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  1. Article ; Online: An interview with Miguel Vicente-Manzanares, Instituto de Biologia Molecular del Cancer, Salamanca, Spain.

    Trevorrow, Paul / Maldonado, Andy / Vicente-Manzanares, Miguel

    Cytoskeleton (Hoboken, N.J.)

    2022  Volume 79, Issue 1-3, Page(s) 5–7

    MeSH term(s) Humans ; Neoplasms/genetics ; Spain
    Language English
    Publishing date 2022-07-04
    Publishing country United States
    Document type Interview
    ZDB-ID 2534372-5
    ISSN 1949-3592 ; 1949-3584
    ISSN (online) 1949-3592
    ISSN 1949-3584
    DOI 10.1002/cm.21712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: The integrin interactome

    Vicente-Manzanares, Miguel

    methods and protocols

    (Methods in molecular biology ; 2217 ; Springer protocols)

    2021  

    Author's details edited by Miguel Vicente-Manzanares
    Series title Methods in molecular biology ; 2217
    Springer protocols
    Collection
    Language English
    Size xix, 315 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020685393
    ISBN 978-1-0716-0961-3 ; 9781071609620 ; 1-0716-0961-0 ; 1071609629
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 7042 -2217- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Editorial - Cell mechanics and mechanobiology.

    Schwarz, Ulrich S / Vicente-Manzanares, Miguel

    European journal of cell biology

    2023  Volume 102, Issue 3, Page(s) 151304

    Language English
    Publishing date 2023-03-09
    Publishing country Germany
    Document type Editorial
    ZDB-ID 391967-5
    ISSN 1618-1298 ; 0070-2463 ; 0171-9335
    ISSN (online) 1618-1298
    ISSN 0070-2463 ; 0171-9335
    DOI 10.1016/j.ejcb.2023.151304
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  4. Article ; Online: A primer on cancer-associated fibroblast mechanics and immunosuppressive ability.

    Talayero, Vanessa C / Vicente-Manzanares, Miguel

    Exploration of targeted anti-tumor therapy

    2023  Volume 4, Issue 1, Page(s) 17–27

    Abstract: Cancer-associated fibroblasts (CAFs) are a major point of interest in modern oncology. Their interest resides in their ability to favor tumor growth without carrying genetic mutations. From a translational standpoint, they are potential therapeutic ... ...

    Abstract Cancer-associated fibroblasts (CAFs) are a major point of interest in modern oncology. Their interest resides in their ability to favor tumor growth without carrying genetic mutations. From a translational standpoint, they are potential therapeutic targets, particularly for hard-to-treat solid cancers. CAFs can be defined as non-tumor cells within the tumor microenvironment that have the morphological traits of fibroblasts, are negative for lineage-specific markers (e.g., leukocyte, endothelium), and enhance tumor progression in a multi-pronged manner. Two often-mentioned aspects of CAF biology are their ability to alter the mechanics and architecture of the tumor microenvironment, and also to drive local immunosuppression. These two aspects are the specific focus of this work, which also contains a brief summary of novel therapeutic interventions under study to normalize or eliminate CAFs from the tumor microenvironment.
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 2692-3114
    ISSN (online) 2692-3114
    DOI 10.37349/etat.2023.00120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: European Journal of Cell Biology - Editorial.

    Rottner, Klemens / Vicente-Manzanares, Miguel

    European journal of cell biology

    2021  Volume 100, Issue 4, Page(s) 151163

    MeSH term(s) Cell Biology ; Europe ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2021-04-20
    Publishing country Germany
    Document type Editorial
    ZDB-ID 391967-5
    ISSN 1618-1298 ; 0070-2463 ; 0171-9335
    ISSN (online) 1618-1298
    ISSN 0070-2463 ; 0171-9335
    DOI 10.1016/j.ejcb.2021.151163
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  6. Article ; Online: Engines of change: Nonmuscle myosin II in mechanobiology.

    Garrido-Casado, Marina / Asensio-Juárez, Gloria / Talayero, Vanessa C / Vicente-Manzanares, Miguel

    Current opinion in cell biology

    2024  Volume 87, Page(s) 102344

    Abstract: The emergence of mechanobiology has unveiled complex mechanisms by which cells adjust intracellular force production to their needs. Most communicable intracellular forces are generated by myosin II, an actin-associated molecular motor that transforms ... ...

    Abstract The emergence of mechanobiology has unveiled complex mechanisms by which cells adjust intracellular force production to their needs. Most communicable intracellular forces are generated by myosin II, an actin-associated molecular motor that transforms adenosine triphosphate (ATP) hydrolysis into contraction in nonmuscle and muscle cells. Myosin II-dependent force generation is tightly regulated, and deregulation is associated with specific pathologies. Here, we focus on the role of myosin II (nonmuscle myosin II, NMII) in force generation and mechanobiology. We outline the regulation and molecular mechanism of force generation by NMII, focusing on the actual outcome of contraction, that is, force application to trigger mechanosensitive events or the building of dissipative structures. We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.
    MeSH term(s) Myosin Type II/chemistry ; Actins ; Biophysics
    Chemical Substances Myosin Type II (EC 3.6.1.-) ; Actins
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2024.102344
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  7. Article ; Online: The interface between biochemical signaling and cell mechanics shapes T lymphocyte migration and activation.

    Millán-Salanova, María / Vicente-Manzanares, Miguel

    European journal of cell biology

    2022  Volume 101, Issue 3, Page(s) 151236

    Abstract: tT cells migrate to lymphoid organs to become activated through specific contacts with antigen-presenting cells bearing foreign antigens. During migration and activation, T lymphocytes are exposed not only to diverse biochemical inputs, but also to ... ...

    Abstract tT cells migrate to lymphoid organs to become activated through specific contacts with antigen-presenting cells bearing foreign antigens. During migration and activation, T lymphocytes are exposed not only to diverse biochemical inputs, but also to different mechanical conditions. Passage from the blood or lymph to solid tissues involves lymphocyte rolling, firm arrest and diapedesis through endothelial monolayers. Throughout this process, cells are subjected to diverse fluid flow regimes. After extravasation, T lymphocytes crawl through viscoelastic media of different biochemical and mechanical properties and geometries. In lymph nodes, T cell contact with antigen-presenting cells is guided by rigidity cues and ligand-receptor interactions. T lymphocyte adaptation to diverse mechanical regimes involves multiple signaling and morphological modifications, many of which enable the conversion of mechanical forces into biochemical signals and vice-versa. These components enable T lymphocyte survival, homing and activation. Here, we review the mechanisms that enable T lymphocytes to survive and thrive under the different mechanical conditions they encounter during their life cycle. These processes require the integration of diverse signaling networks that convert extracellular mechano-chemical cues into force, movement and activation.
    MeSH term(s) Cell Movement/physiology ; Lymphocytes ; Signal Transduction ; T-Lymphocytes
    Language English
    Publishing date 2022-05-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391967-5
    ISSN 1618-1298 ; 0070-2463 ; 0171-9335
    ISSN (online) 1618-1298
    ISSN 0070-2463 ; 0171-9335
    DOI 10.1016/j.ejcb.2022.151236
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  8. Article ; Online: Meeting Report - Workshop 'Actin-based mechanosensation and force generation in health and disease'.

    Polesskaya, Anna / Vicente-Manzanares, Miguel

    Journal of cell science

    2020  Volume 133, Issue 6

    Abstract: ... which sponsored the event. The meeting was organized by Alexis Gautreau, Pekka Lappalainen and Miguel Vicente ... Manzanares, with the support of the European Molecular Biology Organization (EMBO) and the Spanish-based ...

    Abstract International experts in the fields of cellular motility, force generation and mechanosensation met in Baeza, a UNESCO World Heritage city, from the 10th to the 13th of November, 2019. The meeting, part of the 'Current Trends in Biomedicine' series, took place at the 'Sede Antonio Machado', a beautiful 17th century building turned into a conference center of the Universidad Internacional de Andalucía (UNIA), which sponsored the event. The meeting was organized by Alexis Gautreau, Pekka Lappalainen and Miguel Vicente-Manzanares, with the support of the European Molecular Biology Organization (EMBO) and the Spanish-based company IMPETUX. Fifty scientists presented recent results during the talks, poster sessions and thematic discussions. As Baeza itself served as a crossroads of medieval Christian, Moorish and Jewish cultures, the meeting brought together cell biologists, biochemists, biophysicists and engineers from around the world that provided an integrated vision of the role of the actin cytoskeleton, force generation and mechanosensation in diverse physiological processes and pathologies.
    MeSH term(s) Actins ; Molecular Biology
    Chemical Substances Actins
    Language English
    Publishing date 2020-03-17
    Publishing country England
    Document type Congress ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.244319
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  9. Article ; Online: European Journal of Cell Biology - Editorial.

    Rottner, Klemens / Vicente-Manzanares, Miguel

    100 ; 4 ; 151163 ; European journal of cell biology ; Germany

    2021  

    Abstract: No abstract available] ...

    Abstract [No abstract available]
    Language English
    Publishing date 2021-04-20
    Publisher Elsevier
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Host Cell Targets for Unconventional Antivirals against RNA Viruses.

    Roa-Linares, Vicky C / Escudero-Flórez, Manuela / Vicente-Manzanares, Miguel / Gallego-Gómez, Juan C

    Viruses

    2023  Volume 15, Issue 3

    Abstract: The recent COVID-19 crisis has highlighted the importance of RNA-based viruses. The most prominent members of this group are SARS-CoV-2 (coronavirus), HIV (human immunodeficiency virus), EBOV (Ebola virus), DENV (dengue virus), HCV (hepatitis C virus), ... ...

    Abstract The recent COVID-19 crisis has highlighted the importance of RNA-based viruses. The most prominent members of this group are SARS-CoV-2 (coronavirus), HIV (human immunodeficiency virus), EBOV (Ebola virus), DENV (dengue virus), HCV (hepatitis C virus), ZIKV (Zika virus), CHIKV (chikungunya virus), and influenza A virus. With the exception of retroviruses which produce reverse transcriptase, the majority of RNA viruses encode RNA-dependent RNA polymerases which do not include molecular proofreading tools, underlying the high mutation capacity of these viruses as they multiply in the host cells. Together with their ability to manipulate the immune system of the host in different ways, their high mutation frequency poses a challenge to develop effective and durable vaccination and/or treatments. Consequently, the use of antiviral targeting agents, while an important part of the therapeutic strategy against infection, may lead to the selection of drug-resistant variants. The crucial role of the host cell replicative and processing machinery is essential for the replicative cycle of the viruses and has driven attention to the potential use of drugs directed to the host machinery as therapeutic alternatives to treat viral infections. In this review, we discuss small molecules with antiviral effects that target cellular factors in different steps of the infectious cycle of many RNA viruses. We emphasize the repurposing of FDA-approved drugs with broad-spectrum antiviral activity. Finally, we postulate that the ferruginol analog (18-(phthalimide-2-yl) ferruginol) is a potential host-targeted antiviral.
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Zika Virus Infection/drug therapy ; Zika Virus ; Virus Replication ; COVID-19 ; SARS-CoV-2 ; Viruses ; RNA Viruses ; RNA
    Chemical Substances Antiviral Agents ; ferruginol ; RNA (63231-63-0)
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15030776
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