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Article ; Online: Roberto Esposito:

Bruno Vendramin

Perspectivas Revista de Ciencias Sociales, Iss

2017 Volume 3

Abstract: Desde sus últimas publicaciones, Roberto Esposito (Nápoles, 1950) le ha efectuado al derecho ...

Abstract	Desde sus últimas publicaciones, Roberto Esposito (Nápoles, 1950) le ha efectuado al derecho una crítica radical y sobre todo a lo que él denomina dispositivo de la persona. La categoría persona es uno de los pilares sobre los que se han asentado los sistemas jurídicos de Occidente, sobre todo los de raigambre continental. El filósofo napolitano registra tres raíces del concepto de persona: una filosófica, una teológica y otra jurídica. En este trabajo voy a concentrarme en la matriz jurídica de la persona, la que tuvo su indudable origen en el derecho romano y que, con leves modificaciones, ha traspasado hasta la Modernidad y resurgido luego de la segunda guerra mundial. Así, primero analizo la crítica a la persona que expone Esposito, y con ello el concepto de derechos humanos, en virtud de que persona y derechos humanos se encuentran imbricados; luego, estudio la propuesta de Esposito, la que consiste en la formulación de una filosofía de lo impersonal y en la postulación de la tercera persona. Por último, es momento de unir personas y cosas (históricamente separadas) mediante el cuerpo, para transitar de un derecho de las personas a un derecho de los cuerpos.
Keywords	Roberto Esposito ; Derecho ; Persona ; Impersonal ; Cuerpos ; Social Sciences ; H
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	Universidad Nacional de Rosario
Document type	Article ; Online
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Article ; Online: Cancer evolution: Darwin and beyond.

Vendramin, Roberto / Litchfield, Kevin / Swanton, Charles

The EMBO journal

2021 Volume 40, Issue 18, Page(s) e108389

Abstract: Clinical and laboratory studies over recent decades have established branched evolution as a feature of cancer. However, while grounded in somatic selection, several lines of evidence suggest a Darwinian model alone is insufficient to fully explain ... ...

Abstract	Clinical and laboratory studies over recent decades have established branched evolution as a feature of cancer. However, while grounded in somatic selection, several lines of evidence suggest a Darwinian model alone is insufficient to fully explain cancer evolution. First, the role of macroevolutionary events in tumour initiation and progression contradicts Darwin's central thesis of gradualism. Whole-genome doubling, chromosomal chromoplexy and chromothripsis represent examples of single catastrophic events which can drive tumour evolution. Second, neutral evolution can play a role in some tumours, indicating that selection is not always driving evolution. Third, increasing appreciation of the role of the ageing soma has led to recent generalised theories of age-dependent carcinogenesis. Here, we review these concepts and others, which collectively argue for a model of cancer evolution which extends beyond Darwin. We also highlight clinical opportunities which can be grasped through targeting cancer vulnerabilities arising from non-Darwinian patterns of evolution.
MeSH term(s)	Animals ; Cell Plasticity ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Clonal Evolution ; Disease Management ; Disease Susceptibility ; Evolution, Molecular ; Genetic Heterogeneity ; Genetic Predisposition to Disease ; Genomics/methods ; Humans ; Neoplasms/diagnosis ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/therapy ; Selection, Genetic ; Tumor Microenvironment
Language	English
Publishing date	2021-08-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2021108389
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Article ; Online: M(R)apping RNA-Protein Interactions.

Barra, Jasmine / Vendramin, Roberto / Leucci, Eleonora

Methods in molecular biology (Clifton, N.J.)

2020 Volume 2254, Page(s) 259–272

Abstract: The systematic investigation of RNA-protein interactions is a key step towards a better understanding of the functions of RNA molecules.We developed an easy-to-use method to isolate and identify RNAs and proteins bound to long non-coding RNAs (lncRNAs ) ... ...

Abstract	The systematic investigation of RNA-protein interactions is a key step towards a better understanding of the functions of RNA molecules.We developed an easy-to-use method to isolate and identify RNAs and proteins bound to long non-coding RNAs (lncRNAs ) in their native configuration. Similar to other methodologies, we utilize biotinylated antisense oligonucleotides (ASOs) to purify the lncRNA of interest and its associated proteins from different cellular compartments.
MeSH term(s)	Biotinylation ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cytoplasm/genetics ; Cytoplasm/metabolism ; Humans ; MCF-7 Cells ; Mass Spectrometry ; Mitochondria/genetics ; Mitochondria/metabolism ; Proteins/metabolism ; RNA, Antisense/isolation & purification ; RNA, Long Noncoding/metabolism
Chemical Substances	Proteins ; RNA, Antisense ; RNA, Long Noncoding
Language	English
Publishing date	2020-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1158-6_16
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Article ; Online: Non-coding RNAs: the dark side of nuclear-mitochondrial communication.

Vendramin, Roberto / Marine, Jean-Christophe / Leucci, Eleonora

The EMBO journal

2017 Volume 36, Issue 9, Page(s) 1123–1133

Abstract: Mitochondria are critical hubs for the integration of several key metabolic processes implicated in cell growth and survival. They originated from bacterial ancestors through endosymbiosis, following the transfer of more than 90% of their endosymbiont ... ...

Abstract	Mitochondria are critical hubs for the integration of several key metabolic processes implicated in cell growth and survival. They originated from bacterial ancestors through endosymbiosis, following the transfer of more than 90% of their endosymbiont genome to the host cell nucleus. Over time, a mutually beneficial symbiotic relationship has been established, which relies on continuous and elaborate signaling mechanisms between this life-essential organelle and its host. The ability of mitochondria to signal their functional state and trigger compensatory and adaptive cellular responses has long been recognized, but the underlying molecular mechanisms involved have remained poorly understood. Recent evidence indicates that non-coding RNAs (ncRNAs) may contribute to the synchronization of a series of essential cellular and mitochondrial biological processes, acting as "messengers" between the nucleus and the mitochondria. Here, we discuss the emerging putative roles of ncRNAs in various bidirectional signaling pathways established between the host cell and its mitochondria, and how the dysregulation of these pathways may lead to aging-related diseases, including cancer, and offer new promising therapeutic avenues.
MeSH term(s)	Cell Nucleus/metabolism ; Gene Expression Regulation ; Mitochondria/metabolism ; RNA, Untranslated/metabolism
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2017-03-17
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.201695546
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Article ; Online: The Role of Italy in the Use of Advanced Plant Genomic Techniques on Fruit Trees: State of the Art and Future Perspectives.

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Climate change is deeply impacting the food chain production, lowering quality and yield. In this context, the international scientific community has dedicated many efforts to enhancing resilience and sustainability in agriculture. Italy is among the ... ...

Abstract	Climate change is deeply impacting the food chain production, lowering quality and yield. In this context, the international scientific community has dedicated many efforts to enhancing resilience and sustainability in agriculture. Italy is among the main European producers of several fruit trees; therefore, national research centers and universities undertook several initiatives to maintain the specificity of the 'Made in Italy' label. Despite their importance, fruit crops are suffering from difficulties associated with the conventional breeding approaches, especially in terms of financial commitment, land resources availability, and long generation times. The 'new genomic techniques' (NGTs), renamed in Italy as 'technologies for assisted evolution' (TEAs), reduce the time required to obtain genetically improved cultivars while precisely targeting specific DNA sequences. This review aims to illustrate the role of the Italian scientific community in the use of NGTs, with a specific focus on
MeSH term(s)	Trees/genetics ; Fruit/genetics ; Plant Breeding/methods ; Genome, Plant ; Genomics
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24020977
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Article ; Online: Sheathless Versus Sheathed Intra-Aortic Balloon Pump Implantation in Patients Undergoing Cardiac Surgery.

The American journal of cardiology

2022 Volume 189, Page(s) 86–92

Abstract: The intra-aortic balloon pump (IABP) is the most widely available mechanical support device, but its use has been disputed in recent decades. Although several efforts have been made to reduce the associated complication rate, contemporary data on this ... ...

Abstract	The intra-aortic balloon pump (IABP) is the most widely available mechanical support device, but its use has been disputed in recent decades. Although several efforts have been made to reduce the associated complication rate, contemporary data on this matter is lacking. The present study aims to evaluate the differences in vascular complications between the sheathless and the sheathed IABP implantation technique in cardiac surgery patients. A retrospective multi-center cohort, consisting of patients treated in 8 cardiac surgical centers, was evaluated. Patients who underwent cardiac surgery with peri-operative IABP support were included. Primary outcome was a composite end point of vascular complications. Propensity score matching (PSM) was performed, and a multivariable regression model was applied to evaluate predictors of vascular complications. The unmatched cohort consisted of 2,615 patients (sheathless n = 1,414, 54%, sheathed n = 1,201, 46%). A total of 878 patients were matched (n = 439 for both groups). The composite vascular complication end point occurred in 3% of patients in the sheathless group, compared with 8% in the sheathed group (p <0.001). Vascular complications were significantly associated with mortality (odds ratio [OR] 3.86, 95% confidence interval [CI] 2.01 to 7.40, p <0.001). Peripheral arterial disease was associated with vascular complications (OR 3.10, 95% CI 1.46 to 6.55, p = 0.003), whereas the sheathless implantation technique was found to be protective (OR 0.36, 95% CI 0.18 to 0.73, p = 0.005). In conclusion, the present retrospective multi-center analysis demonstrated the sheathless implantation technique to be associated with a significant reduction in vascular complication rate. Future studies should focus on even less invasive implantation techniques using smaller-sized catheters, sheathless implantation, and imaging guiding.
MeSH term(s)	Humans ; Risk Factors ; Cardiac Surgical Procedures ; Intra-Aortic Balloon Pumping ; Heart-Assist Devices ; Retrospective Studies ; Peripheral Arterial Disease/etiology ; Treatment Outcome
Language	English
Publishing date	2022-12-12
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.11.033
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Article ; Online: Contemporary outcomes of cardiac surgery patients supported by the intra-aortic balloon pump.

Interactive cardiovascular and thoracic surgery

2022 Volume 35, Issue 1

Abstract: Objectives: Although the intra-aortic balloon pump (IABP) has been the most widely adopted temporary mechanical support device in cardiac surgical patients, its use has declined. The current study aimed to evaluate the occurrence and predictors of early ...

Abstract	Objectives: Although the intra-aortic balloon pump (IABP) has been the most widely adopted temporary mechanical support device in cardiac surgical patients, its use has declined. The current study aimed to evaluate the occurrence and predictors of early mortality and complication rates in contemporary cardiac surgery patients supported by an IABP. Methods: A multicentre, retrospective analysis was performed of all consecutive cardiac surgical patients receiving perioperative balloon pump support in 8 centres between January 2010 to December 2019. The primary outcome was early mortality, and secondary outcomes were balloon-associated complications. A multivariable binary logistic regression model was applied to evaluate predictors of the primary outcome. Results: The study cohort consisted of 2615 consecutive patients. The median age was 68 years [25th percentile 61, 75th percentile 75 years], with the majority being male (76.9%), and a mean calculated 30-day mortality risk of 10.0%. Early mortality was 12.7% (n = 333), due to cardiac causes (n = 266), neurological causes (=22), balloon-related causes (n = 5) and other causes (n = 40). A composite end point of all vascular complications occurred in 7.2% of patients, and leg ischaemia was observed in 1.3% of patients. The most important predictors of early mortality were peripheral vascular disease [odds ratio (OR) 1.63], postoperative dialysis requirement (OR 10.40) and vascular complications (OR 2.57). Conclusions: The use of the perioperative IABP proved to be safe and demonstrated relatively low complication rates, particularly for leg ischaemia. As such, we believe that specialists should not be held back to use this widely available treatment in high-risk cardiac surgical patients when indicated.
MeSH term(s)	Aged ; Cardiac Surgical Procedures/adverse effects ; Female ; Humans ; Intra-Aortic Balloon Pumping/adverse effects ; Ischemia/etiology ; Male ; Retrospective Studies ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2022-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivac091
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Article ; Online: Extracorporeal life support in mitral papillary muscle rupture: Outcome of multicenter study.

Massimi, Giulio / Matteucci, Matteo / De Bonis, Michele / Kowalewski, Mariusz / Formica, Francesco / Russo, Claudio Francesco / Sponga, Sandro / Vendramin, Igor / Colli, Andrea / Falcetta, Giosuè / Trumello, Cinzia / Carrozzini, Massimiliano / Fischlein, Theodor / Troise, Giovanni / Actis Dato, Guglielmo / D'Alessandro, Stefano / Nia, Peyman Sardari / Lodo, Vittoria / Villa, Emmanuel /

Shah, Shabir Hussain / Scrofani, Roberto / Binaco, Irene / Kalisnik, Jurij Matija / Pettinari, Matteo / Thielmann, Matthias / Meyns, Bart / Khouqeer, Fareed A / Fino, Carlo / Simon, Caterina / Severgnini, Paolo / Kowalowka, Adam / Deja, Marek A / Ronco, Daniele / Lorusso, Roberto

Artificial organs

2023 Volume 47, Issue 8, Page(s) 1386–1394

Abstract: Background: Post-acute myocardial infarction papillary muscle rupture (post-AMI PMR) may present variable clinical scenarios and degree of emergency due to result of cardiogenic shock. Veno-arterial extracorporeal life support (V-A ECLS) has been ... ...

Abstract	Background: Post-acute myocardial infarction papillary muscle rupture (post-AMI PMR) may present variable clinical scenarios and degree of emergency due to result of cardiogenic shock. Veno-arterial extracorporeal life support (V-A ECLS) has been proposed to improve extremely poor pre- or postoperative conditions. Information in this respect is scarce. Methods: From the CAUTION (meChanical complicAtion of acUte myocardial infarcTion: an InternatiOnal multiceNter cohort study) database (16 different Centers, data from 2001 to 2018), we extracted adult patients who were surgically treated for post-AMI PMR and underwent pre- or/and postoperative V-A ECLS support. The end-points of this study were in-hospital survival and ECLS complications. Results: From a total of 214 post-AMI PMR patients submitted to surgery, V-A ECLS was instituted in 23 (11%) patients. The median age was 61.7 years (range 46-81 years). Preoperatively, ECLS was commenced in 10 patients (43.5%), whereas intra/postoperative in the remaining 13. The most common V-A ECLS indication was post-cardiotomy shock, followed by preoperative cardiogenic shock and cardiac arrest. The median duration of V-A ECLS was 4 days. V-A ECLS complications occurred in more than half of the patients. Overall, in-hospital mortality was 39.2% (9/23), compared to 22% (42/219) for the non-ECLS group. Conclusions: In post-AMI PMR patients, V-A ECLS was used in almost 10% of the patients either to promote bridge to surgery or as postoperative support. Further investigations are required to better evaluate a potential for increased use and its effects of V-A ECLS in such a context based on the still high perioperative mortality.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Extracorporeal Membrane Oxygenation/methods ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/surgery ; Cohort Studies ; Papillary Muscles/surgery ; Myocardial Infarction/complications ; Cardiomyopathies/complications ; Heart Valve Diseases/complications
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14541
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Article ; Online: Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3.

De Troyer, Linde / Zhao, Peihua / Pastor, Tibor / Baietti, Maria Francesca / Barra, Jasmine / Vendramin, Roberto / Dok, Ruveyda / Lechat, Benoit / Najm, Paul / Van Haver, Delphi / Impens, Francis / Leucci, Eleonora / Sablina, Anna A

Nucleic acids research

2020 Volume 48, Issue 9, Page(s) 5198–5199

Language	English
Publishing date	2020-04-16
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkaa280
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Article ; Online: Targeted chemotherapy overcomes drug resistance in melanoma.

Yue, Jingyin / Vendramin, Roberto / Liu, Fan / Lopez, Omar / Valencia, Monica G / Gomes Dos Santos, Helena / Gaidosh, Gabriel / Beckedorff, Felipe / Blumenthal, Ezra / Speroni, Lucia / Nimer, Stephen D / Marine, Jean-Christophe / Shiekhattar, Ramin

Genes & development

2020 Volume 34, Issue 9-10, Page(s) 637–649

Abstract: The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escape lethal DNA damage effects by inducing growth arrest ... ...

Abstract	The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escape lethal DNA damage effects by inducing growth arrest commonly referred to as cellular dormancy. We present a therapeutic strategy termed "targeted chemotherapy" by depleting protein phosphatase 2A (PP2A) or its inhibition using a small molecule inhibitor (1,10-phenanthroline-5,6-dione [phendione]) in drug-resistant melanoma. Targeted chemotherapy induces the DNA damage response without causing DNA breaks or allowing cellular dormancy. Phendione treatment reduces tumor growth of BRAF
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Damage/drug effects ; Drug Resistance, Neoplasm/drug effects ; Humans ; Melanoma/drug therapy ; Melanoma/enzymology ; Melanoma/physiopathology ; Protein Phosphatase 2/antagonists & inhibitors ; Pyrazoles/pharmacology
Chemical Substances	Antineoplastic Agents ; Pyrazoles ; Protein Phosphatase 2 (EC 3.1.3.16) ; phenidone (H0U5612P6K)
Language	English
Publishing date	2020-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.333864.119
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