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  1. Book ; Online ; E-Book: Immune biology of allogeneic hematopoietic stem cell transplantation

    Socié, Gérard / Zeiser, Robert / Blazar, Bruce R.

    models in discovery and translation

    2019  

    Author's details edited by Gérard Socié, Robert Zeiser, Bruce R. Blazar
    Keywords Hematopoietic stem cells / Transplantation ; Blood / Diseases ; Immunology ; Graft versus host disease
    Language English
    Size 1 Online-Ressource (xv, 431 Seiten), Illustrationen
    Edition Second edition
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020194964
    ISBN 978-0-12-813439-9 ; 9780128126301 ; 0-12-813439-9 ; 0128126302
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Immune biology of allogeneic hematopoietic stem cell transplantation

    Socié, Gérard / Blazar, Bruce R.

    models in discovery and translation

    2013  

    Title variant Allogeneic heamatopoietic stem cell transplantation
    Author's details ed. by Gérard Socié and Bruce R. Blazar
    Keywords Hematopoietic stem cells--Transplantation ; Immunology ; Graft versus host disease
    Language English
    Size XVIII, 518 S. : Ill., graph. Darst., 28 cm
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017594003
    ISBN 978-0-12-416004-0 ; 0-12-416004-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 258 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Long-Term Outcomes After Transplantation for Acute Myelogenous Leukemia.

    Socie, Gerard

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 28, Page(s) 3235–3238

    Abstract: The Oncology Grand Rounds series is designed to place original reports published in ... ...

    Abstract The Oncology Grand Rounds series is designed to place original reports published in the
    MeSH term(s) Armenia ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute/therapy ; Siblings ; Transplantation, Autologous
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.01177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 650: Show issues

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  4. Article ; Online: Treating chronic GVHD-induced fibrosis?

    Socié, Gerard

    Blood

    2018  Volume 131, Issue 13, Page(s) 1396–1397

    MeSH term(s) Fibrosis ; Graft vs Host Disease ; Humans ; Liposomes ; RNA, Small Interfering ; Vitamin A
    Chemical Substances Liposomes ; RNA, Small Interfering ; Vitamin A (11103-57-4)
    Language English
    Publishing date 2018-03-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-02-830505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The development of ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease.

    Zeiser, Robert / Socié, Gérard

    Blood advances

    2020  Volume 4, Issue 15, Page(s) 3789–3794

    Abstract: Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). Despite the use of prophylactic immunosuppression including calcineurin inhibitors, antimetabolites, antithymocyte ... ...

    Abstract Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). Despite the use of prophylactic immunosuppression including calcineurin inhibitors, antimetabolites, antithymocyte globulin, or posttransplant cyclophosphamide, patients still develop severe aGVHD. In particular, patients with glucocorticoid-refractory GVHD (SR-GVHD) have a dismal prognosis with a low 1-year post-allo-HCT survival rate. Most classical drugs used to prevent or treat aGVHD target 1 specific pathway such as calcineurin inhibitors or mammalian target of rapamycin inhibitors, or they interfere with fast-dividing activated cells (eg, methotrexate, mycophenolate, and cyclophosphamide). In contrast to these drugs, inhibition-of-signaling molecules, used by multiple immune cells and critical for signal transduction of multiple proinflammatory cytokines, could be more efficacious at blocking GVHD. Ruxolitinib blocks Janus kinases 1 and 2, which are required to mediate the downstream signaling of multiple cytokine receptors. Recently, a multicenter phase 3 clinical trial showed that ruxolitinib led to significant improvements in efficacy outcomes compared to best available therapy, which will lead to a paradigm shift in the treatment of SR-GVHD.
    MeSH term(s) Glucocorticoids/therapeutic use ; Graft vs Host Disease/drug therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use
    Chemical Substances Glucocorticoids ; Pyrazoles ; ruxolitinib (82S8X8XX8H)
    Language English
    Publishing date 2020-08-10
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2020002097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Secondary malignancies after transplantation for aplastic anemia.

    Socié, Gérard / Peffault de Latour, Régis

    Bone marrow transplantation

    2021  Volume 56, Issue 10, Page(s) 2324–2325

    MeSH term(s) Anemia, Aplastic/therapy ; Bone Marrow Transplantation ; Humans ; Neoplasms ; Transplantation, Homologous
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01400-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 2168: Show issues Location:
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  7. Article ; Online: Disease severity in chronic graft-versus-host disease: doctors' gut feeling versus biostatistics?

    Socié, Gerard

    Haematologica

    2014  Volume 99, Issue 10, Page(s) 1534–1536

    MeSH term(s) Female ; Graft vs Host Disease/mortality ; Humans ; Male ; Neoplasm Recurrence, Local ; Neoplasms/mortality ; Neoplasms/pathology
    Language English
    Publishing date 2014-09-30
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2014.113878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Allogeneic BM transplantation for the treatment of aplastic anemia: current results and expanding donor possibilities.

    Socié, Gérard

    Hematology. American Society of Hematology. Education Program

    2013  Volume 2013, Page(s) 82–86

    Abstract: Allogeneic BM transplantation from an HLA-identical sibling donor leads to long-term survival in the majority of patients (>80%). Therefore, survival is no longer the sole concern and attention has to be paid to decreasing the incidence and severity of ... ...

    Abstract Allogeneic BM transplantation from an HLA-identical sibling donor leads to long-term survival in the majority of patients (>80%). Therefore, survival is no longer the sole concern and attention has to be paid to decreasing the incidence and severity of long-term complications. For patients without a sibling donor, transplantation from a well-matched unrelated donor can be considered after failure of a previous course of immunosuppressive therapy. After transplantation from an HLA-identical sibling donor or from an unrelated one, the use of peripheral blood stem cells must be strongly discouraged because they have been systematically associated with an increased incidence of chronic GVHD compared with the use of BM as a stem cell source, leading to an unacceptably higher risk of treatment-related mortality in this setting. For as yet unknown reasons, the age limit after which transplantation results are less satisfactory remains 40 years of age.
    MeSH term(s) Adult ; Age Factors ; Allografts ; Anemia, Aplastic/mortality ; Anemia, Aplastic/therapy ; Bone Marrow Transplantation ; Chronic Disease ; Disease-Free Survival ; Graft vs Host Disease/mortality ; Graft vs Host Disease/prevention & control ; Humans ; Immunosuppression/methods ; Incidence ; Peripheral Blood Stem Cell Transplantation ; Siblings ; Survival Rate ; Unrelated Donors
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4383
    ISSN (online) 1520-4383
    DOI 10.1182/asheducation-2013.1.82
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Graft-versus-host disease prophylaxis: does drug dosage matter?

    Socié, Gérard

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2012  Volume 18, Issue 3, Page(s) 331–332

    MeSH term(s) Calcineurin Inhibitors ; Cyclosporine/blood ; Female ; Graft vs Host Disease/blood ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Immunosuppressive Agents/blood ; Male ; Tacrolimus/blood
    Chemical Substances Calcineurin Inhibitors ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2012-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2011.12.583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 462: Show issues

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  10. Article ; Online: Ruxolitinib for Acute Graft-versus-Host Disease. Reply.

    Zeiser, Robert / von Bubnoff, Nikolas / Socié, Gérard

    The New England journal of medicine

    2020  Volume 383, Issue 5

    MeSH term(s) Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Humans ; Pyrazoles
    Chemical Substances Pyrazoles ; ruxolitinib (82S8X8XX8H)
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2020763
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