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  1. Article ; Online: Preparing student-pharmacists to utilize motivational interviewing techniques to address COVID-19 vaccine hesitancy in underrepresented racial/ethnic patient populations.

    Jackson, Jonathan / Guirguis, Erenie / Sourial, Mariette / Pirmal, Sunita / Pinder, Lindsey

    Currents in pharmacy teaching & learning

    2023  Volume 15, Issue 8, Page(s) 742–747

    Abstract: Background and purpose: Vaccine hesitancy disproportionally impacts racial/ethnic minority populations. Regarded as trusted, accessible, and knowledgeable, pharmacists are strategically positioned to address this threat using effective communication ... ...

    Abstract Background and purpose: Vaccine hesitancy disproportionally impacts racial/ethnic minority populations. Regarded as trusted, accessible, and knowledgeable, pharmacists are strategically positioned to address this threat using effective communication strategies such as motivational interviewing (MI). Little data exists on programs that prepare student-pharmacists to use MI to combat vaccine hesitancy in underrepresented populations.
    Educational activity and setting: Student pharmacists elected to participate in co-curricular training on addressing COVID-19 vaccine hesitancy in racial/ethnic minority populations. The training included a web-based module on using MI to address COVID-19 vaccine hesitancy and a live group objective structured clinical examination (OSCE) with standardized patient encounters that included prevalent COVID-19 vaccine concerns. Faculty assessed the group's ability to employ core elements of MI to correct vaccine misinformation. After the OSCE, students received feedback from the standardized actors and evaluators. Change in student confidence was assessed. After the training, students volunteered at eight different community events to utilize MI to address vaccine hesitancy in underrepresented patient populations.
    Findings: A total of 17 students completed the training. Four out of the six groups received a passing score on the OSCE. Students performed satisfactory in the major domains of MI but struggled to answer knowledge-based questions regarding COVID-19 vaccines. As a result of the training, a significant increase in student confidence was seen. All participating students rated the training as either "excellent" or "good."
    Summary: A novel, co-curricular educational initiative was an effective tool to prepare student-pharmacists to utilize MI to combat vaccine hesitancy in underrepresented racial/ethnic minority populations.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Ethnicity ; Motivational Interviewing/methods ; Pharmacists ; Educational Measurement/methods ; Minority Groups ; COVID-19/prevention & control ; Students, Pharmacy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515217-8
    ISSN 1877-1300 ; 1877-1297
    ISSN (online) 1877-1300
    ISSN 1877-1297
    DOI 10.1016/j.cptl.2023.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The importance of histological assessment after neoadjuvant therapy and the need for standardisation.

    Naidoo, K / Pinder, S E

    Clinical radiology

    2018  Volume 73, Issue 8, Page(s) 693–699

    Abstract: Neoadjuvant therapy is increasingly being recognised as a management option for patients with primary invasive breast carcinoma; this may take the form of primary endocrine treatment or primary chemotherapy. Surgical specimens from women treated with ... ...

    Abstract Neoadjuvant therapy is increasingly being recognised as a management option for patients with primary invasive breast carcinoma; this may take the form of primary endocrine treatment or primary chemotherapy. Surgical specimens from women treated with neoadjuvant treatments, particularly primary chemotherapy, may cause a challenge for the histopathologist in handling and interpretation and have, in the past, been sampled, evaluated, and reported in a non-standardised way. This limits comparison between clinical trials and potentially provides clinicians and patients with suboptimal prognostic information. We describe here some of the difficulties faced and the recommendations and standards now applied.
    MeSH term(s) Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Breast Neoplasms/therapy ; Female ; Humans ; Neoadjuvant Therapy ; Neoplasm Invasiveness/pathology ; Pathology, Clinical/standards ; Prognosis ; Survival Analysis
    Language English
    Publishing date 2018-02-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2018.01.005
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  3. Article ; Online: Family and community resilience: a Photovoice study.

    Tan, Yvonne / Pinder, Danielle / Bayoumi, Imaan / Carter, Rifaa / Cole, Michele / Jackson, Logan / Watson, Autumn / Knox, Bruce / Chan-Nguyen, Sophy / Ford, Meghan / Davison, Colleen M / Bartels, Susan A / Purkey, Eva

    International journal for equity in health

    2024  Volume 23, Issue 1, Page(s) 62

    Abstract: Background: Adverse childhood experiences (ACEs), in combination with adverse community environments, can result in traumatic stress reactions, increasing a person's risk for chronic physical and mental health conditions. Family resilience refers to the ...

    Abstract Background: Adverse childhood experiences (ACEs), in combination with adverse community environments, can result in traumatic stress reactions, increasing a person's risk for chronic physical and mental health conditions. Family resilience refers to the ability of families to withstand and rebound from adversity; it involves coping with disruptions as well as positive growth in the face of sudden or challenging life events, trauma, or adversities. This study aimed to identify factors contributing to family and community resilience from the perspective of families who self-identified as having a history of adversity and being resilient during the COVID-19 pandemic.
    Methods: This study used Photovoice, a visual participatory research method which asks participants to take photographs to illustrate their responses to a research question. Participants consisted of a maximum variation sample of families who demonstrated family level resilience in the context of the pair of ACEs during the COVID-19 pandemic. Family members were asked to collect approximately five images or videos that illustrated the facilitators and barriers to well-being for their family in their community. Semi-structured in-depth interviews were conducted using the SHOWeD framework to allow participants to share and elucidate the meaning of their photos. Using thematic analysis, two researchers then independently completed line-by-line coding of interview transcripts before collaborating to develop consensus regarding key themes and interpretations.
    Results: Nine families were enrolled in the study. We identified five main themes that enhanced family resilience: (1) social support networks; (2) factors fostering children's development; (3) access and connection to nature; (4) having a space of one's own; and (5) access to social services and community resources.
    Conclusions: In the context of additional stresses related to the COVID-19 pandemic, resilient behaviours and strategies for families were identified. The creation or development of networks of intra- and inter-community bonds; the promotion of accessible parenting, housing, and other social services; and the conservation and expansion of natural environments may support resilience and health.
    MeSH term(s) Child ; Humans ; Resilience, Psychological ; Family Health ; Pandemics ; Parenting/psychology ; COVID-19
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2092056-8
    ISSN 1475-9276 ; 1475-9276
    ISSN (online) 1475-9276
    ISSN 1475-9276
    DOI 10.1186/s12939-024-02142-2
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  4. Article ; Online: The B3 conundrum-the radiologists' perspective.

    Sharma, Nisha / Wilkinson, Louise S / Pinder, Sarah E

    The British journal of radiology

    2017  Volume 90, Issue 1071, Page(s) 20160595

    Abstract: The management of B3 lesions is both controversial and complicated. There have been recent publications regarding how best to manage this heterogeneous group particularly in light of the Marmot Review and with the advent of vacuum-assisted biopsy ... ...

    Abstract The management of B3 lesions is both controversial and complicated. There have been recent publications regarding how best to manage this heterogeneous group particularly in light of the Marmot Review and with the advent of vacuum-assisted biopsy technique. It is recognized that B3 lesions on core biopsy can be upgraded to malignancy in up to one-third of cases, but this is predominantly to ductal carcinoma in situ or low-grade invasive tumours. The upgrade rate is mainly associated with B3 lesions with epithelial atypia. This review summarizes the current management and focuses on the proposed future management of these B3 lesions.
    MeSH term(s) Biopsy, Needle ; Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Humans ; Image-Guided Biopsy/methods ; Mammography/methods ; Radiologists
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20160595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development and quality appraisal of a new English breast screening linked data set as part of the age, test threshold, and frequency of mammography screening (ATHENA-M) study.

    Brettschneider, Julia / Morrison, Breanna / Jenkinson, David / Freeman, Karoline / Walton, Jackie / Sitch, Alice / Hudson, Sue / Kearins, Olive / Mansbridge, Alice / Pinder, Sarah E / Given-Wilson, Rosalind / Wilkinson, Louise / Wallis, Matthew G / Cheung, Shan / Taylor-Phillips, Sian

    The British journal of radiology

    2024  Volume 97, Issue 1153, Page(s) 98–112

    Abstract: Objectives: To build a data set capturing the whole breast cancer screening journey from individual breast cancer screening records to outcomes and assess data quality.: Methods: Routine screening records (invitation, attendance, test results) from ... ...

    Abstract Objectives: To build a data set capturing the whole breast cancer screening journey from individual breast cancer screening records to outcomes and assess data quality.
    Methods: Routine screening records (invitation, attendance, test results) from all 79 English NHS breast screening centres between January 1, 1988 and March 31, 2018 were linked to cancer registry (cancer characteristics and treatment) and national mortality data. Data quality was assessed using comparability, validity, timeliness, and completeness.
    Results: Screening records were extracted from 76/79 English breast screening centres, 3/79 were not possible due to software issues. Data linkage was successful from 1997 after introduction of a universal identifier for women (NHS number). Prior to 1997 outcome data are incomplete due to linkage issues, reducing validity. Between January 1, 1997 and March 31, 2018, a total of 11 262 730 women were offered screening of whom 9 371 973 attended at least one appointment, with 139 million person-years of follow-up (a median of 12.4 person years for each woman included) with 73 810 breast cancer deaths and 1 111 139 any-cause deaths. Comparability to reference data sets and internal validity were demonstrated. Data completeness was high for core screening variables (>99%) and main cancer outcomes (>95%).
    Conclusions: The ATHENA-M project has created a large high-quality and representative data set of individual women's screening trajectories and outcomes in England from 1997 to 2018, data before 1997 are lower quality.
    Advances in knowledge: This is the most complete data set of English breast screening records and outcomes constructed to date, which can be used to evaluate and optimize screening.
    MeSH term(s) Female ; Humans ; Semantic Web ; State Medicine ; Mammography ; Breast ; Breast Neoplasms
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1093/bjr/tqad023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England.

    Freeman, Karoline / Jenkinson, David / Clements, Karen / Wallis, Matthew G / Pinder, Sarah E / Provenzano, Elena / Stobart, Hilary / Stallard, Nigel / Kearins, Olive / Sharma, Nisha / Shaaban, Abeer / Kirwan, Cliona Clare / Hilton, Bridget / Thompson, Alastair M / Taylor-Phillips, Sian

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) e077039

    Abstract: Objective: To explore how the number and type of breast cancers developed after screen detected atypia compare with the anticipated 11.3 cancers detected per 1000 women screened within one three year screening round in the United Kingdom.: Design: ... ...

    Abstract Objective: To explore how the number and type of breast cancers developed after screen detected atypia compare with the anticipated 11.3 cancers detected per 1000 women screened within one three year screening round in the United Kingdom.
    Design: Observational analysis of the Sloane atypia prospective cohort in England.
    Setting: Atypia diagnoses through the English NHS breast screening programme reported to the Sloane cohort study. This cohort is linked to the English Cancer Registry and the Mortality and Birth Information System for information on subsequent breast cancer and mortality.
    Participants: 3238 women diagnosed as having epithelial atypia between 1 April 2003 and 30 June 2018.
    Main outcome measures: Number and type of invasive breast cancers detected at one, three, and six years after atypia diagnosis by atypia type, age, and year of diagnosis.
    Results: There was a fourfold increase in detection of atypia after the introduction of digital mammography between 2010 (n=119) and 2015 (n=502). During 19 088 person years of follow-up after atypia diagnosis (until December 2018), 141 women developed breast cancer. Cumulative incidence of cancer per 1000 women with atypia was 0.95 (95% confidence interval 0.28 to 2.69), 14.2 (10.3 to 19.1), and 45.0 (36.3 to 55.1) at one, three, and six years after atypia diagnosis, respectively. Women with atypia detected more recently have lower rates of subsequent cancers detected within three years (6.0 invasive cancers per 1000 women (95% confidence interval 3.1 to 10.9) in 2013-18
    Conclusions: Many atypia could represent risk factors rather than precursors of invasive cancer requiring surgery in the short term. Women with atypia detected more recently have lower rates of subsequent cancers detected, which might be associated with changes to mammography and biopsy techniques identifying forms of atypia that are more likely to represent overdiagnosis. Annual mammography in the short term after atypia diagnosis might not be beneficial. More evidence is needed about longer term risks.
    MeSH term(s) Female ; Humans ; Cohort Studies ; Prospective Studies ; State Medicine ; Early Detection of Cancer/methods ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/epidemiology ; Mammography/methods ; England/epidemiology ; Mass Screening
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2023-077039
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  7. Article ; Online: Breast calcification micromorphology classification.

    Scott, Robert / Lyburn, Iain / Cornford, Eleanor / Bouzy, Pascaline / Stone, Nicholas / Greenwood, Charlene / Bouybayoune, Ihsanne / Pinder, Sarah / Rogers, Keith

    The British journal of radiology

    2022  Volume 95, Issue 1139, Page(s) 20220485

    Abstract: Objectives: The importance of consistent terminology in describing the appearance of breast calcifications in mammography is well recognised. Imaging of calcifications using electron microscopy is a globally growing field of research. We therefore ... ...

    Abstract Objectives: The importance of consistent terminology in describing the appearance of breast calcifications in mammography is well recognised. Imaging of calcifications using electron microscopy is a globally growing field of research. We therefore suggest that the time is ripe to develop a lexicon of terms for classifying the micromorphology of breast calcifications.
    Methods: Calcifications within a wide range of histological sections of breast tissue, both benign and malignant, were imaged by Scanning Electron Microscopy (SEM). These images were examined, and the micromorphology of calcifications present was grouped to create a classification system.
    Results: Based on the appearance of the calcifications observed, we propose five main categories for classification of the micromorphology of breast calcifications, namely, Dense Homogenous, Punctulate, Banded, Spongy and Aggregate.
    Conclusions: Use of the descriptive categories outlined here will help to ensure consistency and comparability of published observations on the micromorphology of breast calcifications.
    Advances in knowledge: This is the first time a lexicon and classification system has been proposed for the micromorphology of breast calcifications, as observed by scanning electron microscopy of histological sections. This will facilitate comparability of observed relationships between micromorphology, mammographic appearance, chemistry and pathology.
    MeSH term(s) Humans ; Female ; Breast Diseases/diagnostic imaging ; Breast Diseases/pathology ; Mammography/methods ; Calcinosis/diagnostic imaging ; Calcinosis/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast/diagnostic imaging ; Breast/pathology
    Language English
    Publishing date 2022-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20220485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prognostic Value of ER and PgR Expression and the Impact of Multi-clonal Expression for Recurrence in Ductal Carcinoma

    Thorat, Mangesh A / Levey, Pauline M / Jones, J Louise / Pinder, Sarah E / Bundred, Nigel J / Fentiman, Ian S / Cuzick, Jack

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2021  Volume 27, Issue 10, Page(s) 2861–2867

    Abstract: Purpose: The prognostic value of estrogen receptor (ER)/progesterone receptor (PgR) expression in ductal carcinoma : Experimental design: Formalin-fixed paraffin embedded tissues were collected from UK/ANZ DCIS trial participants (: Results: ER ... ...

    Abstract Purpose: The prognostic value of estrogen receptor (ER)/progesterone receptor (PgR) expression in ductal carcinoma
    Experimental design: Formalin-fixed paraffin embedded tissues were collected from UK/ANZ DCIS trial participants (
    Results: ER expression was multi-clonal in 11% (39/356) of ER-positive (70.6%, 356/504) patients. Ipsilateral breast event (IBE) risk was similarly higher in ER-multi-clonal and ER-negative DCIS as compared with DCIS with uni-clonal ER expression. ER-negative DCIS (clonal) had a higher risk of
    Conclusions: ER expression is a strong predictor of ipsilateral recurrence risk in DCIS. ER-positive DCIS with distinct ER-negative clones has a recurrence risk similar to ER-negative DCIS. ER should be routinely assessed in DCIS, and ER scoring should take clonality of expression into account.
    MeSH term(s) Aged ; Biomarkers, Tumor ; Carcinoma, Ductal, Breast/diagnosis ; Carcinoma, Ductal, Breast/genetics ; Carcinoma, Intraductal, Noninfiltrating/diagnosis ; Carcinoma, Intraductal, Noninfiltrating/genetics ; Clinical Trials as Topic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/genetics ; Receptors, Progesterone/metabolism ; Recurrence ; United Kingdom
    Chemical Substances Biomarkers, Tumor ; Receptors, Estrogen ; Receptors, Progesterone
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-20-4635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727).

    Tovey, Holly / Sipos, Orsolya / Parker, Joel S / Hoadley, Katherine A / Quist, Jelmar / Kernaghan, Sarah / Kilburn, Lucy / Salgado, Roberto / Loi, Sherene / Kennedy, Richard D / Roxanis, Ioannis / Gazinska, Patrycja / Pinder, Sarah E / Bliss, Judith / Perou, Charles M / Haider, Syed / Grigoriadis, Anita / Tutt, Andrew / Cheang, Maggie Chon U

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 18, Page(s) 3691–3705

    Abstract: Purpose: The TNT trial (NCT00532727) showed no evidence of carboplatin superiority over docetaxel in metastatic triple-negative breast cancer (mTNBC), but carboplatin benefit was observed in the germline BRCA1/2 mutation subgroup. Broader response- ... ...

    Abstract Purpose: The TNT trial (NCT00532727) showed no evidence of carboplatin superiority over docetaxel in metastatic triple-negative breast cancer (mTNBC), but carboplatin benefit was observed in the germline BRCA1/2 mutation subgroup. Broader response-predictive biomarkers are needed. We explored the predictive ability of DNA damage response (DDR) and immune markers.
    Experimental design: Tumor-infiltrating lymphocytes were evaluated for 222 of 376 patients. Primary tumors (PT) from 186 TNT participants (13 matched recurrences) were profiled using total RNA sequencing. Four transcriptional DDR-related and 25 immune-related signatures were evaluated. We assessed their association with objective response rate (ORR) and progression-free survival (PFS). Conditional inference forest clustering was applied to integrate multimodal data. The biology of subgroups was characterized by 693 gene expression modules and other markers.
    Results: Transcriptional DDR-related biomarkers were not predictive of ORR to either treatment overall. Changes from PT to recurrence were demonstrated; in chemotherapy-naïve patients, transcriptional DDR markers separated carboplatin responders from nonresponders (P values = 0.017; 0.046). High immune infiltration was associated with docetaxel ORR (interaction P values < 0.05). Six subgroups were identified; the immune-enriched cluster had preferential docetaxel response [62.5% (D) vs. 29.4% (C); P = 0.016]. The immune-depleted cluster had preferential carboplatin response [8.0% (D) vs. 40.0% (C); P = 0.011]. DDR-related subgroups were too small to assess ORR.
    Conclusions: High immune features predict docetaxel response, and high DDR signature scores predict carboplatin response in treatment-naïve mTNBC. Integrating multimodal DDR and immune-related markers identifies subgroups with differential treatment sensitivity. Treatment options for patients with immune-low and DDR-proficient tumors remains an outstanding need. Caution is needed using PT-derived transcriptional signatures to direct treatment in mTNBC, particularly DDR-related markers following prior chemotherapy.
    MeSH term(s) Humans ; Carboplatin ; BRCA1 Protein/genetics ; Docetaxel/therapeutic use ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology ; BRCA2 Protein/genetics ; Biomarkers ; DNA Damage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances Carboplatin (BG3F62OND5) ; BRCA1 protein, human ; BRCA1 Protein ; Docetaxel (15H5577CQD) ; BRCA2 protein, human ; BRCA2 Protein ; Biomarkers
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-0370
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  10. Article ; Online: Inequities in Adverse Maternal and Perinatal Outcomes: The Effect of Maternal Race and Nativity.

    Adegoke, Tejumola M / Pinder, Leeya F / Ndiwane, Ndindam / Parker, Samantha E / Vragovic, Olivera / Yarrington, Christina D

    Maternal and child health journal

    2021  Volume 26, Issue 4, Page(s) 823–833

    Abstract: ... outcomes among U.S.-born and foreign-born women, as well as racial and ethnic disparities in outcomes ... confidence intervals comparing outcomes between U.S.- and foreign-born women were calculated and stratified by race ... Obstetric outcomes among Black and Hispanic women were compared to those of white women within both U.S ...

    Abstract Objectives: To evaluate the effect of race and ethnicity on differences in maternal and perinatal outcomes among U.S.-born and foreign-born women, as well as racial and ethnic disparities in outcomes within these groups.
    Methods: This retrospective study analyzed singleton pregnancies (n = 11,518) among women delivering at Boston Medical Center from January 2010-March 2015. Outcomes of interest included preterm birth, early preterm birth, cesarean delivery, hypertensive disorders, diabetes, low birth weight at term (LBW, < 2500 g), NICU admission and intrauterine fetal demise (IUFD). Prevalence ratios and 95% confidence intervals comparing outcomes between U.S.- and foreign-born women were calculated and stratified by race. Obstetric outcomes among Black and Hispanic women were compared to those of white women within both U.S.- and foreign-born groups.
    Results: Preterm birth, hypertensive disorders, LBW and NICU admission were more likely to occur among U.S.-born women and their neonates compared to foreign-born women. Controlling for sociodemographic characteristics did not significantly impact these disparities. Among foreign-born women, Black women had a higher prevalence of many maternal and neonatal complications, while Hispanic women had a lower prevalence of some complications compared to white women. Black woman and infants consistently exhibit worse outcomes regardless of their nativity, while Hispanic women foreign-born women experience less disparate outcomes.
    Conclusions for practice: Overall, women born in the United States are at higher risk of several adverse perinatal outcomes compared to foreign-born women. Racial and ethnic disparities in birth outcomes exist in both groups. However, the complex interplay between biopsychosocial influences that mediate these inequities appear to have different effects among U.S- and foreign- born women. A better understanding of these factors can be used to combat disparities and improve outcomes for all women.
    MeSH term(s) Ethnicity ; Female ; Humans ; Hypertension, Pregnancy-Induced ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Male ; Pregnancy ; Premature Birth/epidemiology ; Retrospective Studies ; United States/epidemiology
    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-021-03225-0
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