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Article ; Online: Spatiotemporal characteristics analysis of multi-factorial air pollution in the Jing-Jin-Ji region based on improved sequential ICI method and novel grey spatiotemporal incidence models.

Sun, Jing / Dang, Yaoguo / Wang, Junjie / Hua, Chao

2024 , Page(s) 118948

Abstract: ... of the properties of the new models. Finally, in the Jing-Jin-Ji region, the novel models are used to study ...

Abstract	Air pollution shares the attributes of multi-factorial influence and spatiotemporal complexity, leading to air pollution control assistance models easily falling into a state of failure. To address this issue, we design a framework containing improved data fusion method, novel grey incidence models and air pollution spatiotemporal analysis to analyze the complex characteristics of air pollution under the fusion of multiple factors. Firstly, we improve the existing data fusion method for multi-factor fusion. Subsequently, we construct two grey spatiotemporal incidence models to examine the spatiotemporal characteristics of multi-factorial air pollution in network relationships and changing trends. Furthermore, we propose two new properties that can manifest the performance of grey incidence analysis, and we provide detailed proof of the properties of the new models. Finally, in the Jing-Jin-Ji region, the novel models are used to study the network relationships and trend changes of air pollution. The findings are as follows: (1) Two highly polluted belts in the region require attention. (2) Although the air pollution network under multi-factorial fusion obeys the first law of geography, the network density and node density exhibit significant variations. (3) From 2013 to 2021, all pollutants except O
Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118948
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Article ; Online: Revealing the "Yin-Jing" mystery veil of Platycodon grandiflorum by potentiating therapeutic effects and lung-oriented guidance property.

Liang, Jun / Li, Ya-Ge / Chai, Yan-Qun / Zhang, Yi / Gao, Xue / Zhu, Xin-Hua / Sun, Xi-Zhe / Wang, Wen-Fei / Kuang, Hai-Xue / Xia, Yong-Gang

Journal of ethnopharmacology

2023 Volume 322, Page(s) 117587

Abstract: ETHNIC PHARMACOLOGICAL RELEVANCE: "Yin-Jing" medicine (YJM) has been widely used by both ancient ... molecular biology methods to confirm the "Yin-Jing" effect of PG, and further clarify its material basis and related ... used to reveal the "Yin-Jing" mechanism of action. Western blot assay (WB) was employed ...

Abstract	ETHNIC PHARMACOLOGICAL RELEVANCE: "Yin-Jing" medicine (YJM) has been widely used by both ancient and modern Chinese medicine practitioners during long-term clinical practice. However, it remains unclear how to best guide other medicines to the targeted organs in a traditional Chinese medicine (TCM) prescription. Here, in an attempt to explain the scientific connotation of the YJM property (YJMP) attributed to a basic TCM theory, Platycodon grandiflorum (PG) was chosen as a case study to reveal the mystery of YJMP theory. Aim of the study: The main purpose of this study is to employ modern chemical and molecular biology methods to confirm the "Yin-Jing" effect of PG, and further clarify its material basis and related possible mechanism. Materials and methods: The ammonia-induced lung injury rat model was utilized to determine the optimal dosage of traditional prescription Hui Yan Zhu Yu decoction (HYZYD) using Wright Giemsa staining, HE staining, Masson staining, and TUNEL analysis. With the same way, PG was confirmed to have potentiating therapeutic effect (PTE) by comparison with HYZYD and [HYZYD-PG]. TMT proteomics was used to reveal the "Yin-Jing" mechanism of action. Western blot assay (WB) was employed for verification of differentially expressed proteins. Additionally, four non-crossing fragmentations (Fr. A-D) were characterized by RPLC/SEC-ELSD and HILIC-ESI Results: The HYZYD-M (medium dose group) significantly improved the lung injury level in a pneumonia model of rats. PG enhanced the therapeutic effect of HYZYD ascribed to Yin-Jing PTE functions. TMT proteomics revealed a category of differentially expressed proteins ascribed to Golgi-ER between HYZYD and [HYZYD-PG]. Fr. C (i.e., saponins) and Fr. D (i.e., lipids) were determined as therapeutic fragmentations via the LPS-induced A549 cell injury model; however, Fr. B (fructooligosaccharides and small M Conclusions: Fr. B is believed to be a key YJMP material basis of PG attributed to Yin-Jing PTE with characteristic of lung-oriented guidance property, whereas another abound Fr. C was determined to have synergistic effects rather than Yin-Jing material basis.
MeSH term(s)	Rats ; Animals ; Platycodon/chemistry ; Lung Injury ; Medicine, Chinese Traditional ; Chromatography, High Pressure Liquid/methods ; Lung
Language	English
Publishing date	2023-12-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117587
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Article ; Online: Exploiting constructed wetlands for industrial effluent phytodesalination in Jing-Jin-Ji urban agglomeration, China.

Vaudry, Nolwenn / Sun, Yi / Afolabi, Oluwasola O D

International journal of phytoremediation

2022 Volume 25, Issue 7, Page(s) 851–867

Abstract: ... Beijing-Tianjin-Hebei (Jing-Jin-Ji) agglomeration threatens the region's economic growth and drives ...

Abstract	The unsustainable exploitation of water resources and growing salinization impacting China's Beijing-Tianjin-Hebei (Jing-Jin-Ji) agglomeration threatens the region's economic growth and drives the exploration of alternative resources. The region's industries face a financial burden due to increasing constraints on water exploitation and discharge regulations. These have resulted in increased industrial salt concentration rejections/discharges, meanwhile, constructed wetlands (CWs), deployed as a perfunctory receptacle for industrial effluents in the region, are underexploited for treating/removing salts. Also, halophytic plants local to the region have promising chloride uptake (60.6 g/kg and 256.0 g/kg of plant dry weight) and can reduce water conductivity by 40%. Exploitation of CWs, using local halophytes has not been explored for phytodesalination purposes in the region. Hence, this study analyses the water resource and salinization crisis in the agglomeration and further evaluates workable potential and critical technical considerations for using local halophytes in CWs to treat industrial salt-laden effluents. While acknowledging this intervention for removing industrial effluent salt may not meet compliance in the region, effluent post-phytodesalination presents opportunities for industries to meet regulatory stipulations on water reuse rates. Furthermore, such effluent may be used for irrigation and can ameliorate the salinization and groundwater exploitation crisis as a cleaner recharge source.
MeSH term(s)	Wetlands ; Biodegradation, Environmental ; China ; Beijing ; Sodium Chloride ; Water
Chemical Substances	Sodium Chloride (451W47IQ8X) ; Water (059QF0KO0R)
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2055357-2
ISSN	1549-7879 ; 1522-6514
ISSN (online)	1549-7879
ISSN	1522-6514
DOI	10.1080/15226514.2022.2115005
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Article ; Online: Exploiting constructed wetlands for industrial effluent phytodesalination in Jing-Jin-Ji urban agglomeration, China

Vaudry, Nolwenn / Sun, Yi / Afolabi, Oluwasola O. D.

International Journal of Phytoremediation. 2023 June 7, v. 25, no. 7, p. 851-867

2023 , Page(s) 851–867

Abstract: ... Beijing-Tianjin-Hebei (Jing-Jin-Ji) agglomeration threatens the region’s economic growth and drives ...

Abstract	The unsustainable exploitation of water resources and growing salinization impacting China’s Beijing-Tianjin-Hebei (Jing-Jin-Ji) agglomeration threatens the region’s economic growth and drives the exploration of alternative resources. The region’s industries face a financial burden due to increasing constraints on water exploitation and discharge regulations. These have resulted in increased industrial salt concentration rejections/discharges, meanwhile, constructed wetlands (CWs), deployed as a perfunctory receptacle for industrial effluents in the region, are underexploited for treating/removing salts. Also, halophytic plants local to the region have promising chloride uptake (60.6 g/kg and 256.0 g/kg of plant dry weight) and can reduce water conductivity by 40%. Exploitation of CWs, using local halophytes has not been explored for phytodesalination purposes in the region. Hence, this study analyses the water resource and salinization crisis in the agglomeration and further evaluates workable potential and critical technical considerations for using local halophytes in CWs to treat industrial salt-laden effluents. While acknowledging this intervention for removing industrial effluent salt may not meet compliance in the region, effluent post-phytodesalination presents opportunities for industries to meet regulatory stipulations on water reuse rates. Furthermore, such effluent may be used for irrigation and can ameliorate the salinization and groundwater exploitation crisis as a cleaner recharge source.
Keywords	chlorides ; compliance ; economic development ; groundwater ; halophytes ; industrial effluents ; irrigation ; phytodesalination ; salt concentration ; water reuse ; China ; constructed wetlands ; industrial effluent ; remediation ; salt removal
Language	English
Dates of publication	2023-0607
Size	p. 851-867
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2055357-2
ISSN	1549-7879 ; 1522-6514
ISSN (online)	1549-7879
ISSN	1522-6514
DOI	10.1080/15226514.2022.2115005
Database	NAL-Catalogue (AGRICOLA)

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Article: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model.

Yan, Guang / Tian, Fang / Liu, Peng / Sun, Jianming / Mao, Jianmin / Han, Wenjun / Mo, Ran / Guo, Shishuai / Yu, Quanyao

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 3686494

Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used ...

Abstract	Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/3686494
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Article: Simulating highly disturbed vegetation distribution: the case of China's Jing-Jin-Ji region.

Yi, Sangui / Zhou, Jihua / Lai, Liming / Du, Hui / Sun, Qinglin / Yang, Liu / Liu, Xin / Liu, Benben / Zheng, Yuanrun

PeerJ

2020 Volume 8, Page(s) e9839

Abstract: ... vegetation classification units (vegetation group (I), vegetation type (II), and formation and subformation (III)) in Jing ... in all classification units present in the Jing-Jin-Ji region. The RF model produced high accuracy vegetation ...

Abstract	Background: Simulating vegetation distribution is an effective method for identifying vegetation distribution patterns and trends. The primary goal of this study was to determine the best simulation method for a vegetation in an area that is heavily affected by human disturbance. Methods: We used climate, topographic, and spectral data as the input variables for four machine learning models (random forest (RF), decision tree (DT), support vector machine (SVM), and maximum likelihood classification (MLC)) on three vegetation classification units (vegetation group (I), vegetation type (II), and formation and subformation (III)) in Jing-Jin-Ji, one of China's most developed regions. We used a total of 2,789 vegetation points for model training and 974 vegetation points for model assessment. Results: Our results showed that the RF method was the best of the four models, as it could effectively simulate vegetation distribution in all three classification units. The DT method could only simulate vegetation distribution in units I and II, while the other two models could not simulate vegetation distribution in any of the units. Kappa coefficients indicated that the DT and RF methods had more accurate predictions for units I and II than for unit III. The three vegetation classification units were most affected by six variables: three climate variables (annual mean temperature, mean diurnal range, and annual precipitation), one geospatial variable (slope), and two spectral variables (Mid-infrared ratio of winter vegetation index and brightness index of summer vegetation index). Variables Combination 7, including annual mean temperature, annual precipitation, mean diurnal range and precipitation of driest month, produced the highest simulation accuracy. Conclusions: We determined that the RF model was the most effective for simulating vegetation distribution in all classification units present in the Jing-Jin-Ji region. The RF model produced high accuracy vegetation distributions in classification units I and II, but relatively low accuracy in classification unit III. Four climate variables were sufficient for vegetation distribution simulation in such region.
Language	English
Publishing date	2020-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.9839
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Article ; Online: A genome-wide single nucleotide polymorphism scan reveals genetic markers associated with fertility rate in Chinese Jing Hong chicken.

Azmal, Syed Ali / Nan, Jiuhong / Bhuiyan, Ali Akbar / Elokil, Abdelmotaleb Ahmed / Ali, Mohammad Ishaque / Adetula, Adeyinka Abiola / Ma, Shuai / Sun, Chenghao / Han, Zhongdong / Yuan, Jingwei / Li, Shijun

Poultry science

2020 Volume 99, Issue 6, Page(s) 2873–2887

Abstract: ... genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing ... using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated ... with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2 ...

Abstract	The function of the sperm storage tubules is directly correlated with the fertility of laying hens. However, little is known about the molecular mechanisms regulating the fertility traits in chicken. To identify genetic markers associated with reproductive traits, we calculated fertility rate at 61 to 69 wk (51 D) of Jing Hong chickens parent generation as the phenotype and the genotype were detected by the chicken 600K Affymetrix Axiom High Density single nucleotide polymorphisms (SNP)-array. The genome-wide association study using 190 Jing Hong hens showed that the 20 SNP in chromosomes 3 and 13 were significantly associated with fertility rate. To verify these results, a total of 1900 Jing Hong laying hens from 2 populations (P1 and P2) were further genotyped by polymerase chain reaction-restriction fragments length polymorphisms method. The association analysis results revealed that 12 polymorphisms (AX-75769978, AX-76582632, AX-75730546, AX-75730496, AX-75730588, AX-76530282, AX-76530329, AX-76529310, AX-75769906, AX-75755394, AX-80813697 and AX-76582809) out of 20 showed highly significant effects (P < 0.0001) on fertility rate in P1, P2 and P1+P2. Six haplotypes (TTAA, TTGG, TTAG, CTAA, CTGG, and CTAG) were inferred based on significant loci (AX-75730546 and AX-76530282) also showed significant association with fertility rate, where haplotype CTAG was shown to be markedly associated with the significantly highest (P < 0.0001) fertility rate (in P1, 86.42 ± 0.59; P2, 85.98 ± 0.59 and P1+P2, 86.16 ± 0.42) followed by other haplotypes for the irrespective of population studied. Collectively, we report for the first time that 12 SNP in the chromosomes 3 and 13 were significantly associated with fertility rate during the later stage of egg production, which could be used as the potential genetic markers that would be able to facilitate in the selection and improvement of fertility rate through chicken breeding.
MeSH term(s)	Animals ; Breeding ; Chickens/genetics ; Chickens/growth & development ; Fertility/genetics ; Genetic Markers ; Genome-Wide Association Study/veterinary ; Polymerase Chain Reaction/veterinary ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide
Chemical Substances	Genetic Markers
Language	English
Publishing date	2020-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2019.12.068
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Article ; Online: Efficacy and safety of Qi-Jing Hui-Xin Decoction in the treatment of coronary microvascular angina: study protocol for a randomized, controlled, multi-center clinical trial.

Sun, Yuanlong / Huang, Chengxin / Huo, Li / Li, Ying / Chen, Jun / Zhang, Zixiu / Jia, Meijun / Jiang, Meixian / Ruan, Xiaofen

Trials

2021 Volume 22, Issue 1, Page(s) 553

Abstract: ... Jing Hui-Xin Decoction (QJHX) can relieve angina symptoms and improve clinical efficacy, but there is ...

Abstract	Background: With the increased understanding of heart disease, microvascular angina (MVA) is receiving greater attention from clinicians. Studies have shown that patients with MVA have significantly higher major cardiovascular events and all-cause mortality than the control population, and the search for effective treatments is of great clinical importance. Both basic and clinical studies have shown that Qi-Jing Hui-Xin Decoction (QJHX) can relieve angina symptoms and improve clinical efficacy, but there is a lack of high-quality clinical studies to provide a research basis. This article introduces the evaluation protocol of QJHX for the adjunctive treatment of MVA. Methods/design: This is a prospective randomized controlled trial. The trial will enroll 150 patients with MVA. On the basis of Western drug treatment, patients will be randomized into two groups, and the experimental group will receive QJHX treatment for 12 weeks and follow-up at 24 week. The primary indicators are the clinical efficacy of angina pectoris and the evidence of traditional Chinese medicine (TCM) efficacy. Secondary indicators are the Seattle Angina Scale score, serum lipid levels, electrocardiogram, and echocardiogram diagnosis. Additional indicators are endothelial function and immunoinflammatory factors. Adverse events will be monitored throughout the trial. Discussion: Integrated traditional Chinese and Western medicine is commonly used for angina in China. This study will evaluate the clinical effectiveness and safety of adding QJHX based on standardized Western medications. The results of the trial will provide high-level clinical research-based evidence for the application of QJHX in MVA. Trial registration: Chinese Clinical Trial Registry ChiCTR1900027015 . Registered on 28 October 2019.
MeSH term(s)	Drugs, Chinese Herbal/adverse effects ; Heart ; Humans ; Medicine, Chinese Traditional ; Microvascular Angina ; Multicenter Studies as Topic ; Prospective Studies ; Randomized Controlled Trials as Topic
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-08-21
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-021-05508-x
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Article ; Online: Exploring potential biomarkers of coronary heart disease treated by Jing Zhi Guan Xin Pian using high-throughput metabolomics.

Sun, Hui / Li, Xue-Na / Zhang, Ai-Hua / Zhang, Kun-Ming / Yan, Guang-Li / Han, Ying / Wu, Fang-Fang / Wang, Xi-Jun

RSC advances

2019 Volume 9, Issue 20, Page(s) 11420–11432

Abstract: ... prevention method. Jing Zhi Guan Xin Pian (JZGXP) is a new preparation prepared from the effective extract ...

Abstract	Coronary heart disease (CHD) is a relatively complex disease characterized by narrowing of the arterial lumen and reduction of blood flow to the heart. There is no effective early diagnosis and prevention method. Jing Zhi Guan Xin Pian (JZGXP) is a new preparation prepared from the effective extract of Guanxin II. It is made of five components of traditional Chinese medicine and functions by promoting blood circulation and removing blood stasis and is used for the treatment of CHD and angina pectoris. In our study, a CHD rat model was prepared using a high-fat diet combined with intraperitoneal injection of vitamin D3. Clinical biochemical indexes (TG, CHO and HDL-C), histopathology (coronary and myocardial tissue), electrocardiogram and cardiac indexes were used to evaluate the efficacy of JZGXP in the treatment of CHD model rats. UPLC-HDMS-based metabolomics techniques were used to find metabolic profiles, biomarkers and related metabolic pathways in CHD models and to evaluate the effects of JZGXP on them. At the same time, the targets of JZGXP for the treatment of CHD were analyzed. Our study ultimately identified 25 biomarkers associated with CHD models. Further studies found that these 25 biomarkers involved 9 metabolic pathways in the body and found that JZGXP can recall 21 biomarkers in the urine of model rats and these biomarkers involve nine metabolic pathways. Finally, the targets of JZGXP for the treatment of CHD were β-alanine metabolism and tyrosine metabolism,
Language	English
Publishing date	2019-04-11
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c8ra10557j
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Article ; Online: Efficacy and safety of Qi-Jing Hui-Xin Decoction in the treatment of coronary microvascular angina

Yuanlong Sun / Chengxin Huang / Li Huo / Ying Li / Jun Chen / Zixiu Zhang / Meijun Jia / Meixian Jiang / Xiaofen Ruan

Trials, Vol 22, Iss 1, Pp 1-

study protocol for a randomized, controlled, multi-center clinical trial

2021 Volume 9

Abstract: ... shown that Qi-Jing Hui-Xin Decoction (QJHX) can relieve angina symptoms and improve clinical efficacy ...

Abstract	Abstract Background With the increased understanding of heart disease, microvascular angina (MVA) is receiving greater attention from clinicians. Studies have shown that patients with MVA have significantly higher major cardiovascular events and all-cause mortality than the control population, and the search for effective treatments is of great clinical importance. Both basic and clinical studies have shown that Qi-Jing Hui-Xin Decoction (QJHX) can relieve angina symptoms and improve clinical efficacy, but there is a lack of high-quality clinical studies to provide a research basis. This article introduces the evaluation protocol of QJHX for the adjunctive treatment of MVA. Methods/design This is a prospective randomized controlled trial. The trial will enroll 150 patients with MVA. On the basis of Western drug treatment, patients will be randomized into two groups, and the experimental group will receive QJHX treatment for 12 weeks and follow-up at 24 week. The primary indicators are the clinical efficacy of angina pectoris and the evidence of traditional Chinese medicine (TCM) efficacy. Secondary indicators are the Seattle Angina Scale score, serum lipid levels, electrocardiogram, and echocardiogram diagnosis. Additional indicators are endothelial function and immunoinflammatory factors. Adverse events will be monitored throughout the trial. Discussion Integrated traditional Chinese and Western medicine is commonly used for angina in China. This study will evaluate the clinical effectiveness and safety of adding QJHX based on standardized Western medications. The results of the trial will provide high-level clinical research-based evidence for the application of QJHX in MVA. Trial registration Chinese Clinical Trial Registry ChiCTR1900027015 . Registered on 28 October 2019.
Keywords	Microvascular angina ; Randomized controlled trial ; Qi-Jing Hui-Xin Decoction ; Traditional Chinese medicine ; MACE ; SAQ ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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