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  1. Article ; Online: Cytomegalovirus and Your Health: Not a Matter of the Heart, Nor of Life and Death.

    Nikolich-Žugich, Janko

    The Journal of infectious diseases

    2020  Volume 223, Issue 2, Page(s) 181–183

    MeSH term(s) Animals ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/etiology ; Disease Susceptibility/immunology ; Humans ; Immunocompromised Host
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Editorial ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa481
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  2. Article ; Online: Author Correction: Infection-induced type I interferons critically modulate the homeostasis and function of CD8

    Jergović, Mladen / Coplen, Christopher P / Uhrlaub, Jennifer L / Besselsen, David G / Cheng, Shu / Smithey, Megan J / Nikolich-Žugich, Janko

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 470

    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44731-3
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  3. Article ; Online: Author Correction: The twilight of immunity: emerging concepts in aging of the immune system.

    Nikolich-Žugich, Janko

    Nature immunology

    2018  Volume 19, Issue 10, Page(s) 1146

    Abstract: In the version of this Review initially published, the type of cell in the final sentence of the legend to Figure 3 (group 2 innate lymphoid cells) was incorrect. The correct type of cell is group 3 innate lymphoid cells. The error has been corrected in ... ...

    Abstract In the version of this Review initially published, the type of cell in the final sentence of the legend to Figure 3 (group 2 innate lymphoid cells) was incorrect. The correct type of cell is group 3 innate lymphoid cells. The error has been corrected in the HTML and PDF versions of the article.
    Language English
    Publishing date 2018-09-01
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-018-0205-0
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  4. Article ; Online: Charles D. Surh 1960-2017.

    Nikolich-Žugich, Janko

    Nature immunology

    2017  Volume 18, Issue 12, Page(s) 1273

    MeSH term(s) Allergy and Immunology/history ; Animals ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2017-12-11
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.3871
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  5. Article ; Online: Author Correction: Charles D. Surh 1960-2017.

    Nikolich-Žugich, Janko

    Nature immunology

    2017  Volume 19, Issue 9, Page(s) 1035

    Abstract: In the version of this article initially published, the year of birth provided (1960) was incorrect. The correct year is 1961. The error has been corrected in the HTML and PDF versions of the article. ...

    Abstract In the version of this article initially published, the year of birth provided (1960) was incorrect. The correct year is 1961. The error has been corrected in the HTML and PDF versions of the article.
    Language English
    Publishing date 2017-12-08
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-017-0025-7
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  6. Article ; Online: The twilight of immunity: emerging concepts in aging of the immune system.

    Nikolich-Žugich, Janko

    Nature immunology

    2017  Volume 19, Issue 1, Page(s) 10–19

    Abstract: Immunosenescence is a series of age-related changes that affect the immune system and, with time, lead to increased vulnerability to infectious diseases. This Review addresses recent developments in the understanding of age-related changes that affect ... ...

    Abstract Immunosenescence is a series of age-related changes that affect the immune system and, with time, lead to increased vulnerability to infectious diseases. This Review addresses recent developments in the understanding of age-related changes that affect key components of immunity, including the effect of aging on cells of the (mostly adaptive) immune system, on soluble molecules that guide the maintenance and function of the immune system and on lymphoid organs that coordinate both the maintenance of lymphocytes and the initiation of immune responses. I further address the effect of the metagenome and exposome as key modifiers of immune-system aging and discuss a conceptual framework in which age-related changes in immunity might also affect the basic rules by which the immune system operates.
    MeSH term(s) Adaptive Immunity/immunology ; Aging/immunology ; Animals ; Cellular Senescence/immunology ; Humans ; Immune System/immunology ; Immunity, Innate/immunology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Models, Immunological ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2017-12-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-017-0006-x
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  7. Article ; Online: Author Correction

    Mladen Jergović / Christopher P. Coplen / Jennifer L. Uhrlaub / David G. Besselsen / Shu Cheng / Megan J. Smithey / Janko Nikolich-Žugich

    Nature Communications, Vol 15, Iss 1, Pp 1-

    Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells

    2024  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Immune response to COVID-19 in older adults.

    Jergović, Mladen / Coplen, Christopher P / Uhrlaub, Jennifer L / Nikolich-Žugich, Janko

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2021  Volume 40, Issue 10, Page(s) 1082–1089

    Abstract: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV-2 spread from Wuhan, China, across the globe, causing an unprecedented public ... ...

    Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV-2 spread from Wuhan, China, across the globe, causing an unprecedented public healthcare crisis. The virus showed remarkable age dependent pathology, with symptoms resembling common cold in most adults and children while causing more severe respiratory distress and significant mortality in older and frail humans. Even before the SARS-CoV-2 outbreak infectious diseases represented one of the major causes of death of older adults. Loss of immune function and reduced protection from infectious agents with age - immunosenescence - is a result of complex mechanisms affecting production and maintenance of immune cells as well as the initiation, maintenance and termination of properly directed immune responses. Here we briefly discuss the current knowledge on how this process affects age-dependent outcomes of SARS-CoV-2 infection.
    MeSH term(s) Age Factors ; Aged ; COVID-19/immunology ; Humans ; Immunity
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2021.04.017
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  9. Article ; Online: Impact of CMV upon immune aging: facts and fiction.

    Jergović, Mladen / Contreras, Nico A / Nikolich-Žugich, Janko

    Medical microbiology and immunology

    2019  Volume 208, Issue 3-4, Page(s) 263–269

    Abstract: Aging is accompanied by significant defects in immunity and compromised responses to new, previously unencountered microbial pathogens. Most humans carry several persistent or latent viruses as they age, interacting with the host immune systems for years. ...

    Abstract Aging is accompanied by significant defects in immunity and compromised responses to new, previously unencountered microbial pathogens. Most humans carry several persistent or latent viruses as they age, interacting with the host immune systems for years. In that context maybe the most studied persistent virus is Cytomegalovirus, infamous for its ability to recruit very large T cell responses which increase with age and to simultaneously evade elimination by the immune system. Here we will address how lifelong CMV infection and the immunological burden of its control might affect immune reactivity and health of the host over time.
    MeSH term(s) Aging ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/immunology ; Humans ; Immunosenescence ; T-Lymphocytes/immunology
    Language English
    Publishing date 2019-04-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 120933-4
    ISSN 1432-1831 ; 0300-8584
    ISSN (online) 1432-1831
    ISSN 0300-8584
    DOI 10.1007/s00430-019-00605-w
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  10. Article ; Online: Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.

    Nikolich-Žugich, Janko

    Journal of immunology (Baltimore, Md. : 1950)

    2014  Volume 193, Issue 6, Page(s) 2622–2629

    Abstract: Until the mid-20th century, infectious diseases were the major cause of morbidity and mortality in humans. Massive vaccination campaigns, antibiotics, antivirals, and advanced public health measures drastically reduced sickness and death from infections ... ...

    Abstract Until the mid-20th century, infectious diseases were the major cause of morbidity and mortality in humans. Massive vaccination campaigns, antibiotics, antivirals, and advanced public health measures drastically reduced sickness and death from infections in children and younger adults. However, older adults (>65 y of age) remain vulnerable to infections, and infectious diseases remain among the top 5-10 causes of death in this population. The aging of the immune system, often referred to as immune senescence, is the key phenomenon underlying this vulnerability. This review centers on age-related changes in T cells, which are dramatically and reproducibly altered with aging. I discuss changes in T cell production, maintenance, function, and response to latent persistent infection, particularly against CMV, which exerts a profound influence on the aging T cell pool, concluding with a brief list of measures to improve immune function in older adults.
    MeSH term(s) Aging/immunology ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Communication/immunology ; Cytomegalovirus/immunology ; Humans ; Immunologic Memory ; Lymphocyte Activation/immunology ; Mice
    Language English
    Publishing date 2014-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1401174
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