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  1. Book ; Online ; E-Book: Conquering RAS

    Azmi, Asfar S.

    from biology to cancer therapy

    2017  

    Author's details edited by Asfar S. Azmi
    Keywords ras Proteins / genetics ; ras Proteins / metabolism ; Genes, ras / genetics ; Carcinogenesis / metabolism ; Neoplasms / drug therapy ; Molecular Targeted Therapy
    Subject code 616.994071
    Language English
    Size 1 Online-Ressource (xviii, 277 Seiten), Illustrationen
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019451595
    ISBN 978-0-12-803541-2 ; 9780128035054 ; 0-12-803541-2 ; 0128035056
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Animal models in cancer drug discovery

    Azmi, Asfar S. / Mohammad, Ramzi M.

    2019  

    Author's details edited by Asfar Azmi, Ramzi M. Mohammad
    Keywords Cancer/Animal models ; Cancer/Chemotherapy/Research ; Pharmacology, Experimental
    Subject code 616.994027
    Language English
    Size 1 Online-Ressource (xx, 451 Seiten), Illustrationen
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020126726
    ISBN 978-0-12-814705-4 ; 9780128147047 ; 0-12-814705-9 ; 0128147040
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Molecular diagnostics and treatment of pancreatic cancer

    Azmi, Asfar S.

    systems and network biology approaches

    2014  

    Author's details ed. by Asfar S. Azmi
    Keywords Pancreas/Cancer/Molecular diagnosis ; Pancreas/Cancer/Treatment
    Subject code 616.99437075
    Language English
    Size XX, 446 S. : Ill., graph. Darst., 23 cm
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018282887
    ISBN 978-0-12-408103-1 ; 9780124079465 ; 0-12-408103-7 ; 0124079466
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Systems biology in cancer research and drug discovery

    Azmi, Asfar S.

    2012  

    Author's details Asfar S. Azmi ed
    Language English
    Size XII, 423 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017423526
    ISBN 978-94-007-4818-7 ; 94-007-4818-3 ; 9789400748194 ; 9400748191
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Cancer cachexia research: coming of age.

    Muqbil, Irfana / Azmi, Asfar S

    Translational lung cancer research

    2023  Volume 12, Issue 6, Page(s) 1163–1166

    Language English
    Publishing date 2023-05-24
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Penetrating the central nervous system sanctuary of KRAS, a target once thought "undruggable".

    Nagasaka, Misako / Azmi, Asfar S

    Translational lung cancer research

    2023  Volume 12, Issue 4, Page(s) 665–668

    Language English
    Publishing date 2023-04-06
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-71
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinical progress of KRAS-targeted therapies: what next?

    Nagasaka, Misako / Azmi, Asfar S

    Future medicinal chemistry

    2022  Volume 14, Issue 15, Page(s) 1107–1110

    MeSH term(s) Humans ; Lung Neoplasms ; Mitogen-Activated Protein Kinase Kinases ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemical Substances KRAS protein, human ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2022-0128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nuclear export mechanisms of circular RNAs: size does matter.

    Azmi, Asfar S

    Non-coding RNA investigation

    2018  Volume 2

    Language English
    Publishing date 2018-09-14
    Publishing country China
    Document type Journal Article ; Comment
    ISSN 2522-6673
    ISSN (online) 2522-6673
    DOI 10.21037/ncri.2018.08.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Some chinks in RAS armor.

    Azmi, Asfar S

    Seminars in cancer biology

    2018  Volume 54, Page(s) iii–iv

    MeSH term(s) Gene Expression Regulation ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/metabolism ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogenes ; Signal Transduction ; ras Proteins/genetics ; ras Proteins/metabolism
    Chemical Substances Guanosine Diphosphate (146-91-8) ; Guanosine Triphosphate (86-01-1) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2018-08-06
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2018.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Deregulated transcription factors and poor clinical outcomes in cancer patients.

    Li, Yiwei / Azmi, Asfar S / Mohammad, Ramzi M

    Seminars in cancer biology

    2022  Volume 86, Issue Pt 3, Page(s) 122–134

    Abstract: Transcription factors are a group of proteins, which possess DNA-binding domains, bind to DNA strands of promoters or enhancers, and initiate transcription of genes with cooperation of RNA polymerase and other co-factors. They play crucial roles in ... ...

    Abstract Transcription factors are a group of proteins, which possess DNA-binding domains, bind to DNA strands of promoters or enhancers, and initiate transcription of genes with cooperation of RNA polymerase and other co-factors. They play crucial roles in regulating transcription during embryogenesis and development. Their physiological status in different cell types is also important to maintain cellular homeostasis. Therefore, any deregulation of transcription factors will lead to the development of cancer cells and tumor progression. Based on their functions in cancer cells, transcription factors could be either oncogenic or tumor suppressive. Furthermore, transcription factors have been shown to modulate cancer stem cells, epithelial-mesenchymal transition (EMT) and drug response; therefore, measuring deregulated transcription factors is hypothesized to predict treatment outcomes of patients with cancers and targeting deregulated transcription factors could be an encouraging strategy for cancer therapy. Here, we summarize the current knowledge of major deregulated transcription factors and their effects on causing poor clinical outcome of patients with cancer. The information presented here will help to predict the prognosis and drug response and to design novel drugs and therapeutic strategies for the treatment of cancers by targeting deregulated transcription factors.
    MeSH term(s) Humans ; Transcription Factors/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics ; Oncogenes ; Carcinogenesis ; Neoplastic Stem Cells
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2022.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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