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  1. Book ; Online ; E-Book: Epileptische Anfälle und Epilepsien im Erwachsenenalter

    Schmitt, F. C. / Stefan, Hermann / Holtkamp, Martin

    Diagnostik und Therapie

    2021  

    Author's details Friedrich C. Schmitt, Hermann Stefan, Martin Holtkamp (Hrsg.)
    Keywords Electronic books
    Language German
    Size 1 Online-Ressource (XVII, 795 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020926425
    ISBN 978-3-662-59198-7 ; 9783662591970 ; 3-662-59198-7 ; 3662591979
    DOI 10.1007/978-3-662-59198-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: How safe is switching antiepileptic drug manufacturers?

    Holtkamp, Martin

    Nature reviews. Neurology

    2018  Volume 15, Issue 1, Page(s) 8–9

    MeSH term(s) Anticonvulsants ; Epilepsy ; Germany ; Humans ; Seizures
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2018-11-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-018-0108-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Praxisbuch EEG

    Wellach, Ingmar / Haueisen, Jens / Holtkamp, Martin / House, Patrick / Mehldorn, Julia / Speckmann, Erwin-Josef

    Grundlagen, Befundung, Beurteilung und differenzialdiagnostische Abgrenzung

    2021  

    Author's details Ingmar Wellach. Unter Mitarbeit von Jens Haueisen, Martin Holtkamp, Patrick House, Julia Mehldorn, Erwin-Josef Speckmann
    Keywords EEG-DIAGNOSTIK ; MEDIKAMENTENEFFEKTE ; EEG AUSWERTUNG ; EEG-ARTEFAKTE ; NEUROLOGISCHE DIAGNOSTIK ; RICHTLINIEN DER DGKN ; NEUROLOGISCHE ERKRANKUNGEN ; ELEKTROENZEPHALOGRAPHIE ; KLINISCHE NEUROPHYSIOLOGIE ; EEG GERÄT ; NEUROLOGIE ; EEG DIAGNOSTIK ; EEG KURVE ; EEG ; EEG-MUSTER ; BEFUNDUNG ; EEG-ARBEITSPLATZ ; NEUROPHYSIOLOGIE ; BEWUSSTSEINSSTÖRUNGEN ; PHYSIOLOGISCHE GRUNDLAGEN DES EEG ; EEG-ZERTIFIKAT ; DIFFERENZIALDIAGNOSE ; HIRNTODDIAGNOSTIK ; DGKN ; 131 ; Neurologie ; Elektroencephalogramm ; Differentialdiagnose
    Subject Differentialdiagnostik ; Differenzialdiagnostik ; Differenzialdiagnose ;RR ; Elektroenzephalogramm ; EEG
    Subject code 610
    Language German
    Size 603 Seiten, Illustrationen, Diagramme, 24 cm x 17 cm
    Edition 3. überarbeitete Auflage
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Note Online-Version in der eRef
    HBZ-ID HT019950453
    ISBN 978-3-13-242207-0 ; 3-13-242207-X ; 9783132422087 ; 9783132422094 ; 3132422088 ; 3132422096
    Database Catalogue ZB MED Medicine, Health

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    2020 A 1442 available for loan (reading room) Lesesaal EG
    Online-Ressource aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Article ; Online: The SeLECT 2.0 Score-Significance of Treatment With Antiseizure Medication.

    Doerrfuss, Jakob I / Holtkamp, Martin / Vorderwülbecke, Bernd J

    JAMA neurology

    2023  Volume 80, Issue 11, Page(s) 1252

    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.3371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pharmacotherapy for Refractory and Super-Refractory Status Epilepticus in Adults.

    Holtkamp, Martin

    Drugs

    2018  Volume 78, Issue 3, Page(s) 307–326

    Abstract: Patients with prolonged seizures that do not respond to intravenous benzodiazepines and a second-line anticonvulsant suffer from refractory status epilepticus and those with seizures that do not respond to continuous intravenous anesthetic ... ...

    Abstract Patients with prolonged seizures that do not respond to intravenous benzodiazepines and a second-line anticonvulsant suffer from refractory status epilepticus and those with seizures that do not respond to continuous intravenous anesthetic anticonvulsants suffer from super-refractory status epilepticus. Both conditions are associated with significant morbidity and mortality. A strict pharmacological treatment regimen is urgently required, but the level of evidence for the available drugs is very low. Refractory complex focal status epilepticus generally does not require anesthetics, but all intravenous non-anesthetizing anticonvulsants may be used. Most descriptive data are available for levetiracetam, phenytoin and valproate. Refractory generalized convulsive status epilepticus is a life-threatening emergency, and long-term clinical consequences are eminent. Administration of intravenous anesthetics is mandatory, and drugs acting at the inhibitory gamma-aminobutyric acid (GABA)
    MeSH term(s) Adult ; Anesthetics, Intravenous/therapeutic use ; Anticonvulsants/therapeutic use ; Benzodiazepines/therapeutic use ; Diet, Ketogenic ; GABA-A Receptor Antagonists/therapeutic use ; Humans ; Ketamine/therapeutic use ; Midazolam/therapeutic use ; Pentobarbital/therapeutic use ; Propofol/therapeutic use ; Status Epilepticus/diet therapy ; Status Epilepticus/drug therapy ; Status Epilepticus/surgery ; Thiopental/therapeutic use
    Chemical Substances Anesthetics, Intravenous ; Anticonvulsants ; GABA-A Receptor Antagonists ; Benzodiazepines (12794-10-4) ; Ketamine (690G0D6V8H) ; Pentobarbital (I4744080IR) ; Thiopental (JI8Z5M7NA3) ; Midazolam (R60L0SM5BC) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2018-02-25
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-017-0859-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Epileptogenicity of white matter lesions in cerebral small vessel disease: a systematic review and meta-analysis.

    Doerrfuss, Jakob I / Hebel, Jonas M / Holtkamp, Martin

    Journal of neurology

    2023  Volume 270, Issue 10, Page(s) 4890–4902

    Abstract: Background: The epileptogenic properties of white matter lesions (WML) in cerebral small vessel disease (CSVD) are not yet understood. The aim of our systematic review and meta-analysis was to estimate the association between the extent of WML in CSVD ... ...

    Abstract Background: The epileptogenic properties of white matter lesions (WML) in cerebral small vessel disease (CSVD) are not yet understood. The aim of our systematic review and meta-analysis was to estimate the association between the extent of WML in CSVD and epilepsy, analyze whether these WML are associated with an increased risk of seizure recurrence, and evaluate if treatment with anti-seizure medication (ASM) is justified in first-seizure patients with WML and no cortical lesions.
    Methods: Following a pre-registered study protocol (PROSPERO-ID CRD42023390665), we systematically searched Pubmed and Embase for relevant literature comparing WML load between patients with epilepsy and controls as well as studies on seizure recurrence risk and ASM therapy in the presence vs. absence of WML. We calculated pooled estimates using a random effects model.
    Results: Eleven studies comprising 2983 patients were included in our study. Presence of WML (OR 2.14, 95% CI 1.38-3.33) and presence of relevant WML as assessed by visual rating scales (OR 3.96, 95% CI 2.55-6.16) but not WML volume (OR 1.30, 95% CI 0.91-1.85) were significantly associated with seizures. These results stayed robust in sensitivity analyses restricted to studies on patients with late-onset seizures/epilepsy. Only two studies assessed the association between WML and risk of seizure recurrence with conflicting results. Currently, there are no studies on the efficacy of ASM therapy in the presence of WML in CSVD.
    Conclusions: This meta-analysis suggests an association between presence of WML in CSVD and seizures. More research is needed addressing the association between WML and risk of seizure recurrence and ASM therapy focusing on a population of patients with a first unprovoked seizure.
    MeSH term(s) Humans ; Anticonvulsants/therapeutic use ; White Matter/diagnostic imaging ; White Matter/pathology ; Epilepsy/drug therapy ; Epilepsy/complications ; Cerebral Small Vessel Diseases/complications ; Cerebral Small Vessel Diseases/diagnostic imaging
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-023-11828-6
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  7. Book: Werner Villinger (1887 - 1961)

    Holtkamp, Martin

    die Kontinuität des Minderwertigkeitsgedankens in der Jugend- und Sozialpsychiatrie

    (Abhandlungen zur Geschichte der Medizin und der Naturwissenschaften ; 97)

    2002  

    Author's details von Martin Holtkamp
    Series title Abhandlungen zur Geschichte der Medizin und der Naturwissenschaften ; 97
    Collection
    Keywords Villinger, Werner
    Language German
    Size 208 S.
    Publisher Matthiesen
    Publishing place Husum
    Publishing country Germany
    Document type Book
    HBZ-ID HT013437158
    ISBN 3-7868-4097-0 ; 978-3-7868-4097-8
    Database Catalogue ZB MED Medicine, Health

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    Ua II Zs 50 -97- verfügbar in Königswinter Königswinter

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  8. Article ; Online: Status Epilepticus Diagnosis, Management and Outcome: An Update.

    Holtkamp, Martin

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2016  Volume 33, Issue 1, Page(s) 1–2

    MeSH term(s) Anticonvulsants/administration & dosage ; Diagnosis, Differential ; Electroencephalography/drug effects ; Electroencephalography/methods ; Evidence-Based Medicine ; Humans ; Status Epilepticus/diagnosis ; Status Epilepticus/therapy ; Treatment Outcome
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000219
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  9. Article ; Online: Should Barbiturates be Used in Refractory Status Epilepticus?

    Holtkamp, Martin

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2016  Volume 33, Issue 1, Page(s) 22–24

    Abstract: Status epilepticus (SE) is a frequent neurologic emergency, one third of patients do not respond to treatment with benzodiazepines followed by a second antiepileptic drug. While initial treatment of complex partial SE is accordant to that of generalized ... ...

    Abstract Status epilepticus (SE) is a frequent neurologic emergency, one third of patients do not respond to treatment with benzodiazepines followed by a second antiepileptic drug. While initial treatment of complex partial SE is accordant to that of generalized convulsive SE, further management of refractory SE depends on the risk for acute complications and long-term clinical consequences. These risks are low in complex partial SE; therefore, in this clinical form anesthetics commonly are not used. Generalized convulsive SE-even in its early course-is a potentially life-threatening condition; therefore, prompt use of anesthetics is urgently required. Drugs of choice are barbiturates, midazolam, and propofol, all of which exhibit specific advantages and disadvantages. Up to now, data from clinical studies do not allow to prefer or to discard one of these anesthetics, therefore also barbiturates still should be used in refractory SE. A widely accepted in-house protocol for the management of initial and refractory SE is highly recommended.
    MeSH term(s) Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Barbiturates/administration & dosage ; Barbiturates/adverse effects ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Therapy, Combination/adverse effects ; Drug Therapy, Combination/methods ; Electrocardiography/drug effects ; Evidence-Based Medicine ; Humans ; Status Epilepticus/diagnosis ; Status Epilepticus/drug therapy ; Status Epilepticus/prevention & control ; Treatment Outcome
    Chemical Substances Anticonvulsants ; Barbiturates
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000218
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  10. Article ; Online: Subjective cognition is linked to everyday functioning in epilepsy.

    Hohmann, Louisa / Berger, Justus / Kastell, Shirley-Uloma / Holtkamp, Martin

    Epilepsia open

    2023  Volume 8, Issue 2, Page(s) 535–546

    Abstract: Objective: Many people with epilepsy (PWE) suffer from reduced everyday functioning such as unemployment, relationship difficulties, or lifestyle limitations. To identify whether subjective cognitive impairment (SCI) is a potential source of these ... ...

    Abstract Objective: Many people with epilepsy (PWE) suffer from reduced everyday functioning such as unemployment, relationship difficulties, or lifestyle limitations. To identify whether subjective cognitive impairment (SCI) is a potential source of these impairments, associations with restrictions of daily life (RDL) and reduced daily activities (DA) were examined.
    Methods: In a prospective cross-sectional sample of 316 adult in-patients with epilepsy, multiple regression analyses were calculated predicting RDL and DA. The relationships between these two measures and SCI were controlled for age, sex, seizure frequency, presence of structural lesions, epilepsy duration, mono- vs polytherapy and adverse events of antiseizure medication (ASM), level of depressive and anxiety symptoms, education, and employment. We also checked for an interaction between depressive symptoms and SCI, to evaluate whether patients with more depressive symptoms are more vulnerable for unfavorable associations between SCI and RDL or DA, respectively. General dominance indices (GDIs) were calculated to compare predictors.
    Results: Substantial SCI was present in 46% of our sample. SCI was independently associated with RDL and DA. Comparison of relative predictor importance revealed that SCI accounted for 23% of the total variance of RDL (GDI
    Significance: Subjective cognitive impairment represents a frequent concern in PWE and may have detrimental consequences for their everyday life. PWE with depressive symptoms may be at greater risk of unfavorable relationships between SCI and everyday functioning. Exchange and collaboration between professionals offering psychotherapeutic, neuropsychological, and psychosocial interventions are crucial to address the patients' individual needs.
    MeSH term(s) Adult ; Humans ; Cross-Sectional Studies ; Prospective Studies ; Epilepsy/drug therapy ; Cognition ; Seizures/drug therapy
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12726
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