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  1. Article ; Online: Frontiers in neuroepigenetics.

    Qureshi, Irfan A / Mehler, Mark F

    Neurobiology of disease

    2021  Volume 153, Page(s) 105333

    MeSH term(s) Brain/metabolism ; Brain Neoplasms/genetics ; Cellular Reprogramming/genetics ; Epigenesis, Genetic/genetics ; Epigenomics ; Epileptic Syndromes/genetics ; Gene Expression Profiling ; Histone Code ; Humans ; Mental Disorders/genetics ; Neurodegenerative Diseases/genetics ; RNA Processing, Post-Transcriptional/genetics
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2021.105333
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  2. Article ; Online: Shining a light on early stress responses and late-onset disease vulnerability.

    Mehler, Mark F

    Proceedings of the National Academy of Sciences of the United States of America

    2017  Volume 114, Issue 9, Page(s) 2109–2111

    Language English
    Publishing date 2017-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1700323114
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  3. Article: Brain MRI findings in severe COVID-19 patients: a meta-analysis.

    Boparai, Montek S / Musheyev, Benjamin / Hou, Wei / Mehler, Mark F / Duong, Tim Q

    Frontiers in neurology

    2023  Volume 14, Page(s) 1258352

    Abstract: Introduction: Neurocognitive symptoms and dysfunction of various severities have become increasingly recognized as potential consequences of SARS-CoV-2 infection. Although there are numerous observational and subjective survey-reporting studies of ... ...

    Abstract Introduction: Neurocognitive symptoms and dysfunction of various severities have become increasingly recognized as potential consequences of SARS-CoV-2 infection. Although there are numerous observational and subjective survey-reporting studies of neurological symptoms, by contrast, those studies describing imaging abnormalities are fewer in number.
    Methods: This study conducted a metanalysis of 32 studies to determine the incidence of the common neurological abnormalities using magnetic resonance imaging (MRI) in patients with COVID-19.
    Results: We also present the common clinical findings associated with MRI abnormalities. We report the incidence of any MRI abnormality to be 55% in COVID-19 patients with perfusion abnormalities (53%) and SWI abnormalities (44%) being the most commonly reported injuries. Cognitive impairment, ICU admission and/or mechanical ventilation status, older age, and hospitalization or longer length of hospital stay were the most common clinical findings associated with brain injury in COVID-19 patients.
    Discussion: Overall, the presentation of brain injury in this study was diverse with no substantial pattern of injury emerging, yet most injuries appear to be of vascular origin. Moreover, analysis of the association between MRI abnormalities and clinical findings suggests that there are likely many mechanisms, both direct and indirect, by which brain injury occurs in COVID-19 patients.
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1258352
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  4. Article: Epigenetic mechanisms underlying nervous system diseases.

    Qureshi, Irfan A / Mehler, Mark F

    Handbook of clinical neurology

    2018  Volume 147, Page(s) 43–58

    Abstract: Epigenetic mechanisms act as control systems for modulating genomic structure and activity in response to evolving profiles of cell-extrinsic, cell-cell, and cell-intrinsic signals. These dynamic processes are responsible for mediating cell- and tissue- ... ...

    Abstract Epigenetic mechanisms act as control systems for modulating genomic structure and activity in response to evolving profiles of cell-extrinsic, cell-cell, and cell-intrinsic signals. These dynamic processes are responsible for mediating cell- and tissue-specific gene expression and function and gene-gene and gene-environmental interactions. The major epigenetic mechanisms include DNA methylation and hydroxymethylation; histone protein posttranslational modifications, nucleosome remodeling/repositioning, and higher-order chromatin reorganization; noncoding RNA regulation; and RNA editing. These mechanisms are intimately involved in executing fundamental genomic programs, including gene transcription, posttranscriptional RNA processing and transport, translation, X-chromosome inactivation, genomic imprinting, retrotransposon regulation, DNA replication, and DNA repair and the maintenance of genomic stability. For the nervous system, epigenetics offers a novel and robust framework for explaining how brain development and aging occur, neural cellular diversity is generated, synaptic and neural network connectivity and plasticity are mediated, and complex cognitive and behavioral phenotypes are inherited transgenerationally. Epigenetic factors and processes are, not surprisingly, implicated in nervous system disease pathophysiology through several emerging paradigms - mutations and genetic variation in genes encoding epigenetic factors; impairments in epigenetic factor expression, localization, and function; epigenetic mechanisms modulating disease-associated factors and pathways; and the presence of deregulated epigenetic profiles in central and peripheral tissues.
    MeSH term(s) Epigenesis, Genetic/genetics ; Epigenesis, Genetic/physiology ; Humans ; Nervous System Diseases/genetics ; Nervous System Diseases/physiopathology
    Language English
    Publishing date 2018-01-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-63233-3.00005-1
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  5. Article ; Online: Author response: A dedicated scholarly research program in an adult and pediatric neurology residency program.

    Robbins, Matthew S / Mehler, Mark F

    Neurology

    2017  Volume 89, Issue 10, Page(s) 1095–1096

    Language English
    Publishing date 2017-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000004348
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  6. Article ; Online: Neurogenetic disorders across the lifespan: from aberrant development to degeneration.

    Hickman, Richard A / O'Shea, Sarah A / Mehler, Mark F / Chung, Wendy K

    Nature reviews. Neurology

    2022  Volume 18, Issue 2, Page(s) 117–124

    Abstract: Intellectual disability and autism spectrum disorder (ASD) are common, and genetic testing is increasingly performed in individuals with these diagnoses to inform prognosis, refine management and provide information about recurrence risk in the family. ... ...

    Abstract Intellectual disability and autism spectrum disorder (ASD) are common, and genetic testing is increasingly performed in individuals with these diagnoses to inform prognosis, refine management and provide information about recurrence risk in the family. For neurogenetic conditions associated with intellectual disability and ASD, data on natural history in adults are scarce; however, as older adults with these disorders are identified, it is becoming clear that some conditions are associated with both neurodevelopmental problems and neurodegeneration. Moreover, emerging evidence indicates that some neurogenetic conditions associated primarily with neurodegeneration also affect neurodevelopment. In this Perspective, we discuss examples of diseases that have developmental and degenerative overlap. We propose that neurogenetic disorders should be studied continually across the lifespan to understand the roles of the affected genes in brain development and maintenance, and to inform strategies for treatment.
    MeSH term(s) Aged ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/genetics ; Genetic Testing ; Humans ; Intellectual Disability/diagnosis ; Longevity
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-021-00595-5
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  7. Article ; Online: Movement Disorders in COVID-19: Whither Art Thou?

    Geyer, Howard L / Kaufman, David M / Parihar, Raminder K / Mehler, Mark F

    Tremor and other hyperkinetic movements (New York, N.Y.)

    2020  Volume 10, Page(s) 25

    MeSH term(s) COVID-19 ; Coronavirus Infections/complications ; Humans ; Movement Disorders/etiology ; Pandemics ; Pneumonia, Viral/complications
    Keywords covid19
    Language English
    Publishing date 2020-08-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2674453-3
    ISSN 2160-8288 ; 2160-8288
    ISSN (online) 2160-8288
    ISSN 2160-8288
    DOI 10.5334/tohm.553
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  8. Article: Nervous System-Systemic Crosstalk in SARS-CoV-2/COVID-19: A Unique Dyshomeostasis Syndrome.

    Anand, Harnadar / Ende, Victoria / Singh, Gurinder / Qureshi, Irfan / Duong, Tim Q / Mehler, Mark F

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 727060

    Abstract: SARS-CoV-2 infection is associated with a spectrum of acute neurological syndromes. A subset of these syndromes promotes higher in-hospital mortality than is predicted by traditional parameters defining critical care illness. This suggests that ... ...

    Abstract SARS-CoV-2 infection is associated with a spectrum of acute neurological syndromes. A subset of these syndromes promotes higher in-hospital mortality than is predicted by traditional parameters defining critical care illness. This suggests that deregulation of components of the central and peripheral nervous systems compromises the interplay with systemic cellular, tissue and organ interfaces to mediate numerous atypical manifestations of COVID-19 through impairments in organismal homeostasis. This unique dyshomeostasis syndrome involves components of the ACE-2/1 lifecycles, renin-angiotensin system regulatory axes, integrated nervous system functional interactions and brain regions differentially sculpted by accelerated evolutionary processes and more primordial homeostatic functions. These biological contingencies suggest a mechanistic blueprint to define long-term neurological sequelae and systemic manifestations such as premature aging phenotypes, including organ fibrosis, tissue degeneration and cancer. Therapeutic initiatives must therefore encompass innovative combinatorial agents, including repurposing FDA-approved drugs targeting components of the autonomic nervous system and recently identified products of SARS-CoV-2-host interactions.
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.727060
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  9. Article ; Online: Introduction: epigenetics and neuropsychiatric diseases.

    Mehler, Mark F

    Neurobiology of disease

    2010  Volume 39, Issue 1, Page(s) 1–2

    MeSH term(s) Animals ; Epigenesis, Genetic/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Nervous System Diseases/genetics ; Nervous System Diseases/pathology ; Nervous System Diseases/psychology ; Neurons/metabolism ; Neurons/pathology
    Language English
    Publishing date 2010-02-24
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2010.02.006
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  10. Article ; Online: Epigenetics and neuropsychiatric diseases: introduction and meeting summary.

    Mehler, Mark F

    Annals of the New York Academy of Sciences

    2010  Volume 1204 Suppl, Page(s) E1–7

    Abstract: ... Malaspina (New York University Medical Center) and Mark F. Mehler (Albert Einstein College of Medicine ...

    Abstract This volume is an outgrowth of a symposium entitled "Epigenetics and Neuropsychiatric Diseases: Mechanisms Mediating Nature and Nurture" presented at the 88th Annual Conference of the Association for Nervous and Mental Diseases, held on December 5, 2008 at the New York Academy of Medicine. Dolores Malaspina (New York University Medical Center) and Mark F. Mehler (Albert Einstein College of Medicine) organized the symposium as two sessions, "Epigenetics and Brain Behavior Relationships" and "Epigenetics and Neuropsychiatric Diseases." The symposium brought together basic and translational neuroscientists, neurologists, psychiatrists, neuropsychologists, neuropsycho-pharmacologists, and other allied biomedical professionals to establish an enduring dialogue and collaborative interactions concerning epigenetics and epigenomic medicine as a "new science" of brain and behavior relationships. This new discipline has begun to revolutionize our understanding of nervous system development in many specific areas, including neural stem cell biology, fate decisions, and cell diversity and connectivity; learning and memory; neuronal and neural network homeostasis; plasticity and stress responses; the pathogenesis of neuropsychiatric diseases and novel therapeutic interventions involving dynamic cellular reprogramming; reorganization of synaptic and neural network connections; and remodeling of the brain parenchyma and its systemic connections to promote restoration of higher-order cognitive, behavioral, and sensorimotor functions.
    MeSH term(s) Congresses as Topic ; Epigenesis, Genetic/genetics ; Humans ; Nervous System Diseases/genetics ; Nervous System Diseases/psychology
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2010.05717.x
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