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  1. Article ; Online: Forty years of hematopoietic stem cell transplantation in Croatia: First-World options and First-World science.

    Pavletic, Steven Z

    Croatian medical journal

    2023  Volume 64, Issue 2, Page(s) 65–66

    MeSH term(s) Humans ; Croatia ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2023-05-02
    Publishing country Croatia
    Document type Editorial
    ZDB-ID 1157623-6
    ISSN 1332-8166 ; 0353-9504
    ISSN (online) 1332-8166
    ISSN 0353-9504
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  2. Article ; Online: Durable discontinuation of systemic therapy for chronic graft-

    Pavletic, Steven Z / Schultz, Kirk R

    Haematologica

    2023  Volume 108, Issue 2, Page(s) 303–305

    MeSH term(s) Humans ; Bronchiolitis Obliterans Syndrome ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Chronic Disease
    Language English
    Publishing date 2023-02-01
    Publishing country Italy
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281114
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  3. Article ; Online: W"H-Y" antigen/HLA complexes in chronic GVHD.

    Holtzman, Noa G / Pavletic, Steven Z

    Blood

    2023  Volume 142, Issue 11, Page(s) 946–948

    MeSH term(s) Humans ; H-Y Antigen ; Antibodies ; Bronchiolitis Obliterans Syndrome
    Chemical Substances H-Y Antigen ; Antibodies
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021357
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  4. Article ; Online: The clinical landscape of chronic graft-versus-host disease management in 2021.

    Holtzman, Noa G / Pavletic, Steven Z

    British journal of haematology

    2021  Volume 196, Issue 4, Page(s) 830–848

    Abstract: Chronic graft-versus-host disease (cGVHD) is an important systemic complication of allogeneic haematopoietic stem cell transplantation with heterogeneous, multi-organ involvement that can lead to increased morbidity and mortality. Despite significant ... ...

    Abstract Chronic graft-versus-host disease (cGVHD) is an important systemic complication of allogeneic haematopoietic stem cell transplantation with heterogeneous, multi-organ involvement that can lead to increased morbidity and mortality. Despite significant advances in understanding the complex pathophysiology driving the disease, curative treatment options remain suboptimal. The past decade, however, has seen much growth in collaborative research efforts and standardization of criteria for clinical trials that have led to discovery of several new second-line therapies in cGVHD. The key to successful cGVHD control and management includes a comprehensive and sustained multidisciplinary effort with emphasis on ancillary and supportive care for these patients. The focus of this review is to summarize the new developments in systemic, organ-specific, and topical treatments in the management of cGVHD that emerged since the 2014 NIH consensus conference.
    MeSH term(s) Chronic Disease ; Graft vs Host Disease/therapy ; History, 21st Century ; Humans
    Language English
    Publishing date 2021-10-02
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17835
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  5. Article: Development and psychometric testing of a pediatric chronic graft-versus-host disease symptom scale: protocol for a two-phase, mixed methods study.

    Mitchell, Sandra A / Hunter, Rachael / Fry, Abigail / Pavletic, Steven Z / Widemann, Brigitte C / Wiener, Lori

    Frontiers in psychology

    2024  Volume 14, Page(s) 1243005

    Abstract: Background: Chronic graft-versus-host disease (cGVHD) is a debilitating late complication of hematopoietic stem cell transplantation. It is often accompanied by extensive symptom burden. No validated cGVHD patient-reported outcome (PRO) measure exists ... ...

    Abstract Background: Chronic graft-versus-host disease (cGVHD) is a debilitating late complication of hematopoietic stem cell transplantation. It is often accompanied by extensive symptom burden. No validated cGVHD patient-reported outcome (PRO) measure exists to evaluate cGVHD symptom bother in children and adolescents younger than 18 years. This paper presents the study protocol for a multi-center, two-phase protocol to develop a psychometrically valid pediatric cGVHD Symptom Scale (PCSS) and a companion caregiver-proxy measure to capture the symptom burden experienced by children with cGVHD. In the first phase of the study, our aim is to evaluate the comprehension, clarity and ease of response of the PCSS through cognitive interviewing and to iteratively refine the measure to optimize content validity. In the second phase of the study, we will quantitatively examine the measurement properties of the PCSS in children and their caregiver-proxies.
    Methods and analysis: Eligible participants are children/adolescents ages 5-17 with cGVHD who are receiving systemic immunosuppressive treatment or have recently tapered to discontinuation. In the first phase, we are enrolling 60 child and caregiver-proxy dyads in three child age strata (5-7, 8-12, and 13-17 years old). Semi-scripted cognitive debriefing interviews are conducted to assess comprehension, clarity, and ease of response of each PCSS item with the child alone, and then jointly with the caregiver-proxy to explore discordant ratings. In phase two, an age-stratified cohort of 120 child-caregiver dyads will be enrolled to evaluate test-retest reliability, construct validity, and responsiveness. Anchors for known-groups validity include the PedsQL module and clinical variables, including cGVHD clinician-rated severity scores. In participants ages 13-17, we will also compare responses on the PCSS with those from the Lee cGVHD Symptom Scale, to gauge the youngest age at which adolescent respondents can comprehend this adult measure.
    Discussion: This study will yield a well-validated, counterpart measure to the Lee cGVHD Symptom Scale for use in children with cGVHD and their caregiver-proxies. This new patient-reported outcome measure can be integrated into clinical trials and care delivery for pediatric transplant survivors to improve the precision and accuracy with which their cGVHD symptom experience is captured.
    Clinical trial registration: www.ClinicalTrials.gov, NCT04044365.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1243005
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  6. Article ; Online: Moving toward a conceptualization of measurable residual disease in myelodysplastic syndromes.

    Schulz, Eduard / Aplan, Peter D / Freeman, Sylvie D / Pavletic, Steven Z

    Blood advances

    2023  Volume 7, Issue 16, Page(s) 4381–4394

    Abstract: Approximately 90% of patients with myelodysplastic syndromes (MDSs) have somatic mutations that are known or suspected to be oncogenic in the malignant cells. The genetic risk stratification of MDSs has evolved substantially with the introduction of the ... ...

    Abstract Approximately 90% of patients with myelodysplastic syndromes (MDSs) have somatic mutations that are known or suspected to be oncogenic in the malignant cells. The genetic risk stratification of MDSs has evolved substantially with the introduction of the clinical molecular international prognostic scoring system, which establishes next-generation sequencing at diagnosis as a standard of care. Furthermore, the International Consensus Classification of myeloid neoplasms and acute leukemias has refined the MDS diagnostic criteria with the introduction of a new MDS/acute myeloid leukemia category. Monitoring measurable residual disease (MRD) has historically been used to define remission status, improve relapse prediction, and determine the efficacy of antileukemic drugs in patients with acute and chronic leukemias. However, in contrast to leukemias, assessment of MRD, including tracking of patient-specific mutations, has not yet been formally defined as a biomarker for MDS. This article summarizes current evidence and challenges and provides a conceptual framework for incorporating MRD into the treatment of MDS and future clinical trials.
    MeSH term(s) Humans ; Concept Formation ; Mutation ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy ; Myelodysplastic Syndromes/genetics ; Risk Factors ; Leukemia, Myeloid, Acute/genetics ; Neoplasm, Residual/diagnosis
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010098
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    Zs.A 7153: Show issues Location:
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  7. Article ; Online: NCCN Guidelines: Pretransplant Recipient Evaluation and Management of Graft-Versus-Host Disease.

    Cutler, Corey / Pavletic, Steven Z

    Journal of the National Comprehensive Cancer Network : JNCCN

    2020  Volume 18, Issue 5, Page(s) 645–647

    MeSH term(s) Female ; Graft vs Host Disease/therapy ; Guidelines as Topic ; Humans ; Male
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2020.7575
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  8. Article ; Online: Red cell distribution width as a new prognostic biomarker in refractory chronic graft-

    Schulz, Eduard / Pirsl, Filip / Holtzman, Noa G / Beshensky, David / Cowen, Edward W / Mitchell, Sandra A / Steinberg, Seth M / Pavletic, Steven Z

    Haematologica

    2024  Volume 109, Issue 1, Page(s) 298–302

    MeSH term(s) Humans ; Erythrocyte Indices ; Prognosis ; Bronchiolitis Obliterans Syndrome ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/etiology ; Biomarkers ; Chronic Disease
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283646
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  9. Article ; Online: Autoimmunity Following Allogeneic Hematopoietic Stem Cell Transplantation.

    Buxbaum, Nataliya Prokopenko / Pavletic, Steven Z

    Frontiers in immunology

    2020  Volume 11, Page(s) 2017

    Abstract: Autoimmune manifestations after allogeneic hematopoietic stem cell transplantation (AHSCT) are rare and poorly understood due to the complex interplay between the reconstituting immune system and transplant-associated factors. While autoimmune ... ...

    Abstract Autoimmune manifestations after allogeneic hematopoietic stem cell transplantation (AHSCT) are rare and poorly understood due to the complex interplay between the reconstituting immune system and transplant-associated factors. While autoimmune manifestations following AHSCT have been observed in children with graft-versus-host disease (GvHD), an alloimmune process, they are distinct from the latter in that they are generally restricted to the hematopoietic compartment, i.e., autoimmune hemolytic anemia, thrombocytopenia, and/or neutropenia. Autoimmune cytopenias in the setting of ASHCT represent a donor against donor immune reaction. Non-hematologic autoimmune conditions in the post-AHSCT setting have been described and do not currently fall under the GvHD diagnostic criteria, but could represent alloimmunity since they arise from the donor immune attack on the antigens that are shared by the donor and host in the thyroid, peripheral and central nervous systems, integument, liver, and kidney. As in the non-transplant setting, autoimmune conditions are primarily antibody mediated. In this article we review the incidence, risk factors, potential pathophysiology, treatment, and prognosis of hematologic and non-hematologic autoimmune manifestations in children after AHSCT.
    MeSH term(s) Anemia, Hemolytic, Autoimmune/immunology ; Animals ; Autoimmunity ; Cell Self Renewal ; Graft vs Host Disease/immunology ; Hematopoietic Stem Cell Transplantation ; Histocompatibility ; Humans ; Transplantation Conditioning ; Transplantation, Homologous
    Language English
    Publishing date 2020-08-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.02017
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  10. Article ; Online: Challenges in Conducting Studies in Chronic Graft-

    Pusic, Iskra / Pavletic, Steven Z

    Clinical hematology international

    2019  Volume 1, Issue 1, Page(s) 36–44

    Abstract: The lack of standardized criteria for measuring therapeutic response has been a major obstacle to the development of therapeutic trials in chronic graft- ...

    Abstract The lack of standardized criteria for measuring therapeutic response has been a major obstacle to the development of therapeutic trials in chronic graft-
    Language English
    Publishing date 2019-03-18
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2590-0048
    ISSN (online) 2590-0048
    DOI 10.2991/chi.d.190314.001
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