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  1. Article ; Online: Use of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)-(Equine) (BAT

    Parrera, Geraldine S / Astacio, Hugo / Tunga, Priya / Anderson, Deborah M / Hall, Christine L / Richardson, Jason S

    Toxins

    2021  Volume 14, Issue 1

    Abstract: Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. ... ...

    Abstract Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. BAT
    MeSH term(s) Botulinum Antitoxin/adverse effects ; Botulism/chemically induced ; Botulism/therapy ; Humans
    Chemical Substances Botulinum Antitoxin
    Language English
    Publishing date 2021-12-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Systematic Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14010019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Use of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine) (BAT ® ) in Clinical Study Subjects and Patients

    Geraldine S. Parrera / Hugo Astacio / Priya Tunga / Deborah M. Anderson / Christine L. Hall / Jason S. Richardson

    Toxins, Vol 14, Iss 19, p

    A 15-Year Systematic Safety Review

    2022  Volume 19

    Abstract: ... Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine)) is an equine-derived heptavalent botulinum antitoxin ...

    Abstract Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. BAT ® (Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine)) is an equine-derived heptavalent botulinum antitoxin indicated for the treatment of symptomatic botulism in adult and pediatric patients. This review assesses the cumulative safety profile for BAT product from 2006 to 2020, using data received from clinical studies, an expanded-access program, a post-licensure registry, spontaneous and literature reports. The adverse event (AE) incidence rate for BAT product was calculated conservatively using only BAT product exposures for individuals with a record (512) and was alternatively estimated using all BAT product exposure data, including post-licensure deployment information (1128). The most frequently reported BAT product-related AEs occurring in greater than 1% of the 512–1128 BAT product-exposed individuals were hypersensitivity, pyrexia, tachycardia, bradycardia, anaphylaxis, and blood pressure increase reported in 2.3–5.1%, 1.8–3.9%, 1.0–2.2%, 0.89–2.0%, 0.62–1.4%, and 0.62–1.4%, respectively. For patients properly managed in an intensive care setting, the advantages of BAT product appear to outweigh potential risks in patients due to morbidity and mortality of botulism. AEs of special interest, including bradycardia, hemodynamic instability, hypersensitivity, serum sickness, and febrile reactions in the registry, were specifically solicited.
    Keywords safety review ; equine-derived ; Botulism Antitoxin Heptavalent ; BAT product ; botulism ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: [Besprechung von:] Richardson, G. B.: Economic theory, London 1964

    Kalmbach, Peter / Richardson, G. B

    Jahrbücher für Nationalökonomie und Statistik Vol. 178, No. 1/3 , p. 285-287

    1965  Volume 178, Issue 1, Page(s) 285–287

    Author's details Peter Kalmbach
    Publisher Lucius und Lucius
    Publishing place Stuttgart
    Document type Article
    ZDB-ID 215643x
    Database ECONomics Information System

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  4. Article: [Besprechung von:] Richardson, G. B.: Information and investment. A sudy in the working of the competitive economy. London 1960

    Fog, Bjarke / Richardson, G. B

    Weltwirtschaftliches Archiv : Zeitschrift des Instituts für Weltwirtschaft an der Universität Kiel Vol. 90, No. 2 , p. 66-67

    1963  Volume 90, Issue 2, Page(s) 66–67

    Author's details Bjarke Fog
    Publisher Mohr
    Publishing place Tübingen
    Document type Article
    ZDB-ID 518-6
    Database ECONomics Information System

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  5. Article ; Online: The bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions.

    Richardson, Jane S / Williams, Christopher J / Chen, Vincent B / Prisant, Michael G / Richardson, David C

    Acta crystallographica. Section D, Structural biology

    2023  Volume 79, Issue Pt 12, Page(s) 1071–1078

    Abstract: Model building and refinement, and the validation of their correctness, are very effective and reliable at local resolutions better than about 2.5 Å for both crystallography and cryo-EM. However, at local resolutions worse than 2.5 Å both the procedures ... ...

    Abstract Model building and refinement, and the validation of their correctness, are very effective and reliable at local resolutions better than about 2.5 Å for both crystallography and cryo-EM. However, at local resolutions worse than 2.5 Å both the procedures and their validation break down and do not ensure reliably correct models. This is because in the broad density at lower resolution, critical features such as protein backbone carbonyl O atoms are not just less accurate but are not seen at all, and so peptide orientations are frequently wrongly fitted by 90-180°. This puts both backbone and side chains into the wrong local energy minimum, and they are then worsened rather than improved by further refinement into a valid but incorrect rotamer or Ramachandran region. On the positive side, new tools are being developed to locate this type of pernicious error in PDB depositions, such as CaBLAM, EMRinger, Pperp diagnosis of ribose puckers, and peptide flips in PDB-REDO, while interactive modeling in Coot or ISOLDE can help to fix many of them. Another positive trend is that artificial intelligence predictions such as those made by AlphaFold2 contribute additional evidence from large multiple sequence alignments, and in high-confidence parts they provide quite good starting models for loops, termini or whole domains with otherwise ambiguous density.
    MeSH term(s) Models, Molecular ; Artificial Intelligence ; Proteins/chemistry ; Crystallography, X-Ray ; Peptides ; Cryoelectron Microscopy/methods ; Protein Conformation
    Chemical Substances Proteins ; Peptides
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968623-4
    ISSN 2059-7983 ; 0907-4449
    ISSN (online) 2059-7983
    ISSN 0907-4449
    DOI 10.1107/S2059798323008847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Shale weathering profiles show Hg sequestration along a New York-Tennessee transect.

    Richardson, Justin B

    Environmental geochemistry and health

    2021  Volume 44, Issue 10, Page(s) 3515–3526

    Abstract: ... Total Hg concentrations in unweathered shale ranged from 3 to 94 ng/g. Total Hg concentrations decreased ... with depth in the Ultisols and Alfisols, with total Hg concentrations ranging from 18 to 265 ng/g. Across ...

    Abstract Shale-derived soils have higher clay, organic matter, and secondary Fe oxide content than other bedrock types, all of which can sequester Hg. However, shales also can be Hg-rich due to their marine formation. The objectives of this study were to determine the concentration and phase partitioning of Hg in seven upland weathering profiles from New York to Tennessee USA and use geochemical normalization techniques to estimate the extent of Hg inheritance from weathering of shale bedrock or sequestration of atmospheric Hg. Total Hg concentrations in unweathered shale ranged from 3 to 94 ng/g. Total Hg concentrations decreased with depth in the Ultisols and Alfisols, with total Hg concentrations ranging from 18 to 265 ng/g. Across all shale soils and rocks, the oxidizable fraction of Hg (15% H
    MeSH term(s) Bicarbonates ; Citrates ; Clay ; Dithionite ; Environmental Monitoring ; Hydrogen Peroxide ; Mercury/analysis ; Minerals ; New York ; Soil/chemistry ; Soil Pollutants/analysis ; Sulfides ; Tennessee
    Chemical Substances Bicarbonates ; Citrates ; Minerals ; Soil ; Soil Pollutants ; Sulfides ; Dithionite (14844-07-6) ; Hydrogen Peroxide (BBX060AN9V) ; Mercury (FXS1BY2PGL) ; Clay (T1FAD4SS2M)
    Language English
    Publishing date 2021-10-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-021-01110-x
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  7. Article ; Online: Mutation of

    Mlynek, Kevin D / Toothman, Ronald G / Martinez, Elsie E / Qiu, Ju / Richardson, Joshua B / Bozue, Joel A

    Microbiology (Reading, England)

    2024  Volume 170, Issue 2

    Abstract: Two clinically important subspecies, ...

    Abstract Two clinically important subspecies,
    MeSH term(s) Animals ; Mice ; Francisella tularensis/genetics ; Tularemia ; O Antigens/genetics ; Lipopolysaccharides ; Hydroxymethyl and Formyl Transferases/genetics ; Phase Variation ; Mutation ; Francisella
    Chemical Substances O Antigens ; Lipopolysaccharides ; Hydroxymethyl and Formyl Transferases (EC 2.1.2.-)
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Higher-order evidence.

    Cole, Stephen R / Shook-Sa, Bonnie E / Zivich, Paul N / Edwards, Jessie K / Richardson, David B / Hudgens, Michael G

    European journal of epidemiology

    2024  Volume 39, Issue 1, Page(s) 1–11

    Abstract: ... of misclassification comprise the second-order evidence (e.g., sensitivity, specificity) of a binary exposure or ... acknowledged, higher-order evidence is often assumed to be free of measurement error (e.g., gold standard ...

    Abstract Higher-order evidence is evidence about evidence. Epidemiologic examples of higher-order evidence include the settings where the study data constitute first-order evidence and estimates of misclassification comprise the second-order evidence (e.g., sensitivity, specificity) of a binary exposure or outcome collected in the main study. While sampling variability in higher-order evidence is typically acknowledged, higher-order evidence is often assumed to be free of measurement error (e.g., gold standard measures). Here we provide two examples, each with multiple scenarios where second-order evidence is imperfectly measured, and this measurement error can either amplify or attenuate standard corrections to first-order evidence. We propose a way to account for such imperfections that requires third-order evidence. Further illustrations and exploration of how higher-order evidence impacts results of epidemiologic studies is warranted.
    MeSH term(s) Humans ; Bias ; Sensitivity and Specificity
    Language English
    Publishing date 2024-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-023-01062-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clinical validation of an aggregate learning ratio from the neuropsychological assessment battery.

    Hall, Matthew G / Wollman, Scott C / Haines, Mary E / Katschke, Jessica L / Boyle, Mellisa A / Richardson, Hannah K / Hammers, Dustin B

    Applied neuropsychology. Adult

    2024  , Page(s) 1–10

    Abstract: Quantifying learning deficits provides valuable information in identifying and diagnosing mild cognitive impairment and dementia. Previous research has found that a learning ratio (LR) metric, derived from the list learning test from the ... ...

    Abstract Quantifying learning deficits provides valuable information in identifying and diagnosing mild cognitive impairment and dementia. Previous research has found that a learning ratio (LR) metric, derived from the list learning test from the Neuropsychological Assessment Battery (NAB), was able to distinguish between those with normal cognition versus memory impairment. The current study furthers the NAB LR research by validating a NAB story LR, as well as an aggregate LR. The aggregate LR was created by combining the individual list and story LRs. Participants were classified as those with normal cognition (
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2673736-X
    ISSN 2327-9109 ; 2327-9095
    ISSN (online) 2327-9109
    ISSN 2327-9095
    DOI 10.1080/23279095.2024.2329974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4952: Show issues Location:
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  10. Article: Shale weathering profiles show Hg sequestration along a New York–Tennessee transect

    Richardson, Justin B.

    Environmental geochemistry and health. 2022 Oct., v. 44, no. 10

    2022  

    Abstract: ... Total Hg concentrations in unweathered shale ranged from 3 to 94 ng/g. Total Hg concentrations decreased ... with depth in the Ultisols and Alfisols, with total Hg concentrations ranging from 18 to 265 ng/g. Across ...

    Abstract Shale-derived soils have higher clay, organic matter, and secondary Fe oxide content than other bedrock types, all of which can sequester Hg. However, shales also can be Hg-rich due to their marine formation. The objectives of this study were to determine the concentration and phase partitioning of Hg in seven upland weathering profiles from New York to Tennessee USA and use geochemical normalization techniques to estimate the extent of Hg inheritance from weathering of shale bedrock or sequestration of atmospheric Hg. Total Hg concentrations in unweathered shale ranged from 3 to 94 ng/g. Total Hg concentrations decreased with depth in the Ultisols and Alfisols, with total Hg concentrations ranging from 18 to 265 ng/g. Across all shale soils and rocks, the oxidizable fraction of Hg (15% H₂O₂ extraction) comprised a large portion of the total Hg at 68% ± 8%. This fraction was dominated by organic matter as confirmed with positive correlations between Hg and %LOI, but could also be impacted by Hg sulfides. Across all sites, the reducible fraction of Hg (citrate-bicarbonate-dithionite extraction) was only 10% ± 4% of the total Hg on average. Thus, secondary Fe oxides did not contain a significant portion of Hg, as commonly observed in tropical soils. Although colder sites had a higher organic matter and sequestered more Hg, τ values for Hg indexed to Ti suggest that atmospheric deposition, such as pollution sources in Ohio River Valley, drove the highest enrichment of Hg along the transect. These results demonstrate that shale-derived soils have a net accumulation and retention of atmospheric Hg, primarily through stabilization by organic matter.
    Keywords Alfisols ; Ultisols ; atmospheric deposition ; bedrock ; clay ; geochemistry ; highlands ; organic matter ; pollution ; river valleys ; shale ; New York ; Ohio River ; Tennessee
    Language English
    Dates of publication 2022-10
    Size p. 3515-3526.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-021-01110-x
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