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  1. Article ; Online: A critical evaluation of midazolam nasal spray for the treatment of patients with seizure clusters.

    Wheless, James W

    Expert review of neurotherapeutics

    2021  Volume 21, Issue 11, Page(s) 1195–1205

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Administration, Intranasal ; Anticonvulsants/therapeutic use ; Epilepsy/drug therapy ; Humans ; Midazolam/therapeutic use ; Nasal Sprays ; Quality of Life ; Seizures/drug therapy
    Chemical Substances Anticonvulsants ; Nasal Sprays ; Midazolam (R60L0SM5BC)
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2021.1890033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adjunctive cenobamate for the treatment of focal onset seizures in adults with epilepsy: a critical review.

    Wheless, James W

    Expert review of neurotherapeutics

    2020  Volume 20, Issue 11, Page(s) 1085–1098

    Abstract: Introduction: Uncontrolled epilepsy has persisted despite development of numerous antiseizure medications (ASMs) over the past 25 years, and more effective treatments are needed. Cenobamate is a new ASM approved in the US for treatment of adults with ... ...

    Abstract Introduction: Uncontrolled epilepsy has persisted despite development of numerous antiseizure medications (ASMs) over the past 25 years, and more effective treatments are needed. Cenobamate is a new ASM approved in the US for treatment of adults with focal onset seizures.
    Areas covered: This review outlines cenobamate study results from preclinical animal models through phase 2 and 3 clinical studies. Topics include mechanisms of action, pharmacokinetics, efficacy, and safety of cenobamate. Information on dosing, tolerability, and special populations are included to help healthcare providers understand this new ASM.
    Expert opinion: Adjunctive cenobamate shows a high level of efficacy in patients with refractory focal epilepsy compared to that reported for other ASMs. Most notable are reductions in monthly seizure frequency (up to 55%) and unprecedented seizure-free rates (up to 28%) with cenobamate in patients with refractory epilepsy despite the concomitant use of 1-3 ASMs. Cenobamate was generally safe and well-tolerated, with a safety profile similar to other ASMs. Due to 3 early cases of DRESS, however, the cenobamate starting dose was lowered and titration rate slowed; no additional cases occurred. If efficacy responses in real-world use reflect what have been observed in clinical studies, cenobamate would be a welcome new treatment option.
    MeSH term(s) Adult ; Animals ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/pharmacology ; Carbamates/administration & dosage ; Carbamates/adverse effects ; Carbamates/pharmacology ; Chlorophenols/administration & dosage ; Chlorophenols/adverse effects ; Chlorophenols/pharmacology ; Drug Resistant Epilepsy/drug therapy ; Humans ; Tetrazoles/administration & dosage ; Tetrazoles/adverse effects ; Tetrazoles/pharmacology
    Chemical Substances Anticonvulsants ; Carbamates ; Chlorophenols ; Tetrazoles ; Cenobamate (P85X70RZWS)
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2020.1834855
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  3. Article: Sudden Unexpected Death in Epilepsy (SUDEP): How Do We Prevent This Childhood Tragedy?

    Mudigoudar, Basanagoud / Wheless, James W

    The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

    2022  Volume 27, Issue 2, Page(s) 99–101

    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 3028543-4
    ISSN 1551-6776
    ISSN 1551-6776
    DOI 10.5863/1551-6776-27.2.99
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dispensary Cannabidiol (CBD): Nothing to Worry About!

    Elliott, Taylor / Gienapp, Andrew J / Wheless, James W

    Child neurology open

    2023  Volume 10, Page(s) 2329048X231169395

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785453-X
    ISSN 2329-048X ; 2329-048X
    ISSN (online) 2329-048X
    ISSN 2329-048X
    DOI 10.1177/2329048X231169395
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  5. Book ; Online ; E-Book: Fifty years of magnetoencephalography

    Papanicolaou, Andrew C. / Roberts, Timothy P. L. / Wheless, James W.

    beginnings, technical advances, and applications

    2020  

    Author's details edited by Andrew C. Papanicolaou, Timothy P. L. Roberts, and James W. Wheless
    Keywords Magnetoencephalography/History
    Subject code 616.8/047548
    Language English
    Size 1 Online-Ressource (xvii, 416 Seiten), Illustrationen, Diagramme
    Publisher Oxford University Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020534174
    ISBN 978-0-19-093569-6 ; 978-0-19-093570-2 ; 9780190935689 ; 9780190935719 ; 0-19-093569-3 ; 0-19-093570-7 ; 0190935685 ; 0190935715
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Book: Current strategies for the management of Lennox-Gastaut syndrome

    Pellock, John M. / Wheless, James W.

    [the meeting of the expert committee convened to discuss the differential diagnosis of LGS in June 2012 in Chicago, Illinois]

    (Epilepsia ; 55, Suppl. 4)

    2014  

    Author's details guest ed.: John M. Pellock and James W. Wheless
    Series title Epilepsia ; 55, Suppl. 4
    Collection
    Language English
    Size 36 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT018521073
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 517 -55,Suppl.4- not available for loan Zeitschriften-Lesesaal

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  7. Book: Treatment of pediatric epilepsy: expert opinion, 2005

    Wheless, James W.

    (Journal of child neurology ; 20, Suppl. 1)

    2005  

    Author's details guest ed.: James W. Wheless
    Series title Journal of child neurology ; 20, Suppl. 1
    Collection
    Language English
    Size S60 S. : graph. Darst.
    Publisher Decker
    Publishing place Hamilton, Ontario
    Publishing country Canada
    Document type Book
    HBZ-ID HT014707502
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2301 -20,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: Safety and effectiveness of diazepam nasal spray in male and female patients: Post hoc analysis of data from a phase 3 safety study.

    Wheless, James W / Hogan, Robert Edward / Davis, Charles S / Carrazana, Enrique / Rabinowicz, Adrian L

    Epilepsia open

    2024  Volume 9, Issue 2, Page(s) 793–799

    Abstract: Sex differences in drug pharmacokinetics include variations in the expression of the cytochrome P450 enzymes, which are involved in the metabolism of benzodiazepines. It is unclear whether sex influences outcomes associated with intranasally administered ...

    Abstract Sex differences in drug pharmacokinetics include variations in the expression of the cytochrome P450 enzymes, which are involved in the metabolism of benzodiazepines. It is unclear whether sex influences outcomes associated with intranasally administered drugs. A post hoc analysis of sex differences was conducted to evaluate the effectiveness and safety of diazepam nasal spray, which included examining changes in the number of days between seizure clusters over time (SEIzure interVAL [SEIVAL]). Diazepam nasal spray is approved for acute treatment of seizure clusters in patients with epilepsy aged ≥6 years. Data from a phase 3 safety study were used to determine the proportion of second doses used within 24 h (ie, a proxy for effectiveness) and SEIVAL. Adverse events were recorded. Of 163 treated patients, 89 were female, and 74 were male. Approximately 16% of both sexes self-administered the study drug. A slightly higher proportion of seizure clusters was treated with a second dose in female (14.7%) than male (9.4%) patients. SEIVAL increased significantly and substantially over a year for all patients. The safety profile was generally similar between the sexes. These results suggest that potential sex differences in benzodiazepine pharmacokinetics do not meaningfully influence outcomes associated with diazepam nasal spray. PLAIN LANGUAGE SUMMARY: Some drugs may have differences in absorption and metabolism between genders that could translate into differences in safety and effectiveness. This safety study looked at diazepam nasal spray for treating seizure clusters in patients at least 6 years old. It found that safety was about the same for females and males. For both groups, most clusters stopped after only 1 dose of the drug, and the time between treated clusters got longer over a year.
    MeSH term(s) Humans ; Female ; Male ; Child ; Nasal Sprays ; Anticonvulsants/adverse effects ; Diazepam/therapeutic use ; Diazepam/adverse effects ; Benzodiazepines/therapeutic use ; Seizures/drug therapy
    Chemical Substances Nasal Sprays ; Anticonvulsants ; Diazepam (Q3JTX2Q7TU) ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12907
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  9. Article: Zonisamide: A Comprehensive, Updated Review for the Clinician.

    Gidal, Barry E / Resnick, Trevor / Smith, Michael C / Wheless, James W

    Neurology. Clinical practice

    2023  Volume 14, Issue 1, Page(s) e200210

    Abstract: Purpose of review: Zonisamide (ZNS) was first approved in the United States in 2000 for the adjunctive treatment of patients aged 16 years or older with partial (focal) seizures. Although ZNS has been proven to treat multiple seizure types, it has been ... ...

    Abstract Purpose of review: Zonisamide (ZNS) was first approved in the United States in 2000 for the adjunctive treatment of patients aged 16 years or older with partial (focal) seizures. Although ZNS has been proven to treat multiple seizure types, it has been largely underutilized in US clinical practice.
    Recent findings: Published literature demonstrated that antiseizure medications (ASMs) acting on Na
    Summary: The purpose of this review was to provide an update to what is known about the efficacy of ZNS and where it shows benefits in the treatment of patients with epilepsy and other CNS disorders through its many unique mechanisms of action.
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000200210
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  10. Article ; Online: Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs.

    Wheless, James W / Gidal, Barry / Rabinowicz, Adrian L / Carrazana, Enrique

    Paediatric drugs

    2023  Volume 26, Issue 1, Page(s) 49–57

    Abstract: Epilepsy is a common pediatric neurological condition, affecting approximately 470,000 children in the USA and having a prevalence of 0.9% in the global population of approximately 2.6 billion children. Epilepsy is associated with disruptions in several ... ...

    Abstract Epilepsy is a common pediatric neurological condition, affecting approximately 470,000 children in the USA and having a prevalence of 0.9% in the global population of approximately 2.6 billion children. Epilepsy is associated with disruptions in several areas of a child's life, including medical burden, quality of life, cognitive outcomes, and higher risk of mortality. Additionally, some pediatric patients may experience acute seizure emergencies such as seizure clusters (also called acute repetitive seizures), which are intermittent increases in seizure activity that differ from the patient's usual seizure pattern and may occur despite daily antiseizure drug administration. Seizure clusters increase a patient's risk for status epilepticus and emergency room visits. Benzodiazepines are the main category of drugs used as acute seizure therapies for seizure clusters. This narrative review provides a practical discussion of care for pediatric patients with epilepsy and seizure clusters exploring such topics as details about the US Food and Drug Administration-approved acute seizure therapies, safety and ease of use of these medications, benefits of seizure action plans to help ensure optimal treatment, and considerations for transitioning a pediatric patient with acute seizure therapy to adult healthcare management.
    MeSH term(s) Adult ; Humans ; Adolescent ; Child ; Anticonvulsants/adverse effects ; Quality of Life ; Seizures/drug therapy ; Epilepsy/drug therapy ; Status Epilepticus/drug therapy
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2023-10-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1492748-2
    ISSN 1179-2019 ; 1174-5878
    ISSN (online) 1179-2019
    ISSN 1174-5878
    DOI 10.1007/s40272-023-00601-x
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