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  1. Article ; Online: Screening detects a myriad of breast disease - refining practice will increase effectiveness and reduce harm.

    Lyburn, Iain D / Pinder, Sarah E

    The British journal of radiology

    2020  Volume 93, Issue 1115, Page(s) 20200135

    Abstract: For many individuals, the term 'cancer' equates to a disease that if untreated will progress, spread from the area initially affected and ultimately cause death. 'Breast cancer', however, is a diverse of range of pathological entities, incorporating ... ...

    Abstract For many individuals, the term 'cancer' equates to a disease that if untreated will progress, spread from the area initially affected and ultimately cause death. 'Breast cancer', however, is a diverse of range of pathological entities, incorporating indolent to fast-growing and aggressive lesions, with varying histological patterns, clinical presentations, treatment responses and outcomes. Screening for malignancy is based on the assumption that cancer has a gradual, orderly progression and that detecting lesions earlier in their natural history, and intervening, will reduce mortality. The natural history of epithelial atypia, ductal carcinoma
    MeSH term(s) Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/diagnostic imaging ; Carcinoma, Ductal, Breast/genetics ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating/genetics ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Disease Progression ; Early Detection of Cancer ; Female ; Gene Expression Profiling ; Humans ; Hyperplasia/diagnostic imaging ; Hyperplasia/pathology ; Mass Screening/adverse effects ; Mass Screening/methods
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20200135
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  2. Article: Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification.

    Lyburn, Iain D / Scott, Robert / Cornford, Eleanor / Bouzy, Pascaline / Stone, Nicholas / Greenwood, Charlene / Bouybayoune, Ihsanne / Pinder, Sarah E / Rogers, Keith

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27686

    Abstract: ... The crystallographic phase of each microcalcification (e.g., hydroxyapatite, whitlockite) was easily determined ...

    Abstract Rationale and objectives: The potential of breast microcalcification chemistry to provide clinically valuable intelligence is being increasingly studied. However, acquisition of crystallographic details has, to date, been limited to high brightness, synchrotron radiation sources. This study, for the first time, evaluates a laboratory-based system that interrogates histological sections containing microcalcifications. The principal objective was to determine the measurement precision of the laboratory system and assess whether this was sufficient to provide potentially clinical valuable information.
    Materials and methods: Sections from 5 histological specimens from breast core biopsies obtained to evaluate mammographic calcification were examined using a synchrotron source and a laboratory-based instrument. The samples were chosen to represent a significant proportion of the known breast tissue, mineralogical landscape. Data were subsequently analysed using conventional methods and microcalcification characteristics such as crystallographic phase, chemical deviation from ideal stoichiometry and microstructure were determined.
    Results: The crystallographic phase of each microcalcification (e.g., hydroxyapatite, whitlockite) was easily determined from the laboratory derived data even when a mixed phase was apparent. Lattice parameter values from the laboratory experiments agreed well with the corresponding synchrotron values and, critically, were determined to precisions that were significantly greater than required for potential clinical exploitation.
    Conclusion: It has been shown that crystallographic characteristics of microcalcifications can be determined in the laboratory with sufficient precision to have potential clinical value. The work will thus enable exploitation acceleration of these latent microcalcification features as current dependence upon access to limited synchrotron resources is minimized.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27686
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  3. Article ; Online: Low-risk DCIS. What is it? Observe or excise?

    Pinder, Sarah E / Thompson, Alastair M / Wesserling, Jelle

    Virchows Archiv : an international journal of pathology

    2021  Volume 480, Issue 1, Page(s) 21–32

    Abstract: The issue of overdiagnosis and overtreatment of lesions detected by breast screening mammography has been debated in both international media and the scientific literature. A proportion of cancers detected by breast screening would never have presented ... ...

    Abstract The issue of overdiagnosis and overtreatment of lesions detected by breast screening mammography has been debated in both international media and the scientific literature. A proportion of cancers detected by breast screening would never have presented symptomatically or caused harm during the patient's lifetime. The most likely (but not the only) entity which may represent those overdiagnosed and overtreated is low-grade ductal carcinoma in situ (DCIS). In this article, we address what is understood regarding the natural history of DCIS and the diagnosis and prognosis of low-grade DCIS. However, low cytonuclear grade disease may not be the totality of DCIS that can be considered of low clinical risk and we outline the issues regarding active surveillance vs excision of low-risk DCIS and the clinical trials exploring this approach.
    MeSH term(s) Breast Neoplasms/diagnosis ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Intraductal, Noninfiltrating/diagnosis ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Early Detection of Cancer ; Female ; Humans ; Mammography
    Language English
    Publishing date 2021-08-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-021-03173-8
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    Ud III Zs.10: Show issues Location:
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  4. Article ; Online: Low-grade adenosquamous carcinoma arising in association with a nipple adenoma.

    Wilsher, Mark J / Desai, Anil J / Pinder, Sarah E

    Histopathology

    2020  Volume 76, Issue 5, Page(s) 784–787

    MeSH term(s) Adenoma/pathology ; Breast Neoplasms/pathology ; Carcinoma, Adenosquamous/pathology ; Female ; Humans ; Middle Aged ; Neoplasms, Multiple Primary/pathology ; Nipples/pathology ; Papilloma/pathology
    Language English
    Publishing date 2020-02-18
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14033
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    Zs.A 1328: Show issues Location:
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  5. Article ; Online: The impact of human epidermal growth factor receptor 2 neoadjuvant monoclonal antibody (trastuzumab) therapy in ductal carcinoma in situ of the breast.

    Parham, David M / Pinder, Sarah E

    Histopathology

    2017  Volume 70, Issue 6, Page(s) 1009–1011

    MeSH term(s) Adult ; Aged ; Antineoplastic Agents, Immunological/therapeutic use ; Breast Neoplasms/drug therapy ; Carcinoma, Intraductal, Noninfiltrating/drug therapy ; Chemotherapy, Adjuvant/methods ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy/methods ; Receptor, ErbB-2/immunology ; Retrospective Studies ; Trastuzumab/therapeutic use ; Treatment Outcome
    Chemical Substances Antineoplastic Agents, Immunological ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2017
    Publishing country England
    Document type Letter
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.13145
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  6. Article ; Online: Modern therapies and iatrogenic changes in breast pathology.

    Provenzano, Elena / Pinder, Sarah E

    Histopathology

    2017  Volume 70, Issue 1, Page(s) 40–55

    Abstract: Iatrogenic changes within the breast can provide challenges for the histopathologist in routine practice. Diagnostic procedures, such as core biopsies, result in reactive changes and can cause displacement of benign and malignant cells, the ... ...

    Abstract Iatrogenic changes within the breast can provide challenges for the histopathologist in routine practice. Diagnostic procedures, such as core biopsies, result in reactive changes and can cause displacement of benign and malignant cells, the interpretation of which may cause difficulties in the resection specimen. Breast augmentation surgery with implants or injection of fillers, performed for cosmetic reasons or as part of a reconstructive process following removal of breast cancer, also produces reactive changes locally and at distant sites that may mimic cancer. The entity of implant-associated anaplastic large-cell lymphoma is now well recognized, with progress in our understanding of the underlying biological factors that drive its development. Chemotherapy and radiotherapy used in the treatment of breast cancer causes characteristic changes in normal breast tissue, and can alter the histological appearance and receptor status of the tumour. Radiotherapy to the breast, for breast cancer or childhood malignancies, increases the risk of developing a secondary malignancy in the breast long after treatment. In this review, we describe some of the iatrogenic changes that may be seen in histological specimens from the breast.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Biopsy, Large-Core Needle/adverse effects ; Breast Diseases/diagnosis ; Breast Diseases/etiology ; Breast Diseases/pathology ; Breast Implants/adverse effects ; Female ; Humans ; Iatrogenic Disease ; Radiotherapy/adverse effects
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.13098
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    Zs.A 1328: Show issues Location:
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  7. Article: Micro- and macro-metastasis in the axillary lymph node: A review.

    Naidoo, Kalnisha / Pinder, Sarah E

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2017  Volume 15, Issue 2, Page(s) 76–82

    Abstract: ... This, it is thought, increases the chances of detecting small metastatic foci (i.e. macrometastases (>2 mm ...

    Abstract Pathologists typically examine the sentinel lymph nodes excised from patients with invasive breast cancer more thoroughly than they have historically those from axillary lymph node clearance specimens. This, it is thought, increases the chances of detecting small metastatic foci (i.e. macrometastases (>2 mm), micrometastases (0.2-2 mm), or isolated tumour cell clusters (<0.2 mm or <200 cancer cells in one section)). However, the clinical significance of these small metastatic deposits remains unclear. Although an increasing nodal burden is known to proportionally decrease patient survival, the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial has, at the least, raised questions as to how best to manage nodal metastasis in early invasive breast cancer. These issues, and a brief overview of the biology of metastatic spread are presented in this review.
    Language English
    Publishing date 2017-04
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2016.07.002
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  8. Article ; Online: Reply to "Comment on: Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project".

    Shaaban, Abeer M / Hilton, Bridget / Clements, Karen / Pinder, Sarah E / Thompson, Alastair M

    British journal of cancer

    2021  Volume 124, Issue 8, Page(s) 1463–1464

    MeSH term(s) Carcinoma, Intraductal, Noninfiltrating/epidemiology ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Humans ; Mammography ; Mastectomy, Segmental ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-02-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01281-5
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  9. Article ; Online: Immunohistochemistry for Triple-Negative Breast Cancer.

    Naidoo, Kalnisha / Pinder, Sarah E

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1406, Page(s) 39–51

    Abstract: Triple-negative breast cancers are a heterogeneous group of tumors that are, as yet, not entirely understood. Although triple-negative carcinomas are strictly defined as invasive carcinomas lacking expression of estrogen receptor, progesterone receptor, ... ...

    Abstract Triple-negative breast cancers are a heterogeneous group of tumors that are, as yet, not entirely understood. Although triple-negative carcinomas are strictly defined as invasive carcinomas lacking expression of estrogen receptor, progesterone receptor, and HER2, some use the terms triple-negative and basal-like cancer synonymously. It should be noted that these are not entirely equivalent. Nevertheless, it has been shown that a panel of immunohistochemical markers can be used as a surrogate for genomic profiling and thus to identify basal-like breast cancers. We describe the panels of immunohistochemical markers that can be applied and how to interpret these markers herein.
    MeSH term(s) Antibodies/immunology ; Humans ; Immunohistochemistry/methods ; Paraffin/isolation & purification ; Paraffin/metabolism ; Staining and Labeling ; Statistics as Topic ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
    Chemical Substances Antibodies ; Paraffin (8002-74-2)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3444-7_3
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  10. Article ; Online: A multi-modal exploration of heterogeneous physico-chemical properties of DCIS breast microcalcifications.

    Gosling, Sarah / Calabrese, Doriana / Nallala, Jayakrupakar / Greenwood, Charlene / Pinder, Sarah / King, Lorraine / Marks, Jeffrey / Pinto, Donna / Lynch, Thomas / Lyburn, Iain D / Hwang, E Shelley / Grand Challenge Precision Consortium / Rogers, Keith / Stone, Nicholas

    The Analyst

    2022  Volume 147, Issue 8, Page(s) 1641–1654

    Abstract: ... Ductal ... ...

    Abstract Ductal carcinoma
    MeSH term(s) Breast Neoplasms ; Calcinosis/pathology ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Durapatite ; Female ; Humans ; Spectroscopy, Fourier Transform Infrared ; Tumor Microenvironment ; X-Ray Diffraction
    Chemical Substances Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d1an01548f
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