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Article ; Online: The NIDA Avenir award in genetics or epigenetics of substance use disorders.

Satterlee, John S / Pollock, Jonathan D / Volkow, Nora D

2023 Volume 127, Page(s) 103899

Abstract: NIDA's Avenir Program in the Genetics or Epigenetics of Substance Use Disorders (SUDs) was launched to support early stage investigators who propose innovative, high risk, but potentially high impact research and who show promise of being tomorrow's ... ...

Abstract	NIDA's Avenir Program in the Genetics or Epigenetics of Substance Use Disorders (SUDs) was launched to support early stage investigators who propose innovative, high risk, but potentially high impact research and who show promise of being tomorrow's leaders in this scientific field. Since 2015, NIDA has supported 30 Avenir Investigators with unique expertise and creative ideas. This special issue showcases how some of these ideas have germinated, flourished, and borne fruit. In this perspective article we briefly describe the purpose and implementation of the Avenir award and provide a high altitude overview of the awardees and their scientific projects to date.
MeSH term(s)	Humans ; Substance-Related Disorders/genetics ; Awards and Prizes ; Epigenesis, Genetic
Chemical Substances	N-nitrosoiminodiacetic acid (25081-31-6)
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1046640-x
ISSN	1095-9327 ; 1044-7431
ISSN (online)	1095-9327
ISSN	1044-7431
DOI	10.1016/j.mcn.2023.103899
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Article ; Online: Molecular neuroanatomy: a generation of progress.

Pollock, Jonathan D / Wu, Da-Yu / Satterlee, John S

Trends in neurosciences

2013 Volume 37, Issue 2, Page(s) 106–123

Abstract: The neuroscience research landscape has changed dramatically over the past decade. Specifically, an impressive array of new tools and technologies have been generated, including but not limited to: brain gene expression atlases, genetically encoded ... ...

Abstract	The neuroscience research landscape has changed dramatically over the past decade. Specifically, an impressive array of new tools and technologies have been generated, including but not limited to: brain gene expression atlases, genetically encoded proteins to monitor and manipulate neuronal activity, and new methods for imaging and mapping circuits. However, despite these technological advances, several significant challenges must be overcome to enable a better understanding of brain function and to develop cell type-targeted therapeutics to treat brain disorders. This review provides an overview of some of the tools and technologies currently being used to advance the field of molecular neuroanatomy, and also discusses emerging technologies that may enable neuroscientists to address these crucial scientific challenges over the coming decade.
MeSH term(s)	Animals ; Humans ; Molecular Biology/methods ; Molecular Biology/trends ; Neuroanatomy/methods ; Neuroanatomy/trends
Language	English
Publishing date	2013-12-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	282488-7
ISSN	1878-108X ; 0378-5912 ; 0166-2236
ISSN (online)	1878-108X
ISSN	0378-5912 ; 0166-2236
DOI	10.1016/j.tins.2013.11.001
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Article ; Online: Tackling the epigenome: challenges and opportunities for collaboration.

Satterlee, John S / Schübeler, Dirk / Ng, Huck-Hui

Nature biotechnology

2010 Volume 28, Issue 10, Page(s) 1039–1044

Abstract: What are the key considerations to take into account when large-scale epigenomics projects are being implemented? ...

Abstract	What are the key considerations to take into account when large-scale epigenomics projects are being implemented?
MeSH term(s)	Cooperative Behavior ; Databases, Genetic ; Epigenesis, Genetic ; Epigenomics ; Genome/genetics ; Humans ; National Institutes of Health (U.S.) ; Peer Review, Research ; United States
Language	English
Publishing date	2010-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/nbt1010-1039
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Article ; Online: The NIH Common Fund/Roadmap Epigenomics Program: Successes of a comprehensive consortium.

Satterlee, John S / Chadwick, Lisa H / Tyson, Frederick L / McAllister, Kim / Beaver, Jill / Birnbaum, Linda / Volkow, Nora D / Wilder, Elizabeth L / Anderson, James M / Roy, Ananda L

Science advances

2019 Volume 5, Issue 7, Page(s) eaaw6507

Abstract: The NIH Roadmap Epigenomics Program was launched to deliver reference epigenomic data from human tissues and cells, develop tools and methods for analyzing the epigenome, discover novel epigenetic marks, develop methods to manipulate the epigenome, and ... ...

Abstract	The NIH Roadmap Epigenomics Program was launched to deliver reference epigenomic data from human tissues and cells, develop tools and methods for analyzing the epigenome, discover novel epigenetic marks, develop methods to manipulate the epigenome, and determine epigenetic contributions to diverse human diseases. Here, we comment on the outcomes from this program: the scientific contributions made possible by a consortium approach and the challenges, benefits, and lessons learned from this group science effort.
MeSH term(s)	Epigenesis, Genetic ; Epigenomics ; Financial Management ; Humans ; National Institutes of Health (U.S.) ; United States
Language	English
Publishing date	2019-07-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.aaw6507
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Article ; Online: Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures.

Sluka, Kathleen A / Wager, Tor D / Sutherland, Stephani P / Labosky, Patricia A / Balach, Tessa / Bayman, Emine O / Berardi, Giovanni / Brummett, Chad M / Burns, John / Buvanendran, Asokumar / Caffo, Brian / Calhoun, Vince D / Clauw, Daniel / Chang, Andrew / Coffey, Christopher S / Dailey, Dana L / Ecklund, Dixie / Fiehn, Oliver / Fisch, Kathleen M /

Frey Law, Laura A / Harris, Richard E / Harte, Steven E / Howard, Timothy D / Jacobs, Joshua / Jacobs, Jon M / Jepsen, Kristen / Johnston, Nicolas / Langefeld, Carl D / Laurent, Louise C / Lenzi, Rebecca / Lindquist, Martin A / Lokshin, Anna / Kahn, Ari / McCarthy, Robert J / Olivier, Michael / Porter, Linda / Qian, Wei-Jun / Sankar, Cheryse A / Satterlee, John / Swensen, Adam C / Vance, Carol G T / Waljee, Jennifer / Wandner, Laura D / Williams, David A / Wixson, Richard L / Zhou, Xiaohong Joe

Pain

2023 Volume 164, Issue 9, Page(s) 1912–1926

Abstract: Abstract: Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially ... ...

Abstract	Abstract: Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially identify and measure biological pathways and phenotypical expressions that are altered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinical biomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fund launched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop them into biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discusses candidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic, neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will provide the most comprehensive investigation of biomarkers for the transition to chronic postsurgical pain undertaken to date. Data and analytic resources generatedby A2CPS will be shared with the scientific community in hopes that other investigators will extract valuable insights beyond A2CPS's initial findings. This article will review the identified biomarkers and rationale for including them, the current state of the science on biomarkers of the transition from acute to chronic pain, gaps in the literature, and how A2CPS will address these gaps.
MeSH term(s)	Humans ; Chronic Pain ; Proteomics ; Pain, Postoperative/etiology ; Acute Pain/complications ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000002938
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Article ; Online: Community resources and technologies developed through the NIH Roadmap Epigenomics Program.

Satterlee, John S / Beckel-Mitchener, Andrea / McAllister, Kim / Procaccini, Dena C / Rutter, Joni L / Tyson, Frederick L / Chadwick, Lisa Helbling

Methods in molecular biology (Clifton, N.J.)

2015 Volume 1238, Page(s) 27–49

Abstract: This chapter describes resources and technologies generated by the NIH Roadmap Epigenomics Program that may be useful to epigenomics researchers investigating a variety of diseases including cancer. Highlights include reference epigenome maps for a wide ... ...

Abstract	This chapter describes resources and technologies generated by the NIH Roadmap Epigenomics Program that may be useful to epigenomics researchers investigating a variety of diseases including cancer. Highlights include reference epigenome maps for a wide variety of human cells and tissues, the development of new technologies for epigenetic assays and imaging, the identification of novel epigenetic modifications, and an improved understanding of the role of epigenetic processes in a diversity of human diseases. We also discuss future needs in this area including exploration of epigenomic variation between individuals, single-cell epigenomics, environmental epigenomics, exploration of the use of surrogate tissues, and improved technologies for epigenome manipulation.
MeSH term(s)	Animals ; Epigenomics/methods ; Genetic Techniques ; Health Resources ; Humans ; National Institutes of Health (U.S.) ; Residence Characteristics ; United States
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-1804-1_2
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Article: Neuroepigenomics: Resources, Obstacles, and Opportunities.

Satterlee, John S / Beckel-Mitchener, Andrea / Little, Roger / Procaccini, Dena / Rutter, Joni L / Lossie, Amy C

Neuroepigenetics

2014 Volume 1, Page(s) 2–13

Abstract: Long-lived post-mitotic cells, such as the majority of human neurons, must respond effectively to ongoing changes in neuronal stimulation or microenvironmental cues through transcriptional and epigenomic regulation of gene expression. The role of ... ...

Abstract	Long-lived post-mitotic cells, such as the majority of human neurons, must respond effectively to ongoing changes in neuronal stimulation or microenvironmental cues through transcriptional and epigenomic regulation of gene expression. The role of epigenomic regulation in neuronal function is of fundamental interest to the neuroscience community, as these types of studies have transformed our understanding of gene regulation in post-mitotic cells. This perspective article highlights many of the resources available to researchers interested in neuroepigenomic investigations and discusses some of the current obstacles and opportunities in neuroepigenomics.
Language	English
Publishing date	2014-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2835361-4
ISSN	2214-7845
ISSN	2214-7845
DOI	10.1016/j.nepig.2014.10.001
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Article ; Online: Novel RNA modifications in the nervous system: form and function.

Satterlee, John S / Basanta-Sanchez, Maria / Blanco, Sandra / Li, Jin Billy / Meyer, Kate / Pollock, Jonathan / Sadri-Vakili, Ghazaleh / Rybak-Wolf, Agnieszka

The Journal of neuroscience : the official journal of the Society for Neuroscience

2014 Volume 34, Issue 46, Page(s) 15170–15177

Abstract: Modified RNA molecules have recently been shown to regulate nervous system functions. This mini-review and associated mini-symposium provide an overview of the types and known functions of novel modified RNAs in the nervous system, including covalently ... ...

Abstract	Modified RNA molecules have recently been shown to regulate nervous system functions. This mini-review and associated mini-symposium provide an overview of the types and known functions of novel modified RNAs in the nervous system, including covalently modified RNAs, edited RNAs, and circular RNAs. We discuss basic molecular mechanisms involving RNA modifications as well as the impact of modified RNAs and their regulation on neuronal processes and disorders, including neural fate specification, intellectual disability, neurodegeneration, dopamine neuron function, and substance use disorders.
MeSH term(s)	Animals ; Brain/cytology ; Brain/metabolism ; Brain/pathology ; Humans ; Methylation ; RNA/chemistry ; RNA/metabolism ; RNA Editing ; RNA, Untranslated/metabolism ; Receptors, Glutamate/metabolism ; Substance-Related Disorders/genetics ; Substance-Related Disorders/metabolism
Chemical Substances	RNA, Untranslated ; RNA, circular ; Receptors, Glutamate ; RNA (63231-63-0)
Language	English
Publishing date	2014-11-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.3236-14.2014
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Article: Japanese quail selected for high plasma corticosterone response deposit high levels of corticosterone in their eggs.

Hayward, Lisa S / Satterlee, Daniel G / Wingfield, John C

Physiological and biochemical zoology : PBZ

2005 Volume 78, Issue 6, Page(s) 1026–1031

Abstract: Poor habitat quality or body condition often correlates with high responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis rather than with elevated baseline levels of glucocorticoids. We hypothesized that, for egg-laying vertebrates, high ... ...

Abstract	Poor habitat quality or body condition often correlates with high responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis rather than with elevated baseline levels of glucocorticoids. We hypothesized that, for egg-laying vertebrates, high responsiveness of the HPA axis would correspond to high concentrations of corticosterone in yolk. We tested the prediction that Japanese quail (Coturnix coturnix japonica) selected for high plasma corticosterone response to brief immobilization (HS quail) would lay eggs with higher yolk corticosterone concentrations than birds selected for low response (LS quail). Quail from both lines were left undisturbed, outside of the stressors associated with daily management, before a first round of egg collection. In a second experiment, quail of both lines were experimentally stressed during the week before egg collection. In both cases we found quail from the HS line to lay eggs with significantly higher yolk corticosterone concentrations than quail of the LS line. After exposure to added experimental stressors, the line difference was more pronounced (increasing from 62% to 96%). There was no line difference in concentrations of yolk testosterone. Our results suggest that (1) genetic differences underly differences in the transfer of maternal corticosterone to yolk and (2) females may be able to control deposition of corticosterone into yolk through a mechanism independent of baseline corticosterone titers.
MeSH term(s)	Animals ; Corticosterone/metabolism ; Coturnix/genetics ; Coturnix/metabolism ; Egg Yolk/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Pituitary-Adrenal System/metabolism ; Selection, Genetic ; Statistics, Nonparametric ; Testosterone/metabolism
Chemical Substances	Testosterone (3XMK78S47O) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2005-11
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1473845-4
ISSN	1537-5293 ; 1522-2152
ISSN (online)	1537-5293
ISSN	1522-2152
DOI	10.1086/432854
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Article: The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans.

Satterlee, John S / Ryu, William S / Sengupta, Piali

Current biology : CB

2004 Volume 14, Issue 1, Page(s) 62–68

Abstract: The cultivation temperature (T(c)) modulates the thermosensory responses exhibited by C. elegans on thermal gradients. The AFD sensory neurons are essential for thermosensory behaviors, but the molecular mechanisms by which temperature is sensed and the ... ...

Abstract	The cultivation temperature (T(c)) modulates the thermosensory responses exhibited by C. elegans on thermal gradients. The AFD sensory neurons are essential for thermosensory behaviors, but the molecular mechanisms by which temperature is sensed and the memory of the T(c) is encoded are unknown. Here, we show that the CMK-1 Ca2+/calmodulin-dependent protein kinase I (CaMKI) and the TAX-4 cyclic nucleotide-gated channel regulate gene expression, morphology, and functions of the AFD thermosensory neurons. Mutations in cmk-1 and tax-4 result in temperature-dependent defects in AFD-specific gene expression, and TAX-4 functions are required during larval stages to maintain gene expression in the adult. CMK-1 and TAX-4 act cell autonomously to regulate AFD-mediated thermosensory behaviors. The molecular requirements for CMK-1 activity in the AFD neurons appear to be distinct from those previously described. We propose that the activation of distinct programs of AFD-specific gene expression at different temperatures by CMK-1 and TAX-4 enables C. elegans to sense and/or encode a memory for the T(c).
MeSH term(s)	Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins ; Calcium-Calmodulin-Dependent Protein Kinase Type 1 ; Calcium-Calmodulin-Dependent Protein Kinases/genetics ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cluster Analysis ; Gene Components ; Gene Expression ; Gene Expression Profiling ; Ion Channels/genetics ; Ion Channels/metabolism ; Movement/physiology ; Neurons, Afferent/metabolism ; Neurons, Afferent/physiology ; Phylogeny ; Temperature
Chemical Substances	Caenorhabditis elegans Proteins ; Ion Channels ; tax-4 protein, C elegans ; Calcium-Calmodulin-Dependent Protein Kinase Type 1 (EC 2.7.11.17) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17)
Language	English
Publishing date	2004-01-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2003.12.030
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