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Article ; Online: Cobalt-Catalyzed Stereospecific C-N/C-O Bond Formation of Oxiranes with Diaziridines.

Maharana, Prabhat K / Sarkar, Tanumay / Kar, Subhradeep / Purkayastha, Siddhartha K / Guha, Ankur K / Punniyamurthy, Tharmalingam

The Journal of organic chemistry

2023 Volume 88, Issue 13, Page(s) 9447–9458

Abstract: Co-catalyzed stereospecific C-N and C-O bond formation of oxiranes with diaziridines has been ...

Abstract	Co-catalyzed stereospecific C-N and C-O bond formation of oxiranes with diaziridines has been accomplished to furnish tetrahydro-[1,3,4]-oxadiazines at room temperature. Optically active oxiranes can be coupled with high optical purities (>96% ee). Stereoselectivity, functional group tolerance, mechanistic studies using DFT, and natural product modification are the important practical features.
MeSH term(s)	Epoxy Compounds/chemistry ; Cobalt/chemistry ; Ethylene Oxide ; Biological Products ; Catalysis
Chemical Substances	Epoxy Compounds ; Cobalt (3G0H8C9362) ; Ethylene Oxide (JJH7GNN18P) ; Biological Products
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c00445
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Article ; Online: Voltage-controlled NiO/ZnO p-n heterojunction diode: a new approach towards selective VOC sensing.

Dey, Sayan / Nag, Swati / Santra, Sumita / Ray, Samit Kumar / Guha, Prasanta Kumar

Microsystems & nanoengineering

2020 Volume 6, Page(s) 35

Abstract: ... Here, we have proposed a novel NiO/ZnO-based p-n junction single-diode device for selective sensing ...

Abstract	Metal oxide resistive gas sensors suffer from poor selectivity that restricts their practical applicability. Conventional sensor arrays are used to improve selectivity which increased the system complexity. Here, we have proposed a novel NiO/ZnO-based p-n junction single-diode device for selective sensing of several volatile organic compounds (VOCs) simultaneously by tuning bias voltage. The operating voltage was varied between 3 and 5 volts to achieve selective sensing of 2-propanol (19.1 times for 95 ppm with response and recovery times of 70 s and 55 s respectively' at 3 volts), toluene (20.1 times for 95 ppm with response and recovery times of 100 s and 60 s respectively, at 4 volts), and formaldehyde (11.2 times for 95 ppm with response and recovery times of 88 s and 54 s respectively, at 5 volts). A probable mechanism of the tunable selectivity with operating bias voltage due to increase in surface carriers with increasing voltage was hence put forth. Thus, this device may play an important role to develop future selective multiple VOC sensor thereby replacing standard sensor arrays.
Language	English
Publishing date	2020-06-01
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-020-0139-1
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Article ; Online: Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease.

Guha, Sujay / Mathew, Neal D / Konkwo, Chigoziri / Ostrovsky, Julian / Kwon, Young Joon / Polyak, Erzsebet / Seiler, Christoph / Bennett, Michael / Xiao, Rui / Zhang, Zhe / Nakamaru-Ogiso, Eiko / Falk, Marni J

Human molecular genetics

2021 Volume 30, Issue 7, Page(s) 536–551

Abstract: ... 1(fc21) lifespan. Synergistic rescue occurred only with glucose, nicotinic acid and N-acetylcysteine ...

Abstract	Mitochondrial respiratory chain disorders are empirically managed with variable antioxidant, cofactor and vitamin 'cocktails'. However, clinical trial validated and approved compounds, or doses, do not exist for any single or combinatorial mitochondrial disease therapy. Here, we sought to pre-clinically evaluate whether rationally designed mitochondrial medicine combinatorial regimens might synergistically improve survival, health and physiology in translational animal models of respiratory chain complex I disease. Having previously demonstrated that gas-1(fc21) complex I subunit ndufs2-/-C. elegans have short lifespan that can be significantly rescued with 17 different metabolic modifiers, signaling modifiers or antioxidants, here we evaluated 11 random combinations of these three treatment classes on gas-1(fc21) lifespan. Synergistic rescue occurred only with glucose, nicotinic acid and N-acetylcysteine (Glu + NA + NAC), yielding improved mitochondrial membrane potential that reflects integrated respiratory chain function, without exacerbating oxidative stress, and while reducing mitochondrial stress (UPRmt) and improving intermediary metabolic disruptions at the levels of the transcriptome, steady-state metabolites and intermediary metabolic flux. Equimolar Glu + NA + NAC dosing in a zebrafish vertebrate model of rotenone-based complex I inhibition synergistically rescued larval activity, brain death, lactate, ATP and glutathione levels. Overall, these data provide objective preclinical evidence in two evolutionary-divergent animal models of mitochondrial complex I disease to demonstrate that combinatorial Glu + NA + NAC therapy significantly improved animal resiliency, even in the face of stressors that cause severe metabolic deficiency, thereby preventing acute neurologic and biochemical decompensation. Clinical trials are warranted to evaluate the efficacy of this lead combinatorial therapy regimen to improve resiliency and health outcomes in human subjects with mitochondrial disease.
MeSH term(s)	Acetylcysteine/pharmacology ; Animals ; Caenorhabditis elegans ; Disease Models, Animal ; Drug Synergism ; Electron Transport Complex I/genetics ; Electron Transport Complex I/metabolism ; Free Radical Scavengers/pharmacology ; Glucose/pharmacology ; Humans ; Longevity/drug effects ; Longevity/genetics ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/prevention & control ; Mutation ; Niacin/pharmacology ; Oxidative Stress/drug effects ; Zebrafish
Chemical Substances	Free Radical Scavengers ; Niacin (2679MF687A) ; Electron Transport Complex I (EC 7.1.1.2) ; Glucose (IY9XDZ35W2) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddab059
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Article ; Online: ZnCl2 catalyzed cascade conjugative alkynylation/6-endo-dig cyclisation of N,N-dimethyl barbituric acid derived alkenes under ultrasonic irradiation: An improved, base & column-free access to pyrano[2,3-d]pyrimidine-2,4(3H,5H)-diones

Bhuyan, Pubanita / Bhorali, Pratiksha / Kataky, Sudhamoyee / Bharali, Sourav Jyoti / Guha, Ankur Kanti / Saikia, Lakhinath

Sustainable Chemistry and Pharmacy. 2022 Dec., v. 30 p.100852-

2022

Abstract: ... diones by the reaction of N,N-dimethyl barbituric acid, aromatic aldehydes and terminal alkynes using ...

Abstract	A simple and efficient cascade pathway for the synthesis of pyrano[2,3-d]pyrimidine-2,4(3H,5H)-diones by the reaction of N,N-dimethyl barbituric acid, aromatic aldehydes and terminal alkynes using ultrasonic irradiation as the energy source has been developed. The methodology describes the first use of easily accessible ZnCl₂ in alkynylide formation leading to multicomponent synthesis of the heterocycle. Additionally, the final products are obtained by recrystallization from hot ethanol without involving the laborious and solvent consuming chromatographic techniques. The proposed mechanistic pathway has been studied with Density Functional Theory and the compounds synthesized are characterized with SC-XRD, ¹H NMR ¹³C NMR, and HRMS analysis.
Keywords	alkenes ; alkynes ; chromatography ; crystallization ; density functional theory ; energy ; ethanol ; green chemistry ; solvents ; ultrasonic treatment ; zinc chloride ; Cascade synthesis ; Green synthesis ; pyrano[2,3-d]pyrimidine ; Ultrasonication ; DFT ; Conjugative alkynylation
Language	English
Dates of publication	2022-12
Publishing place	Elsevier B.V.
Document type	Article ; Online
ISSN	2352-5541
DOI	10.1016/j.scp.2022.100852
Database	NAL-Catalogue (AGRICOLA)

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Article: Poly(N-vinyl imidazole) Cross-Linked β-Cyclodextrin Hydrogel for Rapid Hemostasis in Severe Renal Arterial Hemorrhagic Model

Roy, Arpita / Guha Ray, Preetam / Manna, Kalipada / Banerjee, Chiranjib / Dhara, Santanu / Pal, Sagar

Biomacromolecules. 2021 Nov. 10, v. 22, no. 12

2021

Abstract: A unique facile process has been adopted for fast assembly of a poly(N-vinyl imidazole ... cross-linked β-cyclodextrin hydrogel through microwave-assisted free radical polymerization, using N,N ...

Abstract	A unique facile process has been adopted for fast assembly of a poly(N-vinyl imidazole) cross-linked β-cyclodextrin hydrogel through microwave-assisted free radical polymerization, using N,N′-methylenebis(acrylamide) cross-linker. The copolymer possesses positive surface charge, one of the characteristic properties of an ideal hemostatic hydrogel. The functionalized imidazole-based hydrogel demonstrates rapid, superior blood coagulation kinetics under in vitro and in vivo conditions. On application to a major renal arterial hemorrhagic model, this hydrogel shows better blood clotting kinetics, leading to complete hemostasis in as few as ∼144 ± 7 s. Additionally, 350 μL of whole blood was clotted instantly, in ∼35 s, and therefore, reinforcing its hemostatic potential. The hydrogel demonstrates excellent biocompatibility, when seeded with human dermal fibroblast cells, retaining the native property of its predecessor. In addition, the hydrogel presents excellent hemocompatibility when tested with whole blood with the highest hemolytic ratio of 1.07 ± 0.05%. Moreover, it also demonstrates potential as a carrier for sustained release of an anesthetic drug, lidocaine hydrochloride monohydrate (∼83% in 24 h). The rapid hemostatic behavior of the hydrogel is coupled with its cytocompatibility and hemocompatibilty properties along with controlled drug release characteristics. These behaviors evidently demonstrate it to be an excellent alternative for a superior hemostatic material for severe hemorrhagic conditions.
Keywords	anesthetics ; biocompatibility ; blood ; blood coagulation ; composite polymers ; crosslinking ; drug delivery systems ; fibroblasts ; free radicals ; hemostasis ; humans ; hydrogels ; imidazole ; lidocaine ; microwave treatment ; models ; polymerization
Language	English
Dates of publication	2021-1110
Size	p. 5256-5269.
Publishing place	American Chemical Society
Document type	Article
ISSN	1526-4602
DOI	10.1021/acs.biomac.1c01174
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Article: N,N-bis-(2-benzimidazolylmethyl)L-methionine: An efficient Ag(I) extractant

Saha, Raja / Guha, Subarna / Sahana, Animesh / Das, Debasis

Journal of analytical chemistry. 2013 May, v. 68, no. 5

2013

Abstract: A new ligand N,N-bis-(2-benzimidazolylmethyl)L-methionine has been synthesized and well ...

Abstract	A new ligand N,N-bis-(2-benzimidazolylmethyl)L-methionine has been synthesized and well characterized by different analytical techniques. The ligand has a very strong affinity for silver(I) and is used for the selective extraction of silver ions from aqueous solution into 1-butanol. The effect of concentration of Ag(I), pH, diverse ions, and temperature on the extraction is reported. The developed method has success-fully been applied to the determination of silver in different samples. Radiotracer technique, using ¹¹⁰ᵐAg(I) as a tracer, has been used for monitoring the concentration of silver ion.
Keywords	analytical methods ; aqueous solutions ; ions ; monitoring ; silver ; temperature
Language	English
Dates of publication	2013-05
Size	p. 398-402.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2057336-4
ISSN	1608-3199 ; 1061-9348
ISSN (online)	1608-3199
ISSN	1061-9348
DOI	10.1134/S1061934813050146
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Article ; Online: Direct Intracranial Injection of AAVrh8 Encoding Monkey β-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain.

Golebiowski, Diane / van der Bom, Imramsjah M J / Kwon, Churl-Su / Miller, Andrew D / Petrosky, Keiko / Bradbury, Allison M / Maitland, Stacy / Kühn, Anna Luisa / Bishop, Nina / Curran, Elizabeth / Silva, Nilsa / GuhaSarkar, Dwijit / Westmoreland, Susan V / Martin, Douglas R / Gounis, Matthew J / Asaad, Wael F / Sena-Esteves, Miguel

Human gene therapy

2017 Volume 28, Issue 6, Page(s) 510–522

Abstract: ... storage disorders caused by deficiencies in β-N-acetylhexosaminidase (Hex). Patients are afflicted primarily ...

Abstract	GM2 gangliosidoses, including Tay-Sachs disease and Sandhoff disease, are lysosomal storage disorders caused by deficiencies in β-N-acetylhexosaminidase (Hex). Patients are afflicted primarily with progressive central nervous system (CNS) dysfunction. Studies in mice, cats, and sheep have indicated safety and widespread distribution of Hex in the CNS after intracranial vector infusion of AAVrh8 vectors encoding species-specific Hex α- or β-subunits at a 1:1 ratio. Here, a safety study was conducted in cynomolgus macaques (cm), modeling previous animal studies, with bilateral infusion in the thalamus as well as in left lateral ventricle of AAVrh8 vectors encoding cm Hex α- and β-subunits. Three doses (3.2 × 10
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2016.109
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Zs.A 2988: Show issues

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Article ; Online: A versatile and one-pot strategy to synthesize α-amino ketones from benzylic secondary alcohols using N-bromosuccinimide.

Guha, Somraj / Rajeshkumar, Venkatachalam / Kotha, Surya Srinivas / Sekar, Govindasamy

Organic letters

2015 Volume 17, Issue 3, Page(s) 406–409

Abstract: ... important α-amino ketones from readily available benzylic secondary alcohols and amines using N ...

Abstract	A metal-free one-pot strategy has been developed for the first time to synthesize pharmaceutically important α-amino ketones from readily available benzylic secondary alcohols and amines using N-bromosuccinimide. This new reaction proceeds via three consecutive steps involving oxidation of alcohols, α-bromination of ketones, and nucleophilic substitution of α-bromo ketones to give α-amino ketones. Importantly, this novel one-pot greener reaction avoids direct usage of toxic and corrosive bromine. This methodology has been employed efficiently to synthesize pharmaceutically important amfepramone and pyrovalerone in a single step.
MeSH term(s)	Alcohols/chemistry ; Amines/chemistry ; Bromosuccinimide/chemistry ; Catalysis ; Diethylpropion/chemical synthesis ; Diethylpropion/chemistry ; Halogenation ; Ketones/chemical synthesis ; Ketones/chemistry ; Molecular Structure ; Oxidation-Reduction ; Pyrrolidines/chemical synthesis ; Pyrrolidines/chemistry ; Stereoisomerism
Chemical Substances	Alcohols ; Amines ; Ketones ; Pyrrolidines ; Bromosuccinimide (K8G1F2UCJF) ; Diethylpropion (Q94YYU22B8) ; pyrovalerone (VOU69C02JP)
Language	English
Publishing date	2015-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/ol503683q
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Article ; Online: Identification of Global Minimum of HNBeCO Complex.

Guha, Ankur K

The journal of physical chemistry. A

2023 Volume 127, Issue 46, Page(s) 9743–9747

Abstract: Multiple bonding has always excited chemists. Recently, triple bonding between beryllium and N ... potential energy surface scan. The global minimum geometry features only a weak partial Be-N double bond ...

Abstract	Multiple bonding has always excited chemists. Recently, triple bonding between beryllium and N atoms in the HNBeCO complex has been reported based on experimental infrared spectroscopy and theoretical calculations. However, the present work reports a different structure based on a detailed potential energy surface scan. The global minimum geometry features only a weak partial Be-N double bond. The global minimum geometry lies very deep in the potential energy surface with respect to the reported one. Isomerization kinetics reveals that the reported structure has to overcome a very small barrier (5.4 kcal/mol) to isomerize to the global one. Although the previously reported structure is a real minimum, the present study identifies a much lower energy structure. A re-examination of the experimental spectra might show that the global minimum has also been observed.
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.3c05289
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Article ; Online: The

Guha, Partha

Entropy (Basel, Switzerland)

2022 Volume 24, Issue 11

Abstract: ... equations and the N=2 Relativistic Toda lattice systems using this class of Lagrangians. We take advantage ...

Abstract	The Calogero-Leyvraz Lagrangian framework, associated with the dynamics of a charged particle moving in a plane under the combined influence of a magnetic field as well as a frictional force, proposed by Calogero and Leyvraz, has some special features. It is endowed with a Shannon "entropic" type kinetic energy term. In this paper, we carry out the constructions of the 2D Lotka-Volterra replicator equations and the N=2 Relativistic Toda lattice systems using this class of Lagrangians. We take advantage of the special structure of the kinetic term and deform the kinetic energy term of the Calogero-Leyvraz Lagrangians using the κ-deformed logarithm as proposed by Kaniadakis and Tsallis. This method yields the new construction of the κ-deformed Lotka-Volterra replicator and relativistic Toda lattice equations.
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24111673
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