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Article ; Online: Correction: Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial.

2023 Volume 130, Issue 1, Page(s) 163

Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Published Erratum
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-023-02520-7
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Article ; Online: Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial.

British journal of cancer

2023 Volume 130, Issue 1, Page(s) 43–52

Abstract: Background: The TeloVac study indicated GV1001 did not improve the survival of advanced pancreatic ductal adenocarcinoma (PDAC). However, the cytokine examinations suggested that high serum eotaxin levels may predict responses to GV1001. This Phase III ... ...

Abstract	Background: The TeloVac study indicated GV1001 did not improve the survival of advanced pancreatic ductal adenocarcinoma (PDAC). However, the cytokine examinations suggested that high serum eotaxin levels may predict responses to GV1001. This Phase III trial assessed the efficacy of GV1001 with gemcitabine/capecitabine for eotaxin-high patients with untreated advanced PDAC. Methods: Patients recruited from 16 hospitals received gemcitabine (1000 mg/m Results: Total 148 patients were randomly assigned to the GV1001 (n = 75) and control groups (n = 73). The GV1001 group showed improved median OS (11.3 vs. 7.5 months, P = 0.021) and TTP (7.3 vs. 4.5 months, P = 0.021) compared to the control group. Grade >3 adverse events were reported in 77.3% and 73.1% in the GV1001 and control groups (P = 0.562), respectively. Conclusions: GV1001 plus gemcitabine/capecitabine improved OS and TTP compared to gemcitabine/capecitabine alone in eotaxin-high patients with advanced PDAC. Clinical trial registration: NCT02854072.
MeSH term(s)	Humans ; Gemcitabine ; Capecitabine/adverse effects ; Deoxycytidine/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Pancreatic Neoplasms/pathology ; Adenocarcinoma/chemically induced
Chemical Substances	Gemcitabine ; Capecitabine (6804DJ8Z9U) ; Deoxycytidine (0W860991D6)
Language	English
Publishing date	2023-10-30
Publishing country	England
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-023-02474-w
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Article: Anti-cancer effects of lucidadiol against malignant melanoma cells

Shin, Seong-Ah / Lee, Jun Seob / Joo, Byeong Jun / Ryu, Gyoungah / Han, Minjoo / Kim, Huiji / An, Jangeun / Koo, Man Hyung / Youn, Ui Joung / Lee, Jun Hyuck / Park, Hyun Ho / Lee, Chang Sup

Applied biological chemistry. 2021 Dec., v. 64, no. 1

2021

Abstract: Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol is a triterpenoid isolated from Ganoderma lucidum and is known to have various biological functions, including antibacterial effects. However, the anti-cancer effects and ... ...

Abstract	Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol is a triterpenoid isolated from Ganoderma lucidum and is known to have various biological functions, including antibacterial effects. However, the anti-cancer effects and mechanism of action of lucidadiol in malignant melanoma are unknown. In this study, lucidadiol significantly reduced B16 melanoma cell viability in a dose- and time-dependent manner. In addition, lucidadiol induced apoptosis and suppressed cell mobility in B16 melanoma cells. Moreover, our findings revealed that lucidadiol remarkably downregulated phospho-Akt/ERK/JNK, but not p38. Taken together, our results suggest that lucidadiol could exerts its anti-cancer effects by inducing apoptosis via modulation of the Akt/MAPK pathway. Therefore, lucidadiol may be a potential cancer therapeutic agent for malignant melanoma.
Keywords	Ganoderma lucidum ; apoptosis ; cell viability ; mechanism of action ; melanoma ; therapeutics ; triterpenoids
Language	English
Dates of publication	2021-12
Size	p. 75.
Publishing place	Springer Singapore
Document type	Article
ZDB-ID	2846955-0
ISSN	2468-0842 ; 2468-0834
ISSN (online)	2468-0842
ISSN	2468-0834
DOI	10.1186/s13765-021-00647-w
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Article ; Online: Molecular mechanisms involved in farnesol-induced apoptosis.

Joo, Joung Hyuck / Jetten, Anton M

Cancer letters

2009 Volume 287, Issue 2, Page(s) 123–135

Abstract: The isoprenoid alcohol farnesol is an effective inducer of cell cycle arrest and apoptosis in a variety of carcinoma cell types. In addition, farnesol has been reported to inhibit tumorigenesis in several animal models suggesting that it functions as a ... ...

Abstract	The isoprenoid alcohol farnesol is an effective inducer of cell cycle arrest and apoptosis in a variety of carcinoma cell types. In addition, farnesol has been reported to inhibit tumorigenesis in several animal models suggesting that it functions as a chemopreventative and anti-tumor agent in vivo. A number of different biochemical and cellular processes have been implicated in the growth-inhibitory and apoptosis-inducing effects of farnesol. These include regulation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and CTP:phosphocholine cytidylyltransferase alpha (CCTalpha), rate-limiting enzymes in the mevalonate pathway and phosphatidylcholine biosynthesis, respectively, and the generation of reactive oxygen species. In some cell types the action of farnesol is mediated through nuclear receptors, including activation of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptors (PPARs). Recent studies have revealed that induction of endoplasmic reticulum (ER) stress and the subsequent activation of the unfolded protein response (UPR) play a critical role in the induction of apoptosis by farnesol in lung carcinoma cells. This induction was found to be dependent on the activation of the MEK1/2-ERK1/2 pathway. In addition, farnesol induces activation of the NF-kappaB signaling pathway and a number of NF-kappaB target genes. Optimal activation of NF-kappaB was reported to depend on the phosphorylation of p65/RelA by the MEK1/2-MSK1 signaling pathway. In a number of cells farnesol-induced apoptosis was found to be linked to activation of the apoptosome. This review provides an overview of the biochemical and cellular processes regulated by farnesol in relationship to its growth-inhibitory, apoptosis-promoting, and anti-tumor effects.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosomes/metabolism ; Cell Proliferation ; Cytidine Diphosphate Choline/metabolism ; Endoplasmic Reticulum/metabolism ; Farnesol/metabolism ; Farnesol/pharmacology ; Humans ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidative Stress ; PPAR gamma/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction/drug effects ; Thyroid Hormone Receptors beta/metabolism ; Unfolded Protein Response
Chemical Substances	Antineoplastic Agents ; Apoptosomes ; NF-kappa B ; PPAR gamma ; Receptors, Cytoplasmic and Nuclear ; Thyroid Hormone Receptors beta ; farnesoid X-activated receptor (0C5V0MRU6P) ; Farnesol (4602-84-0) ; Cytidine Diphosphate Choline (536BQ2JVC7) ; Hydroxymethylglutaryl CoA Reductases (EC 1.1.1.-) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2009-06-10
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2009.05.015
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Article: Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development.

Jetten, Anton M / Joo, Joung Hyuck

Advances in developmental biology (Amsterdam, Netherlands)

2008 Volume 16, Page(s) 313–355

Abstract: Retinoid-related orphan receptors RORalpha, -beta, and -gamma are transcription factors belonging to the steroid hormone receptor superfamily. During embryonic development RORs are expressed in a spatial and temporal manner and are critical in the ... ...

Abstract	Retinoid-related orphan receptors RORalpha, -beta, and -gamma are transcription factors belonging to the steroid hormone receptor superfamily. During embryonic development RORs are expressed in a spatial and temporal manner and are critical in the regulation of cellular differentiation and the development of several tissues. RORalpha plays a key role in the development of the cerebellum particularly in the regulation of the maturation and survival of Purkinje cells. In RORalpha-deficient mice, the reduced production of sonic hedgehog by these cells appears to be the major cause of the decreased proliferation of granule cell precursors and the observed cerebellar atrophy. RORalpha has been implicated in the regulation of a number of other physiological processes, including bone formation. RORbeta expression is largely restricted to several regions of the brain, the retina, and pineal gland. Mice deficient in RORbeta develop retinal degeneration that results in blindness. RORgamma is essential for lymph node organogenesis. In the intestine RORgamma is required for the formation of several other lymphoid tissues: Peyer's patches, cryptopatches, and isolated lymphoid follicles. RORgamma plays a key role in the generation of lymphoid tissue inducer (LTi) cells that are essential for the development of these lymphoid tissues. In addition, RORgamma is a critical regulator of thymopoiesis. It controls the differentiation of immature single-positive thymocytes into double-positive thymocytes and promotes the survival of double-positive thymocytes by inducing the expression of the anti-apoptotic gene Bcl-X(L). Interestingly, all three ROR receptors appear to play a role in the control of circadian rhythms. RORalpha positively regulates the expression of Bmal1, a transcription factor that is critical in the control of the circadian clock. This review intends to provide an overview of the current status of the functions RORs have in these biological processes.
Language	English
Publishing date	2008-04-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	1574-3349
ISSN	1574-3349
DOI	10.1016/S1574-3349(06)16010-X
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Article: NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway.

Joo, Joung Hyuck / Jetten, Anton M

The Journal of biological chemistry

2008 Volume 283, Issue 24, Page(s) 16391–16399

Abstract: In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1alpha, and COX-2. This response was dependent on ... ...

Abstract	In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1alpha, and COX-2. This response was dependent on the activation of the NF-kappaB signaling pathway. Farnesol treatment reduces the level of IkappaBalpha and induces translocation of p65/RelA to the nucleus, its phosphorylation at Ser(276), and transactivation of NF-kappaB-dependent transcription. Moreover, overexpression of IkappaBalpha or treatment with the NF-kappaB inhibitor caffeic acid phenethyl ester greatly diminishes the induction of inflammatory gene expression by farnesol. We provide evidence indicating that the farnesol-induced phosphorylation of p65/RelA at Ser(276) is important for optimal transcriptional activity of NF-kappaB. The MEK1/2 inhibitor U0126 and knockdown of MEK1/2 expression with small interfering RNAs effectively blocked the phosphorylation of p65/RelA(Ser(276)) but not that of Ser(536), suggesting that this phosphorylation is dependent on the activation of the MEK1/2-ERK1/2 pathway. We further show that inhibition of MSK1, a kinase acting downstream of MEK1/2-ERK1/2, by H89 or knockdown of MSK1 expression also inhibited phosphorylation of p65/RelA(Ser(276)), suggesting that this phosphorylation is dependent on MSK1. Knockdown of MEK1/2 or MSK1 expression inhibits farnesol-induced expression of CXCL3, IL-1alpha, and COX-2 mRNA. Our results indicate that the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB pathway and involves MEK1/2-ERK1/2-MSK1-dependent phosphorylation of p65/RelA(Ser(276)). The activation of the NF-kappaB pathway by farnesol might be part of a prosurvival response during farnesol-induced ER stress.
MeSH term(s)	Cell Line, Tumor ; Farnesol/pharmacology ; Gene Expression Regulation, Neoplastic ; Humans ; I-kappa B Proteins/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; NF-KappaB Inhibitor alpha ; NF-kappa B/metabolism ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Signal Transduction ; Transcription Factor RelA/metabolism ; Transcriptional Activation
Chemical Substances	I-kappa B Proteins ; NF-kappa B ; NFKBIA protein, human ; Transcription Factor RelA ; NF-KappaB Inhibitor alpha (139874-52-5) ; Farnesol (4602-84-0) ; MAP2K2 protein, human (EC 2.7.1.-) ; Ribosomal Protein S6 Kinases, 90-kDa (EC 2.7.11.1) ; mitogen and stress-activated protein kinase 1 (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; MAP Kinase Kinase 1 (EC 2.7.12.2) ; MAP Kinase Kinase 2 (EC 2.7.12.2)
Language	English
Publishing date	2008-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M800945200
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Article ; Online: Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells.

Joo, Joung Hyuck / Ueda, Eiichiro / Bortner, Carl D / Yang, Xiao-Ping / Liao, Grace / Jetten, Anton M

Biochemical pharmacology

2015 Volume 97, Issue 3, Page(s) 256–268

Abstract: In this study, we demonstrate that treatment of T lymphoblastic leukemic Molt4 cells with farnesol activates the apoptosome via the intrinsic pathway of apoptosis. This induction was associated with changes in the level of intracellular potassium and ... ...

Abstract	In this study, we demonstrate that treatment of T lymphoblastic leukemic Molt4 cells with farnesol activates the apoptosome via the intrinsic pathway of apoptosis. This induction was associated with changes in the level of intracellular potassium and calcium, the dissipation of the mitochondrial and plasma membrane potential, release of cytochrome c, activation of several caspases, and PARP cleavage. The induction of apoptosis by farnesol was inhibited by the addition of the pan-caspase inhibitor Z-VAD-fmk and by the exogenous expression of the anti-apoptotic protein Bcl2. Analysis of the gene expression profiles by microarray analysis revealed that farnesol increased the expression of several genes related to the unfolded protein response (UPR), including CHOP and CHAC1. This induction was associated with the activation of the PERK-eIF2α-ATF3/4 cascade, but not the XBP-1 branch of the UPR. Although farnesol induced activation of the ERK1/2, p38, and JNK pathways, inhibition of these MAPKs had little effect on farnesol-induced apoptosis or the induction of UPR-related genes. Our data indicate that the induction of apoptosis in leukemic cells by farnesol is mediated through a pathway that involves activation of the apoptosome via the intrinsic pathway and induction of the PERK-eIF2α-ATF3/4 cascade in a manner that is independent of the farnesol-induced activation of MAPKs.
MeSH term(s)	Activating Transcription Factor 3/metabolism ; Activating Transcription Factor 4/metabolism ; Anticarcinogenic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Farnesol/pharmacology ; Humans ; MAP Kinase Signaling System/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Reactive Oxygen Species/metabolism ; Transcription Factor CHOP/metabolism ; Transcriptome/drug effects ; Transfection
Chemical Substances	ATF3 protein, human ; ATF4 protein, human ; Activating Transcription Factor 3 ; Anticarcinogenic Agents ; DDIT3 protein, human ; Proto-Oncogene Proteins c-bcl-2 ; Reactive Oxygen Species ; Activating Transcription Factor 4 (145891-90-3) ; Transcription Factor CHOP (147336-12-7) ; Farnesol (4602-84-0)
Language	English
Publishing date	2015-08-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2015.08.086
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Zs.A 19: Show issues

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Article ; Online: Long-Term Outcomes Following Trabeculectomy Combined with 25-Gauge Transconjunctival Sutureless Vitrectomy in Uveitis Patients.

Kim, Bo Hyuck / Shin, Joo Young / Lee, Min Joung / Kim, Suk Hwan / Yu, Hyeong Gon

Ocular immunology and inflammation

2015 Volume 23, Issue 3, Page(s) 212–218

Abstract: Purpose: To evaluate the efficacy of combined trabeculectomy (TLE) and 25-gauge transconjunctival sutureless vitrectomy (TSV-25) for uveitis patients.: Methods: Combined TSV-25/TLE was performed in 9 eyes of 6 patients with vitreoretinal ... ...

Abstract	Purpose: To evaluate the efficacy of combined trabeculectomy (TLE) and 25-gauge transconjunctival sutureless vitrectomy (TSV-25) for uveitis patients. Methods: Combined TSV-25/TLE was performed in 9 eyes of 6 patients with vitreoretinal complications and intractable glaucoma. Visual acuity, intraocular pressure (IOP), inflammatory control, and number of hypotensive medications were evaluated. Results: Visual acuity improved in 7 of 9 eyes and inflammation was controlled with a decreased oral anti-inflammatory agent dosage in all eyes. Mean IOP, which was 28.11 ± 4.83 mmHg preoperatively, was significantly reduced (15.77 ± 2.68 mmHg) 5 years after surgery (p = 0.008). The mean number of IOP-lowering medications was 3.33 ± 0.71 before surgery and 1.11 ± 0.92 5 years after surgery (p = 0.007). Two eyes required implant of an Ahmed drainage valve during the follow-up period. Conclusion: Combined TSV-25/TLE can be effective in managing vitreoretinal complications and elevated IOP in uveitis patients.
MeSH term(s)	Adult ; Conjunctiva/surgery ; Female ; Follow-Up Studies ; Glaucoma/complications ; Glaucoma/physiopathology ; Glaucoma/surgery ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Retrospective Studies ; Suture Techniques ; Time Factors ; Trabeculectomy/methods ; Treatment Outcome ; Uveitis/complications ; Uveitis/physiopathology ; Uveitis/surgery ; Visual Acuity ; Vitrectomy/methods
Language	English
Publishing date	2015-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.3109/09273948.2014.892626
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Zs.A 4004: Show issues

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Article ; Online: ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.

Wang, Bo / Maxwell, Brian A / Joo, Joung Hyuck / Gwon, Youngdae / Messing, James / Mishra, Ashutosh / Shaw, Timothy I / Ward, Amber L / Quan, Honghu / Sakurada, Sadie Miki / Pruett-Miller, Shondra M / Bertorini, Tulio / Vogel, Peter / Kim, Hong Joo / Peng, Junmin / Taylor, J Paul / Kundu, Mondira

Molecular cell

2019 Volume 74, Issue 4, Page(s) 742–757.e8

Abstract: Disturbances in autophagy and stress granule dynamics have been implicated as potential mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet the roles of core autophagy proteins in IBM and stress granule dynamics remain poorly ... ...

Abstract	Disturbances in autophagy and stress granule dynamics have been implicated as potential mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet the roles of core autophagy proteins in IBM and stress granule dynamics remain poorly characterized. Here, we demonstrate that disrupted expression of the core autophagy proteins ULK1 and ULK2 in mice causes a vacuolar myopathy with ubiquitin and TDP-43-positive inclusions; this myopathy is similar to that caused by VCP/p97 mutations, the most common cause of familial IBM. Mechanistically, we show that ULK1/2 localize to stress granules and phosphorylate VCP, thereby increasing VCP's activity and ability to disassemble stress granules. These data suggest that VCP dysregulation and defective stress granule disassembly contribute to IBM-like disease in Ulk1/2-deficient mice. In addition, stress granule disassembly is accelerated by an ULK1/2 agonist, suggesting ULK1/2 as targets for exploiting the higher-order regulation of stress granules for therapeutic intervention of IBM and related disorders.
MeSH term(s)	Adenosine Triphosphatases/genetics ; Animals ; Autophagy/genetics ; Autophagy-Related Protein-1 Homolog/genetics ; DNA-Binding Proteins/genetics ; Disease Models, Animal ; Humans ; Inclusion Bodies/genetics ; Inclusion Bodies/pathology ; Lysosomal Storage Diseases/genetics ; Lysosomal Storage Diseases/metabolism ; Lysosomal Storage Diseases/pathology ; Mice ; Muscular Diseases/genetics ; Muscular Diseases/metabolism ; Muscular Diseases/pathology ; Phosphorylation/genetics ; Protein-Serine-Threonine Kinases/genetics ; Stress, Physiological/genetics ; Ubiquitin/genetics ; Valosin Containing Protein/genetics
Chemical Substances	DNA-Binding Proteins ; TDP-43 protein, mouse ; Ubiquitin ; Ulk2 protein, mouse (EC 2.7.1.11) ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Ulk1 protein, mouse (EC 2.7.11.1) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Valosin Containing Protein (EC 3.6.4.6) ; Vcp protein, mouse (EC 3.6.4.6)
Language	English
Publishing date	2019-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2019.03.027
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Article ; Online: The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.

Joo, Joung Hyuck / Wang, Bo / Frankel, Elisa / Ge, Liang / Xu, Lu / Iyengar, Rekha / Li-Harms, XiuJie / Wright, Christopher / Shaw, Timothy I / Lindsten, Tullia / Green, Douglas R / Peng, Junmin / Hendershot, Linda M / Kilic, Fusun / Sze, Ji Ying / Audhya, Anjon / Kundu, Mondira

Molecular cell

2016 Volume 62, Issue 6, Page(s) 982

Language	English
Publishing date	2016-06-16
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2016.05.030
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