannosidase was higher in yeasts than hyphae in three P. brasiliensis isolates with different virulence degrees that were grown in Ham's F12 synthetic medium for 15 days. But in complex media YPD and Fava Netto, the significantly higher gene expression in yeasts than in hyphae was seen only for the virulent isolate Pb18, but not for intermediate virulence Pb339 and low virulence Pb265 isolates. These results about the high expression of the α-mannosidase gene in the pathogenic yeast form of P. brasiliensis open perspectives for studying this α-mannosidase concerning the virulence of P. brasiliensis isolates. Lay summary: Paracoccidioides brasiliensis causes deep mycosis, paracoccidioidomycosis. We determined for the first time the biochemical properties of an α-mannosidase released by this fungus. We suggest that the enzyme gene expression in the fungus is associated with fungal morphology, stress, and virulence.
MeSH term(s)	Animals ; Gene Expression ; Paracoccidioides/genetics ; Paracoccidioidomycosis/veterinary ; Virulence ; alpha-Mannosidase/genetics
Chemical Substances	alpha-Mannosidase (EC 3.2.1.24)
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myac002
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Article ; Online: Depressive Symptoms and Self-Rated Health among Brazilian Older Adults: Baseline Data from the Elsi Brazil Study.

Ito, Natalia T / Oliveira, Déborah / Rodrigues, Fabricio M S / Castro-Costa, Erico / Lima-Costa, Maria F / Ferri, Cleusa P

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2023

Abstract: Objective: This study investigates whether having a higher number of depressive symptoms is associated with negative self-rated health even in the presence of illnesses.: Methods: This is a secondary analysis of the baseline data from the ... ...

Abstract	Objective: This study investigates whether having a higher number of depressive symptoms is associated with negative self-rated health even in the presence of illnesses. Methods: This is a secondary analysis of the baseline data from the Longitudinal Study of the Health of Elderly Brazilians (ELSI - Brazil), conducted in 2015-2016, using a national sample of 9,412 people aged 50 or over. Self-rated health was dichotomized into "bad or very bad" and "very good or excellent, good or average". Depressive symptoms were assessed through the eight-item Center for Epidemiologic Studies Depression (CES-D8). Sociodemographic variables, information about unhealthy behaviours, and the number of chronic conditions were also analysed. Results: Having depressive symptoms was strongly associated with bad or very bad self-rated health both in the unadjusted and adjusted analyses. There was a reduction in the magnitude of the association when the number of chronic illnesses was included in the multivariate analysis, along with the other sociodemographic variables and unhealthy behaviours (OR 1,35 95% CI 1,31 - 1,39). Conclusion: Having depressive symptoms may contribute towards having a poorer perception of health, even in the absence of health conditions. Self-rated health is a multidimensional construct that can accurately reflect a person's state of general mental health.
Language	English
Publishing date	2023-11-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2024119-7
ISSN	1809-452X ; 1809-452X
ISSN (online)	1809-452X
ISSN	1809-452X
DOI	10.47626/1516-4446-2023-3331
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ophthalmic artery Doppler in the complementary diagnosis of preeclampsia: a systematic review and meta-analysis.

de Melo, Pollyanna F M Vaz / Roever, Leonardo / Mendonça, Tânia M S / da Silva Costa, Fabrício / Rolnik, Daniel Lorber / Diniz, Angélica L D

BMC pregnancy and childbirth

2023 Volume 23, Issue 1, Page(s) 343

Abstract: Objective: To evaluate the accuracy of different parameters of the ophthalmic artery Doppler (OAD) in the complementary diagnosis of preeclampsia (PE).: Methods: This meta-analysis adhered to the PRISMA guidelines. To investigate the mean difference ... ...

Abstract	Objective: To evaluate the accuracy of different parameters of the ophthalmic artery Doppler (OAD) in the complementary diagnosis of preeclampsia (PE). Methods: This meta-analysis adhered to the PRISMA guidelines. To investigate the mean difference in OAD values, peak systolic velocity (PSV), end-diastolic velocity (EDV), second systolic velocity peak (P2), resistance index (RI), pulsatility index (PI), and peak ratio (PR), between PE cases (overall and according to severity) and controls, random-effects meta-analyses were conducted for each Doppler parameter, with overall PE and mild and severe PE subgroups. Diagnostic performance and heterogeneity were evaluated with summary receiver operating characteristic (sROC) curves and 95% confidence intervals obtained with bivariate models. Results: Eight studies stratified the results into mild and severe or late and early PE, involving 1,425 pregnant women. PR and P2 had better diagnostic performance than the other indexes, with the PR of AUsROC at 0.885, the sensitivity of 84%, and specificity of 92%, with a low false-positive rate of 0.08 and the P2 with AUsROC of 0.926, the sensitivity of 85% and specificity of 88%. RI, PI, and EDV showed good performance and consistency across studies but lower AUsROC values of 0.833, 0.794, and 0.772, respectively. Conclusion: Ophthalmic artery Doppler is a complementary tool with good performance for the diagnosis of overall and severe preeclampsia, with high and best sensitivity and specificity when using PR and P2 parameters.
MeSH term(s)	Pregnancy ; Female ; Humans ; Pre-Eclampsia/diagnostic imaging ; Ophthalmic Artery/diagnostic imaging ; Sensitivity and Specificity ; ROC Curve ; Ultrasonography, Doppler/methods ; Blood Flow Velocity
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-05656-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Big data in biomedicine.

Costa, Fabricio F

Drug discovery today

2014 Volume 19, Issue 4, Page(s) 433–440

Abstract: The increasing availability and growth rate of biomedical information, also known as 'big data', provides an opportunity for future personalized medicine programs that will significantly improve patient care. Recent advances in information technology (IT) ...

Abstract	The increasing availability and growth rate of biomedical information, also known as 'big data', provides an opportunity for future personalized medicine programs that will significantly improve patient care. Recent advances in information technology (IT) applied to biomedicine are changing the landscape of privacy and personal information, with patients getting more control of their health information. Conceivably, big data analytics is already impacting health decisions and patient care; however, specific challenges need to be addressed to integrate current discoveries into medical practice. In this article, I will discuss the major breakthroughs achieved in combining omics and clinical health data in terms of their application to personalized medicine. I will also review the challenges associated with using big data in biomedicine and translational science.
MeSH term(s)	Biomedical Research ; Genomics ; Humans ; Medical Informatics ; Precision Medicine
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2013.10.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4725: Show issues

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Article: Epigenome-Driven Strategies for Personalized Cancer Immunotherapy.

Rocha, Gabriel Iudy Yamaguchi / Gomes, Jonathas Eduardo Miranda / Leite, Michel Lopes / da Cunha, Nicolau B / Costa, Fabricio F

Cancer management and research

2023 Volume 15, Page(s) 1351–1367

Abstract: Fighting cancer remains one of the greatest challenges for science in the 21st century. Advances in immunotherapy against different types of cancer have greatly contributed to the treatment, remission, and cure of patients. In this context, knowledge of ... ...

Abstract	Fighting cancer remains one of the greatest challenges for science in the 21st century. Advances in immunotherapy against different types of cancer have greatly contributed to the treatment, remission, and cure of patients. In this context, knowledge of epigenetic phenomena, their relationship with tumor cells and how the immune system can be epigenetically modulated represent some of the greatest advances in the development of anticancer therapies. Epigenetics is a rapidly growing field that studies how environmental factors can affect gene expression without altering DNA sequence. Epigenomic changes include DNA methylation, histone modifications, and non-coding RNA regulation, which impact cellular function. Epigenetics has shown promise in developing cancer therapies, such as immunotherapy, which aims to stimulate the immune system to attack cancer cells. For example, PD-1 and PD-L1 are biomarkers that regulate the immune response to cancer cells and recent studies have shown that epigenetic modifications can affect their expression, potentially influencing the efficacy of immunotherapy. New therapies targeting epigenetic modifications, such as histone deacetylases and DNA methyltransferases, are being developed for cancer treatment, and some have shown promise in preclinical studies and clinical trials. With growing understanding of epigenetic regulation, we can expect more personalized and effective cancer immunotherapies in the future. This review highlights key advances in the use of epigenetic and epigenomic tools and modern immuno-oncology strategies to treat several types of tumors.
Language	English
Publishing date	2023-12-01
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S272031
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Social networks, web-based tools and diseases: implications for biomedical research.

Costa, Fabricio F

Drug discovery today

2013 Volume 18, Issue 5-6, Page(s) 272–281

Abstract: ... medical research?" In this article, I will review how social networks and other web-based tools are ...

Abstract	Advances in information technology have improved our ability to gather, collect and analyze information from individuals online. Social networks can be seen as a nonlinear superposition of a multitude of complex connections between people where the nodes represent individuals and the links between them capture a variety of different social interactions. The emergence of different types of social networks has fostered connections between individuals, thus facilitating data exchange in a variety of fields. Therefore, the question posed now is "can these same tools be applied to life sciences in order to improve scientific and medical research?" In this article, I will review how social networks and other web-based tools are changing the way we approach and track diseases in biomedical research.
MeSH term(s)	Biomedical Research ; Disease Outbreaks ; Drug Discovery ; Humans ; Internet ; Precision Medicine ; Privacy
Language	English
Publishing date	2013-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2012.10.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4725: Show issues

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Article: Text mining for identification of biological entities related to antibiotic resistant organisms.

Fortunato Costa, Kelle / Almeida Araújo, Fabrício / Morais, Jefferson / Lisboa Frances, Carlos Renato / Ramos, Rommel T J

PeerJ

2022 Volume 10, Page(s) e13351

Abstract: ... learning algorithm to classify new records. The model's overall performance reached 90% accuracy and the f ...

Abstract	Antimicrobial resistance is a significant public health problem worldwide. In recent years, the scientific community has been intensifying efforts to combat this problem; many experiments have been developed, and many articles are published in this area. However, the growing volume of biological literature increases the difficulty of the biocuration process due to the cost and time required. Modern text mining tools with the adoption of artificial intelligence technology are helpful to assist in the evolution of research. In this article, we propose a text mining model capable of identifying and ranking prioritizing scientific articles in the context of antimicrobial resistance. We retrieved scientific articles from the PubMed database, adopted machine learning techniques to generate the vector representation of the retrieved scientific articles, and identified their similarity with the context. As a result of this process, we obtained a dataset labeled "Relevant" and "Irrelevant" and used this dataset to implement one supervised learning algorithm to classify new records. The model's overall performance reached 90% accuracy and the f-measure (harmonic mean between the metrics) reached 82% accuracy for positive class and 93% for negative class, showing quality in the identification of scientific articles relevant to the context. The dataset, scripts and models are available at https://github.com/engbiopct/TextMiningAMR.
Language	English
Publishing date	2022-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.13351
Database	MEDical Literature Analysis and Retrieval System OnLINE

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