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  1. Article ; Online: Are We Ready to Simplify and Improve LI-RADS?

    Sirlin, Claude B / Chernyak, Victoria

    Radiology

    2023  Volume 309, Issue 3, Page(s) e233164

    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Contrast Media ; Magnetic Resonance Imaging ; Retrospective Studies ; Sensitivity and Specificity
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.233164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: LI-RADS: Future Directions.

    Chernyak, Victoria / Sirlin, Claude B

    Clinical liver disease

    2021  Volume 17, Issue 3, Page(s) 149–153

    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MR Imaging of Chronic Liver Diseases and Liver Cancer.

    Elsayes, Khaled M / Sirlin, Claude B

    Magnetic resonance imaging clinics of North America

    2021  Volume 29, Issue 3, Page(s) xvii–xviii

    MeSH term(s) Contrast Media ; Humans ; Liver ; Liver Diseases/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 1196851-5
    ISSN 1557-9786 ; 1064-9689
    ISSN (online) 1557-9786
    ISSN 1064-9689
    DOI 10.1016/j.mric.2021.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial for "A New Reporting System for Diagnosis of Hepatocellular Carcinoma in Chronic Hepatitis B With Clinical and Gadoxetic Acid-Enhanced MRI Features".

    Chernyak, Victoria / Sirlin, Claude B

    Journal of magnetic resonance imaging : JMRI

    2021  Volume 55, Issue 6, Page(s) 1887–1889

    MeSH term(s) Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/diagnostic imaging ; Contrast Media ; Gadolinium DTPA ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/diagnostic imaging ; Humans ; Liver Neoplasms/pathology ; Magnetic Resonance Imaging ; Retrospective Studies ; Sensitivity and Specificity
    Chemical Substances Contrast Media ; gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.27963
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    Zs.A 3648: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 236: Show issues

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  5. Article ; Online: The LI-RADS adventure-a personal statement.

    Sirlin, Claude B

    Abdominal radiology (New York)

    2017  Volume 43, Issue 1, Page(s) 1–2

    MeSH term(s) Algorithms ; Consensus ; Humans ; Liver Diseases/diagnostic imaging ; Magnetic Resonance Imaging ; Observer Variation ; Radiology Information Systems/standards ; Terminology as Topic ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-12-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-017-1386-y
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    Zs.A 1262: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Editorial for "Interreader Agreement of Liver Imaging Reporting and Data System on MRI: A Systematic Review and Meta Analysis".

    Chernyak, Victoria / Sirlin, Claude B

    Journal of magnetic resonance imaging : JMRI

    2020  Volume 52, Issue 3, Page(s) 805–806

    Abstract: Level of evidence: 5 TECHNICAL EFFICACY STAGE: 2 J. Magn. Reson. Imaging 2020;52:805-806. ...

    Abstract Level of evidence: 5 TECHNICAL EFFICACY STAGE: 2 J. Magn. Reson. Imaging 2020;52:805-806.
    MeSH term(s) Liver/diagnostic imaging ; Magnetic Resonance Imaging ; Reproducibility of Results
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Editorial ; Meta-Analysis ; Systematic Review
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.27133
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 236: Show issues

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  7. Article ; Online: Interpretation, Reporting, and Clinical Applications of Liver MR Elastography.

    Moura Cunha, Guilherme / Fan, Boyan / Navin, Patrick J / Olivié, Damien / Venkatesh, Sudhakar K / Ehman, Richard L / Sirlin, Claude B / Tang, An

    Radiology

    2024  Volume 310, Issue 3, Page(s) e231220

    Abstract: Chronic liver disease is highly prevalent and often leads to fibrosis or cirrhosis and complications such as liver failure and hepatocellular carcinoma. The diagnosis and staging of liver fibrosis is crucial to determine management and mitigate ... ...

    Abstract Chronic liver disease is highly prevalent and often leads to fibrosis or cirrhosis and complications such as liver failure and hepatocellular carcinoma. The diagnosis and staging of liver fibrosis is crucial to determine management and mitigate complications. Liver biopsy for histologic assessment has limitations such as sampling bias and high interreader variability that reduce precision, which is particularly challenging in longitudinal monitoring. MR elastography (MRE) is considered the most accurate noninvasive technique for diagnosing and staging liver fibrosis. In MRE, low-frequency vibrations are applied to the abdomen, and the propagation of shear waves through the liver is analyzed to measure liver stiffness, a biomarker for the detection and staging of liver fibrosis. As MRE has become more widely used in clinical care and research, different contexts of use have emerged. This review focuses on the latest developments in the use of MRE for the assessment of liver fibrosis; provides guidance for image acquisition and interpretation; summarizes diagnostic performance, along with thresholds for diagnosis and staging of liver fibrosis; discusses current and emerging clinical applications; and describes the latest technical developments.
    MeSH term(s) Humans ; Elasticity Imaging Techniques ; Abdomen ; Liver Cirrhosis/diagnostic imaging ; Liver Neoplasms/diagnostic imaging
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.231220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.106: Show issues Location:
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  8. Article ; Online: Is It Time to Expand the Definition of Washout Appearance in LI-RADS?

    Fowler, Kathryn J / Sirlin, Claude B

    Radiology

    2019  Volume 291, Issue 3, Page(s) 658–659

    MeSH term(s) Carcinoma, Hepatocellular ; Gadolinium DTPA ; Humans ; Liver Neoplasms ; Magnetic Resonance Imaging
    Chemical Substances gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2019190552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.106: Show issues Location:
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  9. Article ; Online: Cost-Effectiveness Analysis of Hepatocellular Carcinoma Surveillance in Nonalcoholic Fatty Liver Disease Cirrhosis Using US Visualization Score C-Triggered Abbreviated MRI.

    Mulgaonkar, Ashwini / Huang, Daniel Q / Siddiqi, Harris / Fowler, Kathryn / Sirlin, Claude B / Marks, Robert / Loomba, Rohit / Konijeti, Gauree G

    The American journal of gastroenterology

    2024  

    Abstract: ... with scores A/B did US alone. We performed a sensitivity analysis comparing US plus visualization score ...

    Abstract Introduction: Ultrasound (US) is associated with severe visualization limitations (US Liver Imaging Reporting and Data System visualization score C) in one-third of patients with nonalcoholic fatty liver disease (NAFLD) cirrhosis undergoing hepatocellular carcinoma (HCC) screening. Data suggest abbreviated MRI (aMRI) may improve HCC screening efficacy. This study analyzed the cost-effectiveness of HCC screening strategies, including an US visualization score-based approach with aMRI, in patients with NAFLD cirrhosis.
    Methods: We constructed a Markov model simulating adults with compensated NAFLD cirrhosis in the United States undergoing HCC screening, comparing strategies of US plus visualization score, US alone, or no surveillance. We modeled aMRI in patients with visualization score C and negative US, while patients with scores A/B did US alone. We performed a sensitivity analysis comparing US plus visualization score with US plus alpha fetoprotein or no surveillance. The primary outcome was the incremental cost-effectiveness ratio (ICER), with a willingness-to-pay threshold of $100,000 per quality-adjusted life-year. Sensitivity analyses were performed for all variables.
    Results: US plus visualization score was the most cost-effective strategy, with an ICER of $59,005 relative to no surveillance. The ICER for US alone to US plus visualization score was $822,500. On sensitivity analysis, screening using US plus visualization score remained preferred across several parameters. Even with alpha fetoprotein added to US, the US plus visualization score strategy remained cost-effective, with an ICER of $62,799 compared with no surveillance.
    Discussion: HCC surveillance using US visualization score-based approach, using aMRI for visualization score C, seems to be the most cost-effective strategy in patients with NAFLD cirrhosis.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002636
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  10. Article: Multi-Modality, Multi-Dimensional Characterization of Pediatric Non-Alcoholic Fatty Liver Disease.

    Jamshidi, Neema / Feizi, Alborz / Sirlin, Claude B / Lavine, Joel E / Kuo, Michael D

    Metabolites

    2023  Volume 13, Issue 8

    Abstract: Non-alcoholic fatty liver disease is a multifaceted disease that progresses through multiple phases; it involves metabolic as well as structural changes. These alterations can be measured directly or indirectly through blood, non-invasive imaging, and/or ...

    Abstract Non-alcoholic fatty liver disease is a multifaceted disease that progresses through multiple phases; it involves metabolic as well as structural changes. These alterations can be measured directly or indirectly through blood, non-invasive imaging, and/or tissue analyses. While some studies have evaluated the correlations between two sets of measurements (e.g., histopathology with cross-sectional imaging or blood biomarkers), the interrelationships, if any, among histopathology, clinical blood profiles, cross-sectional imaging, and metabolomics in a pediatric cohort remain unknown. We created a multiparametric clinical MRI-histopathologic NMR network map of pediatric NAFLD through multimodal correlation networks, in order to gain insight into how these different sets of measurements are related. We found that leptin and other blood markers were correlated with many other measurements; however, upon filtering out the blood biomarkers, the network was decomposed into three independent hubs centered around histopathological features, each with associated MRI and plasma metabolites. These multi-modality maps could serve as a framework for characterizing disease status and progression and could potentially guide medical interventions.
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13080929
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