LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 201

Search options

  1. Article: Prediction of ground vibrations induced by rail traffic in Lisbon urban area.

    Manso, João / Gomes, Jorge / Marcelino, João

    Heliyon

    2022  Volume 8, Issue 7, Page(s) e10001

    Abstract: The possibility of introducing high-speed trains in Portugal will challenge the regular train circulation of existing railways tracks. To carry this traffic, improvements and maintenance programmes will be intensified together with the evaluation of the ... ...

    Abstract The possibility of introducing high-speed trains in Portugal will challenge the regular train circulation of existing railways tracks. To carry this traffic, improvements and maintenance programmes will be intensified together with the evaluation of the railway performance and its consequences on neighbourhood structures, including the execution of several vibration measurement tests. One of them was performed in Lisbon's urban area for measure of ground-borne vibration due to the train traffic. It was used to develop an efficient numerical model, which allowed to study the influence of introducing high-speed vehicles on the generation and propagation of vibrations through the free field and the impact on the wayside buildings. To access the effect of introducing such trains in the existing tracks, three bi-dimensional numerical models for each measurement profile were developed. Numerical models were calibrated using the monitoring records. Then, new simulations were performed with Thalys
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Prediction of ground vibrations induced by rail traffic in Lisbon urban area

    Manso, João / Gomes, Jorge / Marcelino, João

    Heliyon. 2022 July, v. 8, no. 7 p.e10001-

    2022  

    Abstract: The possibility of introducing high-speed trains in Portugal will challenge the regular train circulation of existing railways tracks. To carry this traffic, improvements and maintenance programmes will be intensified together with the evaluation of the ... ...

    Abstract The possibility of introducing high-speed trains in Portugal will challenge the regular train circulation of existing railways tracks. To carry this traffic, improvements and maintenance programmes will be intensified together with the evaluation of the railway performance and its consequences on neighbourhood structures, including the execution of several vibration measurement tests. One of them was performed in Lisbon's urban area for measure of ground-borne vibration due to the train traffic. It was used to develop an efficient numerical model, which allowed to study the influence of introducing high-speed vehicles on the generation and propagation of vibrations through the free field and the impact on the wayside buildings. To access the effect of introducing such trains in the existing tracks, three bi-dimensional numerical models for each measurement profile were developed. Numerical models were calibrated using the monitoring records. Then, new simulations were performed with Thalys HST train allowing to conclude that the introduction of high-speed trains will not lead to an increase of level of vibrations, for the adopted traffic conditions.
    Keywords mathematical models ; prediction ; railroads ; traffic ; urban areas ; vibration ; Portugal ; High-speed trains ; Ground vibrations ; Measurement campaigns ; 2D finite element ; Vehicle-track-soil dynamic interaction ; Track irregularities
    Language English
    Dates of publication 2022-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10001
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: A 60-Year-Old Swiss Woman Presenting with Migratory Radicular Pain Diagnosed with Lyme Disease by Western Blot.

    Marcelino, Gisela / Cerveira, João / Teychené, André / Eichenberger, Armand

    The American journal of case reports

    2022  Volume 23, Page(s) e935717

    Abstract: BACKGROUND Many diagnostic guidelines have been established to support the diagnosis of Lyme disease, but a recent meta-analysis did not find that 2-tier tests were better than individual tests. Here, we present the case of a patient who was diagnosed by ...

    Abstract BACKGROUND Many diagnostic guidelines have been established to support the diagnosis of Lyme disease, but a recent meta-analysis did not find that 2-tier tests were better than individual tests. Here, we present the case of a patient who was diagnosed by immunoblot only, a second-line test that is usually not performed if the first-line test is negative. CASE REPORT A 60-year-old Swiss woman, without relevant comorbidities, presented to our clinic with 1-week symptoms of migratory radiculitis in the L1, L2, and L5-S1 right dermatomes. Blood analysis and lumbar and brain MRI did not show any significant abnormalities. However, unexpected results were obtained after testing Lyme serologies. They were performed first with LIAISON® test (Diasorin, Italy) then with Borrelia VIRAstripe® immunoblot (Viramed, Germany) and a positive IgM result was only obtained with the latter. Consequently, doxycycline 100 mg 2×/day was initiated and the symptoms completely resolved after 6 weeks of treatment. Ever since, and more than 1 year after the initial presentation, the patient remains symptom-free. CONCLUSIONS As shown, it was possible to diagnose this patient and treat her successfully by testing all the available serologies. Furthermore, we were surprised to find out after a review of the literature that the IgM sensitivity in neuroborreliosis with the LIAISON® test is only 43.9-46% versus 90-100% with VIRAstripe®. Hence, clinicians need to understand the pitfalls of these tests before excluding Lyme disease.
    MeSH term(s) Antibodies, Bacterial ; Blotting, Western ; Female ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Lyme Disease/complications ; Lyme Disease/diagnosis ; Lyme Disease/drug therapy ; Middle Aged ; Pain ; Switzerland
    Chemical Substances Antibodies, Bacterial ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2022-04-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.935717
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Study of the mechanical behaviour of rockfill subjected to creep, for different values of relative humidity, using the discrete element method

    Manso João / Marcelino João / Caldeira Laura

    E3S Web of Conferences, Vol 205, p

    2020  Volume 13010

    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: A Novel Approach for Design and Manufacturing of Curvature-Featuring Scaffolds for Osteochondral Repair.

    Marcelino, Pedro / Silva, João Carlos / Moura, Carla S / Meneses, João / Cordeiro, Rachel / Alves, Nuno / Pascoal-Faria, Paula / Ferreira, Frederico Castelo

    Polymers

    2023  Volume 15, Issue 9

    Abstract: Osteochondral (OC) defects affect both articular cartilage and the underlying subchondral bone. Due to limitations in the cartilage tissue's self-healing capabilities, OC defects exhibit a degenerative progression to which current therapies have not yet ... ...

    Abstract Osteochondral (OC) defects affect both articular cartilage and the underlying subchondral bone. Due to limitations in the cartilage tissue's self-healing capabilities, OC defects exhibit a degenerative progression to which current therapies have not yet found a suitable long-term solution. Tissue engineering (TE) strategies aim to fabricate tissue substitutes that recreate natural tissue features to offer better alternatives to the existing inefficient treatments. Scaffold design is a key element in providing appropriate structures for tissue growth and maturation. This study presents a novel method for designing scaffolds with a mathematically defined curvature, based on the geometry of a sphere, to obtain TE constructs mimicking native OC tissue shape. The lower the designed radius, the more curved the scaffold obtained. The printability of the scaffolds using fused filament fabrication (FFF) was evaluated. For the case-study scaffold size (20.1 mm × 20.1 mm projected dimensions), a limit sphere radius of 17.064 mm was determined to ensure printability feasibility, as confirmed by scanning electron microscopy (SEM) and micro-computed tomography (μ-CT) analysis. The FFF method proved suitable to reproduce the curved designs, showing good shape fidelity and replicating the expected variation in porosity. Additionally, the mechanical behavior was evaluated experimentally and by numerical modelling. Experimentally, curved scaffolds showed strength comparable to conventional orthogonal scaffolds, and finite element analysis was used to identify the scaffold regions more susceptible to higher loads.
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15092129
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Contact Dermatitis: Overcoming Challenges of Specific Patients, Deciphering the Results and Reaching a Correct Diagnosis.

    Marcelino, João / Giménez-Arnau, Ana M

    Handbook of experimental pharmacology

    2021  Volume 268, Page(s) 227–246

    Abstract: Skin lesions caused by allergic contact dermatitis are an important occupational and environmental disease. Patch testing is the gold-standard procedure used to diagnose allergic contact dermatitis.The present chapter summarizes aspects of patch testing ... ...

    Abstract Skin lesions caused by allergic contact dermatitis are an important occupational and environmental disease. Patch testing is the gold-standard procedure used to diagnose allergic contact dermatitis.The present chapter summarizes aspects of patch testing for the diagnosis of contact allergy: important working definitions, relevance of treating contact dermatitis, materials, technique, test result and interpretation, and special consideration regarding individual factors which influence the patch test outcome or necessitate special attention.Performing and interpreting patch tests requires know-how. Knowing how to perform them and the particularities of specific cases is essential to correctly interpret the results. A correct evaluation and diagnosis will significantly impact the natural history of the disease and significantly improve the quality of life of the patient.
    MeSH term(s) Allergens ; Dermatitis, Allergic Contact/diagnosis ; Humans ; Patch Tests ; Quality of Life
    Chemical Substances Allergens
    Language English
    Publishing date 2021-07-08
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_481
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A Novel Approach for Design and Manufacturing of Curvature-Featuring Scaffolds for Osteochondral Repair

    Pedro Marcelino / João Carlos Silva / Carla S. Moura / João Meneses / Rachel Cordeiro / Nuno Alves / Paula Pascoal-Faria / Frederico Castelo Ferreira

    Polymers, Vol 15, Iss 2129, p

    2023  Volume 2129

    Abstract: Osteochondral (OC) defects affect both articular cartilage and the underlying subchondral bone. Due to limitations in the cartilage tissue’s self-healing capabilities, OC defects exhibit a degenerative progression to which current therapies have not yet ... ...

    Abstract Osteochondral (OC) defects affect both articular cartilage and the underlying subchondral bone. Due to limitations in the cartilage tissue’s self-healing capabilities, OC defects exhibit a degenerative progression to which current therapies have not yet found a suitable long-term solution. Tissue engineering (TE) strategies aim to fabricate tissue substitutes that recreate natural tissue features to offer better alternatives to the existing inefficient treatments. Scaffold design is a key element in providing appropriate structures for tissue growth and maturation. This study presents a novel method for designing scaffolds with a mathematically defined curvature, based on the geometry of a sphere, to obtain TE constructs mimicking native OC tissue shape. The lower the designed radius, the more curved the scaffold obtained. The printability of the scaffolds using fused filament fabrication (FFF) was evaluated. For the case-study scaffold size (20.1 mm × 20.1 mm projected dimensions), a limit sphere radius of 17.064 mm was determined to ensure printability feasibility, as confirmed by scanning electron microscopy (SEM) and micro-computed tomography (μ-CT) analysis. The FFF method proved suitable to reproduce the curved designs, showing good shape fidelity and replicating the expected variation in porosity. Additionally, the mechanical behavior was evaluated experimentally and by numerical modelling. Experimentally, curved scaffolds showed strength comparable to conventional orthogonal scaffolds, and finite element analysis was used to identify the scaffold regions more susceptible to higher loads.
    Keywords 3D printing ; curvature-featuring scaffolds ; finite element modelling ; mechanical properties ; osteochondral regeneration ; tissue engineering ; Organic chemistry ; QD241-441
    Subject code 670
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Synergy between 3D-extruded electroconductive scaffolds and electrical stimulation to improve bone tissue engineering strategies.

    Silva, João C / Marcelino, Pedro / Meneses, João / Barbosa, Frederico / Moura, Carla S / Marques, Ana C / Cabral, Joaquim M S / Pascoal-Faria, Paula / Alves, Nuno / Morgado, Jorge / Ferreira, Frederico Castelo / Garrudo, Fábio F F

    Journal of materials chemistry. B

    2024  Volume 12, Issue 11, Page(s) 2771–2794

    Abstract: In this work, we propose a simple, reliable, and versatile strategy to create 3D electroconductive scaffolds suitable for bone tissue engineering (TE) applications with electrical stimulation (ES). The proposed scaffolds are made of 3D-extruded poly(ε- ... ...

    Abstract In this work, we propose a simple, reliable, and versatile strategy to create 3D electroconductive scaffolds suitable for bone tissue engineering (TE) applications with electrical stimulation (ES). The proposed scaffolds are made of 3D-extruded poly(ε-caprolactone) (PCL), subjected to alkaline treatment, and of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), anchored to PCL with one of two different crosslinkers: (3-glycidyloxypropyl)trimethoxysilane (GOPS) and divinyl sulfone (DVS). Both cross-linkers allowed the formation of a homogenous and continuous coating of PEDOT:PSS to PCL. We show that these PEDOT:PSS coatings are electroconductive (11.3-20.1 S cm
    MeSH term(s) Humans ; Tissue Engineering/methods ; Tissue Scaffolds ; Osteogenesis ; Sodium Hydroxide ; Gelatin ; Electric Stimulation
    Chemical Substances Sodium Hydroxide (55X04QC32I) ; Gelatin (9000-70-8)
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02673f
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Cost-Effectiveness of Inpatient Continuous Glucose Monitoring.

    Veríssimo, David / Pereira, Beatriz R / Vinhais, Joana / Ivo, Catarina / Martins, Ana C / Silva, João N / Passos, Dolores / Lopes, Luís / Jácome de Castro, João / Marcelino, Mafalda

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55999

    Abstract: Introduction Our department conducted a retrospective cohort study to compare the efficacy of continuous glucose monitoring devices versus capillary blood glucose in the glycemic control of inpatient type 2 diabetes on intensive insulin therapy in a ... ...

    Abstract Introduction Our department conducted a retrospective cohort study to compare the efficacy of continuous glucose monitoring devices versus capillary blood glucose in the glycemic control of inpatient type 2 diabetes on intensive insulin therapy in a Portuguese hospital. The use of continuous glucose monitoring devices was associated with improved glycemic control, including an increased number of glucose readings within target range and reduced hyperglycemic events, being safe concerning hypoglycemias. This is the cost-effectiveness analysis associated with these results. Aim The primary objective was to compare the cost-effectiveness of achieving glycemic control, defined as the number of patients within glycemic goals, between groups. Secondary endpoints included cost-effectiveness analyses of each time in range goal, and each percentual increment in time in range. Methods We defined each glycemic goal as: "readings within range (70-180 mg/dL) >70%", "readings below range (below 70 mg/dL) <4%", "severe hypoglycemia (below 54 mg/dL) <1%", "readings above range (above 180 mg/dL) <25%", "very high glycemic readings (above 250 mg/dL) <5%". Results Continuous glucose monitoring showed lower median cost per effect for the primary outcome (€11.1 vs. €34.9/patient), with lower cost for readings in range (€7.8 vs. €11.6/patient) and for both readings above range goals ("above 180mg/dL": €7.4 vs. €9.9/patient, and "above 250mg/dL": €6.9 vs. €17.4/patient). Conclusions There are no published data regarding the cost-effectiveness of continuous glucose monitoring devices in inpatient settings. Our results show that continuous glucose monitoring devices were associated with an improved glycemic control, at a lower cost, and endorse the feasibility of incorporating these devices into hospital settings, presenting a favorable cost-effective option compared to capillary blood glucose.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55999
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Skin testing with Pfizer SARS-CoV-2 vaccine and PEG 2000.

    Vieira, João / Marcelino, João / Ferreira, Fátima / Farinha, Sofia / Silva, Rita / Proença, Miguel / Tomaz, Elza

    Asia Pacific allergy

    2021  Volume 11, Issue 2, Page(s) e18

    Language English
    Publishing date 2021-04-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2614800-6
    ISSN 2233-8268 ; 2233-8276
    ISSN (online) 2233-8268
    ISSN 2233-8276
    DOI 10.5415/apallergy.2021.11.e18
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top