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  1. Article ; Online: Relapse of acute leukemia after a second allogeneic stem- cell transplantation; Is there any hope for cure?

    Shimoni, Avichai

    Bone marrow transplantation

    2022  Volume 57, Issue 3, Page(s) 336–337

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute/therapy ; Recurrence ; Retrospective Studies
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01508-2
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    Zs.A 2168: Show issues Location:
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  2. Article ; Online: How to predict response to treatment and outcome in patients with gastro-intestinal acute GVHD; Can

    Shimoni, Avichai

    Transplantation and cellular therapy

    2021  Volume 27, Issue 7, Page(s) 525–526

    MeSH term(s) Fluorodeoxyglucose F18 ; Graft vs Host Disease ; Humans ; Positron-Emission Tomography ; Radiopharmaceuticals ; Treatment Outcome
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-07-02
    Document type Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2021.06.009
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    Zs.A 5082: Show issues Location:
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  3. Article ; Online: Treosulfan-based or busulfan-based conditioning for allogeneic transplantation: the role of dose intensity.

    Shimoni, Avichai

    The Lancet. Haematology

    2019  Volume 7, Issue 1, Page(s) e4–e5

    MeSH term(s) Busulfan/analogs & derivatives ; Cyclophosphamide ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute ; Neoplasm Recurrence, Local ; Transplantation, Homologous ; Vidarabine/analogs & derivatives
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; treosulfan (CO61ER3EPI) ; Vidarabine (FA2DM6879K) ; Busulfan (G1LN9045DK) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 2019-10-09
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(19)30198-X
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  4. Article ; Online: The role of stem-cell transplantation in the treatment of marginal zone lymphoma.

    Shimoni, Avichai

    Best practice & research. Clinical haematology

    2016  Volume 30, Issue 1-2, Page(s) 166–171

    Abstract: High-dose chemotherapy and autologous stem-cell transplantation (ASCT) is standard therapy in relapsed/refractory aggressive lymphoma. The optimal therapy of relapsed/refractory disseminated marginal-zone lymphoma (MZL) has not been defined. Limited data ...

    Abstract High-dose chemotherapy and autologous stem-cell transplantation (ASCT) is standard therapy in relapsed/refractory aggressive lymphoma. The optimal therapy of relapsed/refractory disseminated marginal-zone lymphoma (MZL) has not been defined. Limited data on ASCT in this setting suggests outcomes are similar to what is expected in follicular lymphoma. International guidelines suggest that ASCT should be considered in follicular lymphoma in second or subsequent remission, in particular in high-risk disease, or following disease transformation. These guidelines can be extrapolated to MZL. ASCT is not considered curative but a subset of patients achieve very long remissions. The major concern is the occurrence of secondary malignancies possibly related to total-body irradiation. Allogeneic SCT is usually considered after failure of ASCT, but can also be considered upfront in younger patients seeking curative approach. The introduction of novel/targeted therapies may change the role and timing SCT may have in the treatment algorithm of indolent lymphomas.
    MeSH term(s) Algorithms ; Allografts ; Autografts ; Humans ; Lymphoma, B-Cell, Marginal Zone/therapy ; Practice Guidelines as Topic ; Stem Cell Transplantation
    Language English
    Publishing date 2016-11-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2016.08.027
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  5. Article ; Online: Second malignancies after allogeneic stem cell transplantation with reduced-intensity conditioning: is the incidence reduced?

    Shimoni, Avichai

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2014  Volume 20, Issue 11, Page(s) 1669–1670

    MeSH term(s) Colorectal Neoplasms/therapy ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Immunotherapy, Adoptive/methods ; Male ; Neoplasms, Second Primary/etiology ; Transplantation Conditioning/adverse effects ; Transplantation Conditioning/methods
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2014.09.004
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    Zs.MO 462: Show issues

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  6. Article ; Online: Risk stratification of patients with multiple myeloma prior to autologous stem cell transplant: what is the role of serum ferritin levels?

    Shimoni, Avichai

    Leukemia & lymphoma

    2014  Volume 55, Issue 11, Page(s) 2419–2420

    MeSH term(s) Biomarkers, Tumor/blood ; Female ; Ferritins/blood ; Humans ; Male ; Multiple Myeloma/therapy ; Stem Cell Transplantation/methods
    Chemical Substances Biomarkers, Tumor ; Ferritins (9007-73-2)
    Language English
    Publishing date 2014-06-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.3109/10428194.2014.921915
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    Zs.A 2997: Show issues Location:
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  7. Article ; Online: Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation.

    Davidov, Yana / Shem-Tov, Noga / Yerushalmi, Ronit / Hod, Tammy / Ben-Ari, Ziv / Nagler, Arnon / Shimoni, Avichai / Danylesko, Ivetta

    Bone marrow transplantation

    2024  

    Abstract: Sinusoidal Obstructive Syndrome (SOS) is a life-threatening complication after hematopoietic stem-cell transplantation (HSCT), characterized by post-sinusoidal portal hypertension. FibroScan is used to assess portal hypertension non-invasively. We ... ...

    Abstract Sinusoidal Obstructive Syndrome (SOS) is a life-threatening complication after hematopoietic stem-cell transplantation (HSCT), characterized by post-sinusoidal portal hypertension. FibroScan is used to assess portal hypertension non-invasively. We assessed transient elastography (TE) applicability in diagnosing SOS. The study included 27 adult patients, 11 underwent TE for high SOS risk pre-HSCT, 17 underwent TE post-HSCT due to bilirubin ≥2 mg/dl with no definite diagnosis of SOS. The first group had median Liver Stiffness Measurement (LSM) of 7.4 kPa (range, 3.3-22.5). Based on LSM results, conditioning regimen was modified for six patients and two of them developed SOS. Only one patient who did not have protocol adjustment experienced SOS. No patient with LSM < 7 kPa developed SOS. The second group had median LSM of 7.7 kPa (4.4-31.5). Median LSM after HSCT was significantly higher in patients who subsequently developed established SOS (n = 10) compared to patients who did not (n = 8), with values of 10.7 kPa (5.6-31.5) and 5.9 kPa (4.4-13.8), respectively (p = 0.02). An LSM cut-off of 7.5 kPa had a sensitivity and specificity of 75 and 80% for diagnosing SOS. In conclusion, pre-HSCT LSM can help adjustment of conditioning regimen in patients with high-risk for SOS. Post-HSCT LSM can help in early diagnosis of SOS.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02288-1
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    Zs.A 2168: Show issues Location:
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  8. Article ; Online: Haploidentical stem-cell transplant: the challenge of immune reconstitution.

    Shimoni, Avichai

    Leukemia & lymphoma

    2013  Volume 54, Issue 12, Page(s) 2579–2580

    MeSH term(s) Cell Transformation, Neoplastic ; Female ; Humans ; Leukemia, Myeloid, Acute/blood ; Leukemia, Myeloid, Acute/mortality ; Lymphocyte Count ; Lymphocytes ; Male ; Myelodysplastic Syndromes/blood ; Myelodysplastic Syndromes/mortality
    Language English
    Publishing date 2013-07-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.3109/10428194.2013.814129
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    Zs.A 2997: Show issues Location:
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  9. Article ; Online: The occurrence of thrombosis during intensive chemotherapy treatment for acute myeloid leukemia patients does not impact on long-term survival.

    Hellou, Tamer / Cohen, Omri / Avigdor, Abraham / Amitai, Irina / Shimoni, Avichai / Misgav, Mudi / Canaani, Jonathan

    Annals of hematology

    2023  Volume 102, Issue 5, Page(s) 1037–1043

    Abstract: Venous thromboembolism (VTE) is frequently seen in acute myeloid leukemia (AML) patients and presents a significant clinical challenge. The association of VTE during intensive chemotherapy with risk models such as the Medical Research Council (MRC) ... ...

    Abstract Venous thromboembolism (VTE) is frequently seen in acute myeloid leukemia (AML) patients and presents a significant clinical challenge. The association of VTE during intensive chemotherapy with risk models such as the Medical Research Council (MRC) cytogenetic-based assessment and the European LeukemiaNet (ELN) 2017 molecular risk model have not been rigorously evaluated. Additionally, there is a paucity of data pertaining to the long-term prognostic impact of VTE in AML patients. We performed an analysis of baseline parameters of AML patients diagnosed with VTE during intensive chemotherapy and compared them with patients without VTE. The analyzed cohort consisted of 335 newly diagnosed AML patients with a median age of 55 years. Thirty-five patients (11%) were classified as MRC favorable risk, 219 (66%) patients as intermediate risk, 58 patients (17%) as adverse risk. Per ELN 2017, 132 patients (40%) had favorable risk disease, 122 patients (36%) intermediate risk, and 80 patients (24%) had adverse risk. VTE was seen in 33 patients (9.9%), occurring mostly during induction (70%), and required catheter removal in 9 patients (28%). Baseline clinical, laboratory, molecular, and ELN 2017 parameters were not significantly different groups. However, MRC intermediate-risk group patients were significantly more likely to experience thrombosis compared to favorable risk and adverse risk patients (12.8% versus 5.7% and 1.7%, respectively; p = 0.049). Median overall survival was not significantly impacted by the diagnosis of thrombosis (3.7 years versus 2.2 years; p = 0.47). VTE is tightly associated with temporal and cytogenetic parameters in AML but does not significantly impact on long-term outcomes.
    MeSH term(s) Humans ; Middle Aged ; Venous Thromboembolism/epidemiology ; Leukemia, Myeloid, Acute/therapy ; Prognosis ; Risk Factors ; Thrombosis/chemically induced ; Thrombosis/epidemiology
    Language English
    Publishing date 2023-03-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-023-05158-w
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  10. Article ; Online: Real-World Efficacy Outcomes of FLT3-ITD

    Gueta, Itai / Marcu-Malina, Victoria / Avigdor, Abraham / Shimoni, Avichai / Loebstein, Ronen / Canaani, Jonathan

    Clinical lymphoma, myeloma & leukemia

    2022  Volume 23, Issue 2, Page(s) 154–157

    MeSH term(s) Humans ; Staurosporine/pharmacology ; Staurosporine/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy ; fms-Like Tyrosine Kinase 3/genetics ; Mutation
    Chemical Substances midostaurin (ID912S5VON) ; Staurosporine (H88EPA0A3N) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; FLT3 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2022.11.012
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