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Article ; Online: Tracking of NK Cells by Positron Emission Tomography Using

Sato, Noriko / Szajek, Lawrence P / Choyke, Peter L

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2463, Page(s) 153–161

Abstract: ... ...

Abstract	A
MeSH term(s)	Killer Cells, Natural ; Oxyquinoline ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Zirconium
Chemical Substances	Oxyquinoline (5UTX5635HP) ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2160-8_11
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Article: Tumor Suppression by Anti-Fibroblast Activation Protein Near-Infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts.

Glabman, Raisa A / Olkowski, Colleen P / Minor, Hannah A / Bassel, Laura L / Kedei, Noemi / Choyke, Peter L / Sato, Noriko

Cancers

2024 Volume 16, Issue 2

Abstract: Cancer-associated fibroblasts (CAFs) constitute a prominent cellular component of the tumor stroma, with various pro-tumorigenic roles. Numerous attempts to target fibroblast activation protein (FAP), a highly expressed marker in immunosuppressive CAFs, ... ...

Abstract	Cancer-associated fibroblasts (CAFs) constitute a prominent cellular component of the tumor stroma, with various pro-tumorigenic roles. Numerous attempts to target fibroblast activation protein (FAP), a highly expressed marker in immunosuppressive CAFs, have failed to demonstrate anti-tumor efficacy in human clinical trials. Near-infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor therapy that utilizes an antibody-photo-absorbing conjugate activated by near-infrared light. In this study, we examined the therapeutic efficacy of CAF depletion by NIR-PIT in two mouse tumor models. Using CAF-rich syngeneic lung and spontaneous mammary tumors, NIR-PIT against FAP or podoplanin was performed. Anti-FAP NIR-PIT effectively depleted FAP
Language	English
Publishing date	2024-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020449
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Article ; Online: Deep Semisupervised Transfer Learning for Fully Automated Whole-Body Tumor Quantification and Prognosis of Cancer on PET/CT.

Leung, Kevin H / Rowe, Steven P / Sadaghiani, Moe S / Leal, Jeffrey P / Mena, Esther / Choyke, Peter L / Du, Yong / Pomper, Martin G

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024 Volume 65, Issue 4, Page(s) 643–650

Abstract: Automatic detection and characterization of cancer are important clinical needs to optimize early treatment. We developed a deep, semisupervised transfer learning approach for fully automated, whole-body tumor segmentation and prognosis on PET/CT. ...

Abstract	Automatic detection and characterization of cancer are important clinical needs to optimize early treatment. We developed a deep, semisupervised transfer learning approach for fully automated, whole-body tumor segmentation and prognosis on PET/CT.
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Melanoma ; Retrospective Studies ; Prostate-Specific Antigen ; Prognosis ; Prostatic Neoplasms ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/therapy ; Lymphoma ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/therapy ; Lung Neoplasms ; Machine Learning
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.267048
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Article ; Online: Advances in PET Imaging of the CXCR4 Receptor: [

Lindenberg, Liza / Ahlman, Mark / Lin, Frank / Mena, Esther / Choyke, Peter

Seminars in nuclear medicine

2023 Volume 54, Issue 1, Page(s) 163–170

Abstract: ...

Abstract	[
MeSH term(s)	Humans ; Receptors, CXCR4/metabolism ; Gallium Radioisotopes ; Positron-Emission Tomography/methods ; Peptides, Cyclic/metabolism ; Coordination Complexes/metabolism ; Positron Emission Tomography Computed Tomography/methods
Chemical Substances	68Ga-pentixafor ; Receptors, CXCR4 ; Gallium Radioisotopes ; Peptides, Cyclic ; Coordination Complexes ; CXCR4 protein, human
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120248-0
ISSN	1558-4623 ; 0001-2998
ISSN (online)	1558-4623
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2023.09.002
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Article ; Online: The Impact of PSMA PET/CT Imaging in Prostate Cancer Radiation Treatment.

Mena, Esther / Lindenberg, Liza / Choyke, Peter

Seminars in nuclear medicine

2022 Volume 52, Issue 2, Page(s) 255–262

Abstract: Imaging of prostate cancer is rapidly evolving with the introduction of the novel prostate-specific membrane antigen (PSMA)-targeted PET imaging tool for managing recurrent prostate cancer. One immediate impact of PSMA PET is the identification of ... ...

Abstract	Imaging of prostate cancer is rapidly evolving with the introduction of the novel prostate-specific membrane antigen (PSMA)-targeted PET imaging tool for managing recurrent prostate cancer. One immediate impact of PSMA PET is the identification of residual or recurrent lesions that are amenable to external beam radiotherapy. Radiotherapy is used as a definitive curative treatment option for patients with localized prostate cancer alone or in combination therapy. In the setting of biochemical failure after radical prostatectomy, salvage radiation is a potential curative option, and the application of metastasis-directed radiotherapy in the setting of oligometastatic prostate cancer is currently being studied. To maximize the chances of curative therapy, the irradiated tumor volumes should completely encompass the actual extent of disease. Thus, an accurate estimation of the location and delineation of disease targets is critical for radiotherapy planning. The integration of PSMA PET imaging into the routine evaluation of prostate cancer has markedly improved sensitivity and specificity for recurrent disease, even at very low PSA values, which may enable further tailored radiation treatment plans, and help reduce the risk of radiation to adjacent normal tissues. However, while the introduction of PSMA PET will likely change behavior regarding earlier application of radiotherapy, the long-term impact of PSMA PET on patient outcomes is yet to be determined. The aim of the review is to give an overview of the use of PSMA-PET/CT imaging in the setting of radiation therapy for prostate cancer.
MeSH term(s)	Gallium Radioisotopes ; Humans ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/surgery ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy
Chemical Substances	Gallium Radioisotopes
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120248-0
ISSN	1558-4623 ; 0001-2998
ISSN (online)	1558-4623
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2021.12.008
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Article ; Online: Application of Spectral Algorithm Applied to Spatially Registered Bi-Parametric MRI to Predict Prostate Tumor Aggressiveness

Rulon Mayer / Baris Turkbey / Peter L. Choyke / Charles B. Simone

Diagnostics, Vol 13, Iss 2008, p

A Pilot Study

2023 Volume 2008

Abstract: Background: Current prostate cancer evaluation can be inaccurate and burdensome. Quantitative evaluation of Magnetic Resonance Imaging (MRI) sequences non-invasively helps prostate tumor assessment. However, including Dynamic Contrast Enhancement (DCE) ... ...

Abstract	Background: Current prostate cancer evaluation can be inaccurate and burdensome. Quantitative evaluation of Magnetic Resonance Imaging (MRI) sequences non-invasively helps prostate tumor assessment. However, including Dynamic Contrast Enhancement (DCE) in the examined MRI sequence set can add complications, inducing possible side effects from the IV placement or injected contrast material and prolonging scanning time. More accurate quantitative MRI without DCE and artificial intelligence approaches are needed. Purpose: Predict the risk of developing Clinically Significant (Insignificant) prostate cancer CsPCa (CiPCa) and correlate with the International Society of Urologic Pathology (ISUP) grade using processed Signal to Clutter Ratio (SCR) derived from spatially registered bi-parametric MRI (SRBP-MRI) and thereby enhance non-invasive management of prostate cancer. Methods: This pilot study retrospectively analyzed 42 consecutive prostate cancer patients from the PI-CAI data collection. BP-MRI (Apparent Diffusion Coefficient, High B-value, T2) were resized, translated, cropped, and stitched to form spatially registered SRBP-MRI. Efficacy of noise reduction was tested by regularizing, eliminating principal components (PC), and minimizing elliptical volume from the covariance matrix to optimize the SCR. MRI guided biopsy (MRBx), Systematic Biopsy (SysBx), combination (MRBx + SysBx), or radical prostatectomy determined the ISUP grade for each patient. ISUP grade ≥ 2 (<2) was judged as CsPCa (CiPCa). Linear and logistic regression were fitted to ISUP grade and CsPCa/CiPCa SCR. Correlation Coefficients (R) and Area Under the Curves (AUC) for Receiver Operator Curves (ROC) evaluated the performance. Results: High correlation coefficients (R) (>0.55) and high AUC (=1.0) for linear and/or logistic fit from processed SCR and z-score for SRBP-MRI greatly exceed fits using prostate serum antigen, prostate volume, and patient age (R ~ 0.17). Patients assessed with combined MRBx + SysBx and from individual MRI scanners ...
Keywords	logistic probability ; prostate cancer ; bi-parametric magnetic resonance imaging (BP-MRI) ; Gleason score (GS) ; signal-to-clutter ratio (SCR) ; regularization ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: An Automated Deep Learning-Based Framework for Uptake Segmentation and Classification on PSMA PET/CT Imaging of Patients with Prostate Cancer.

Li, Yang / Imami, Maliha R / Zhao, Linmei / Amindarolzarbi, Alireza / Mena, Esther / Leal, Jeffrey / Chen, Junyu / Gafita, Andrei / Voter, Andrew F / Li, Xin / Du, Yong / Zhu, Chengzhang / Choyke, Peter L / Zou, Beiji / Jiao, Zhicheng / Rowe, Steven P / Pomper, Martin G / Bai, Harrison X

Journal of imaging informatics in medicine

2024

Abstract: Uptake segmentation and classification on PSMA PET/CT are important for automating whole-body tumor burden determinations. We developed and evaluated an automated deep learning (DL)-based framework that segments and classifies uptake on PSMA PET/CT. We ... ...

Abstract	Uptake segmentation and classification on PSMA PET/CT are important for automating whole-body tumor burden determinations. We developed and evaluated an automated deep learning (DL)-based framework that segments and classifies uptake on PSMA PET/CT. We identified 193 [
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article
ISSN	2948-2933
ISSN (online)	2948-2933
DOI	10.1007/s10278-024-01104-y
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Article ; Online: A Phase 1 Trial of Salvage Stereotactic Body Radiation Therapy for Radiorecurrent Prostate Cancer After Brachytherapy.

Patel, Krishnan R / Rydzewski, Nicholas R / Schott, Erica / Cooley-Zgela, Theresa / Ning, Holly / Cheng, Jason / Salerno, Kilian / Huang, Erich P / Lindenberg, Liza / Mena, Esther / Choyke, Peter / Turkbey, Baris / Citrin, Deborah E

International journal of radiation oncology, biology, physics

2024

Abstract: Purpose: NCT03253744 is a phase 1 trial with the primary objective to identify the maximum tolerated dose (MTD) of salvage stereotactic body radiation therapy (SBRT) in patients with local prostate cancer recurrence after brachytherapy. Additional ... ...

Abstract	Purpose: NCT03253744 is a phase 1 trial with the primary objective to identify the maximum tolerated dose (MTD) of salvage stereotactic body radiation therapy (SBRT) in patients with local prostate cancer recurrence after brachytherapy. Additional objectives included biochemical control and imaging response. Methods and materials: This trial was initially designed to test 3 therapeutic dose levels (DLs): 40 Gy (DL1), 42.5 Gy (DL2), and 45 Gy (DL3) in 5 fractions. Intensity modulation was used to deliver the prescription dose to the magnetic resonance imaging and prostate-specific membrane antigen-based positron emission tomography imaging-defined gross tumor volume while simultaneously delivering 30 Gy to an elective volume defined by the prostate gland. This phase 1 trial followed a 3+3 design with a 3-patient expansion at the MTD. Toxicities were scored until trial completion at 2 years post-SBRT using Common Terminology Criteria for Adverse Events version 5.0. Escalation was halted if 2 dose limiting toxicities occurred, defined as any persistent (>4 days) grade 3 toxicity occurring within the first 3 weeks after SBRT or any grade ≥3 genitourinary (GU) or grade 4 gastrointestinal toxicity thereafter. Results: Between August 2018 and January 2023, 9 patients underwent salvage SBRT and were observed for a median of 22 months (Q1-Q3, 20-43 months). No grade 3 to 5 adverse events related to study treatment were observed; thus, no dose limiting toxicities occurred during the observation period. Escalation was halted by amendment given excellent biochemical control in DL1 and DL2 in the setting of a high incidence of clinically significant late grade 2 GU toxicity. Therefore, the MTD was considered 42.5 Gy in 5 fractions (DL2). One- and 2-year biochemical progression-free survival were 100% and 86%, representing a single patient in the trial cohort with biochemical failure (prostate-specific antigen [PSA] nadir + 2.0) at 20 months posttreatment. Conclusions: The MTD of salvage SBRT for the treatment of intraprostatic radiorecurrence after brachytherapy was 42.5 Gy in 5 fractions producing an 86% 2-year biochemical progression-free survival rate, with 1 poststudy failure at 20 months. The most frequent clinically significant toxicity was late grade 2 GU toxicity.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2024.02.014
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Article ; Online: Evaluating Diagnostic Accuracy and Inter-reader Agreement of the Prostate Imaging After Focal Ablation Scoring System.

Gelikman, David G / Kenigsberg, Alexander P / Mee Law, Yan / Yilmaz, Enis C / Harmon, Stephanie A / Parikh, Sahil H / Hyman, Jason A / Huth, Hannah / Koller, Christopher R / Nethala, Daniel / Hesswani, Charles / Merino, Maria J / Gurram, Sandeep / Choyke, Peter L / Wood, Bradford J / Pinto, Peter A / Turkbey, Baris

European urology open science

2024 Volume 62, Page(s) 74–80

Abstract: Background and objective: Focal therapy (FT) is increasingly recognized as a promising approach for managing localized prostate cancer (PCa), notably reducing treatment-related morbidities. However, post-treatment anatomical changes present significant ... ...

Abstract	Background and objective: Focal therapy (FT) is increasingly recognized as a promising approach for managing localized prostate cancer (PCa), notably reducing treatment-related morbidities. However, post-treatment anatomical changes present significant challenges for surveillance using current imaging techniques. This study aimed to evaluate the inter-reader agreement and efficacy of the Prostate Imaging after Focal Ablation (PI-FAB) scoring system in detecting clinically significant prostate cancer (csPCa) on post-FT multiparametric magnetic resonance imaging (mpMRI). Methods: A retrospective cohort study was conducted involving patients who underwent primary FT for localized csPCa between 2013 and 2023, followed by post-FT mpMRI and a prostate biopsy. Two expert genitourinary radiologists retrospectively evaluated post-FT mpMRI using PI-FAB. The key measures included inter-reader agreement of PI-FAB scores, assessed by quadratic weighted Cohen's kappa ( Key findings and limitations: Scans from 38 patients were analyzed, revealing a moderate level of agreement in PI-FAB scoring ( Conclusions and clinical implications: The PI-FAB scoring system exhibited high sensitivity with moderate inter-reader agreement in detecting in-field recurrence of csPCa. Despite promising results, its low specificity and PPV necessitate further refinement. These findings underscore the need for larger studies to validate the clinical utility of PI-FAB, potentially aiding in standardizing post-treatment surveillance. Patient summary: Focal therapy has emerged as a promising approach for managing localized prostate cancer, but limitations in current imaging techniques present significant challenges for post-treatment surveillance. The Prostate Imaging after Focal Ablation (PI-FAB) scoring system showed high sensitivity for detecting in-field recurrence of clinically significant prostate cancer. However, its low specificity and positive predictive value necessitate further refinement. Larger, more comprehensive studies are needed to fully validate its clinical utility.
Language	English
Publishing date	2024-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2024.02.012
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Article ; Online: Unsaturated PFOS and Other PFASs in Human Serum and Drinking Water from an AFFF-Impacted Community.

McDonough, Carrie A / Choyke, Sarah / Barton, Kelsey E / Mass, Sarah / Starling, Anne P / Adgate, John L / Higgins, Christopher P

Environmental science & technology

2021 Volume 55, Issue 12, Page(s) 8139–8148

Abstract: ... elevated in the water district nearest the source zone (median ∑PFSA of 618 ng/L in water and 33 ng/mL ...

Abstract	Understanding how exposure to aqueous film-forming foam (AFFF)-impacted drinking water translates to bioaccumulation of per- and polyfluoroalkyl substances (PFASs) is essential to assess health risks. To investigate spatial variability of PFAS exposure in communities near an AFFF source zone, blood serum was collected in 2018 from 220 adult residents of El Paso County (Colorado), as were raw water samples from several wells. C6 and C8 perfluoroalkyl sulfonates (PFSAs) were predominant in serum and water. PFASs were most elevated in the water district nearest the source zone (median ∑PFSA of 618 ng/L in water and 33 ng/mL in serum). A novel PFAS, unsaturated perfluorooctane sulfonate, was detected in >80% of water and serum samples at low concentrations (≤1.9 ng/mL in serum). Drinking water wells nearest the source zone displayed increased prevalence of perfluoroalkyl sulfonamide precursors not detected in serum. Serum-to-water ratios were the greatest for long-chain PFASs and were elevated in the least impacted water district. Additional serum samples collected from a subset of study participants in June 2019 showed that PFAS concentrations in serum declined after exposure ceased, although declines for perfluoropentane sulfonate were minimal. Our findings demonstrate that AFFF-impacted communities are exposed to complex, spatially variable mixtures of PFASs.
MeSH term(s)	Adult ; Alkanesulfonic Acids/analysis ; Colorado ; Drinking Water ; Fluorocarbons/analysis ; Humans ; Serum ; Water Pollutants, Chemical/analysis
Chemical Substances	Alkanesulfonic Acids ; Drinking Water ; Fluorocarbons ; Water Pollutants, Chemical
Language	English
Publishing date	2021-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.1c00522
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