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  1. Article: Connecting the spots: Leopard print fashion and Panthera pardus conservation

    Good, Caroline / Burnham, Dawn / Moorhouse, Tom P. / Macdonald, David W.

    Journal for nature conservation

    2021  Volume 61, Issue -, Page(s) 125976

    Language English
    Document type Article
    ZDB-ID 2077553-2
    ISSN 1617-1381
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 6016: Show issues

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  2. Article ; Online: Monophosphoryl lipid A pretreatment suppresses sepsis- and LPS-induced proinflammatory cytokine production in the medullary thick ascending limb.

    Watts, Bruns A / Tamayo, Esther / Sherwood, Edward R / Good, David W

    American journal of physiology. Renal physiology

    2020  Volume 319, Issue 1, Page(s) F8–F18

    Abstract: Sepsis is the leading cause of acute kidney injury in critically ill patients. Tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of septic kidney injury; however, the sites and mechanisms of renal TNF-α production during sepsis ... ...

    Abstract Sepsis is the leading cause of acute kidney injury in critically ill patients. Tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of septic kidney injury; however, the sites and mechanisms of renal TNF-α production during sepsis remain to be defined. In the present study, we showed that TNF-α expression is increased in medullary thick ascending limbs (MTALs) of mice with sepsis induced by cecal ligation and puncture. Treatment with lipopolysaccharide (LPS) for 3 h in vitro also increased MTAL TNF-α production. Sepsis and LPS increased MTAL TNF-α expression through activation of the myeloid differentiation factor 88 (MyD88)-IL-1 receptor-associated kinase 1-ERK signaling pathway. Pretreatment with monophosphoryl lipid A (MPLA), a nontoxic immunomodulator that protects against bacterial infection, eliminated the sepsis- and LPS-induced increases in MTAL TNF-α production. The suppressive effect of MPLA on TNF-α was mediated through activation of a phosphatidylinositol 3-kinase-dependent pathway that inhibits MyD88-dependent ERK activation. This likely involves MPLA-phosphatidylinositol 3-kinase-mediated induction of Tollip, which negatively regulates the MyD88-ERK pathway by inhibiting activation of IL-1 receptor-associated kinase 1. These regulatory mechanisms are similar to those previously shown to mediate the effect of MPLA to prevent sepsis-induced inhibition of MTAL [Formula: see text] absorption. These results identify the MTAL as a site of local TNF-α production in the kidney during sepsis and identify molecular mechanisms that can be targeted to attenuate renal TNF-α expression. The ability of MPLA pretreatment to suppress MyD88-dependent ERK signaling in the MTAL during sepsis has the dual beneficial effects of protecting tubule transport functions and attenuating harmful proinflammatory responses.
    MeSH term(s) Animals ; Cytokines/metabolism ; Kidney Medulla/drug effects ; Kidney Medulla/metabolism ; Lipid A/analogs & derivatives ; Lipid A/pharmacology ; Lipopolysaccharides/pharmacology ; Loop of Henle/drug effects ; Loop of Henle/metabolism ; Male ; Mice ; Mice, Knockout ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Sepsis/metabolism ; Signal Transduction/drug effects
    Chemical Substances Cytokines ; Lipid A ; Lipopolysaccharides ; Myeloid Differentiation Factor 88 ; monophosphoryl lipid A (MWC0ET1L2P)
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00178.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Antifungal Polymeric Materials and Nanocomposites.

    Ntow-Boahene, Winnie / Cook, David / Good, Liam

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 780328

    Abstract: Rising global populations due to medicinal advancements increases the patient population susceptible to superficial and severe fungal infections. Fungi often implicated in these diseases includes the dermatophytes ( ...

    Abstract Rising global populations due to medicinal advancements increases the patient population susceptible to superficial and severe fungal infections. Fungi often implicated in these diseases includes the dermatophytes (
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.780328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Erratum: Caroline Good; et al.; A Cultural Conscience for Conservation. Animals 2017, 7, 52.

    Good, Caroline / Burnham, Dawn / Macdonald, David W

    Animals : an open access journal from MDPI

    2017  Volume 7, Issue 8

    Language English
    Publishing date 2017-08-04
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani7080058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK-1.

    Watts, Bruns A / Tamayo, Esther / Sherwood, Edward R / Good, David W

    American journal of physiology. Renal physiology

    2019  Volume 317, Issue 3, Page(s) F705–F719

    Abstract: ... LPS ... ...

    Abstract LPS inhibits
    MeSH term(s) Adaptor Proteins, Vesicular Transport/genetics ; Adaptor Proteins, Vesicular Transport/metabolism ; Adjuvants, Immunologic/pharmacology ; Animals ; Bicarbonates/metabolism ; Cytoprotection ; Disease Models, Animal ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Lipid A/analogs & derivatives ; Lipid A/pharmacology ; Loop of Henle/drug effects ; Loop of Henle/metabolism ; Loop of Henle/physiopathology ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphorylation ; Rats, Sprague-Dawley ; Renal Reabsorption/drug effects ; Sepsis/drug therapy ; Sepsis/metabolism ; Sepsis/physiopathology ; Signal Transduction ; Toll-Like Receptor 4/metabolism
    Chemical Substances Adaptor Proteins, Vesicular Transport ; Adjuvants, Immunologic ; Bicarbonates ; Intracellular Signaling Peptides and Proteins ; Lipid A ; Myd88 protein, mouse ; Myeloid Differentiation Factor 88 ; TICAM-1 protein, mouse ; Tlr4 protein, mouse ; Toll-Like Receptor 4 ; Tollip protein, mouse ; tollip protein, rat ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; IRAK1 protein, rat (EC 2.7.11.1) ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1) ; Irak1 protein, mouse (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; monophosphoryl lipid A (MWC0ET1L2P)
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00170.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Ocular and developmental outcomes of a dosing study of bevacizumab for retinopathy of prematurity.

    Wallace, David K / Hercinovic, Amra / Freedman, Sharon F / Crouch, Eric R / Bhatt, Amit R / Hartnett, M Elizabeth / Yang, Michael B / Rogers, David L / Hutchinson, Amy K / Good, William V / Repka, Michael X / Li, Zhuokai / Beck, Roy W / Kraker, Raymond T / Cotter, Susan A / Holmes, Jonathan M

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2023  Volume 27, Issue 1, Page(s) 10.e1–10.e8

    Abstract: Purpose: To report 2-year ocular and developmental outcomes for infants receiving low doses of intravitreal bevacizumab for type 1 retinopathy of prematurity (ROP).: Methods: A total of 120 premature infants (mean birthweight, 687 g; mean gestational ...

    Abstract Purpose: To report 2-year ocular and developmental outcomes for infants receiving low doses of intravitreal bevacizumab for type 1 retinopathy of prematurity (ROP).
    Methods: A total of 120 premature infants (mean birthweight, 687 g; mean gestational age, 24.8 weeks) with type 1 ROP were enrolled in a multicenter, phase 1 dose de-escalation study. One eye per infant received 0.25 mg, 0.125 mg, 0.063 mg, 0.031 mg, 0.016 mg, 0.008 mg, 0.004 mg, or 0.002 mg of intravitreal bevacizumab; fellow eyes when treated received one dosage level higher. At 2 years, 70 of 120 children (58%) underwent ocular examinations; 51 (43%) were assessed using the Bayley Scale of Infant and Toddler Development.
    Results: Correlation coefficients for the association of total dosage of bevacizumab with Bayley subscales were -0.20 for cognitive (95% CI, -0.45 to 0.08), -0.15 for motor (95% CI, -0.41 to 0.14), and -0.19 for language (95% CI, -0.44 to 0.10). Fourteen children (21%) had myopia greater than -5.00 D in one or both eyes, 7 (10%) had optic nerve atrophy and/or cupping, 20 (29%) had strabismus, 8 (11%) had manifest nystagmus, and 9 (13%) had amblyopia.
    Conclusions: In this study cohort, there was no statistically significant correlation between dosage of bevacizumab and Bayley scores at 2 years. However, the sample size was small and the retention rate relatively low, limiting our conclusions. Rates of high myopia and ocular abnormalities do not differ from those reported after larger bevacizumab doses.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Bevacizumab/therapeutic use ; Retinopathy of Prematurity/drug therapy ; Angiogenesis Inhibitors/therapeutic use ; Vascular Endothelial Growth Factor A ; Gestational Age ; Myopia ; Intravitreal Injections ; Retrospective Studies
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2022.11.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: A Cultural Conscience for Conservation.

    Good, Caroline / Burnham, Dawn / Macdonald, David W

    Animals : an open access journal from MDPI

    2017  Volume 7, Issue 7

    Abstract: On 2 July 2015, the killing of a lion nicknamed "Cecil" prompted the largest global reaction in the history of wildlife conservation. In response to this, it is propitious to consider the ways in which this moment can be developed into a financial ... ...

    Abstract On 2 July 2015, the killing of a lion nicknamed "Cecil" prompted the largest global reaction in the history of wildlife conservation. In response to this, it is propitious to consider the ways in which this moment can be developed into a financial movement to transform the conservation of species such as the lion that hold cultural significance and sentiment but whose numbers in the wild are dwindling dangerously. This provocative piece explores how a species royalty could be used effectively by drawing revenue from the heavy symbolic use of charismatic animals in affluent economies. This would, in turn, reduce strain on limited government funds in threatened animals' native homelands. Three potential areas of lucrative animal symbolism-fashion, sports mascots, and national animals-provide examples of the kind of revenue that could be created from a species royalty. These examples also demonstrate how this royalty could prove to be a desirable means by which both corporations and consumers could positively develop their desired selves while simultaneously contributing to a relevant and urgent cause. These examples intend to ignite a multi-disciplinary conversation on the global cultural economy's use of endangered species symbols. An overhaul in perspective and practice is needed because time is running out for much of the wildlife and their ecosystems that embellish products and embody anthropocentric business identities.
    Language English
    Publishing date 2017-07-20
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani7070052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Cultural Conscience for Conservation

    Good, Caroline / Burnham, Dawn / Macdonald, David W

    Animals. 2017 July 20, v. 7, no. 7

    2017  

    Abstract: On 2 July 2015, the killing of a lion nicknamed “Cecil” prompted the largest global reaction in the history of wildlife conservation. In response to this, it is propitious to consider the ways in which this moment can be developed into a financial ... ...

    Abstract On 2 July 2015, the killing of a lion nicknamed “Cecil” prompted the largest global reaction in the history of wildlife conservation. In response to this, it is propitious to consider the ways in which this moment can be developed into a financial movement to transform the conservation of species such as the lion that hold cultural significance and sentiment but whose numbers in the wild are dwindling dangerously. This provocative piece explores how a species royalty could be used effectively by drawing revenue from the heavy symbolic use of charismatic animals in affluent economies. This would, in turn, reduce strain on limited government funds in threatened animals’ native homelands. Three potential areas of lucrative animal symbolism—fashion, sports mascots, and national animals—provide examples of the kind of revenue that could be created from a species royalty. These examples also demonstrate how this royalty could prove to be a desirable means by which both corporations and consumers could positively develop their desired selves while simultaneously contributing to a relevant and urgent cause. These examples intend to ignite a multi-disciplinary conversation on the global cultural economy’s use of endangered species symbols. An overhaul in perspective and practice is needed because time is running out for much of the wildlife and their ecosystems that embellish products and embody anthropocentric business identities.
    Keywords Felidae ; animals ; corporations ; ecosystems ; endangered species ; income ; sports ; wildlife
    Language English
    Dates of publication 2017-0720
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ISSN 2076-2615
    DOI 10.3390/ani7070052
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Erratum

    Caroline Good / Dawn Burnham / David W. Macdonald

    Animals, Vol 7, Iss 8, p

    Caroline Good; et al.; A Cultural Conscience for Conservation. Animals 2017, 7, 52

    2017  Volume 58

    Abstract: ... n/ ... ...

    Abstract n/a
    Keywords n/a ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Nongenomic actions of aldosterone on the renal tubule.

    Good, David W

    Hypertension (Dallas, Tex. : 1979)

    2007  Volume 49, Issue 4, Page(s) 728–739

    MeSH term(s) Aldosterone/metabolism ; Aldosterone/physiology ; Animals ; Carrier Proteins/physiology ; Genome/physiology ; Humans ; Ion Transport/physiology ; Kidney/physiology ; Kidney Diseases/etiology ; Kidney Tubules/physiology ; Nephrons/physiology ; Receptors, Cell Surface/physiology ; Signal Transduction/physiology
    Chemical Substances Carrier Proteins ; Receptors, Cell Surface ; Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2007-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/01.HYP.0000259797.48382.b2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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