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  1. Article: How Epileptic Spikes Impair Memory.

    Gotman, Jean

    Epilepsy currents

    2021  Volume 22, Issue 1, Page(s) 31–32

    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/15357597211051940
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  2. Article: Can EEG Abnormalities be a Biomarker of Epileptogenesis?

    Gotman, Jean

    Epilepsy currents

    2021  Volume 21, Issue 3, Page(s) 157–158

    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759721999681
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  3. Article: How Would You Like Your Epileptic Network? Linear, Nonlinear, Virtual?

    Gotman, Jean

    Epilepsy currents

    2020  Volume 20, Issue 2, Page(s) 80–82

    Language English
    Publishing date 2020-02-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759720904161
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  4. Article ; Online: Understanding Heightened Seizure Risk: The Pro-Ictal State.

    Wiebe, Samuel / Gotman, Jean

    NEJM evidence

    2023  Volume 2, Issue 3, Page(s) EVIDe2300004

    Abstract: The large-scale neuronal networks that underpin normal brain function are disrupted during seizures, which are characterized by a transition to abnormal, hypersynchronous neuronal activity. Many factors can contribute to transitions from interictal to ... ...

    Abstract The large-scale neuronal networks that underpin normal brain function are disrupted during seizures, which are characterized by a transition to abnormal, hypersynchronous neuronal activity. Many factors can contribute to transitions from interictal to ictal states, and an enduring predisposition to spontaneous, dynamic changes results in recurrent seizures - that is, epilepsy. Unpredictability and the apparent randomness of seizure occurrence seem to be a hallmark of many epilepsies, yet clinicians and patients are aware of periods during which a variety of converging factors may increase the risk of seizures.
    MeSH term(s) Humans ; Electroencephalography/methods ; Seizures ; Brain ; Epilepsy ; Neurons
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Editorial
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDe2300004
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  5. Article: Not Just Where, But How Does a Seizure Start?

    Gotman, Jean

    Epilepsy currents

    2019  Volume 19, Issue 4, Page(s) 229–230

    Abstract: The Repertoire of Seizure Onset Patterns in Human Focal Epilepsies: Determinants and Prognostic Values: Methods: To this end, we analyzed 820 seizures from 252 consecutive patients explored by stereoelectroencephalography (total of 2148 electrodes), ... ...

    Abstract The Repertoire of Seizure Onset Patterns in Human Focal Epilepsies: Determinants and Prognostic Values
    Methods: To this end, we analyzed 820 seizures from 252 consecutive patients explored by stereoelectroencephalography (total of 2148 electrodes), including various forms of focal refractory epilepsies. We used a reproducible method combining visual and time-frequency analyses.
    Results: We described 8 SOPs: low-voltage fast activity (LVFA), preictal spiking followed by LVFA, burst of polyspikes followed by LVFA, slow wave/DC shift followed by LVFA, sharp theta/alpha waves, beta sharp waves, rhythmic spikes/spike-waves, and delta-brush. Low-voltage fast activity occurred in 79% of patients. The SOP was significantly associated with (1) underlying etiology (burst of polyspikes followed by LVFA with the presence of a focal cortical dysplasia, LVFA with malformation of cortical development, postvascular and undetermined epilepsies), (2) spatial organization of the epileptogenic zone (EZ; burst of polyspikes followed by LVFA with focal organization, slow wave/DC shift followed by LVFA with network organization), and (3) postsurgical seizure outcome (better outcome when LVFA present).
    Significance: This study demonstrates that the main determinants of the SOP are the underlying etiology and the spatial organization of the EZ. Concerning the postsurgical seizure outcome, the main determinant factor is the spatial organization of the EZ, but the SOP plays also a role, conferring better prognosis when LVFA is present.
    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759719854756
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  6. Article ; Online: Delineating the epileptogenic zone: spikes versus oscillations.

    Perucca, Piero / Gotman, Jean

    The Lancet. Neurology

    2022  Volume 21, Issue 11, Page(s) 949–951

    MeSH term(s) Humans ; Electroencephalography ; Brain Mapping
    Language English
    Publishing date 2022-10-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00396-9
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  7. Article ; Online: Oh surprise! Fast ripples on scalp EEG.

    Gotman, Jean

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2018  Volume 129, Issue 7, Page(s) 1449–1450

    MeSH term(s) Biomarkers ; Child ; Electroencephalography ; Epilepsy ; Humans ; Scalp ; Tuberous Sclerosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-04-30
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2018.04.612
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  8. Article ; Online: Gamma oscillations or spikes?

    Gotman, Jean

    Epilepsia

    2016  Volume 57, Issue 9, Page(s) 1523–1524

    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Letter
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.13459
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  9. Article ; Online: Electroencephalography-functional magnetic resonance imaging for clinical evaluation in focal epilepsy.

    Ikemoto, Satoru / Pana, Raluca / von Ellenrieder, Nicolás / Gotman, Jean

    Epilepsia open

    2023  Volume 9, Issue 1, Page(s) 84–95

    Abstract: Objective: We aimed to evaluate the contribution of simultaneous recording of electroencephalography-functional magnetic resonance imaging (EEG-fMRI) in the diagnosis of epilepsy syndrome, localization of the epileptogenic zone (EZ), and decision-making ...

    Abstract Objective: We aimed to evaluate the contribution of simultaneous recording of electroencephalography-functional magnetic resonance imaging (EEG-fMRI) in the diagnosis of epilepsy syndrome, localization of the epileptogenic zone (EZ), and decision-making regarding surgical treatment.
    Methods: We performed a retrospective study to evaluate patients with focal epilepsy who underwent EEG-fMRI. Two evaluators assessed epilepsy syndrome, presumed focus, and surgical candidacy and defined confidence levels. They assessed these clinical characteristics first without EEG-fMRI and then including EEG-fMRI to assess how the results of EEG-fMRI changed the evaluations. We also determined how the clinical evaluation was affected by the concordance level between the blood oxygen level-dependent (BOLD) response and the presumed focus location, and by the confidence level of the BOLD response itself based on the t-value of the primary and secondary clusters.
    Results: Fifty-one scans from 48 patients were included. The BOLD map affected 66.7% of the evaluations by altering evaluation items (epilepsy syndrome, presumed focus, or surgical candidacy) or their confidence levels. EEG-fMRI results increased the confidence levels of epilepsy syndrome, presumed focus, or surgical candidacy in 47.1% of patients but reduced clinical confidence in these features in 11.8%. More specifically, the confidence levels increased for epilepsy syndrome in 28.5%, identification of presumed focus in 33.9%, and determination of surgical candidacy in 29.4%. The BOLD signal confidence level, whether high or low, did not influence these clinical factors.
    Significance: Previous studies have emphasized the utility of EEG-fMRI for the localization of the epileptogenic zone. This study demonstrated the potential of EEG-fMRI to influence clinical confidence when determining epilepsy syndrome, the presumed epileptic focus, and surgical candidacy.
    MeSH term(s) Humans ; Retrospective Studies ; Brain Mapping/methods ; Epilepsies, Partial/diagnostic imaging ; Electroencephalography/methods ; Magnetic Resonance Imaging/methods ; Epileptic Syndromes
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12829
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  10. Article ; Online: Region-specific complexity of the intracranial EEG in the sleeping human brain.

    Olejarczyk, Elzbieta / Gotman, Jean / Frauscher, Birgit

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 451

    Abstract: As the brain is a complex system with occurrence of self-similarity at different levels, a dedicated analysis of the complexity of brain signals is of interest to elucidate the functional role of various brain regions across the various stages of ... ...

    Abstract As the brain is a complex system with occurrence of self-similarity at different levels, a dedicated analysis of the complexity of brain signals is of interest to elucidate the functional role of various brain regions across the various stages of vigilance. We exploited intracranial electroencephalogram data from 38 cortical regions using the Higuchi fractal dimension (HFD) as measure to assess brain complexity, on a dataset of 1772 electrode locations. HFD values depended on sleep stage and topography. HFD increased with higher levels of vigilance, being highest during wakefulness in the frontal lobe. HFD did not change from wake to stage N2 in temporo-occipital regions. The transverse temporal gyrus was the only area in which the HFD did not differ between any two vigilance stages. Interestingly, HFD of wakefulness and stage R were different mainly in the precentral gyrus, possibly reflecting motor inhibition in stage R. The fusiform and parahippocampal gyri were the only areas showing no difference between wakefulness and N2. Stages R and N2 were similar only for the postcentral gyrus. Topographical analysis of brain complexity revealed that sleep stages are clearly differentiated in fronto-central brain regions, but that temporo-occipital regions sleep differently.
    MeSH term(s) Arousal/physiology ; Brain/physiology ; Electrocorticography ; Humans ; Sleep Stages/physiology
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-04213-8
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