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Article ; Online: M

Bobylev, Eduard O / Poole, David A / de Bruin, Bas / Reek, Joost N H

Journal of the American Chemical Society

2022 Volume 144, Issue 34, Page(s) 15633–15642

Abstract: ... which exhibit ideal thermal and photochemical stability. In this contribution we describe readily accessible M ...

Abstract	Singlet oxygen is a potent oxidant with major applications in organic synthesis and medicinal treatment. An efficient way to produce singlet oxygen is the photochemical generation by fullerenes which exhibit ideal thermal and photochemical stability. In this contribution we describe readily accessible M
MeSH term(s)	Binding Sites ; Fullerenes/chemistry ; Nanospheres ; Singlet Oxygen ; Water
Chemical Substances	Fullerenes ; Water (059QF0KO0R) ; Singlet Oxygen (17778-80-2)
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c05507
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Article ; Online: A Novel M

Mouarrawis, Valentinos / Bobylev, Eduard O / de Bruin, Bas / Reek, Joost N H

Chemistry (Weinheim an der Bergstrasse, Germany)

2021 Volume 27, Issue 32, Page(s) 8390–8397

Abstract: Confinement of a catalyst can have a significant impact on catalytic performance and can lead to otherwise difficult to achieve catalyst properties. Herein, we report the design and synthesis of a novel caged catalyst system Co-G@ ... ...

Abstract	Confinement of a catalyst can have a significant impact on catalytic performance and can lead to otherwise difficult to achieve catalyst properties. Herein, we report the design and synthesis of a novel caged catalyst system Co-G@Fe
Language	English
Publishing date	2021-05-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202100344
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Article ; Online: Selective Co-Encapsulation Inside an M

Leenders, Stefan H A M / Becker, René / Kumpulainen, Tatu / de Bruin, Bas / Sawada, Tomohisa / Kato, Taito / Fujita, Makoto / Reek, Joost N H

Chemistry (Weinheim an der Bergstrasse, Germany)

2016 Volume 22, Issue 43, Page(s) 15468–15474

Abstract: ... encapsulated inside a self-assembled M ...

Abstract	There is broad interest in molecular encapsulation as such systems can be utilized to stabilize guests, facilitate reactions inside a cavity, or give rise to energy-transfer processes in a confined space. Detailed understanding of encapsulation events is required to facilitate functional molecular encapsulation. In this contribution, it is demonstrated that Ir and Rh-Cp-type metal complexes can be encapsulated inside a self-assembled M
Language	English
Publishing date	2016-09-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201603017
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Article ; Online: Neoadjuvant Radiotherapy After (m)FOLFIRINOX for Borderline Resectable Pancreatic Adenocarcinoma: A TAPS Consortium Study.

Janssen, Quisette P / van Dam, Jacob L / Prakash, Laura R / Doppenberg, Deesje / Crane, Christopher H / van Eijck, Casper H J / Ellsworth, Susannah G / Jarnagin, William R / O'Reilly, Eileen M / Paniccia, Alessandro / Reyngold, Marsha / Besselink, Marc G / Katz, Matthew H G / Tzeng, Ching-Wei D / Zureikat, Amer H / Groot Koerkamp, Bas / Wei, Alice C

Journal of the National Comprehensive Cancer Network : JNCCN

2022 Volume 20, Issue 7, Page(s) 783–791.e1

Abstract: ... oxaliplatin, and irinotecan, with or without dose modifications [(m)FOLFIRINOX], for patients with borderline ... an international retrospective cohort study including consecutive patients with BR PDAC who received (m)FOLFIRINOX ... to administer RT is made after chemotherapy, patients with metastases or deterioration after (m)FOLFIRINOX or ...

Abstract	Background: The value of neoadjuvant radiotherapy (RT) after 5-fluorouracil with leucovorin, oxaliplatin, and irinotecan, with or without dose modifications [(m)FOLFIRINOX], for patients with borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC) is uncertain. Methods: We conducted an international retrospective cohort study including consecutive patients with BR PDAC who received (m)FOLFIRINOX as initial treatment (2012-2019) from the Trans-Atlantic Pancreatic Surgery Consortium. Because the decision to administer RT is made after chemotherapy, patients with metastases or deterioration after (m)FOLFIRINOX or a performance score ≥2 were excluded. Patients who received RT after (m)FOLFIRINOX were matched 1:1 by nearest neighbor propensity scores with patients who did not receive RT. Propensity scores were calculated using sex, age (≤70 vs >70 years), WHO performance score (0 vs 1), tumor size (0-20 vs 21-40 vs >40 mm), tumor location (head/uncinate vs body/tail), number of cycles (1-4 vs 5-8 vs >8), and baseline CA 19-9 level (≤500 vs >500 U/mL). Primary outcome was overall survival (OS) from diagnosis. Results: Of 531 patients who received neoadjuvant (m)FOLFIRINOX for BR PDAC, 424 met inclusion criteria and 300 (70.8%) were propensity score-matched. After matching, median OS was 26.2 months (95% CI, 24.0-38.4) with RT versus 32.8 months (95% CI, 25.3-42.0) without RT (P=.71). RT was associated with a lower resection rate (55.3% vs 72.7%; P=.002). In patients who underwent a resection, RT was associated with a comparable margin-negative resection rate (>1 mm) (70.6% vs 64.8%; P=.51), more node-negative disease (57.3% vs 37.6%; P=.01), and more major pathologic response with <5% tumor viability (24.7% vs 8.3%; P=.006). The OS associated with conventional and stereotactic body RT approaches was similar (median OS, 25.7 vs 26.0 months; P=.92). Conclusions: In patients with BR PDAC, neoadjuvant RT following (m)FOLFIRINOX was associated with more node-negative disease and better pathologic response in patients who underwent resection, yet no difference in OS was found. Routine use of RT cannot be recommended based on these data.
MeSH term(s)	Adenocarcinoma/pathology ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/radiotherapy ; Carcinoma, Pancreatic Ductal/surgery ; Cohort Studies ; Fluorouracil/administration & dosage ; Humans ; Irinotecan/administration & dosage ; Leucovorin/administration & dosage ; Neoadjuvant Therapy ; Oxaliplatin/administration & dosage ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/radiotherapy ; Pancreatic Neoplasms/surgery ; Retrospective Studies
Chemical Substances	folfirinox ; Oxaliplatin (04ZR38536J) ; Irinotecan (7673326042) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2250759-0
ISSN	1540-1413 ; 1540-1405
ISSN (online)	1540-1413
ISSN	1540-1405
DOI	10.6004/jnccn.2022.7008
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Article ; Online: Neoadjuvant Radiotherapy After (m)FOLFIRINOX for Borderline Resectable Pancreatic Adenocarcinoma

Janssen, Quisette P. / van Dam, Jacob L. / Prakash, Laura R. / Doppenberg, Deesje / Crane, Christopher H. / van Eijck, Casper H.J. / Ellsworth, Susannah G. / Jarnagin, William R. / O’Reilly, Eileen M. / Paniccia, Alessandro / Reyngold, Marsha / Besselink, Marc G. / Katz, Matthew H.G. / Tzeng, Ching-Wei D. / Zureikat, Amer H. / Groot Koerkamp, Bas / Wei, Alice C. / _, _

Journal of the National Comprehensive Cancer Network

A TAPS Consortium Study

2022 Volume 20, Issue 7, Page(s) 783–791.e1

Abstract: ... oxaliplatin, and irinotecan, with or without dose modifications [(m)FOLFIRINOX], for patients with borderline ... retrospective cohort study including consecutive patients with BR PDAC who received (m)FOLFIRINOX as initial ... to administer RT is made after chemotherapy, patients with metastases or deterioration after (m)FOLFIRINOX or ...

Abstract	Background: The value of neoadjuvant radiotherapy (RT) after 5-fluorouracil with leucovorin, oxaliplatin, and irinotecan, with or without dose modifications [(m)FOLFIRINOX], for patients with borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC) is uncertain. Methods: We conducted an international retrospective cohort study including consecutive patients with BR PDAC who received (m)FOLFIRINOX as initial treatment (2012–2019) from the Trans-Atlantic Pancreatic Surgery Consortium. Because the decision to administer RT is made after chemotherapy, patients with metastases or deterioration after (m)FOLFIRINOX or a performance score ≥2 were excluded. Patients who received RT after (m)FOLFIRINOX were matched 1:1 by nearest neighbor propensity scores with patients who did not receive RT. Propensity scores were calculated using sex, age (≤70 vs >70 years), WHO performance score (0 vs 1), tumor size (0–20 vs 21–40 vs >40 mm), tumor location (head/uncinate vs body/tail), number of cycles (1–4 vs 5–8 vs >8), and baseline CA 19-9 level (≤500 vs >500 U/mL). Primary outcome was overall survival (OS) from diagnosis. Results: Of 531 patients who received neoadjuvant (m)FOLFIRINOX for BR PDAC, 424 met inclusion criteria and 300 (70.8%) were propensity score–matched. After matching, median OS was 26.2 months (95% CI, 24.0–38.4) with RT versus 32.8 months (95% CI, 25.3–42.0) without RT ( P =.71). RT was associated with a lower resection rate (55.3% vs 72.7%; P =.002). In patients who underwent a resection, RT was associated with a comparable margin-negative resection rate (>1 mm) (70.6% vs 64.8%; P =.51), more node-negative disease (57.3% vs 37.6%; P =.01), and more major pathologic response with <5% tumor viability (24.7% vs 8.3%; P =.006). The OS associated with conventional and stereotactic body RT approaches was similar (median OS, 25.7 vs 26.0 months; P =.92). Conclusions: In patients with BR PDAC, neoadjuvant RT following (m)FOLFIRINOX was associated with more ...
Keywords	Oncology
Publisher	Harborside Press, LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2250759-0
ISSN	1540-1405
ISSN	1540-1405
DOI	10.6004/jnccn.2022.7008
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Article ; Online: Impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX: Trans-Atlantic Pancreatic Surgery (TAPS) Consortium study.

Theijse, Rutger T / Stoop, Thomas F / Janssen, Quisette P / Prakash, Laura R / Katz, Matthew H G / Doppenberg, Deesje / Tzeng, Ching-Wei D / Wei, Alice C / Zureikat, Amer H / Groot Koerkamp, Bas / Besselink, Marc G

The British journal of surgery

2024 Volume 111, Issue 3

Abstract: ... with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX chemotherapy.: Methods ... locally advanced pancreatic cancer treated with at least one cycle of (m)FOLFIRINOX (2012-2019). Patients ... explored patients with locally advanced pancreatic cancer after induction (m)FOLFIRINOX did not undergo ...

Abstract	Background: Surgery in selected patients with locally advanced pancreatic cancer after induction chemotherapy may have drawbacks related to surgical risks and breaks or delays in oncological treatment, in particular when curative intent resection is not possible (that is non-therapeutic laparotomy). The aim of this study was to assess the incidence and oncological impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX chemotherapy. Methods: This was a retrospective international multicentre study including patients diagnosed with pathology-proven locally advanced pancreatic cancer treated with at least one cycle of (m)FOLFIRINOX (2012-2019). Patients undergoing a non-therapeutic laparotomy (group A) were compared with those not undergoing surgery (group B) and those undergoing resection (group C). Results: Overall, 663 patients with locally advanced pancreatic cancer were included (67 patients (10.1%) in group A, 425 patients (64.1%) in group B, and 171 patients (25.8%) in group C). A non-therapeutic laparotomy occurred in 28.2% of all explorations (67 of 238), with occult metastases in 30 patients (30 of 67, 44.8%) and a 90-day mortality rate of 3.0% (2 of 67). Administration of palliative therapy (65.9% versus 73.1%; P = 0.307) and median overall survival (20.4 [95% c.i. 15.9 to 27.3] versus 20.2 [95% c.i. 19.1 to 22.7] months; P = 0.752) did not differ between group A and group B respectively. The median overall survival in group C was 36.1 (95% c.i. 30.5 to 41.2) months. The 5-year overall survival rates were 11.4%, 8.7%, and 24.7% in group A, group B, and group C, respectively. Compared with group B, non-therapeutic laparotomy (group A) was not associated with reduced overall survival (HR = 0.88 [95% c.i. 0.61 to 1.27]). Conclusion: More than a quarter of surgically explored patients with locally advanced pancreatic cancer after induction (m)FOLFIRINOX did not undergo a resection. Such non-therapeutic laparotomy does not appear to substantially impact oncological outcomes.
MeSH term(s)	Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Laparotomy ; Retrospective Studies ; Fluorouracil ; Leucovorin/therapeutic use ; Neoadjuvant Therapy ; Irinotecan ; Oxaliplatin
Chemical Substances	folfirinox ; Fluorouracil (U3P01618RT) ; Leucovorin (Q573I9DVLP) ; Irinotecan (7673326042) ; Oxaliplatin (04ZR38536J)
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znae033
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Article ; Online: “At least someone thinks I’m doing well”

Eline Meijer / Janneke S. Korst / Kristiene G. Oosting / Eline Heemskerk / Sander Hermsen / Marc C. Willemsen / Bas van den Putte / Niels H. Chavannes / Jamie Brown

Addiction Science & Clinical Practice, Vol 16, Iss 1, Pp 1-

a real-world evaluation of the quit-smoking app StopCoach for lower socio-economic status smokers

2021 Volume 14

Abstract: Abstract Background Smoking is more prevalent and persistent among lower socio-economic status (SES) compared with higher-SES groups, and contributes greatly to SES-based health inequities. Few interventions exist that effectively help lower-SES smokers ... ...

Abstract	Abstract Background Smoking is more prevalent and persistent among lower socio-economic status (SES) compared with higher-SES groups, and contributes greatly to SES-based health inequities. Few interventions exist that effectively help lower-SES smokers quit. This study evaluated “De StopCoach”, a mobile phone delivered eHealth intervention targeted at lower-SES smokers based on the evidence-based StopAdvisor, in a real-world setting (five municipalities) in The Netherlands in 2019–2020. Method We conducted individual semi-structured interviews with project leaders, healthcare professionals, and participating smokers (N = 22), and examined log data from the app (N = 235). For practical reasons, SES of app users was not measured. Qualitative data were analysed using the Framework Approach, with the Consolidated Framework for Implementation Research (CFIR) and Unified Theory of Acceptance and Use of Technology (UTAUT) as theoretical models. Results Qualitative data showed that factors from the Intervention and Setting domains were most important for the implementation. StopCoach seemed suitable for lower-SES smokers in terms of performance and effort expectancy, especially when integrated with regular smoking cessation counseling (SCC). Key barriers to implementation of the app were limited integration of the app in SCC programs in practice, difficulty experienced by project leaders and healthcare professionals to engage the local community, and barriers to SCC more generally (e.g., perceived resistance to quitting in patients) that prevented healthcare professionals from offering the app to smokers. Quantitative data showed that 48% of app users continued using the app after the preparation phase and pre-quit day, and that 33% of app users had attempted to quit. Both app adherence and quit attempts were more likely if smokers also received SCC from a professional coach. Posthoc analyses suggest that adherence is related to higher likelihood of a quit attempt among participants with and without a professional ...
Keywords	Socio-economic status ; Smoking ; eHealth ; Blended care ; Real-world evaluation ; Implementation ; Medicine (General) ; R5-920 ; Social pathology. Social and public welfare. Criminology ; HV1-9960
Subject code	616
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article: The single recombinant M. tuberculosis protein DPPD provides enhanced performance of skin testing among HIV-infected tuberculosis patients.

Badaro, Roberto / Machado, Bruna A S / Duthie, Malcolm S / Araujo-Neto, C A / Pedral-Sampaio, D / Nakatani, Maria / Reed, Steven G

AMB Express

2020 Volume 10, Issue 1, Page(s) 133

Abstract: Diagnostic testing for M. tuberculosis infection has advanced with QuantiFERON and GeneXpert ...

Abstract	Diagnostic testing for M. tuberculosis infection has advanced with QuantiFERON and GeneXpert, but simple cost-effective alternatives for widespread TB screening has remained elusive and purified protein derivative (PPD)-based tuberculin skin testing (TST) remains the most widely used method. PPD-based tests have reduced performance, however, in BCG vaccinees and in individuals with immune deficiencies. We compared the performance of skin testing with the recombinant DPPD protein against that of a standard PPD-based skin test. Our data indicates similar performance of DPPD and PPD (r
Language	English
Publishing date	2020-07-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2621432-5
ISSN	2191-0855
ISSN	2191-0855
DOI	10.1186/s13568-020-01068-6
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Article ; Online: Feasibility of sentinel node navigated surgery in high-risk T1b esophageal adenocarcinoma patients using a hybrid tracer of technetium-99 m and indocyanine green.

Overwater, Anouk / Weusten, Bas L A M / Ruurda, Jelle P / van Hillegersberg, Richard / Bennink, Roel J / de Keizer, Bart / Meijer, Sybren L / Brosens, Lodewijk A A / Pouw, Roos E / Bergman, Jacques J G H M / van Berge Henegouwen, Mark I / Gisbertz, Suzanne S

Surgical endoscopy

2021 Volume 36, Issue 4, Page(s) 2671–2679

Abstract: ... of this study was to evaluate the feasibility and safety of SNNS with a hybrid tracer (technetium-99 m ... detected in the surgical resection specimen.: Conclusions: SNNS using technetium-99 m/indocyanine green ...

Abstract	Background: Minimally invasive esophagectomy with two-field lymphadenectomy is standard of care for T1b esophageal adenocarcinoma (EAC) with a high risk of lymph node metastasis. Sentinel node navigation surgery (SNNS) is a well-known concept to tailor the extent of lymphadenectomy. The aim of this study was to evaluate the feasibility and safety of SNNS with a hybrid tracer (technetium-99 m/indocyanine green/nanocolloid) for patients with high-risk T1b EAC. Methods: In this prospective, multicenter pilot study, 5 patients with high-risk T1b EAC were included. The tracer was injected endoscopically around the endoscopic resection scar the day before surgery, followed by preoperative imaging (lymphoscintigraphy/SPECT-CT). During surgery, first the SNs were localized and resected based on preoperative imaging and intraoperative gammaprobe- and fluorescence-based detection, followed by esophagectomy. Primary endpoints were the percentage of patients with detectable SNs, concordance between preoperative and intraoperative SN detection, and the additive value of indocyanine green. Results: SNs could be identified and resected in all patients (median 3 SNs per patient, range 2-7). There was a high concordance between preoperative and intraoperative SN detection. In 2 patients additional peritumoral SNs were identified with fluorescence-based detection. None of the resected lymph nodes showed signs of (micro)metastases and no nodal metastases were detected in the surgical resection specimen. Conclusions: SNNS using technetium-99 m/indocyanine green/nanocolloid seems feasible and safe in patients with high-risk T1b EAC. Indocyanine green fluorescence seems to be of additive value for detection of peritumoral SNs. Whether this approach can optimize selection for esophagectomy needs to be studied in future research.
MeSH term(s)	Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Esophageal Neoplasms ; Feasibility Studies ; Humans ; Indocyanine Green ; Lymph Node Excision/methods ; Lymph Nodes/pathology ; Pilot Projects ; Prospective Studies ; Sentinel Lymph Node Biopsy/methods ; Technetium
Chemical Substances	Technetium-99 ; Technetium (7440-26-8) ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2021-05-27
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-021-08551-6
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Article ; Online: Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit.

Hagen, Bas / van Dijk, J Hessel M / Zhang, Qingju / Overkleeft, Herman S / van der Marel, Gijsbert A / Codée, Jeroen D C

Organic letters

2017 Volume 19, Issue 10, Page(s) 2514–2517

Abstract: The synthesis of the Staphylococcus aureus strain M capsular polysaccharide repeating unit is ...

Abstract	The synthesis of the Staphylococcus aureus strain M capsular polysaccharide repeating unit is reported. A postglycosylation oxidation strategy was utilized for the construction of the α-galactosaminuronic acid linkages, relying on a stereoselective 2-azido-4,6-O-di-tert-butylsilylidene galactopyranoside donor, for which the selectivity was assessed by model glycosylations. The α-fucosamine linkage was installed stereoselectively, using a reactive 2-azidofucosyl donor. An unexpected glycosidic bond cleavage during the TEMPO/PhI(OAc)
MeSH term(s)	Glycosylation ; Molecular Structure ; Oxidation-Reduction ; Polysaccharides, Bacterial ; Staphylococcus aureus
Chemical Substances	Polysaccharides, Bacterial
Language	English
Publishing date	2017-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.7b00747
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