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Book ; Online ; E-Book: Physiologic anchorage control

Xu, Tian Min

a new orthodontic concept and its clinical application

2017

Author's details	Tian Min Xu editor
Keywords	Craniofacial growth ; Light Force Low Friction Appliance ; Orthodontic anchorage design ; Orthodontic biomechanics ; Spee-archwire System ; Upper molar movement ; physiologic anchorage loss
Subject code	610
Language	English
Size	1 Online-Ressource (xii, 264 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019402565
ISBN	978-3-319-48333-7 ; 9783319483313 ; 3-319-48333-1 ; 3319483315
DOI	10.1007/978-3-319-48333-7
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Mechanical force increases tooth movement and promotes remodeling of alveolar bone defects augmented with bovine bone mineral.

Deng, Jie / Zhuang, Zi-Meng / Xu, Xiao / Han, Bing / Song, Guang-Ying / Xu, Tian-Min

Progress in orthodontics

2024 Volume 25, Issue 1, Page(s) 2

Abstract: Background: Orthodontic tooth movement (OTM) in a region containing alveolar bone defects with insufficient height and width is hard to achieve. Bovine bone mineral (Bio-Oss) is available to restore the alveolar defect; however, whether the region ... ...

Abstract	Background: Orthodontic tooth movement (OTM) in a region containing alveolar bone defects with insufficient height and width is hard to achieve. Bovine bone mineral (Bio-Oss) is available to restore the alveolar defect; however, whether the region augmented with a bovine bone mineral graft (BG) is feasible for OTM, and the mechanisms by which macrophages remodel the BG material, is uncertain under the mechanical force induced by OTM. Material and methods: Rats were divided into three groups: OTM (O), OTM + BG material (O + B), and Control (C). First molars were extracted to create bone defects in the O and O + B groups with bovine bone mineral grafting in the latter. Second molars received OTM towards the bone defects in both groups. After 28 days, maxillae were analyzed using microfocus-computed tomography (μCT) and scanning-electron-microscopy (SEM); and macrophages (M1/M2) were stained using immunofluorescence. THP-1 cell-induced macrophages were cultured under mechanical force (F), BG material (B), or both (F + B). Phagocytosis-related signaling molecules (cAMP/PKA/RAC1) were analyzed, and conditioned media was analyzed for MMP-9 and cytokines (IL-1β, IL-4). Results: Our study demonstrated that alveolar defects grafted with BG materials are feasible for OTM, with significantly increased OTM distance, bone volume, and trabecular thickness in this region. SEM observation revealed that the grafts served as a scaffold for cells to migrate and remodel the BG materials in the defect during OTM. Moreover, the population of M2 macrophages increased markedly both in vivo and in cell culture, with enhanced phagocytosis via the cAMP/PKA/RAC1 pathway in response to mechanical force in combination with BG particles. By contrast, M1 macrophage populations were decreased under the same circumstances. In addition, M2 macrophage polarization was also indicated by elevated IL-4 levels, reduced IL-1β levels, and less active MMP-9 in cell culture. Conclusion: This study explored the mechanisms of mechanical force-induced alveolar bone remodeling with bovine bone mineral grafts during OTM. The results might provide molecular insights into the related clinical problems of whether we can move teeth into the grafted materials; and how these materials become biologically remodeled and degraded under mechanical force.
MeSH term(s)	Animals ; Cattle ; Rats ; Interleukin-4 ; Matrix Metalloproteinase 9 ; Tooth Movement Techniques ; Minerals
Chemical Substances	Interleukin-4 (207137-56-2) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; bone meal (TRS31EO6ZN) ; Minerals
Language	English
Publishing date	2024-01-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2040711-7
ISSN	2196-1042 ; 1600-9975 ; 1723-7785 ; 1399-7513
ISSN (online)	2196-1042 ; 1600-9975
ISSN	1723-7785 ; 1399-7513
DOI	10.1186/s40510-023-00501-3
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Zs.A 5560: Show issues

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Article ; Online: CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy.

Zhang, Xi-Wen / Wu, Yi-Shi / Xu, Tian-Min / Cui, Man-Hua

Biomolecules

2023 Volume 13, Issue 3

Abstract: Ovarian cancer (OC) is among the most common gynecologic malignancies with a poor prognosis and a high mortality rate. Most patients are diagnosed at an advanced stage (stage III or IV), with 5-year survival rates ranging from 25% to 47% worldwide. ... ...

Abstract	Ovarian cancer (OC) is among the most common gynecologic malignancies with a poor prognosis and a high mortality rate. Most patients are diagnosed at an advanced stage (stage III or IV), with 5-year survival rates ranging from 25% to 47% worldwide. Surgical resection and first-line chemotherapy are the main treatment modalities for OC. However, patients usually relapse within a few years of initial treatment due to resistance to chemotherapy. Cell-based therapies, particularly adoptive T-cell therapy and chimeric antigen receptor T (CAR-T) cell therapy, represent an alternative immunotherapy approach with great potential for hematologic malignancies. However, the use of CAR-T-cell therapy for the treatment of OC is still associated with several difficulties. In this review, we comprehensively discuss recent innovations in CAR-T-cell engineering to improve clinical efficacy, as well as strategies to overcome the limitations of CAR-T-cell therapy in OC.
MeSH term(s)	Humans ; Female ; Receptors, Chimeric Antigen/genetics ; Receptors, Antigen, T-Cell ; Ovarian Neoplasms/therapy ; T-Lymphocytes ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13030465
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Article ; Online: Comparison of achieved and predicted crown movement in adults after 4 first premolar extraction treatment with Invisalign.

Dai, Fan-Fan / Xu, Tian-Min / Shu, Guang

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

2021 Volume 160, Issue 6, Page(s) 805–813

Abstract: Introduction: In this study, we compared achieved and predicted crown movements of maxillary and mandibular first molars, canines, and central incisors in adults after 4 first premolar extraction treatment with Invisalign.: Methods: Seventeen adult ... ...

Abstract	Introduction: In this study, we compared achieved and predicted crown movements of maxillary and mandibular first molars, canines, and central incisors in adults after 4 first premolar extraction treatment with Invisalign. Methods: Seventeen adult patients who received 4 first premolar extraction treatment with Invisalign and completed the first series of aligners were included. Superimposition of pretreatment and actual posttreatment dental models was acquired using registrations of pretreatment and posttreatment craniofacial models on the basis of bone surfaces and registrations of craniofacial and dental models on the basis of dental crown surfaces, respectively. Superimposition of pretreatment and predicted posttreatment models was acquired from ClinCheck software. Achieved and predicted 3-dimensional crown movements of maxillary and mandibular first molars, canines, and central incisors were then compared using the paired t test. Results: Relative to predicted changes, first molars achieved greater mesial displacement, mesial tipping, and buccal inclination in both the maxilla and mandible, greater intrusion in the maxilla, and greater mesial-lingual rotation and less constriction in the mandible. Canines achieved greater distal tipping in both the maxilla and mandible, less retraction in the maxilla, and greater lingual inclination and extrusion in the mandible. Central incisors achieved greater distal tipping and lingual inclination and extrusion in both the maxilla and mandible and less retraction in the maxilla. Conclusions: Tooth crown movements were not fully achieved as predicted following Invisalign treatment. Differences focused on mesial tipping, buccal inclination, mesial displacement, and intrusion of the first molars, as well as distal tipping, lingual inclination, insufficient retraction, and intrusion of the canines and central incisors.
MeSH term(s)	Adult ; Bicuspid/surgery ; Crowns ; Humans ; Incisor ; Mandible ; Maxilla ; Orthodontic Appliances, Removable ; Tooth Crown ; Tooth Movement Techniques
Language	English
Publishing date	2021-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	356699-7
ISSN	1097-6752 ; 0889-5406 ; 0002-9416
ISSN (online)	1097-6752
ISSN	0889-5406 ; 0002-9416
DOI	10.1016/j.ajodo.2020.06.041
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Article ; Online: Potential clinical implications of iron metabolism in ovarian endometriosis.

Liu, Meng-Na / Chen, Lei / Xu, Tian-Min / Zhang, Kun

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2022 Volume 73, Page(s) 127017

Abstract: Objective: The purpose of this study was to investigate iron metabolism indices in ovarian endometriosis (OEMs) and to demonstrate the potential clinical implications in the initiation and development of OEMs.: Methods: Three datasets in Gene ... ...

Abstract	Objective: The purpose of this study was to investigate iron metabolism indices in ovarian endometriosis (OEMs) and to demonstrate the potential clinical implications in the initiation and development of OEMs. Methods: Three datasets in Gene Expression Omnibus (GEO) database were selected to assess the expression levels of iron metabolites in endometrial tissues from patients with EMs and the health. To evaluate the differential expression of serum iron indices , hospitalized patients with OEMs and health examinees in Jilin University Second Hospital from November 2018 to December 2019 were recruited. Serum samples were obtained from 38 patients with OEMs and 36 health examinees. To compare the iron metabolism between peripheral circulation blood and local ectopic lesion, cyst fluid samples were obtained from 15 patients with ovarian chocolate cyst at the time of surgery. Iron metabolism indices include iron, transferrin (TF), ferritin, and unsaturated iron-binding capacity (UIBC)), which were measured by automatic biochemical analyzer. Results: The present study indicated the increased levels of the iron storage protein, ferritin, in the endometriotic tissues of patients with EMs. The expression of iron and ferritin in cyst fluid of patients with OEMs showed higher than that in serum, the results of TF and UIBC were opposite (P < 0.05). There was no statistical difference in the content of iron metabolites between patients with OEMs and the healthy examinees(P > 0.05). Conclusion: The ovarian chocolate cyst fluid and endometriotic tissues in patients with OEMs could more directly reflect the pathological changes of local ectopic lesion, which usually manifested as high levels of free iron and/or iron deposits in the ectopic sites. The implications of our work suggest iron metabolites in the serum may have potentially limited value as circulating biomarkers for OEMs. The iron variation in local lesions may be not only regulated by liver that mainly manipulate the systematic iron homeostasis, but also be tuned by the iron regulatory protein (IRP)/ iron responsive element (IRE) system. In summary, the iron metabolites, especially the iron and ferritin in the cyst fluid and endometriotic tissues, are meaningful biomarkers involved in the process of pathophysiology and pathogenesis of OEMs.
MeSH term(s)	Biomarkers/analysis ; Biomarkers/blood ; Biomarkers/metabolism ; Cyst Fluid/chemistry ; Cyst Fluid/metabolism ; Endometriosis/blood ; Endometriosis/etiology ; Endometriosis/metabolism ; Female ; Ferritins/blood ; Ferritins/metabolism ; Humans ; Iron/analysis ; Iron/blood ; Iron/metabolism ; Ovarian Diseases/blood ; Ovarian Diseases/etiology ; Ovarian Diseases/metabolism ; Transferrin/analysis ; Transferrin/metabolism
Chemical Substances	Biomarkers ; Transferrin ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-06-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2022.127017
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Article ; Online: New concept of physiologic anchorage control

Tian-Min Xu

APOS Trends in Orthodontics, Vol 5, Iss 6, Pp 250-

2015 Volume 254

Abstract: Molar anchorage loss in extraction case is believed due to the reaction of mechanical force applied to retract anterior teeth. While it may be close to truth in adult patients, it is certainly not true in adolescents. Studies on molar growth show upper ... ...

Abstract	Molar anchorage loss in extraction case is believed due to the reaction of mechanical force applied to retract anterior teeth. While it may be close to truth in adult patients, it is certainly not true in adolescents. Studies on molar growth show upper molar move forward as mandible growing forward, probably through intercuspation force. Hence, for adolescents, molar anchorage loss shall consist of two parts. One is from retraction force - mechanical anchorage loss; another from biologic force - physiologic anchorage loss. Since physiologic anchorage loss is caused by the continuous biologic force, the strategy of physiologic anchorage control (PAC) is different from the strategy of mechanical anchorage control. A new PAC method is introduced in this article that can reduce the headgear and temporary anchorage device used as sagittal anchorage dramatically in orthodontic clinic.
Keywords	Anchorage loss ; mandible growth ; physiologic anchorage control ; Medicine ; R ; Dentistry ; RK1-715
Subject code	570
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A highly sensitive and selective chemiluminescent probe for peroxynitrite detection in vitro, in vivo and in human liver cancer tissue.

Wang, Baoqu / Kong, Yating / Tian, Xiaoxue / Xu, Min

Journal of hazardous materials

2024 Volume 469, Page(s) 134094

Abstract: Peroxynitrite ( ... ...

Abstract	Peroxynitrite (ONOO
MeSH term(s)	Humans ; Mice ; Animals ; Fluorescent Dyes ; Peroxynitrous Acid ; Necrosis ; Liver Neoplasms
Chemical Substances	Fluorescent Dyes ; Peroxynitrous Acid (14691-52-2)
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.134094
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Article ; Online: A novel modified-curcumin 2.24 resolves inflammation by promoting M2 macrophage polarization.

Deng, Jie / Golub, Lorne M / Lee, Hsi-Ming / Bhatt, Heta-Dinesh / Johnson, Francis / Xu, Tian-Min / Gu, Ying

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15513

Abstract: To assess resolving-like activity by a novel chemically-modified curcumin (CMC2.24) in a "two-hit" model of diabetes-associated periodontitis. Macrophages from rats were cultured in the presence/absence of either Lipopolysaccharide (LPS, 1st hit); or ... ...

Abstract	To assess resolving-like activity by a novel chemically-modified curcumin (CMC2.24) in a "two-hit" model of diabetes-associated periodontitis. Macrophages from rats were cultured in the presence/absence of either Lipopolysaccharide (LPS, 1st hit); or advanced-glycation-end products (AGE, 2nd hit); or both combined. CMC2.24 was added as treatment. The conditioned media were analyzed for MMP-9, cytokines (IL-1β, IL-6, TNF-α), resolvins (RvD
MeSH term(s)	Animals ; Rats ; Curcumin/pharmacology ; Matrix Metalloproteinase 9 ; Interleukin-6 ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Inflammation/drug therapy ; Cytokines ; Macrophages
Chemical Substances	1,7-bis(4-hydroxyphenyl)-4-N-phenylaminocarbonylhepta-1,6-dien-3,5-dione ; Curcumin (IT942ZTH98) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Interleukin-6 ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Cytokines
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42848-x
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Article ; Online: The role of BMP15 and GDF9 in the pathogenesis of primary ovarian insufficiency.

Liu, Meng-Na / Zhang, Kun / Xu, Tian-Min

Human fertility (Cambridge, England)

2019 Volume 24, Issue 5, Page(s) 325–332

Abstract: Endocrine and paracrine signals can be key regulators of ovarian physiology. The oocyte secretes growth factors which directly induce follicular development by a complex paracrine signalling process, and the transforming growth factorβ (TGF-β) ... ...

Abstract	Endocrine and paracrine signals can be key regulators of ovarian physiology. The oocyte secretes growth factors which directly induce follicular development by a complex paracrine signalling process, and the transforming growth factorβ (TGF-β) superfamily has a pivotal role in this process. The bone morphogenetic protein 15 (
MeSH term(s)	Bone Morphogenetic Protein 15/genetics ; Bone Morphogenetic Protein 15/metabolism ; Female ; Fragile X Mental Retardation Protein ; Growth Differentiation Factor 9/genetics ; Growth Differentiation Factor 9/metabolism ; Humans ; Membrane Proteins ; Oocytes/metabolism ; Ovarian Follicle ; Primary Ovarian Insufficiency/genetics ; Receptors, Progesterone
Chemical Substances	BMP15 protein, human ; Bone Morphogenetic Protein 15 ; FMR1 protein, human ; GDF9 protein, human ; Growth Differentiation Factor 9 ; Membrane Proteins ; PGRMC1 protein, human ; Receptors, Progesterone ; Fragile X Mental Retardation Protein (139135-51-6)
Language	English
Publishing date	2019-10-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2086960-5
ISSN	1742-8149 ; 1464-7273
ISSN (online)	1742-8149
ISSN	1464-7273
DOI	10.1080/14647273.2019.1672107
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Article ; Online: Comparison of achieved and predicted tooth movement of maxillary first molars and central incisors:

Dai, Fan-Fan / Xu, Tian-Min / Shu, Guang

The Angle orthodontist

2019 Volume 89, Issue 5, Page(s) 679–687

Abstract: Objectives: To compare achieved and predicted tooth movements of maxillary first molars and central incisors in first premolar extraction cases treated with Invisalign.: Materials and methods: The present study included 30 patients who received ... ...

Abstract	Objectives: To compare achieved and predicted tooth movements of maxillary first molars and central incisors in first premolar extraction cases treated with Invisalign. Materials and methods: The present study included 30 patients who received maxillary first premolar extraction treatment with Invisalign. The actual posttreatment model was registered with the pretreatment model on the palatal stable region and superimposed with the virtual posttreatment model. Achieved and predicted tooth movements of maxillary first molars and central incisors were compared using paired Results: First molars achieved greater mesial tipping, mesial translation, and intrusion than predicted. Central incisors achieved less retraction and greater lingual crown torque and extrusion than predicted. Adolescents showed greater DPATM in the mesiodistal translation of first molars and labiolingual translation of central incisors and smaller DPATM in the occlusogingival translation of the first molars and crown torque of the central incisors than adults. The 3-mm vertical attachment group showed greater DPATM in the mesiodistal translation of the first molars vs the G6-optimized attachment group. Initial crowding had an inverse correlation with DPATM in angulation and mesiodistal translation of the first molars. Conclusions: First molar anchorage control and central incisor retraction were not fully achieved as predicted in first premolar extraction treatment with Invisalign. Age, attachment, and initial crowding affected the differences between predicted and achieved tooth movement.
MeSH term(s)	Adolescent ; Adult ; Bicuspid ; Humans ; Incisor ; Maxilla ; Molar ; Orthodontic Appliances, Removable ; Tooth Extraction ; Tooth Movement Techniques
Language	English
Publishing date	2019-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	390289-4
ISSN	1945-7103 ; 0003-3219
ISSN (online)	1945-7103
ISSN	0003-3219
DOI	10.2319/090418-646.1
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