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  1. Article ; Online: Restorative Neurology and Neuroscience: Celebrating the 40th volume of an academic journal.

    Sabel, Bernhard A

    Restorative neurology and neuroscience

    2023  Volume 40, Issue 4-6, Page(s) 209–215

    Abstract: Since the first issue of the academic journal Restorative Neurology and Neuroscience (RNN) was published in 1989, 40 volumes with a total of 1,550 SCI publications have helped advance basic and clinical sciences in the fields of central and peripheral ... ...

    Abstract Since the first issue of the academic journal Restorative Neurology and Neuroscience (RNN) was published in 1989, 40 volumes with a total of 1,550 SCI publications have helped advance basic and clinical sciences in the fields of central and peripheral nervous system rescue, regeneration, restoration and plasticity in experimental and clinical disorders. In this way RNN helped advance the development of a range of neuropsychiatric intervention across a broad spectrum of approaches such as drugs, training (rehabilitation), psychotherapy or neuromodulation with current stimulation. Today, RNN remains a focused, innovative and viable source of scientific information in the neurosciences with high visibility in an ever changing world of academic publishing.
    Language English
    Publishing date 2023-06-29
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1017098-4
    ISSN 1878-3627 ; 0922-6028
    ISSN (online) 1878-3627
    ISSN 0922-6028
    DOI 10.3233/RNN-239003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects.

    Zhou, Wanshu / Sabel, Bernhard A

    The EPMA journal

    2023  Volume 14, Issue 1, Page(s) 87–99

    Abstract: Purpose: Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a major factor. To optimize therapy, an improved understanding of concepts of predictive, preventive, ... ...

    Abstract Purpose: Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a major factor. To optimize therapy, an improved understanding of concepts of predictive, preventive, and personalized medicine (3PM) is needed which is based on a more detailed understanding of VD pathology. Specifically, to learn if the root cause of glaucomatous vision loss is of neuronal (degeneration) or vascular origin, we now studied neurovascular coupling (NVC) and vessel morphology and their relationship to vision loss in glaucoma.
    Methods: In patients with primary open angle glaucoma (POAG) (
    Results: Retinal arterial and venous vessels had significantly smaller diameters in patients with POAG in comparison to controls. However, both arterial and venous dilation reached normal values during neuronal activation despite their smaller diameters. This was largely independent of visual field depth and varied among patients.
    Conclusions: Because dilation/constriction is normal, VD in POAG can be explained by chronic vasoconstriction which limits energy supply to retinal (and brain) neurons with subsequent hypo-metabolism ("silent" neurons) or neuronal cell death. We propose that the root cause of POAG is primarily of vascular and not neuronal origin. This understanding can help to better personalize POAG therapy of not only targeting eye pressure but also vasoconstriction to prevent low vision, slowing its progression and supporting recovery and restoration.
    Trial registration: ClinicalTrials.gov, # NCT04037384 on July 3, 2019.
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2545928-4
    ISSN 1878-5085 ; 1878-5077
    ISSN (online) 1878-5085
    ISSN 1878-5077
    DOI 10.1007/s13167-023-00316-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Movie therapy for children with amblyopia: restoring binocular vision with brain plasticity.

    Sabel, Bernhard A / Levi, Dennis M

    Science China. Life sciences

    2022  Volume 65, Issue 3, Page(s) 654–656

    MeSH term(s) Amblyopia/therapy ; Child ; Humans ; Motion Pictures ; Neuronal Plasticity ; Vision, Binocular ; Visual Acuity
    Language English
    Publishing date 2022-01-13
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2546732-3
    ISSN 1869-1889 ; 1674-7305
    ISSN (online) 1869-1889
    ISSN 1674-7305
    DOI 10.1007/s11427-021-2050-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Vascular dysregulation in glaucoma

    Zhou, Wanshu / Sabel, Bernhard A.

    EPMA Journal

    Retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects

    2023  Volume 14, Page(s) 87–99

    Abstract: Purpose: Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a major factor. To optimize therapy, an improved understanding of concepts of predictive, preventive, and ...

    Title translation Vaskuläre Dysregulation bei Glaukom: Retinale Vasokonstriktion und normale neurovaskuläre Kopplung bei höhenabhängigen Gesichtsfelddefekten
    Abstract Purpose: Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a major factor. To optimize therapy, an improved understanding of concepts of predictive, preventive, and personalized medicine (3PM) is needed which is based on a more detailed understanding of VD pathology. Specifically, to learn if the root cause of glaucomatous vision loss is of neuronal (degeneration) or vascular origin, we now studied neurovascular coupling (NVC) and vessel morphology and their relationship to vision loss in glaucoma. Methods: In patients with primary open angle glaucoma (POAG) (n = 30) and healthy controls (n = 22), NVC was studied using dynamic vessel analyzer to quantify retinal vessel diameter before, during, and after flicker light stimulation to evaluate the dilation response following neuronal activation. Vessel features and dilation were then related to branch level and visual field impairment. Results: Retinal arterial and venous vessels had significantly smaller diameters in patients with POAG in comparison to controls. However, both arterial and venous dilation reached normal values during neuronal activation despite their smaller diameters. This was largely independent of visual field depth and varied among patients. Conclusions: Because dilation/constriction is normal, VD in POAG can be explained by chronic vasoconstriction which limits energy supply to retinal (and brain) neurons with subsequent hypo-metabolism ("silent" neurons) or neuronal cell death. We propose that the root cause of POAG is primarily of vascular and not neuronal origin. This understanding can help to better personalize POAG therapy of not only targeting eye pressure but also vasoconstriction to prevent low vision, slowing its progression and supporting recovery and restoration.
    Keywords Blood Flow ; Blood Vessels ; Blutfluss ; Blutgefäße ; Glaucoma ; Grüner Star ; Neurodegeneration ; Precision Medicine ; Prediction ; Prevention ; Prävention ; Präzisionsmedizin ; Sehfeld ; Sehstörungen ; Vasoconstriction ; Vasokonstriktion ; Vision Disorders ; Visual Field ; Vorhersage
    Language English
    Document type Article
    ZDB-ID 2545928-4
    ISSN 1878-5085 ; 1878-5077
    ISSN (online) 1878-5085
    ISSN 1878-5077
    DOI 10.1007/s13167-023-00316-6
    Database PSYNDEX

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  5. Article: Nanoparticles as a tool to deliver drugs to the retina and brain: an update.

    You, Qing / Sabel, Bernhard A

    Neural regeneration research

    2020  Volume 16, Issue 2, Page(s) 283–284

    Language English
    Publishing date 2020-08-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.290886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Spacetime in the brain: rapid brain network reorganization in visual processing and recovery.

    Wu, Zheng / Sabel, Bernhard A

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 17940

    Abstract: Functional connectivity networks (FCN) are the physiological basis of brain synchronization to integrating neural activity. They are not rigid but can reorganize under pathological conditions or during mental or behavioral states. However, because mental ...

    Abstract Functional connectivity networks (FCN) are the physiological basis of brain synchronization to integrating neural activity. They are not rigid but can reorganize under pathological conditions or during mental or behavioral states. However, because mental acts can be very fast, like the blink of an eye, we now used the visual system as a model to explore rapid FCN reorganization and its functional impact in normal, abnormal and post treatment vision. EEG-recordings were time-locked to visual stimulus presentation; graph analysis of neurophysiological oscillations were used to characterize millisecond FCN dynamics in healthy subjects and in patients with optic nerve damage before and after neuromodulation with alternating currents stimulation and were correlated with visual performance. We showed that rapid and transient FCN synchronization patterns in humans can evolve and dissolve in millisecond speed during visual processing. This rapid FCN reorganization is functionally relevant because disruption and recovery after treatment in optic nerve patients correlated with impaired and recovered visual performance, respectively. Because FCN hub and node interactions can evolve and dissolve in millisecond speed to manage spatial and temporal neural synchronization during visual processing and recovery, we propose "Brain Spacetime" as a fundamental principle of the human mind not only in visual cognition but also in vision restoration.
    MeSH term(s) Adult ; Brain/physiopathology ; Cognition ; Double-Blind Method ; Electric Stimulation Therapy/methods ; Electroencephalography/methods ; Electroencephalography Phase Synchronization ; Evoked Potentials, Visual ; Female ; Humans ; Male ; Middle Aged ; Nerve Net/physiopathology ; Optic Nerve Diseases/physiopathology ; Optic Nerve Diseases/therapy ; Recovery of Function ; Treatment Outcome ; Visual Field Tests/methods ; Visual Fields ; Visual Perception
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-96971-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is Mental Stress the Primary Cause of Glaucoma?

    Sabel, Bernhard A / Lehnigk, Luisa

    Klinische Monatsblatter fur Augenheilkunde

    2021  Volume 238, Issue 2, Page(s) 132–145

    Abstract: The prognosis of going blind is very stressful for patients diagnosed with "glaucoma". Worries and fear of losing independence is a constant mental burden, with secondary risks of depression and social isolation. But stress is not only a result of ... ...

    Title translation Ist Stress die primäre Ursache von Glaukom?
    Abstract The prognosis of going blind is very stressful for patients diagnosed with "glaucoma". Worries and fear of losing independence is a constant mental burden, with secondary risks of depression and social isolation. But stress is not only a result of glaucoma but also a possible cause (risk factor). This should not be surprising, given that chronic stress can trigger "psychosomatic" organ dysfunctions anywhere in the body. Why should the organ "eye" be an exception? Indeed, glaucoma patients often suspect that severe emotional stress caused their visual field loss or "foggy vision". The hypothesis that stress is a possible cause of glaucoma is supported by different observations: (i) acute and chronic stress increases intraocular pressure and (ii) long-term stress can lead to vascular dysregulation of the microcirculation in the eye and brain ("Flammer's syndrome"), leading to partial hypoxia and hypoglycaemia (hypo-metabolism). Even if nerve cells do not die, they may then become inactive ("silent" neurons). (iii) Degenerative changes have been reported in the brain of glaucoma patients, affecting not only anterograde or transsynaptic areas of the central visual pathway, but degeneration is also found (iv) in brain areas involved in emotional appraisal and the physiological regulation of stress hormones. There are also psychological hints indicating that stress is a cause of glaucoma: (v) Glaucoma patients with Flammer's syndrome show typical personality traits that are associated with low stress resilience: they often have cold hands or feet, are ambitious (professionally successful), perfectionistic, obsessive, brooding and worrying a lot. (vi) If stress hormone levels and inflammation parameters are reduced in glaucoma patients by relaxation with meditation, this correlates with normalisation of intraocular pressure, and yet another clue is that (vii) visual field improvements after non-invasive current stimulation therapy, that are known to improve circulation and neuronal synchronisation, are much most effective in patients with stress resilient personalities. An appreciation of stress as a "cause" of glaucoma suggests that in addition to standard therapy (i) stress reduction through relaxation techniques should be recommended (e.g. meditation), and (ii) self-medication compliance should not be induced by kindling anxiety and worries with negative communication ("You will go blind!"), but communication should be positive ("The prognosis is optimistic").
    MeSH term(s) Glaucoma ; Humans ; Intraocular Pressure ; Tonometry, Ocular ; Visual Field Tests ; Visual Pathways
    Language German
    Publishing date 2021-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-1303-8025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reply to "The role of primary visual cortex after transorbital alternating current stimulation in low vision patients".

    Sabel, Bernhard A / Antal, Andrea

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2020  Volume 131, Issue 9, Page(s) 2329–2330

    MeSH term(s) Humans ; Vision, Low ; Vision, Ocular ; Visual Cortex ; Visual Field Tests
    Language English
    Publishing date 2020-06-24
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2020.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retinal prosthesis and "bionic eyes" for vision restoration in the blind: From dawn to dusk.

    Sabel, Bernhard A / Richard, Gisbert

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2020  Volume 131, Issue 6, Page(s) 1375–1378

    MeSH term(s) Blindness ; Humans ; Vision, Ocular ; Visual Prosthesis
    Language English
    Publishing date 2020-03-08
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2020.02.018
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  10. Article ; Online: How criminal science publishing gangs damage the genesis of knowledge and technology-a call to action to restore trust.

    Sabel, Bernhard A / Seifert, Roland

    Naunyn-Schmiedeberg's archives of pharmacology

    2020  Volume 394, Issue 11, Page(s) 2147–2151

    MeSH term(s) Crime/prevention & control ; Fraud/prevention & control ; Humans ; Publications/standards ; Publishing/standards ; Scientific Misconduct ; Trust
    Language English
    Publishing date 2020-05-14
    Publishing country Germany
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-021-02158-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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