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  1. Article: Drug-induced Liver Injury from Hormonal and Non-hormonal Therapies: Insights from a Large Case Series.

    Vuppalanchi, Raj / Chalasani, Naga

    Journal of clinical and experimental hepatology

    2024  Volume 14, Issue 3, Page(s) 101401

    Language English
    Publishing date 2024-03-19
    Publishing country India
    Document type Editorial
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2024.101401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: liver and kidney injury from remdesivir-an issue not as much as its purpose.

    Vuppalanchi, Shireesha / Vuppalanchi, Raj

    Alimentary pharmacology & therapeutics

    2022  Volume 55, Issue 11, Page(s) 1456

    MeSH term(s) Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/analogs & derivatives ; Alanine/adverse effects ; Alanine/analogs & derivatives ; Humans ; Kidney ; Liver
    Chemical Substances remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2022-05-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial: The evolving paradigms and treatments for primary biliary cholangitis.

    Vuppalanchi, Raj / Kowdley, Kris V

    Alimentary pharmacology & therapeutics

    2023  Volume 59, Issue 2, Page(s) 280–281

    MeSH term(s) Humans ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/drug therapy ; Ursodeoxycholic Acid/therapeutic use ; Cholangitis/diagnosis
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR)
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Editorial
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Distinction of autoimmune hepatitis from drug-induced autoimmune like hepatitis: The answer lies at the interface.

    Alkashash, Ahmad / Zhang, Xin / Vuppalanchi, Raj / Lammert, Craig / Saxena, Romil

    Journal of hepatology

    2024  

    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.01.023
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  5. Article ; Online: Treating Itch in Primary Biliary Cholangitis: A GLIMMER of Hope That Needs a Nugget of Validation.

    Vuppalanchi, Raj / Karpen, Saul J

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2022  Volume 21, Issue 7, Page(s) 1706–1707

    MeSH term(s) Humans ; Liver Cirrhosis, Biliary ; Pruritus/etiology ; Cholangitis
    Language English
    Publishing date 2022-12-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2022.11.034
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  6. Article ; Online: Review article: clinical assessment of suspected drug-induced liver injury and its management.

    Vuppalanchi, Raj / Ghabril, Marwan

    Alimentary pharmacology & therapeutics

    2022  Volume 56, Issue 11-12, Page(s) 1516–1531

    Abstract: Background: Idisyncratic drug-induced liver injury (DILI) is a rare instance of liver injury after exposure to an otherwise safe drug or herbal or dietary supplement. DILI can be associated with significant morbidity and mortality. Furthermore, it is an ...

    Abstract Background: Idisyncratic drug-induced liver injury (DILI) is a rare instance of liver injury after exposure to an otherwise safe drug or herbal or dietary supplement. DILI can be associated with significant morbidity and mortality. Furthermore, it is an important consideration in drug development due to safety concerns.
    Aims and methods: To highlight pearls and pitfalls to aid clinicians in diagnosing DILI and surmising the management options. We also share the best practices from personal insights developed from decades long participation in the causality assessment committee meetings of the DILI Network.
    Results: DILI lacks a diagnostic test and is currently diagnosed through a process of exclusion of competing aetiologies of liver injury. This requires a high degree of suspicion to consider the possibility of DILI, skill in ruling out the obvious and less obvious competing liver insults, and an understanding of the expected phenotypes of DILI. The facets of DILI cover multiple aspects, including the latency, liver injury pattern, course of injury, and associated autoimmune or immuno-allergic features. Care for patients with DILI is geared towards stopping the offending drug and symptom management that include the use of corticosteroids in select cases.
    Conclusion: The diagnosis of DILI is challenging and is primarily made through a carefully crafted patient interview, temporal relationship with the implicated drug or supplement, and exclusion of competing aetiology. LiverTox is a useful resource for clinicians to review the literature and recognise the likelihood of the implicated agent in causing DILI.
    MeSH term(s) Humans ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/therapy ; Liver ; Dietary Supplements/adverse effects ; Risk Factors
    Language English
    Publishing date 2022-10-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: COVID-Associated Cast-Forming Cholangiopathy: A Commentary on Disease Mechanism, Treatment, and Prognosis.

    Sarkis, Yara / Saleem, Nasir / Vuppalanchi, Raj / Gromski, Mark

    Hepatic medicine : evidence and research

    2023  Volume 15, Page(s) 27–32

    Abstract: The complete impact of COVID-19 infection continues to develop since the onset of the COVID-19 pandemic. COVID-19 cholangiopathy has been recently described in a subset of patients who recovered from severe COVID-19 infection. The most common phenotype ... ...

    Abstract The complete impact of COVID-19 infection continues to develop since the onset of the COVID-19 pandemic. COVID-19 cholangiopathy has been recently described in a subset of patients who recovered from severe COVID-19 infection. The most common phenotype of patients suffering from COVID-19 cholangiopathy had severe infection requiring a stay in the intensive care unit, mechanical ventilation and vasopressor medications. Patients with COVID-cholangiopathy present with severe and prolonged cholestatic liver injury. In cases where biliary cast formation is identified, we defined the entity as "COVID-19 cast-forming cholangiopathy". This subset of COVID-19 cholangiopathy is not well understood and there are no standardized diagnosis or management to this date. The reported clinical outcomes are variable, from resolution of symptoms and liver test abnormalities to liver transplant and death. In this commentary, we discuss the proposed pathophysiology, diagnosis, management, and prognosis of this disease.
    Language English
    Publishing date 2023-03-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520732-5
    ISSN 1179-1535
    ISSN 1179-1535
    DOI 10.2147/HMER.S384176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Noninvasive Tests to Phenotype Nonalcoholic Fatty Liver Disease: Sequence and Consequences of Arranging the Tools in the Tool Box.

    Vuppalanchi, Raj / Loomba, Rohit

    Hepatology (Baltimore, Md.)

    2021  Volume 73, Issue 6, Page(s) 2095–2098

    MeSH term(s) Algorithms ; Biomarkers/analysis ; Biopsy/adverse effects ; Humans ; Liver Cirrhosis/pathology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/pathology ; Phenotype
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31734
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    Zs.A 1660: Show issues Location:
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  9. Article: Duodenal mucosal resurfacing for nonalcoholic fatty liver disease.

    Shamseddeen, Hani / Vuppalanchi, Raj / Gromski, Mark A

    Clinical liver disease

    2022  Volume 20, Issue 5, Page(s) 166–169

    Abstract: Content available: Author Interview and Audio Recording. ...

    Abstract Content available: Author Interview and Audio Recording.
    Language English
    Publishing date 2022-11-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1255
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  10. Article ; Online: Endoscopic Sedation in Roux-en-Y Gastric Bypass.

    Vuppalanchi, Raj

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2016  Volume 14, Issue 8, Page(s) 1221

    MeSH term(s) Gastric Bypass ; Humans ; Laparoscopy
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2015.08.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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