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Article ; Online: COQ7 defect causes prenatal onset of mitochondrial CoQ

Pettenuzzo, Ilaria / Carli, Sara / Sánchez-Cuesta, Ana / Isidori, Federica / Montanari, Francesca / Grippa, Mina / Lanzoni, Giulia / Ambrosetti, Irene / Di Pisa, Veronica / Cordelli, Duccio Maria / Mondardini, Maria Cristina / Pippucci, Tommaso / Ragni, Luca / Cenacchi, Giovanna / Costa, Roberta / Lima, Mario / Capristo, Maria Antonietta / Tropeano, Concetta Valentina / Caporali, Leonardo /

Carelli, Valerio / Brunelli, Elena / Maffei, Monica / Ahmed Sheikhmaye, Hodman / Fetta, Anna / Brea-Calvo, Gloria / Garone, Caterina

European journal of human genetics : EJHG

2024

Abstract: COQ7 pathogenetic variants cause primary ... ...

Abstract	COQ7 pathogenetic variants cause primary CoQ
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-024-01615-w
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Article: The role of uterine artery embolization in the management of uterine fibroids.

Tropeano, Giovanna

Current opinion in obstetrics & gynecology

2005 Volume 17, Issue 4, Page(s) 329–332

Abstract: Purpose of review: Uterine artery embolization is increasingly being offered as an alternative to hysterectomy and myomectomy for the treatment of symptomatic uterine fibroids. This review is intended to evaluate the role of this technique in the ... ...

Abstract	Purpose of review: Uterine artery embolization is increasingly being offered as an alternative to hysterectomy and myomectomy for the treatment of symptomatic uterine fibroids. This review is intended to evaluate the role of this technique in the management of uterine fibroids using information provided from recently published literature. Recent findings: A growing body of literature supports the efficacy of uterine artery embolization in relieving fibroid-related menorrhagia, pelvic pain and pressure symptoms and in substantially reducing the fibroid size in most patients. Recent publications also show significant improvements in health-related quality of life and high long-term satisfaction rates. The procedure is associated with shorter hospitalization and recovery times and lower morbidity rates compared with conventional surgical treatments. However, serious complications, such as uterine infarction or infection leading to emergency hysterectomy, have been reported in a few cases, and considerable work is currently underway to determine how the safety of the procedure can be enhanced. Although no long-term data on subsequent fertility are yet available, early reports on ovarian function and pregnancy outcomes after uterine artery embolization are encouraging. Summary: Based on current evidence, uterine artery embolization can be considered a valuable alternative to surgical therapy in the management of well-selected women with symptomatic uterine fibroids. Additional research is needed to help define the place of this technique for women who desire future pregnancy.
MeSH term(s)	Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Female ; Humans ; Infarction ; Leiomyoma/complications ; Leiomyoma/therapy ; Menorrhagia/etiology ; Menorrhagia/therapy ; Prognosis ; Treatment Outcome ; Uterine Neoplasms/complications ; Uterine Neoplasms/therapy
Language	English
Publishing date	2005-06-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1049382-7
ISSN	1473-656X ; 1040-872X
ISSN (online)	1473-656X
ISSN	1040-872X
DOI	10.1097/01.gco.0000175347.64942.61
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Article ; Online: Non-surgical management of uterine fibroids.

Tropeano, Giovanna / Amoroso, Sonia / Scambia, Giovanni

Human reproduction update

2008 Volume 14, Issue 3, Page(s) 259–274

Abstract: Background: Efforts to develop alternatives to surgery for management of symptomatic uterine fibroids have provided new techniques and new medications. This review summarizes the existing literature on uterine artery embolization (UAE) and ... ...

Abstract	Background: Efforts to develop alternatives to surgery for management of symptomatic uterine fibroids have provided new techniques and new medications. This review summarizes the existing literature on uterine artery embolization (UAE) and investigational studies on four newer approaches. Methods: PubMed, Cochrane and Embase were searched up to December 2007. Studies reporting side-effects and complications and presenting numerical data on at least one outcome measure were included. Results: Case studies report 50-60% reduction in fibroid size and 85-95% relief of symptoms following UAE. The largest of these studies reported an in-hospital complication rate of 2.7% (90 of 3041 patients) and a post-discharge complication rate of 26% (710 of 2729 patients). Eight studies compared UAE with conventional surgery. Best evidence suggested that UAE offered shorter hospital stays (1-2 days UAE versus 5-5.8 days surgery, 3 randomized controlled trials (RCTs)) and recovery times (9.5-28 days UAE versus 36.2-63 days surgery, 3 RCTs) and similar major complication rates (2-15% UAE versus 2.7-20% surgery, 3 RCTs). Four studies analysing cost-effectiveness found UAE more cost-effective than surgery. There is insufficient evidence regarding fertility and pregnancy outcome after UAE. Five feasibility studies after transvaginal temporary uterine artery occlusion in 75 women showed a 40-50% reduction in fibroid volume and two early studies using magnetic resonance guided-focused ultrasound showed symptom relief at 6 months in 71% of 109 women. Two small RCTs assessing mifepristone and asoprisnil showed promising results. Conclusions: Good quality evidence supports the safety and effectiveness of UAE for women with symptomatic fibroids. The current available data are insufficient to routinely offer UAE to women who wish to preserve or enhance their fertility. Newer treatments are still investigational.
MeSH term(s)	Arteries ; Constriction ; Embolization, Therapeutic ; Estrenes/therapeutic use ; Female ; Hormone Antagonists/therapeutic use ; Humans ; Leiomyoma/therapy ; Mifepristone/therapeutic use ; Oximes/therapeutic use ; Receptors, Progesterone/antagonists & inhibitors ; Ultrasonic Therapy/methods ; Uterine Neoplasms/therapy ; Uterus/blood supply
Chemical Substances	Estrenes ; Hormone Antagonists ; Oximes ; Receptors, Progesterone ; Mifepristone (320T6RNW1F) ; asoprisnil (72W09924WP)
Language	English
Publishing date	2008-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1286738-x
ISSN	1460-2369 ; 1355-4786
ISSN (online)	1460-2369
ISSN	1355-4786
DOI	10.1093/humupd/dmn006
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Article: The timing of natural menopause after uterine fibroid embolization: a prospective cohort study

Tropeano, Giovanna / Amoroso, Sonia / di Stasi, Carmine / Vizzielli, Giuseppe / Bonomo, Lorenzo / Scambia, Giovanni

Fertility and sterility. 2011 Oct., v. 96, no. 4

2011

Abstract: OBJECTIVE: To determine whether uterine fibroid embolization before the age of 45 years advances the timing of natural menopause. DESIGN: Prospective cohort study. SETTING: University tertiary-care center. PARTICIPANT(S): Forty-three regularly cycling ... ...

Abstract	OBJECTIVE: To determine whether uterine fibroid embolization before the age of 45 years advances the timing of natural menopause. DESIGN: Prospective cohort study. SETTING: University tertiary-care center. PARTICIPANT(S): Forty-three regularly cycling women aged 35–44 years who underwent embolization and 43 age-matched control subjects. INTERVENTION(S): Annual assessments of menopausal status using prospectively recorded menstrual diaries and hormonal (serum FSH and E₂) and ultrasound measures (ovarian volume and antral follicle count). Women were followed for 7 years or until they reached menopause. MAIN OUTCOME MEASURE(S): Age at menopause as computed by subtracting the date of birth from the exact date of the last menstrual period. RESULT(S): Over the study period, 9 patients (25%) and 12 control subjects (33%) became menopausal, 19 patients (53%) and 18 control subjects (50%) entered the menopausal transition (irregular cycles), and 8 patients (22%) and 6 control subjects (17%) continued to menstruate regularly. Mean menopausal age in the embolization group (48.94 ± 2.48 years) was not significantly different from that in the control group (49.52 ± 1.25 years). There was no significant difference of menopause occurrence between the groups. Longitudinal changes in hormonal and ultrasound measures were similar for the two groups. CONCLUSION(S): This long-term follow-up study found no evidence for fibroid embolization advancing the timing of menopause in women before the age of 45 years.
Keywords	animal ovaries ; blood serum ; cohort studies ; follicle-stimulating hormone ; menopause ; patients ; ultrasonics ; women
Language	English
Dates of publication	2011-10
Size	p. 980-984.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2011.07.007
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Article ; Online: Selective arterial embolization as a first-line treatment for postpartum hematomas.

Distefano, Mariagrazia / Casarella, Lucia / Amoroso, Sonia / Di Stasi, Carmine / Scambia, Giovanni / Tropeano, Giovanna

Obstetrics and gynecology

2012 Volume 121, Issue 2 Pt 2 Suppl 1, Page(s) 443–447

Abstract: Background: Postpartum hematomas are a potentially serious obstetric complication for which management options are not standardized. We report successful treatment of a large postpartum hematoma using arterial embolization as primary approach.: Case: ...

Abstract	Background: Postpartum hematomas are a potentially serious obstetric complication for which management options are not standardized. We report successful treatment of a large postpartum hematoma using arterial embolization as primary approach. Case: A 29-year-old woman at term gestation underwent vacuum-assisted vaginal delivery. Two hours later, marked rectal pain developed. Examination revealed a large left vaginal hematoma and no obvious bleeding sites. Computed tomography demonstrated a 10-cm supralevator hematoma and extrauterine arterial bleeding. Angiography revealed contrast extravasation from a branch of the left internal pudendal artery. Selective embolization of this branch stopped the bleeding. The patient was discharged on the third postpartum day. Eight weeks after delivery, there was no evidence of the hematoma. Conclusion: Arterial embolization can be used as a first-line treatment for large postpartum hematomas.
MeSH term(s)	Adult ; Embolization, Therapeutic ; Female ; Hematoma/diagnostic imaging ; Hematoma/therapy ; Humans ; Puerperal Disorders/therapy ; Radiography ; Vacuum Extraction, Obstetrical ; Vaginal Diseases/diagnostic imaging ; Vaginal Diseases/therapy
Language	English
Publishing date	2012-10-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	http://10.1097/AOG.0b013e31827d90e1
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Article ; Online: Is myomectomy always the best choice for infertile women with symptomatic uterine fibroids?

Tropeano, Giovanna / Romano, Domenico / Mascilini, Floriana / Gaglione, Raffaele / Amoroso, Sonia / Scambia, Giovanni

The journal of obstetrics and gynaecology research

2012 Volume 38, Issue 4, Page(s) 733–736

Abstract: Uterine artery embolization (UAE) is still regarded by most gynaecologists as contraindicated for women with symptomatic fibroids and otherwise unexplained infertility. For such patients, myomectomy is the usual option. We performed UAE as treatment of ... ...

Abstract	Uterine artery embolization (UAE) is still regarded by most gynaecologists as contraindicated for women with symptomatic fibroids and otherwise unexplained infertility. For such patients, myomectomy is the usual option. We performed UAE as treatment of menorrhagia in an infertile woman with multiple subserosal and intramural fibroids who had previously failed multiple myomectomy. UAE resulted in durable symptom relief and substantial reduction of the uterine and fibroid size. The patient conceived spontaneously 20 months after UAE and progressed through pregnancy uneventfully. At 38 weeks of gestation, she underwent elective cesarean section and delivered a normal, healthy, 3180-g fetus without complications. The present case demonstrates that in symptomatic women with multiple subserosal and intramural fibroids and otherwise unexplained infertility, UAE may have symptomatic and reproductive outcomes superior to those of myomectomy.
MeSH term(s)	Adult ; Female ; Humans ; Infertility, Female/therapy ; Leiomyoma/surgery ; Leiomyoma/therapy ; Pregnancy ; Uterine Artery Embolization ; Uterine Neoplasms/surgery ; Uterine Neoplasms/therapy
Language	English
Publishing date	2012-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/j.1447-0756.2011.01779.x
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Article ; Online: Polarisation of Tumor-Associated Macrophages toward M2 Phenotype Correlates with Poor Response to Chemoradiation and Reduced Survival in Patients with Locally Advanced Cervical Cancer.

Petrillo, Marco / Zannoni, Gian Franco / Martinelli, Enrica / Pedone Anchora, Luigi / Ferrandina, Gabriella / Tropeano, Giovanna / Fagotti, Anna / Scambia, Giovanni

PloS one

2015 Volume 10, Issue 9, Page(s) e0136654

Abstract: Objective: We investigate the prognostic role of pre-treatment ratio between Type 1 (M1) and Type 2 (M2) tumor-associated macrophages (TAMs) in locally advanced cervical cancer (LACC) patients treated with chemoradiation (CT/RT).: Methods: 84 ... ...

Abstract	Objective: We investigate the prognostic role of pre-treatment ratio between Type 1 (M1) and Type 2 (M2) tumor-associated macrophages (TAMs) in locally advanced cervical cancer (LACC) patients treated with chemoradiation (CT/RT). Methods: 84 consecutive LACC patients treated with cisplatin-based CT/RT for a total dose of 50.0 Gy, followed by radical surgery were analysed. Double-staining immunohistochemistry of CD163/p-STAT, CD68/pSTAT1, CD163/c-MAF, and CD68/c-MAF was performed on tumor samples taken at the time of diagnosis. TAMs with CD163+pSTAT1+, or CD68+pSTAT1+ were defined M1; CD163+c-MAF+ or CD68+c-MAF+ defined the M2 phenotype. The number of M1 and M2 cells was counted at low magnification by evaluating for each case the same tumour area. The ratio between M1 and M2 (M1/M2) was finally calculated. Results: At diagnosis, we observed a direct correlation between the number of circulating monocytes and of TAMs (p-value = 0.001). Patients with high M1/M2 experienced more frequently complete pathologic response (no residual tumor) to CT/RT, compared to cases with low M1/M2 (55.0% Vs 29.5%; p-value = 0.029). At multivariate analysis M1/M2 (OR = 2.067; p-value = 0.037) emerged as independent predictor of pathologic response to CT/RT. Women with high M1/M2 showed a longer 5-yrs Disease-free (67.2% Vs. 44.3%; p-value = 0.019), and 5-yrs Overall (69.3% Vs. 46.9%; p-value = 0.037) survival, compared to cases with low M1/M2. The presence of a high M1/M2 ratio was independently associated with an unfavourable survival outcome in multivariate analysis. Conclusions: Polarisation of TAMs toward a M2 phenotype, as reflected by a lower M1/M2 ratio, is an independent predictor of poor response to CT/RT, and shorter survival in LACC.
MeSH term(s)	Adult ; Aged ; Cell Polarity ; Female ; Humans ; Immunohistochemistry ; Immunophenotyping ; Macrophages/immunology ; Middle Aged ; Survival Analysis ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/radiotherapy ; Young Adult
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0136654
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Article ; Online: Incidence and risk factors for clinical failure of uterine leiomyoma embolization.

Tropeano, Giovanna / Di Stasi, Carmine / Amoroso, Sonia / Vizzielli, Giuseppe / Mascilini, Floriana / Scambia, Giovanni

Obstetrics and gynecology

2012 Volume 120, Issue 2 Pt 1, Page(s) 269–276

Abstract: Objective: To estimate the incidence of clinical failure after uterine leiomyoma embolization and identify possible risk factors.: Methods: One hundred seventy-six consecutive women undergoing uterine leiomyoma embolization were followed ... ...

Abstract	Objective: To estimate the incidence of clinical failure after uterine leiomyoma embolization and identify possible risk factors. Methods: One hundred seventy-six consecutive women undergoing uterine leiomyoma embolization were followed prospectively for a median of 48 months (range 12-84 months) to estimate the occurrence of clinical failure, defined as persistence or recurrence of leiomyoma symptoms, and any subsequent invasive treatment. Cumulative failure and reintervention rates were estimated by survival analysis and log-rank tests according to baseline patient characteristics. Multivariable Cox proportional hazards analysis was performed to adjust for confounders. Results: Overall, there were 18 failures at a median of 36 months (range 3-84 months). The cumulative failure rate increased steadily over time, 3% at 1 year, 7% at 3 years, 14% at 5 years, and 18% at 7 years. Of the 18 failures, 11 had reintervention, including six hysterectomies, four myomectomies, and one repeat uterine leiomyoma embolization, at a median of 56 months (range 15-84 months). The cumulative reintervention rate was 0 at 1 year, 3% at 3 years, 7% at 5 years, and 15% at 7 years. Women aged 40 years or younger had a higher failure risk (hazard ratio [HR] 5.89, 95% confidence interval [CI] 2.50-20.02, P=.023) compared with older women. A history of previous myomectomy was also associated with an increased failure risk (HR 3.79, 95% CI 2.07-13.23, P=.037). Conclusion: The 7-year cumulative rates of clinical failure and reintervention after uterine leiomyoma embolization were 18% (95% CI 8.2-27.8) and 15% (95% CI 5.2-24.8), respectively. The failure risk was higher for younger patients and for those with a prior myomectomy. Level of evidence: III.
MeSH term(s)	Adult ; Female ; Follow-Up Studies ; Humans ; Leiomyoma/therapy ; Middle Aged ; Risk Factors ; Treatment Failure ; Uterine Artery Embolization/statistics & numerical data ; Uterine Neoplasms/therapy
Language	English
Publishing date	2012-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0b013e31825cb88e
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Article ; Online: Polarisation of Tumor-Associated Macrophages toward M2 Phenotype Correlates with Poor Response to Chemoradiation and Reduced Survival in Patients with Locally Advanced Cervical Cancer.

Marco Petrillo / Gian Franco Zannoni / Enrica Martinelli / Luigi Pedone Anchora / Gabriella Ferrandina / Giovanna Tropeano / Anna Fagotti / Giovanni Scambia

PLoS ONE, Vol 10, Iss 9, p e

2015 Volume 0136654

Abstract: We investigate the prognostic role of pre-treatment ratio between Type 1 (M1) and Type 2 (M2) tumor-associated macrophages (TAMs) in locally advanced cervical cancer (LACC) patients treated with chemoradiation (CT/RT).84 consecutive LACC patients treated ...

Abstract	We investigate the prognostic role of pre-treatment ratio between Type 1 (M1) and Type 2 (M2) tumor-associated macrophages (TAMs) in locally advanced cervical cancer (LACC) patients treated with chemoradiation (CT/RT).84 consecutive LACC patients treated with cisplatin-based CT/RT for a total dose of 50.0 Gy, followed by radical surgery were analysed. Double-staining immunohistochemistry of CD163/p-STAT, CD68/pSTAT1, CD163/c-MAF, and CD68/c-MAF was performed on tumor samples taken at the time of diagnosis. TAMs with CD163+pSTAT1+, or CD68+pSTAT1+ were defined M1; CD163+c-MAF+ or CD68+c-MAF+ defined the M2 phenotype. The number of M1 and M2 cells was counted at low magnification by evaluating for each case the same tumour area. The ratio between M1 and M2 (M1/M2) was finally calculated.At diagnosis, we observed a direct correlation between the number of circulating monocytes and of TAMs (p-value = 0.001). Patients with high M1/M2 experienced more frequently complete pathologic response (no residual tumor) to CT/RT, compared to cases with low M1/M2 (55.0% Vs 29.5%; p-value = 0.029). At multivariate analysis M1/M2 (OR = 2.067; p-value = 0.037) emerged as independent predictor of pathologic response to CT/RT. Women with high M1/M2 showed a longer 5-yrs Disease-free (67.2% Vs. 44.3%; p-value = 0.019), and 5-yrs Overall (69.3% Vs. 46.9%; p-value = 0.037) survival, compared to cases with low M1/M2. The presence of a high M1/M2 ratio was independently associated with an unfavourable survival outcome in multivariate analysis.Polarisation of TAMs toward a M2 phenotype, as reflected by a lower M1/M2 ratio, is an independent predictor of poor response to CT/RT, and shorter survival in LACC.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: The timing of natural menopause after uterine fibroid embolization: a prospective cohort study.

Tropeano, Giovanna / Amoroso, Sonia / di Stasi, Carmine / Vizzielli, Giuseppe / Bonomo, Lorenzo / Scambia, Giovanni

Fertility and sterility

2011 Volume 96, Issue 4, Page(s) 980–984

Abstract: Objective: To determine whether uterine fibroid embolization before the age of 45 years advances the timing of natural menopause.: Design: Prospective cohort study.: Setting: University tertiary-care center.: Participant(s): Forty-three ... ...

Abstract	Objective: To determine whether uterine fibroid embolization before the age of 45 years advances the timing of natural menopause. Design: Prospective cohort study. Setting: University tertiary-care center. Participant(s): Forty-three regularly cycling women aged 35-44 years who underwent embolization and 43 age-matched control subjects. Intervention(s): Annual assessments of menopausal status using prospectively recorded menstrual diaries and hormonal (serum FSH and E(2)) and ultrasound measures (ovarian volume and antral follicle count). Women were followed for 7 years or until they reached menopause. Main outcome measure(s): Age at menopause as computed by subtracting the date of birth from the exact date of the last menstrual period. Result(s): Over the study period, 9 patients (25%) and 12 control subjects (33%) became menopausal, 19 patients (53%) and 18 control subjects (50%) entered the menopausal transition (irregular cycles), and 8 patients (22%) and 6 control subjects (17%) continued to menstruate regularly. Mean menopausal age in the embolization group (48.94 ± 2.48 years) was not significantly different from that in the control group (49.52 ± 1.25 years). There was no significant difference of menopause occurrence between the groups. Longitudinal changes in hormonal and ultrasound measures were similar for the two groups. Conclusion(s): This long-term follow-up study found no evidence for fibroid embolization advancing the timing of menopause in women before the age of 45 years.
MeSH term(s)	Adult ; Age Factors ; Cohort Studies ; Embolization, Therapeutic/methods ; Estradiol/blood ; Female ; Follicle Stimulating Hormone/blood ; Follow-Up Studies ; Humans ; Leiomyoma/blood ; Leiomyoma/therapy ; Menopause/blood ; Middle Aged ; Prospective Studies
Chemical Substances	Estradiol (4TI98Z838E) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2011.07.007
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