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  1. Article ; Online: Medical nuclomics: a new order in nuclear medicine practice.

    Loutfi, Issa

    Nuclear medicine communications

    2019  Volume 40, Issue 3, Page(s) 294–296

    MeSH term(s) Humans ; Medical Informatics ; Nuclear Medicine/instrumentation ; Radioactive Tracers ; Radionuclide Imaging ; Radiopharmaceuticals ; Salivary Glands/diagnostic imaging
    Chemical Substances Radioactive Tracers ; Radiopharmaceuticals
    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000000975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Physiochemical Responses of Stevia rebaudiana Bertoni Subjected to Sodium Chloride (NaCl) Salinity and Exogenous Salicylic Acid Application

    Janah, Iman / Elhasnaoui, Abdelhadi / Issa Ali, Oudou / Lamnai, Kamal / Aissam, Salama / Loutfi, Kenza

    Gesunde Pflanzen. 2021 Dec., v. 73, no. 4

    2021  

    Abstract: Soil salinity is one of the ecological problems limiting plant growth and development, especially in semi-arid and arid regions where water availability is very limited. Stevia rebaudiana Bertoni (Asteraceae) is known for its sweetness and non-caloric ... ...

    Title translation Physiochemische Reaktionen von Stevia rebaudiana Bertoni unter Natriumchlorid (NaCl)-Salinität und exogener Salicylsäureapplikation
    Abstract Soil salinity is one of the ecological problems limiting plant growth and development, especially in semi-arid and arid regions where water availability is very limited. Stevia rebaudiana Bertoni (Asteraceae) is known for its sweetness and non-caloric products (steviol glycosides). It can be considered as a plant for the future sugar industry and human health nutrition. The present work aims to study the modulation of salt stress (NaCl: 80 mM) effects on Stevia rebaudiana Bertoni plants by an exogenous application of salicylic acid (0 mM, 0.1 mM and 0.5 mM). The results obtained show that saline stress influences the growth and development of the plant through several metabolism aspects. The exogenous application of salicylic acid to plants subjected to saline stress has improved plant biomass, chlorophyll content, chlorophyll fluorescence, stomatal conductance, antioxidant enzyme activity, MDA content and electrolyte leakage. All these results show a potential role of salicylic acid in strengthening tolerance mechanisms and mitigating physiological and biochemical damage caused by saline stress on Stevia rebaudiana Bertoni plant.
    Keywords Stevia rebaudiana ; antioxidant enzymes ; chlorophyll ; electrolyte leakage ; enzyme activity ; glycosides ; growth and development ; human health ; metabolism ; nutrition ; phytomass ; plant growth ; salicylic acid ; salinity ; salt stress ; sodium chloride ; soil salinity ; steviol ; stomatal conductance ; sugar industry ; sweetness
    Language English
    Dates of publication 2021-12
    Size p. 509-520.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 820036-1
    ISSN 1439-0345 ; 0367-4223
    ISSN (online) 1439-0345
    ISSN 0367-4223
    DOI 10.1007/s10343-021-00570-6
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: (99m)Tc sulfur colloid and (99m)Tc mebrofenin hepatobiliary functional liver imaging in normal and diabetic rats.

    Al-Saeedi, Fatma / Loutfi, Issa

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2011  Volume 20, Issue 2, Page(s) 129–132

    Abstract: Objectives: To use (99m)Tc sulfur colloid ((99m)Tc-SC) and (99m)Tc mebrofenin ((99m)Tc-BrIDA) to study liver function in normal and diabetic rats.: Materials and methods: Radionuclide imaging was performed on 2 groups of rats, using (99m)Tc-SC for ... ...

    Abstract Objectives: To use (99m)Tc sulfur colloid ((99m)Tc-SC) and (99m)Tc mebrofenin ((99m)Tc-BrIDA) to study liver function in normal and diabetic rats.
    Materials and methods: Radionuclide imaging was performed on 2 groups of rats, using (99m)Tc-SC for one group and (99m)Tc-BrIDA for the other (20 rats per group) before and after induction of diabetes mellitus (DM) using streptozotocin administration (55 mg/kg i.p.). Dynamic acquisition was obtained for 1 h after the injection of 37 MBq of radiotracer. For the (99m)Tc-SC group, organ/tissue uptake was determined by drawing regions of interest (ROI) over the heart, liver, spleen and also the whole body (WB). The ratio of the ROI of each organ to the WB ROI was calculated. For (99m)Tc-BrIDA, ratios of cumulative count rates in liver, liver parenchyma, biliary tree and abdomen ROI to a WB ROI were also calculated. Statistical analysis was performed to compare the ratios of organ/tissue uptake to WB uptake before and after DM induction using the paired t test.
    Results: (99m)Tc-SC uptake ratios (means ±SD) showed a lower liver-to-WB uptake ratio (0.75 ± 0.05) in the rats after DM induction compared to baseline (0.81 ± 0.06), while the cardiac blood pool showed higher uptake ratios in the rats after DM induction (p = 0.026). For (99m)Tc-BrIDA, there was no significant difference in radiotracer uptake ratios obtained from the rats before and after DM induction (p = 0.41).
    Conclusion: Using functional liver imaging, there was a statistically significant decrease in the liver phagocytic/reticuloendothelial system function after DM induction, as evidenced by decreased (99m)Tc-SC liver uptake and increased blood pool compared to prediabetes, while the hepatobiliary function remained unchanged after DM induction using (99m)Tc-BrIDA imaging.
    MeSH term(s) Animals ; Diabetes Mellitus, Experimental/pathology ; Disease Models, Animal ; Imino Acids/pharmacokinetics ; Imino Acids/pharmacology ; Liver/diagnostic imaging ; Liver Function Tests ; Male ; Organotechnetium Compounds/pharmacokinetics ; Organotechnetium Compounds/pharmacology ; Phagocytosis ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Radiopharmaceuticals/pharmacology ; Rats ; Rats, Sprague-Dawley ; Statistics as Topic ; Technetium Tc 99m Sulfur Colloid/pharmacokinetics ; Technetium Tc 99m Sulfur Colloid/pharmacology ; Time Factors
    Chemical Substances Imino Acids ; Organotechnetium Compounds ; Radiopharmaceuticals ; Technetium Tc 99m Sulfur Colloid (556Q0P6PB1) ; technetium Tc 99m mebrofenin (F2NQ468L52)
    Language English
    Publishing date 2011
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000321216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differential regional lung uptake analysis of the lung scan as an adjunct to interpretation of pulmonary embolism.

    Ali, Layla / Loutfi, Issa / Hadi, Nadiyah / Burezq, Salwa

    Nuclear medicine communications

    2014  Volume 35, Issue 6, Page(s) 638–642

    Abstract: Objective: Differential regional lung uptake (DRLU) analysis of a lung perfusion scan is used to provide information on diversion of the radiotracer from areas supplied by obstructed pulmonary artery branches to areas with patent vessels, which could ... ...

    Abstract Objective: Differential regional lung uptake (DRLU) analysis of a lung perfusion scan is used to provide information on diversion of the radiotracer from areas supplied by obstructed pulmonary artery branches to areas with patent vessels, which could assist in the diagnosis of pulmonary embolism (PE), especially the intermediate-probability studies.
    Methods: Lung perfusion scans performed over 3 years (n=121) were analyzed using a computer overlay of six regions of interest per lung on the posterior view. DRLU was defined for neighboring region pairs as the ratio of the difference in the average count rate to the sum of the count rate in the region pair for a total of 18 region pairs per study.
    Results: Comparison of the DRLU for high-probability studies (n=30) with normal scans (n=40) showed significant deviation in a least three region pairs per study. For low-probability scans (n=30), there was no significant deviation from the normal. For the intermediate category (n=21), a subgroup (n=7) showed significant deviation in at least three region pairs, which also had a positive computed tomography pulmonary angiography for PE, and another subgroup (n=14) had deviation in two or fewer region pairs with a negative computed tomography pulmonary angiography.
    Conclusion: Using DRLU analysis, intermediate scans for PE could be redefined as low or high probability, on the basis of the number of region pairs showing deviation of DRLU. This could lead to improved diagnostic performance of the study without recourse to additional maneuvers or specialized equipment and would obviate the need for more tests on the patient.
    MeSH term(s) Aged ; Biological Transport ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Lung/diagnostic imaging ; Lung/metabolism ; Perfusion Imaging ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/metabolism ; Retrospective Studies
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000000098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Optimal imaging positions for 3-phase bone scanning of patients with bony pathology of the feet.

    Baqer, Mona M / Loutfi, Issa

    Journal of nuclear medicine technology

    2010  Volume 38, Issue 2, Page(s) 69–75

    Abstract: Unlabelled: The aim of the study was to optimize imaging positions of (99m)Tc-methylene diphosphonate ((99m)Tc-MDP) 3-phase bone scanning for the accurate localization of foot pathology in patients with trauma and diabetes-related complications.: ... ...

    Abstract Unlabelled: The aim of the study was to optimize imaging positions of (99m)Tc-methylene diphosphonate ((99m)Tc-MDP) 3-phase bone scanning for the accurate localization of foot pathology in patients with trauma and diabetes-related complications.
    Methods: (99m)Tc-MDP 3-phase bone scanning was performed for 26 controls and 27 patients with foot pathology. Flow was acquired in 1 of the following projections: anterior-posterior, medial-lateral, or plantar. Blood-pool and delayed images were acquired in a set of 5 projections (anterior, posterior, medial, lateral, and plantar). Images from the control group were checked for the views that best visualized individual bones or regions of the foot. These views were cross-correlated with images from the patient group to see whether they localized the exact site of the foot lesion.
    Results: In the controls, the plantar view was the best view for visualization of the forefoot region. The mid foot was best assessed on the anterior view. Medial-lateral views were best suited for imaging the hind foot, and the posterior view was the best for the ankle joint. In the subjects with foot pathology, lesions were accurately assigned to the affected bone using the imaging criteria derived from the controls. In a few cases, however, additional views were needed because of overlap or shine-through of activity, particularly in mid-foot lesions.
    Conclusion: Optimal imaging positioning of the foot by bone scanning can be achieved using 5 views, which can yield accurate localization of a particular structure or bone, thereby improving the diagnostic accuracy of the procedure.
    MeSH term(s) Bone and Bones/diagnostic imaging ; Bone and Bones/pathology ; Female ; Foot Diseases/diagnostic imaging ; Foot Diseases/etiology ; Foot Diseases/pathology ; Humans ; Male ; Middle Aged ; Prospective Studies ; Radionuclide Imaging/methods ; Technetium Tc 99m Medronate
    Chemical Substances Technetium Tc 99m Medronate (X89XV46R07)
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 189163-7
    ISSN 1535-5675 ; 0091-4916
    ISSN (online) 1535-5675
    ISSN 0091-4916
    DOI 10.2967/jnmt.109.070771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Tc Sulfur Colloid and ; Tc Mebrofenin Hepatobiliary Functional Liver Imaging in Normal and Diabetic Rats

    Al-Saeedi, Fatma / Loutfi, Issa

    Medical Principles and Practice

    2011  Volume 20, Issue 2, Page(s) 129–132

    Abstract: Objectives: To use 99mTc sulfur colloid (99mTc-SC) and 99mTc mebrofenin (99mTc-BrIDA) to study liver function in normal and diabetic rats. Materials and Methods: Radionuclide imaging was performed on 2 groups of rats, using 99mTc-SC for one group and ... ...

    Institution Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Abstract Objectives: To use 99mTc sulfur colloid (99mTc-SC) and 99mTc mebrofenin (99mTc-BrIDA) to study liver function in normal and diabetic rats. Materials and Methods: Radionuclide imaging was performed on 2 groups of rats, using 99mTc-SC for one group and 99mTc-BrIDA for the other (20 rats per group) before and after induction of diabetes mellitus (DM) using streptozotocin administration (55 mg/kg i.p.). Dynamic acquisition was obtained for 1 h after the injection of 37 MBq of radiotracer. For the 99mTc-SC group, organ/tissue uptake was determined by drawing regions of interest (ROI) over the heart, liver, spleen and also the whole body (WB). The ratio of the ROI of each organ to the WB ROI was calculated. For 99mTc-BrIDA, ratios of cumulative count rates in liver, liver parenchyma, biliary tree and abdomen ROI to a WB ROI were also calculated. Statistical analysis was performed to compare the ratios of organ/tissue uptake to WB uptake before and after DM induction using the paired t test. Results:99mTc-SC uptake ratios (means ±SD) showed a lower liver-to-WB uptake ratio (0.75 ± 0.05) in the rats after DM induction compared to baseline (0.81 ± 0.06), while the cardiac blood pool showed higher uptake ratios in the rats after DM induction (p = 0.026). For 99mTc-BrIDA, there was no significant difference in radiotracer uptake ratios obtained from the rats before and after DM induction (p = 0.41). Conclusion: Using functional liver imaging, there was a statistically significant decrease in the liver phagocytic/reticuloendothelial system function after DM induction, as evidenced by decreased 99mTc-SC liver uptake and increased blood pool compared to prediabetes, while the hepatobiliary function remained unchanged after DM induction using 99mTc-BrIDA imaging.
    Keywords Liver scan ; Phagocytic system ; Reticuloendothelial system ; Hepatobiliary system ; Diabetes ; Rat
    Language English
    Publishing date 2011-01-20
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000321216
    Database Karger publisher's database

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  7. Article ; Online: Improved delineation of parathyroid lesions in patients with chronic renal failure using magnified pinhole imaging.

    Ali, Layla / Loutfi, Issa / Biswas, Gautam / Hadi, Nadia / Girgis, Tamer

    Journal of nuclear medicine technology

    2011  Volume 39, Issue 1, Page(s) 35–39

    Abstract: Unlabelled: (99m)Tc-sestamibi dual-phase scintigraphy is currently established for parathyroid localization. However, the imaging technique is not standardized, and the role of the pinhole collimator, especially, is not fully recognized in the imaging ... ...

    Abstract Unlabelled: (99m)Tc-sestamibi dual-phase scintigraphy is currently established for parathyroid localization. However, the imaging technique is not standardized, and the role of the pinhole collimator, especially, is not fully recognized in the imaging protocol. The aim of this study was to check whether the use of a pinhole collimator in parathyroid scintigraphy would enhance lesion detectability and delineation more than does a parallel-hole collimator or SPECT in patients with secondary hyperparathyroidism due to chronic renal failure with a mixed pattern of abnormalities.
    Methods: Thirty-five patients referred for a parathyroid scan were included. Imaging was performed at 10 min and 2 h after injection of 925 MBq (25 mCi) of (99m)Tc-sestamibi using both a pinhole collimator and a high-resolution parallel-hole collimator fitted to a scintillation camera. SPECT was also performed at 1.5 h after injection. The images were reviewed by 2 experienced nuclear medicine physicians, and the results were analyzed. In addition, the contrast of visualized lesions was evaluated.
    Results: Twenty-three patients (65.7%) had abnormal scan findings. The McNemar test revealed better detection of parathyroid lesions using pinhole imaging than with planar parallel-hole imaging and SPECT (P < 0.001 and P < 0.03, respectively). Both observers showed good agreement in evaluating different imaging techniques (κ = 0.76). Observers were in favor of pinhole imaging because SPECT suffered from noise. Lesion contrast was significantly higher in pinhole imaging than in parallel-hole imaging and SPECT (P < 0.05), with a 16% and 11% improvement in contrast, respectively.
    Conclusion: Pinhole imaging better delineates and detects lesions in parathyroid scintigraphy than does parallel-hole imaging and SPECT. Pinhole imaging increases confidence in image interpretation because of high lesion contrast and better magnification and resolution. The use of this technique is therefore recommended as part of the routine imaging protocol for (99m)Tc-sestamibi parathyroid scintigraphy.
    MeSH term(s) Adolescent ; Adult ; Aged ; Female ; Humans ; Hyperparathyroidism, Secondary/complications ; Image Enhancement/methods ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diagnostic imaging ; Male ; Middle Aged ; Observer Variation ; Radionuclide Imaging/methods ; Thyroid Gland/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon ; Young Adult
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189163-7
    ISSN 1535-5675 ; 0091-4916
    ISSN (online) 1535-5675
    ISSN 0091-4916
    DOI 10.2967/jnmt.110.076984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Nonosseous abnormalities on bone scans.

    Loutfi, Issa / Collier, B David / Mohammed, Ahmed M

    Journal of nuclear medicine technology

    2003  Volume 31, Issue 3, Page(s) 149–53; quiz 154–6

    Abstract: Although bone scanning is a test primarily concerned with skeletal abnormalities, important nonosseous findings are occasionally present on the images. To gauge the significance of such nonosseous uptake and, in particular, to determine whether these ... ...

    Abstract Although bone scanning is a test primarily concerned with skeletal abnormalities, important nonosseous findings are occasionally present on the images. To gauge the significance of such nonosseous uptake and, in particular, to determine whether these findings contain useful diagnostic information, the technical and medical staff in nuclear medicine must recognize the various patterns of nonbony uptake and understand their causes. The objectives of this article are to demonstrate the appearances of nonosseous uptake on bone scans, to categorize the forms of soft-tissue uptake, to emphasize technical artifacts leading to soft-tissue uptake, and to highlight the clinical significance of pathologic soft-tissue uptake.
    MeSH term(s) Artifacts ; Bone and Bones/diagnostic imaging ; Bone and Bones/metabolism ; Connective Tissue/diagnostic imaging ; Connective Tissue/metabolism ; Diagnosis, Differential ; Extravasation of Diagnostic and Therapeutic Materials/diagnostic imaging ; Extravasation of Diagnostic and Therapeutic Materials/metabolism ; Humans ; Incidental Findings ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/metabolism ; Technetium Tc 99m Medronate/pharmacokinetics ; Tomography, Emission-Computed, Single-Photon/methods ; Urologic Diseases/diagnostic imaging ; Urologic Diseases/metabolism ; Viscera/diagnostic imaging
    Chemical Substances Technetium Tc 99m Medronate (X89XV46R07)
    Language English
    Publishing date 2003-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 189163-7
    ISSN 1535-5675 ; 0091-4916
    ISSN (online) 1535-5675
    ISSN 0091-4916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Minimizing radiation exposure from patients treated with iodine-131 for hyperthyroidism using a lead collar: a simple and effective approach.

    Loutfi, Issa / Sakr, Mohamed / Al-Shummari, Awatef M

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2003  Volume 12, Issue 4, Page(s) 203–207

    Abstract: Objective: To construct a lead collar useful for shielding the electromagnetic radiation from the thyroid of patients treated with radioiodine (131)I for hyperthyroidism, thereby reducing the radiation emitted from these patients.: Materials and ... ...

    Abstract Objective: To construct a lead collar useful for shielding the electromagnetic radiation from the thyroid of patients treated with radioiodine (131)I for hyperthyroidism, thereby reducing the radiation emitted from these patients.
    Materials and methods: A specially designed cervical lead collar was used to shield radiation exposure from 'hot thyroids' of 20 patients treated with iodine-131 for hyperthyroidism. The collar was made of lead strips stacked together around a plastic neck support fastened around the patient's neck. Measurements of the radiation exposure rate were obtained at increasing distances from the patients (50, 100, 200 cm), with and without the lead collar, at various times after (131)I treatment.
    Results: Radiation exposure measurements over 3 weeks showed relatively high exposure rates in the first week after treatment. The radiation exposure from the patients wearing the lead collar was half that found in the same patients not wearing the collar.
    Conclusion: The use of the lead collar significantly reduced the radiation exposure of patients' surroundings. It was particularly useful in patients who could not abide strictly to the standard restrictive protocols after treatment with (131)I.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Hyperthyroidism/radiotherapy ; Iodine Radioisotopes/adverse effects ; Iodine Radioisotopes/therapeutic use ; Lead ; Male ; Middle Aged ; Protective Devices ; Radiation Injuries/prevention & control ; Radiation Protection/methods
    Chemical Substances Iodine Radioisotopes ; Lead (2P299V784P)
    Language English
    Publishing date 2003-10
    Publishing country Switzerland
    Document type Clinical Trial ; Comparative Study ; Journal Article
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000072284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Salivary gland scintigraphy: the use of semiquantitative analysis for uptake and clearance.

    Loutfi, Issa / Nair, Madhusoodanan K / Ebrahim, Ali K

    Journal of nuclear medicine technology

    2003  Volume 31, Issue 2, Page(s) 81–85

    Abstract: Objective: Quantitative analysis of (99m)Tc-pertechnetate salivary gland scintigraphy has been used in the evaluation of salivary gland function, but so far no one method can be considered optimal for this task. In this study, a semiquantitative method ... ...

    Abstract Objective: Quantitative analysis of (99m)Tc-pertechnetate salivary gland scintigraphy has been used in the evaluation of salivary gland function, but so far no one method can be considered optimal for this task. In this study, a semiquantitative method providing 2 functional parameters for objective assessment of salivary gland function by scintillation camera imaging was tested.
    Methods: Twenty-one patients referred for (99m)Tc-pertechnetate thyroid scanning were studied. Two patients with salivary complaints were also included. Dynamic imaging of the anterior head using a scintillation camera was started after a bolus intravenous injection of 185 MBq (5 mCi) (99m)Tc-pertechnetate at 1 frame per 30 s for 30 min. At 15 min after injection, diluted lemon juice was administered orally. Analysis of the dynamic study included time-activity curves of 4 salivary glands (right and left parotid and right and left submandibular). Two parameters of function were defined: uptake rate, taken as the value of the initial slope of the time-activity curve, and washout fraction, which was the relative mobilizable radioactivity from each salivary gland after ingestion of the sialogogue. A parametric image of the washout fraction was also generated.
    Results: The images showed gradual uptake in the parotid and submandibular glands. Washout was noted immediately after ingestion of the lemon juice. The pattern of the time-activity curve in all glands showed an early fast-rising part followed by a slow-rising component to nearly a plateau within 6-10 min after injection. The mean value of the uptake rate parameter was 0.10 +/- 0.09 cps/s. There was no significant difference between the parotid and submandibular glands or the right and left sides. Uptake in the parotid gland was 1.5-2 times that in the submandibular gland. The washout fraction was 1.40 +/- 1.60 for the parotid glands and 0.77 +/- 0.41 for the submandibular glands (P = 0.005).
    Conclusion: The quantitative analysis method including the uptake rate and the washout fraction parameters would enable objective assessment of salivary function and provide a reproducible means for follow-up of functional impairment in certain diseases.
    MeSH term(s) Adolescent ; Adult ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; Models, Biological ; Parotid Gland/diagnostic imaging ; Parotid Gland/metabolism ; Radiography ; Radioisotope Dilution Technique ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Reproducibility of Results ; Salivary Gland Diseases/diagnostic imaging ; Salivary Gland Diseases/metabolism ; Salivary Glands/diagnostic imaging ; Salivary Glands/metabolism ; Sensitivity and Specificity ; Sjogren's Syndrome/diagnostic imaging ; Sjogren's Syndrome/metabolism ; Sodium Pertechnetate Tc 99m/pharmacokinetics ; Submandibular Gland/diagnostic imaging
    Chemical Substances Radiopharmaceuticals ; Sodium Pertechnetate Tc 99m (A0730CX801)
    Language English
    Publishing date 2003-06
    Publishing country United States
    Document type Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article
    ZDB-ID 189163-7
    ISSN 1535-5675 ; 0091-4916
    ISSN (online) 1535-5675
    ISSN 0091-4916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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