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  1. Article ; Online: Postextubation Respiratory Support: Of Clinical Trials and Clinical Decisions.

    Goligher, Ewan C / Peñuelas, Oscar

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 3, Page(s) 245–247

    MeSH term(s) Airway Extubation ; Humans ; Ventilator Weaning
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202104-0844ED
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  2. Article ; Online: Noninvasive ventilation for acute respiratory failure: the next step is to know when to stop.

    Peñuelas, Óscar / Esteban, Andrés

    The European respiratory journal

    2018  Volume 52, Issue 2

    MeSH term(s) Dyspnea ; Humans ; Noninvasive Ventilation ; Prevalence ; Prognosis ; Prospective Studies ; Respiratory Insufficiency ; Risk Factors
    Language English
    Publishing date 2018-08-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01185-2018
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    Zs.MO 292: Show issues

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  3. Article ; Online: Invasive Mechanical Ventilation in Chronic Obstructive Pulmonary Disease Exacerbations.

    Peñuelas, Óscar / Frutos-Vivar, Fernando / Mancebo, Jordi

    Seminars in respiratory and critical care medicine

    2020  Volume 41, Issue 6, Page(s) 798–805

    Abstract: Chronic obstructive pulmonary disease (COPD) continues to be an important cause of morbidity, mortality, and health care costs worldwide. Although there exist some heterogeneity between patients, the course of COPD is characterized by recurrent acute ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) continues to be an important cause of morbidity, mortality, and health care costs worldwide. Although there exist some heterogeneity between patients, the course of COPD is characterized by recurrent acute exacerbations, which are among the most common causes of medical admission to hospital. Patients with frequent exacerbations have accelerated lung function decline, worse quality of life, and greater mortality. Therefore, interest is growing in assessing the effectiveness of interventions used to treat exacerbations. The present review summarizes the current evidence regarding the use of ventilatory management to treat COPD and the implementation of novel cost-effective strategies, such as high-flow oxygenation or extracorporeal carbon dioxide removal to improve clinical outcomes and functional recovery in this disease and to reduce the associated costs.
    MeSH term(s) Disease Progression ; Hospital Mortality ; Humans ; Lung/physiopathology ; Oxygen Inhalation Therapy ; Pulmonary Disease, Chronic Obstructive/mortality ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0040-1714396
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    Zs.A 1555: Show issues Location:
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  4. Article: Bringing translational research in acute lung injury closer.

    Peñuelas, Oscar / Rello, Jordi

    Annals of translational medicine

    2015  Volume 6, Issue 2, Page(s) 22

    Language English
    Publishing date 2015-06-04
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2017.12.29
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  5. Article: MicroRNAs as biomarkers of acute lung injury.

    Ferruelo, Antonio / Peñuelas, Óscar / Lorente, José A

    Annals of translational medicine

    2018  Volume 6, Issue 2, Page(s) 34

    Abstract: Acute respiratory distress syndrome (ARDS) is a common and complex inflammatory lung diseases affecting critically ill patients requiring mechanical ventilation. MicroRNAs (miRNAs), a novel pathway of non-coding RNA molecules that regulate gene ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is a common and complex inflammatory lung diseases affecting critically ill patients requiring mechanical ventilation. MicroRNAs (miRNAs), a novel pathway of non-coding RNA molecules that regulate gene expression at the post-transcriptional level, have emerged as a novel class of gene expression, and can play important roles in inflammation or apoptosis, which are common manifestations of ARDS and diffuse alveolar damage (DAD). In the present review, we discuss the role of miRNAs as biomarkers of ARDS and DAD, and their potential use as therapeutic targets for this condition.
    Language English
    Publishing date 2018-02-05
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.01.10
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  6. Article ; Online: Early acute kidney injury is associated with in-hospital adverse outcomes in critically ill burn patients: an observational study.

    Martins, Judith / Nin, Nicolás / Muriel, Alfonso / Peñuelas, Óscar / Vasco, Dovami / Vaquero, Pablo / Schultz, Marcus J / Lorente, José A

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 38, Issue 9, Page(s) 2002–2008

    Abstract: Background: There are no studies in large series of burn patients on the relationship between acute kidney injury (AKI) and adverse outcomes using the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.: Methods: We retrospectively analysed ...

    Abstract Background: There are no studies in large series of burn patients on the relationship between acute kidney injury (AKI) and adverse outcomes using the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.
    Methods: We retrospectively analysed data from a cohort of burn patients admitted to the intensive care unit (ICU) with the diagnosis of burn injury. The diagnosis of AKI over the first 7 days after injury was made according to the KDIGO guidelines. The primary outcome was ICU mortality. We used estimative models using univariable and multivariable logistic regression analyses.
    Results: A total of 960 patients were studied and AKI was diagnosed in 50.5%. In multivariable analysis, AKI was associated, as compared with patients without AKI, with ICU mortality {adjusted odds ratio [aOR] 2.135 [95% confidence interval (CI) 1.384-3.293]} and secondary outcomes [kidney replacement therapy, aOR 4.030 (95% CI 1.838-8.835); infection, aOR 1.437 (95% CI 1.107-1.866); hospital mortality, aOR 1.652 (95% CI 1.139-2.697)]. AKI stage 1 was associated with a higher ICU [aOR 1.869 (95% CI 1.183-2.954)] and hospital mortality [aOR 1.552 (95% CI 1.050-2.296)] and infection [aOR 1.383 (95% CI 1.049-1.823)]. AKI meeting the urine output (UO) criterion alone was not associated with increased mortality. Ignoring the UO criterion would have missed 50 (10.3%) cases with AKI.
    Conclusion: The KDIGO guidelines are useful to diagnose AKI in burn patients. Even the mild form of AKI is independently associated with increased mortality. Considering the UO criterion is important to more accurately assess the incidence of AKI, but AKI meeting the UO criterion alone is not associated with increased mortality.
    MeSH term(s) Humans ; Retrospective Studies ; Critical Illness/epidemiology ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Intensive Care Units ; Burns/complications ; Burns/therapy ; Hospitals
    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfac339
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  7. Article: Invasive Mechanical Ventilation in Chronic Obstructive Pulmonary Disease Exacerbations

    Peñuelas, Óscar / Frutos-Vivar, Fernando / Mancebo, Jordi

    Seminars in Respiratory and Critical Care Medicine

    (COPD in the Intensive Care Unit)

    2020  Volume 41, Issue 06, Page(s) 798–805

    Abstract: Chronic obstructive pulmonary disease (COPD) continues to be an important cause of morbidity, mortality, and health care costs worldwide. Although there exist some heterogeneity between patients, the course of COPD is characterized by recurrent acute ... ...

    Series title COPD in the Intensive Care Unit
    Abstract Chronic obstructive pulmonary disease (COPD) continues to be an important cause of morbidity, mortality, and health care costs worldwide. Although there exist some heterogeneity between patients, the course of COPD is characterized by recurrent acute exacerbations, which are among the most common causes of medical admission to hospital. Patients with frequent exacerbations have accelerated lung function decline, worse quality of life, and greater mortality. Therefore, interest is growing in assessing the effectiveness of interventions used to treat exacerbations. The present review summarizes the current evidence regarding the use of ventilatory management to treat COPD and the implementation of novel cost-effective strategies, such as high-flow oxygenation or extracorporeal carbon dioxide removal to improve clinical outcomes and functional recovery in this disease and to reduce the associated costs.
    Keywords chronic obstructive pulmonary disease ; exacerbation ; mechanical ventilation
    Language English
    Publishing date 2020-08-03
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0040-1714396
    Database Thieme publisher's database

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  8. Article ; Online: Assessing intraspecific trait variability during seedling establishment to improve restoration of tropical dry forests

    Oscar R. Lanuza / Josep M. Espelta / Josep Peñuelas / Guille Peguero

    Ecosphere, Vol 11, Iss 2, Pp n/a-n/a (2020)

    2020  

    Abstract: Abstract Forest restoration is an effective tool to mitigate climate change, but its implementation in highly diverse and threatened tropical dry forests (TDFs) is particularly challenging due to the hostile environment. Intraspecific trait variability ( ... ...

    Abstract Abstract Forest restoration is an effective tool to mitigate climate change, but its implementation in highly diverse and threatened tropical dry forests (TDFs) is particularly challenging due to the hostile environment. Intraspecific trait variability (ITV) in response to these constraints may be very informative for predicting the potential for species acclimation and therefore for improving trait‐based species screenings that best match each particular scenario of forest restoration. We analyzed ITV during seedling establishment of three widely distributed and ecologically contrasting TDF species in a greenhouse multifactorial experiment crossing levels of resource availability (nutrients and water) and herbivory to assess the capacity of ITV to discern strategies of seedling establishment and to predict species’ growth rates and acclimation potential. The three species studied had contrasting responses to the experimental treatments, suggesting different strategies of seedling establishment. The species with the most plastic pattern of growth performed the best, especially due to its ability to modulate the trade‐off of root‐to‐shoot allocation of biomass depending on nutrient availability. Almost 50% of the variation in the root mass ratio was within species, half of which was a direct response of the treatments, indicating a strong acclimation potential. Individual‐level trait measurements, however, were poor predictors of seedling growth rates. ITV, particularly the ability to adapt the pattern of biomass allocation, can be critical during seedling establishment. We propose incorporating information about ITV and the ability of species to modulate their phenotypic expression to cope with environmental variability into programs of forest restoration. Easily implemented and standardized greenhouse experiments are an inexpensive way to obtain high‐quality data on the plasticity of forest species, which can be very valuable for predicting the potential of species acclimation and thus improving the selection ...
    Keywords biomass allocation ; forest restoration ; functional traits ; intraspecific trait variability ; plasticity ; seedlings ; Ecology ; QH540-549.5
    Subject code 580 ; 590
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Searching for the Lost Road of the Non-Invasive Positive Pressure Ventilation in the Acute Respiratory Distress Syndrome

    Óscar Peñuelas / Fernando Frutos-Vivar / Andrés Esteban

    Eurasian Journal of Emergency Medicine, Vol 16, Iss 3, Pp 90-

    2017  Volume 91

    Keywords Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Multidisciplinary Consensus on the Management of Non-Invasive Respiratory Support in the COVID-19 Patient.

    Luján, Manel / Cinesi Gómez, César / Peñuelas, Oscar / Ferrando, Carlos / Heili-Frades, Sarah Béatrice / Carratalá Perales, José Manuel / Mas, Arantxa / Sayas Catalán, Javier / Mediano, Olga / Roca, Oriol / García Fernández, Javier / González Varela, Antonio / Sempere Montes, Gonzalo / Rialp Cervera, Gemma / Hernández, Gonzalo / Millán, Teresa / Ferrer Monreal, Miquel / Egea Santaolalla, Carlos

    Archivos de bronconeumologia

    2024  

    Abstract: Acute respiratory failure due to COVID-19 pneumonia often requires a comprehensive approach that includes non-pharmacological strategies such as non-invasive support (including positive pressure modes, high flow therapy or awake proning) in addition to ... ...

    Abstract Acute respiratory failure due to COVID-19 pneumonia often requires a comprehensive approach that includes non-pharmacological strategies such as non-invasive support (including positive pressure modes, high flow therapy or awake proning) in addition to oxygen therapy, with the primary goal of avoiding endotracheal intubation. Clinical issues such as determining the optimal time to initiate non-invasive support, choosing the most appropriate modality (based not only on the acute clinical picture but also on comorbidities), establishing criteria for recognition of treatment failure and strategies to follow in this setting (including palliative care), or implementing de-escalation procedures when improvement occurs are of paramount importance in the ongoing management of severe COVID-19 cases. Organizational issues, such as the most appropriate setting for management and monitoring of the severe COVID-19 patient or protective measures to prevent virus spread to healthcare workers in the presence of aerosol-generating procedures, should also be considered. While many early clinical guidelines during the pandemic were based on previous experience with acute respiratory distress syndrome, the landscape has evolved since then. Today, we have a wealth of high-quality studies that support evidence-based recommendations to address these complex issues. This document, the result of a collaborative effort between four leading scientific societies (SEDAR, SEMES, SEMICYUC, SEPAR), draws on the experience of 25 experts in the field to synthesize knowledge to address pertinent clinical questions and refine the approach to patient care in the face of the challenges posed by severe COVID-19 infection.
    Language Spanish
    Publishing date 2024-03-04
    Publishing country Spain
    Document type Practice Guideline
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2024.02.017
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