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Article: Predictors of Depression in Elderly According to Gender during COVID-19: Using the Data of 2020 Community Health Survey.

Jun, Hye-Jung / Kim, Kyoung-Mi

2024 Volume 12, Issue 5

Abstract: Background: This study aimed to examine factors influencing depression according to gender in people during COVID-19.: Methods: This study was conducted on 61,147 elderly individuals over the age of 65 who participated in the 2020 Community Health ... ...

Abstract	Background: This study aimed to examine factors influencing depression according to gender in people during COVID-19. Methods: This study was conducted on 61,147 elderly individuals over the age of 65 who participated in the 2020 Community Health Survey (CHS). Data analysis was conducted using SAS 9.4. Results: Elderly females had a higher perceived fear of COVID-19 than males. The common factors affecting depression in elderly individuals were age, monthly income, economic activity, stress, subjective health status, and social support. Among elderly women, changes in residential areas and daily life due to COVID-19 were identified as factors affecting depression. Conclusions: Therefore, during COVID-19, it was necessary to provide customized depression relief programs for the elderly, and it was necessary to find ways for them to positively perceive their health status and increase healthcare efficacy. In the future, it is necessary to pay attention to elderly women living in rural areas and make efforts to ensure that their daily lives are not interrupted by infectious diseases.
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12050551
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Article ; Online: Calcifying Odontogenic Cyst Demonstrates Recurrent WNT Pathway Mutations and So-Called Adenoid Ameloblastoma-Like Histology: Evidence Supporting Its Classification as a Neoplasm.

Oh, Kyu-Young / Kim, Ji-Hoon / Yoon, Hye-Jung

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2024 Volume 37, Issue 6, Page(s) 100484

Abstract: Calcifying odontogenic cyst (COC), once called calcifying cystic odontogenic tumor, is classified under the category of odontogenic cysts. However, the proliferative capacity of the lesional epithelium and consistent nuclear β-catenin expression raise ... ...

Abstract	Calcifying odontogenic cyst (COC), once called calcifying cystic odontogenic tumor, is classified under the category of odontogenic cysts. However, the proliferative capacity of the lesional epithelium and consistent nuclear β-catenin expression raise questions about its current classification. This study aimed to determine whether COC would be better classified as a neoplasm in the histologic and molecular context. Eleven odontogenic lesions diagnosed as COC or calcifying cystic odontogenic tumor were included in this study. The growth patterns of the lesional epithelium were analyzed histologically in all cases. β-catenin immunohistochemistry and molecular profiling using Sanger sequencing and whole-exome sequencing were performed in 10 cases. Of the 11 cases studied, histologic features reminiscent of so-called adenoid ameloblastoma were observed in 72.7% (8/11), and small islands of clear cells extended into the wall in 36.4% (4/11). Intraluminal and/or mural epithelial proliferation was found in 72.7% of the cases (8/11). Nuclear β-catenin expression was observed focally in all 10 cases studied, mainly highlighting epithelial cells forming morules and adjacent to dentinoid. CTNNB1 hotspot mutations were detected in 60.0% of the cases (6/10). All the remaining cases had frameshift mutations in tumor-suppressor genes involved in the WNT pathway, including APC and NEDD4L. Recurrent WNT pathway mutations leading to nuclear translocation of β-catenin and distinct epithelial growth patterns found in COC are the neoplastic features shared by its solid counterpart, dentinogenic ghost cell tumor, supporting its classification as a tumor rather than a cyst.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1016/j.modpat.2024.100484
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Zs.A 2450: Show issues

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Article: Blackcurrant Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice.

Moon, Hye-Jung / Cha, Youn-Soo / Kim, Kyung-Ah

Foods (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: Previous studies have reported that anthocyanin (ACN)-rich materials have beneficial effects on ulcerative colitis (UC). Blackcurrant (BC) has been known as one of the foods rich in ACN, while studies demonstrating its effect on UC are rare. This study ... ...

Abstract	Previous studies have reported that anthocyanin (ACN)-rich materials have beneficial effects on ulcerative colitis (UC). Blackcurrant (BC) has been known as one of the foods rich in ACN, while studies demonstrating its effect on UC are rare. This study attempted to investigate the protective effects of whole BC in mice with colitis using dextran sulfate sodium (DSS). Mice were orally given whole BC powder at a dose of 150 mg daily for four weeks, and colitis was induced by drinking 3% DSS for six days. Whole BC relieved symptoms of colitis and pathological changes in the colon. The overproduction of pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-6 in serum and colon tissues was also reduced by whole BC. In addition, whole BC significantly lowered the levels of mRNA and protein of downstream targets in the NF-κB signaling pathway. Furthermore, BC administration increased the expression of genes related to barrier function: ZO-1, occludin, and mucin. Moreover, the whole BC modulated the relative abundance of gut microbiota altered with DSS. Therefore, the whole BC has demonstrated the potential to prevent colitis through attenuation of the inflammatory response and regulation of the gut microbial composition.
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12051073
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Article ; Online: Impact of 17β-Estradiol on the Shape, Survival, Osteogenic Transformation, and mRNA Expression of Gingiva-Derived Stem Cell Spheroids.

Kim, Ju-Hwan / Lee, Hyun-Jin / Song, Hye-Jung / Park, Jun-Beom

Medicina (Kaunas, Lithuania)

2023 Volume 60, Issue 1

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Core Binding Factor Alpha 1 Subunit ; Gingiva ; Osteogenesis/genetics ; Stem Cells ; Estradiol/pharmacology ; RNA, Messenger
Chemical Substances	Core Binding Factor Alpha 1 Subunit ; Estradiol (4TI98Z838E) ; RNA, Messenger
Language	English
Publishing date	2023-12-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60010060
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Zs.A 6270: Show issues

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Article ; Online: From antibody specificity to T cell recognition.

Kim, Hye-Jung / Cantor, Harvey

The Journal of experimental medicine

2021 Volume 218, Issue 4

Abstract: Landsteiner's definition of human blood groups and the genetic rules that govern blood transfusion represents a milestone in human genetics and a historic event in public health. His research into the specificity of serological reactions, although less ... ...

Abstract	Landsteiner's definition of human blood groups and the genetic rules that govern blood transfusion represents a milestone in human genetics and a historic event in public health. His research into the specificity of serological reactions, although less well known, has had a critical influence on the development of contemporary views on immune recognition, clonal selection, and immunological self-tolerance.
MeSH term(s)	Animals ; Antibody Specificity ; Blood Transfusion/history ; Erythrocytes/immunology ; Hemagglutination/immunology ; History, 20th Century ; Humans ; Immunity, Cellular ; Isoantibodies/history ; Rh-Hr Blood-Group System/history ; Self Tolerance ; T-Lymphocytes/immunology
Chemical Substances	Isoantibodies ; Rh-Hr Blood-Group System
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20202038
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Article ; Online: Effect of recombinant human bone morphogenetic protein-2 and osteoprotegerin-Fc in MC3T3-E1 cells.

Kim, Sang-Hyon / Choi, Hye-Jung / Lee, Sang-Min / Yoon, Dae Sung / Son, Chang-Nam

Journal of rheumatic diseases

2024 Volume 31, Issue 2, Page(s) 79–85

Abstract: Objective: We compared the osteoblastogenesis by serially administrating recombinant human bone morphogenetic protein-2 (rhBMP-2) and osteoprotegerin-immunoglobulin Fc segment complex (OPG-Fc).: Methods: The MC3T3-E1 preosteoblast cell line was ... ...

Abstract	Objective: We compared the osteoblastogenesis by serially administrating recombinant human bone morphogenetic protein-2 (rhBMP-2) and osteoprotegerin-immunoglobulin Fc segment complex (OPG-Fc). Methods: The MC3T3-E1 preosteoblast cell line was differentiated for 1, 3, and 7 days with a treatment of OPG-Fc in 10~200 ng/mL concentration and the cell viability was evaluated by Cell Counting Kit-8 analysis. The level of differentiation from MC3T3-E1 cells to osteoblasts was determined by alkaline phosphatase activity. The level of runt domain-containing transcription factor 2 (Runx2) and osteopontin (OPN) manifestation, involved in osteoblast differentiation, was examined by real-time polymerase chain reaction and western blotting. Results: During MC3T3-E1 cell differentiation, the differentiation level was high with 1-day treatment using 100 ng/mL OPG-Fc. The treatment with 50 ng/mL rhBMP-2 for 7 days, followed by 1-day treatment with 100 ng/mL OPG-Fc produced the highest differentiation level, which was approximately 5.3 times that of the control group (p<0.05). The expression of Runx2 mRNA significantly increased, reaching 2.5 times the level of the control group under the condition of 7-day treatment with rhBMP-2 and 1-day treatment with OPG-Fc (p<0.001). The expression of Runx2 protein significantly increased to approximately 5.7 times that of the control group under the condition of 7-day treatment with rhBMP-2, followed by 1-day treatment with OPG-Fc (p<0.01). The expression of OPN protein showed no change from that of the control group under various conditions of rhBMP-2 and OPG-Fc combinations. Conclusion: These results imply that the treating preosteoblasts with rhBMP-2 first and then with OPG-Fc increased osteoblast differentiation efficacy.
Language	English
Publishing date	2024-02-01
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2233-4718
ISSN (online)	2233-4718
DOI	10.4078/jrd.2023.0043
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Article: Correction: GPR110 promotes progression and metastasis of triple-negative breast cancer.

Nam, Hye-Jung / Kim, Yeon-Ju / Kang, Jae-Hyeok / Lee, Su-Jae

Cell death discovery

2022 Volume 8, Issue 1, Page(s) 483

Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Published Erratum
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-022-01266-0
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Article ; Online: Sialadenoma papilliferum-like intraductal papillary tumour: an emerging entity with intercalated duct differentiation showing MAPK pathway activation in both ductal and myoepithelial cells.

Oh, Kyu-Young / Kim, Ji-Hoon / Hong, Seong-Doo / Yoon, Hye-Jung

Pathology

2023 Volume 56, Issue 1, Page(s) 52–58

Abstract: Sialadenoma papilliferum-like intraductal papillary tumour (SP-IPT) is a recently described salivary gland tumour that shows identical morphology to sialadenoma papilliferum (SP) except for the lack of an exophytic papillary component. However, the ... ...

Abstract	Sialadenoma papilliferum-like intraductal papillary tumour (SP-IPT) is a recently described salivary gland tumour that shows identical morphology to sialadenoma papilliferum (SP) except for the lack of an exophytic papillary component. However, the immunohistochemical phenotypes and molecular profiles of SP-IPT remain unclear. This study aims to report new cases of SP-IPT and to determine its cellular differentiation and molecular basis. After histopathological review, four cases of SP-IPT were retrieved. Immunohistochemical staining was performed to analyse the expression patterns of cytokeratin 7 (CK7), p63, smooth muscle actin (SMA), vimentin, S100, mammaglobin, androgen receptor, SOX10, BRAF V600E-mutated protein, and phosphorylated ERK. Sanger sequencing was performed to determine the mutation status of the BRAF, KRAS, NRAS, and HRAS genes. All four cases affected the posterior mandible with a mean age of 62 years and a male-to-female ratio of 3:1. Histologically, all cases consisted of multiple tubular and cystic structures with varying sizes and shapes. The tubulocystic components were lined by a double or few-layered epithelium frequently showing a micropapillary pattern. The outer layer consisted of a rim of myoepithelial cells, which were CK7+/p63+/SMA+/vimentin+/S100+/SOX10+. The inner ductal cells were CK7+/S100+/SOX10+, consistent with intercalated duct differentiation. All cases harboured BRAF V600E mutations, but no other mutations were detected. The BRAF V600E-mutated protein and phosphorylated ERK were expressed in both ductal and myoepithelial cells. These findings demonstrate the immunohistochemical and molecular similarities between SP-IPT and SP and the role and extent of MAPK pathway activation in the pathogenesis of SP-IPT.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Vimentin ; Proto-Oncogene Proteins B-raf/genetics ; Salivary Gland Neoplasms/genetics ; Salivary Gland Neoplasms/pathology ; Epithelial Cells/pathology ; Neoplasms, Glandular and Epithelial ; Cell Differentiation
Chemical Substances	Vimentin ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2023.09.004
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Zs.A 723: Show issues

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Article ; Online: Proteomic analysis of sequential isolates of multidrug-resistant Mycobacterium tuberculosis during treatment failure.

Lee, Da-Gyum / Kim, Hye-Jung / Park, Mi-Jung / Hong, Ji-Hye / Ryoo, Sungweon

The Journal of infection

2022 Volume 85, Issue 5, Page(s) e137–e139

MeSH term(s)	Antitubercular Agents/therapeutic use ; Humans ; Mycobacterium tuberculosis ; Proteomics ; Treatment Failure ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2022-08-17
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.08.010
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Article ; Online: A new chapter in the CD8 T reg story.

Cantor, Harvey / Kim, Hye-Jung

The Journal of experimental medicine

2020 Volume 218, Issue 1

Abstract: CD8+ T reg cells play an important role in the maintenance of self-tolerance and can inhibit the development of autoimmune disease. In this issue of JEM, Mishra et al. (https://doi.org/10.1084/jem.20200030) reveal that TGF-β signaling and an Eomes- ... ...

Abstract	CD8+ T reg cells play an important role in the maintenance of self-tolerance and can inhibit the development of autoimmune disease. In this issue of JEM, Mishra et al. (https://doi.org/10.1084/jem.20200030) reveal that TGF-β signaling and an Eomes-dependent genetic program contribute to CD8 T reg cell differentiation and function.
MeSH term(s)	CD8-Positive T-Lymphocytes ; Cell Differentiation ; Immune Tolerance ; Self Tolerance
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20201746
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