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Article ; Online: When radical uncertainty is too much: Clinical aspects of Conviction Narrative Theory.

Linkovski, Omer / Eitan, Renana

2023 Volume 46, Page(s) e101

Abstract: We propose extrapolating Conviction Narrative Theory (CNT) to clinical psychology and psychiatry. We demonstrate how CNT principles may benefit assessment, therapy, and possibly even modify public health views of neuropsychiatric disorders. Our ... ...

Abstract	We propose extrapolating Conviction Narrative Theory (CNT) to clinical psychology and psychiatry. We demonstrate how CNT principles may benefit assessment, therapy, and possibly even modify public health views of neuropsychiatric disorders. Our commentary focuses on hoarding disorder as a model, elaborates on discrepancies in the scientific literature and suggests how the CNT may resolve them.
MeSH term(s)	Humans ; Uncertainty ; Hoarding Disorder/psychology ; Hoarding Disorder/therapy
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	423721-3
ISSN	1469-1825 ; 0140-525X
ISSN (online)	1469-1825
ISSN	0140-525X
DOI	10.1017/S0140525X2200259X
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Article ; Online: An internet based virtual reality intervention for preventing posttraumatic stress disorder

Sara A. Freedman / Ehud Dayan / Renana Eitan

Frontiers in Virtual Reality, Vol

2022 Volume 3

Abstract: Introduction: Research examining the prevention of Posttraumatic Stress Disorder (PTSD) has shown that selective treatments to those with high symptom levels, using trauma focused CBT are relatively successful in reducing symptoms and preventing chronic ... ...

Abstract	Introduction: Research examining the prevention of Posttraumatic Stress Disorder (PTSD) has shown that selective treatments to those with high symptom levels, using trauma focused CBT are relatively successful in reducing symptoms and preventing chronic PTSD. However, uptake of these early treatments is often low. This study aimed to provide an internet based Virtual Reality treatment to overcome some of these barriers to early treatment.Method: The study received IRB approval from Hadassah Hospital (HMO 0056-013); its ClinicalTrials.gov identifier is NCT01760213. Recent survivors of motor vehicle accidents (N = 1,500) were assessed by telephone and online questionnaires. Patients meeting study criteria were randomly assigned to a Virtual Reality internet-based trauma-focused cognitive behavioral therapy (CBT) or waitlist control.Results: the majority of subjects recruited did not meet study criteria or were unwilling to participate. 14 subjects were randomly assigned to treatment or waitlist control. Results indicate that both groups show a decline in PTSD symptoms at follow up, with no significant differences between groups.Discussion: prevention of PTSD is a challenging goal, and internet-based interventions may play a role in this. The current study was not able to recruit sufficient participants to draw conclusions regarding the efficacy of the treatment. Proving services via the internet may not reduce barriers to care in this population.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT01760213?term=Freedman&cond=PTSD&cntry=IL&draw=2&rank=2, identifier NCT01760213.
Keywords	internet ; PTSD ; prevention ; RCT ; virtual reality ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	150
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Tuned to Tremor: Increased Sensitivity of Cortico-Basal Ganglia Neurons to Tremor Frequency in the MPTP Nonhuman Primate Model of Parkinson's Disease.

Rahamim, Noa / Slovik, Maya / Mevorach, Tomer / Linkovski, Omer / Bergman, Hagai / Rosin, Boris / Eitan, Renana

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 45, Page(s) 7712–7722

Abstract: Rest tremor is one of the most prominent clinical features of Parkinson's disease (PD). Here, we hypothesized that cortico-basal ganglia neurons tend to fire in a pattern that matches PD tremor frequency, suggesting a resonance phenomenon. We recorded ... ...

Abstract	Rest tremor is one of the most prominent clinical features of Parkinson's disease (PD). Here, we hypothesized that cortico-basal ganglia neurons tend to fire in a pattern that matches PD tremor frequency, suggesting a resonance phenomenon. We recorded spiking activity in the primary motor cortex (M1) and globus pallidus external segment of 2 female nonhuman primates, before and after parkinsonian state induction with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The arm of nonhuman primates was passively rotated at seven different frequencies surrounding and overlapping PD tremor frequency. We found entrainment of the spiking activity to arm rotation and a significant sharpening of the tuning curves in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine state, with a peak response at frequencies that matched the frequency of PD tremor. These results reveal increased sensitivity of the cortico-basal ganglia network to tremor frequency and could indicate that this network acts not only as a tremor switch but is involved in setting its frequency.
MeSH term(s)	Animals ; Female ; Parkinson Disease ; Tremor ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; Basal Ganglia ; Globus Pallidus ; Neurons/physiology ; Primates
Chemical Substances	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (9P21XSP91P)
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0529-23.2023
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Article ; Online: Bridging language barriers in developing valid health policy research tools: insights from the translation and validation process of the SHEMESH questionnaire.

Shalev, Ligat / Helfrich, Christian D / Ellen, Moriah / Avirame, Keren / Eitan, Renana / Rose, Adam J

Israel journal of health policy research

2023 Volume 12, Issue 1, Page(s) 36

Abstract: Background: The use of research tools developed and validated in one cultural and linguistic context to another often faces challenges. One major challenge is poor performance of the tool in the new context. This potentially impact the legitimacy of ... ...

Abstract	Background: The use of research tools developed and validated in one cultural and linguistic context to another often faces challenges. One major challenge is poor performance of the tool in the new context. This potentially impact the legitimacy of health policy research conducted with informal adaptations of existing tools which have not been subjected to formal validation. Best practices exist to guide researchers in adapting and validating research tools effectively. We present here, as an extended example, our validation of the SHEMESH questionnaire ('Organizational Readiness to Change Assessment'; In Hebrew: 'SHE'elon Muchanut Ergunit le'SHinuy'), a Hebrew-language version of the Organizational Readiness to Change Assessment (ORCA). SHEMESH is tailored to support implementation science projects, whose aim is to promote a more rapid and complete adoption of evidence-based health policies and practices. Methods: The SHEMESH included originally eleven questions from the Evidence (item 1-4) and Context (items 5-11) domains. We validated SHEMESH through the following steps: 1. Professional translation to Hebrew and discussion of the translation by multidisciplinary committee; 2. Back-translation into English by a different translator to detect discrepancies; 3. Eleven cognitive interviews with psychiatric emergency department physicians and nurses; and 4. Pilot testing and psychometric analyses, including Cronbach's alpha for subscales and factor analyses. Results: Following translation and cognitive interviews, SHEMESH was administered to 222 psychiatrists and nurses. Pearson correlation showed significant and strong correlations of items 1-4 to the Evidence construct and items 6-11 to the Context construct. Item 5 did not correlate with the other items, and therefore was removed from the other psychometric procedures and eventually from the SHEMESH. Factor analysis with the remaining 10 items yielded two factors, which together explained a total of 69.7% of variance. Cronbach's Alpha scores for the two subscales were high (Evidence, 0.887, and Context, 0.852). Conclusions: This multi-step validation process of the SHEMESH questionnaire may serve as a comprehensive guideline for others who are willing to adapt research tools that were developed in other languages. Practically, SHEMESH has been validated for use in implementation science research projects in Israel.
MeSH term(s)	Humans ; Reproducibility of Results ; Israel ; Surveys and Questionnaires ; Language ; Psychometrics/methods
Language	English
Publishing date	2023-11-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2657655-7
ISSN	2045-4015 ; 2045-4015
ISSN (online)	2045-4015
ISSN	2045-4015
DOI	10.1186/s13584-023-00583-8
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Article ; Online: Bridging language barriers in developing valid health policy research tools

Ligat Shalev / Christian D. Helfrich / Moriah Ellen / Keren Avirame / Renana Eitan / Adam J. Rose

Israel Journal of Health Policy Research, Vol 12, Iss 1, Pp 1-

insights from the translation and validation process of the SHEMESH questionnaire

2023 Volume 10

Abstract: Abstract Background The use of research tools developed and validated in one cultural and linguistic context to another often faces challenges. One major challenge is poor performance of the tool in the new context. This potentially impact the legitimacy ...

Abstract	Abstract Background The use of research tools developed and validated in one cultural and linguistic context to another often faces challenges. One major challenge is poor performance of the tool in the new context. This potentially impact the legitimacy of health policy research conducted with informal adaptations of existing tools which have not been subjected to formal validation. Best practices exist to guide researchers in adapting and validating research tools effectively. We present here, as an extended example, our validation of the SHEMESH questionnaire ('Organizational Readiness to Change Assessment'; In Hebrew: 'SHE'elon Muchanut Ergunit le'SHinuy'), a Hebrew-language version of the Organizational Readiness to Change Assessment (ORCA). SHEMESH is tailored to support implementation science projects, whose aim is to promote a more rapid and complete adoption of evidence-based health policies and practices. Methods The SHEMESH included originally eleven questions from the Evidence (item 1–4) and Context (items 5–11) domains. We validated SHEMESH through the following steps: 1. Professional translation to Hebrew and discussion of the translation by multidisciplinary committee; 2. Back-translation into English by a different translator to detect discrepancies; 3. Eleven cognitive interviews with psychiatric emergency department physicians and nurses; and 4. Pilot testing and psychometric analyses, including Cronbach’s alpha for subscales and factor analyses. Results Following translation and cognitive interviews, SHEMESH was administered to 222 psychiatrists and nurses. Pearson correlation showed significant and strong correlations of items 1–4 to the Evidence construct and items 6–11 to the Context construct. Item 5 did not correlate with the other items, and therefore was removed from the other psychometric procedures and eventually from the SHEMESH. Factor analysis with the remaining 10 items yielded two factors, which together explained a total of 69.7% of variance. Cronbach's Alpha scores for the two ...
Keywords	Validation process ; Implementation science ; Emergency department ; Psychometrics ; Organizational innovation ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Subject code	306
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Next generation programming.

Israel, Zvi / Bergman, Hagai / Eitan, Renana

Movement disorders : official journal of the Movement Disorder Society

2018 Volume 33, Issue 2, Page(s) 186

MeSH term(s)	Deep Brain Stimulation
Language	English
Publishing date	2018-01-25
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.27322
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Perceiving Dynamic Emotions Expressed Simultaneously in the Face and Body Minimizes Perceptual Differences Between Young and Older Adults.

Abo Foul, Yasmin / Eitan, Renana / Mortillaro, Marcello / Aviezer, Hillel

The journals of gerontology. Series B, Psychological sciences and social sciences

2021 Volume 77, Issue 1, Page(s) 84–93

Abstract: Objectives: It is commonly argued that older adults show difficulties in standardized tasks of emotional expression perception, yet most previous works relied on classic sets of static, decontextualized, and stereotypical facial expressions. In real ... ...

Abstract	Objectives: It is commonly argued that older adults show difficulties in standardized tasks of emotional expression perception, yet most previous works relied on classic sets of static, decontextualized, and stereotypical facial expressions. In real life, facial expressions are dynamic and embedded in a rich context, 2 key factors that may aid emotion perception. Specifically, body language provides important affective cues that may disambiguate facial movements. Method: We compared emotion perception of dynamic faces, bodies, and their combination in a sample of older (age 60-83, n = 126) and young (age 18-30, n = 124) adults. We used the Geneva Multimodal Emotion Portrayals set, which includes a full view of expressers' faces and bodies, displaying a diverse range of positive and negative emotions, portrayed dynamically and holistically in a nonstereotypical, unconstrained manner. Critically, we digitally manipulated the dynamic cue such that perceivers viewed isolated faces (without bodies), isolated bodies (without faces), or faces with bodies. Results: Older adults showed better perception of positive and negative dynamic facial expressions, while young adults showed better perception of positive isolated dynamic bodily expressions. Importantly, emotion perception of faces with bodies was comparable across ages. Discussion: Dynamic emotion perception in young and older adults may be more similar than previously assumed, especially when the task is more realistic and ecological. Our results emphasize the importance of contextualized and ecological tasks in emotion perception across ages.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging/physiology ; Emotions/physiology ; Facial Expression ; Facial Recognition/physiology ; Female ; Humans ; Kinesics ; Male ; Middle Aged ; Social Perception ; Young Adult
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1223664-0
ISSN	1758-5368 ; 1079-5014
ISSN (online)	1758-5368
ISSN	1079-5014
DOI	10.1093/geronb/gbab064
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Article: Interrupting traumatic memories in the emergency department: a randomized controlled pilot study.

Freedman, Sara A / Eitan, Renana / Weiniger, Carolyn F

European journal of psychotraumatology

2020 Volume 11, Issue 1, Page(s) 1750170

Abstract: Background: The hours immediately following a traumatic event may present a window of opportunity to interrupt the consolidation of memories of the traumatic event, and this may prevent PTSD development. This theory has been validated in a series of ... ...

Abstract	Background: The hours immediately following a traumatic event may present a window of opportunity to interrupt the consolidation of memories of the traumatic event, and this may prevent PTSD development. This theory has been validated in a series of analogue studies, showing that a visuo-spatial task reduces intrusive memories, however clinical studies are scarce. Objective: This pilot RCT examined the use of a semi-immersive Virtual Reality visuospatial task, as an intervention to interrupt memory consolidation, in the Emergency Department (ED) in the immediate hours following a traumatic event. We hypothesised that participants who had received the intervention would present with lower levels of PTSD symptoms than the control group who received no intervention. Method: Seventy-seven adult survivors of traumatic events, meeting study criteria, were recruited in the ED of a Level III Trauma Centre. Survivors arrived at the ED less than one hour, on average, after the trauma. After signing informed consent, participants were randomized to the SnowWorld intervention or control group. Both groups completed self-report questionnaires, and the intervention group used SnowWorld for up to 10 minutes. Results: No significant differences between the intervention and control groups were found regarding PTSD symptom levels two weeks and six months following the traumatic event. Conclusions: These results add to the growing literature examining the use of a concurrent task to reduce intrusions following a traumatic event. In contrast to previous clinical studies, this study did not show significant group differences; however, it replicates an analogue study that used a specifically developed app. Further studies are needed to elucidate possible reasons for these conflicting results.
Language	English
Publishing date	2020-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2586642-4
ISSN	2000-8066
ISSN	2000-8066
DOI	10.1080/20008198.2020.1750170
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Book ; Online: Topical Segmentation of Spoken Narratives

Wagner, Eitan / Keydar, Renana / Pinchevski, Amit / Abend, Omri

A Test Case on Holocaust Survivor Testimonies

2022

Abstract: The task of topical segmentation is well studied, but previous work has mostly addressed it in the context of structured, well-defined segments, such as segmentation into paragraphs, chapters, or segmenting text that originated from multiple sources. We ... ...

Abstract	The task of topical segmentation is well studied, but previous work has mostly addressed it in the context of structured, well-defined segments, such as segmentation into paragraphs, chapters, or segmenting text that originated from multiple sources. We tackle the task of segmenting running (spoken) narratives, which poses hitherto unaddressed challenges. As a test case, we address Holocaust survivor testimonies, given in English. Other than the importance of studying these testimonies for Holocaust research, we argue that they provide an interesting test case for topical segmentation, due to their unstructured surface level, relative abundance (tens of thousands of such testimonies were collected), and the relatively confined domain that they cover. We hypothesize that boundary points between segments correspond to low mutual information between the sentences proceeding and following the boundary. Based on this hypothesis, we explore a range of algorithmic approaches to the task, building on previous work on segmentation that uses generative Bayesian modeling and state-of-the-art neural machinery. Compared to manually annotated references, we find that the developed approaches show considerable improvements over previous work.
Keywords	Computer Science - Computation and Language ; Computer Science - Machine Learning
Subject code	004
Publishing date	2022-10-25
Publishing country	us
Document type	Book ; Online
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Article: Enabling Expedited Disposition of Emergencies Using Telepsychiatry in Israel: Protocol for a Hybrid Implementation Study.

Shalev, Ligat / Bistre, Moises / Lubin, Gadi / Avirame, Keren / Raskin, Sergey / Linkovski, Omer / Eitan, Renana / Rose, Adam J

JMIR research protocols

2023 Volume 12, Page(s) e49405

Abstract: Background: Telepsychiatry is the use of virtual communication, such as a video link, to deliver mental health assessment, treatment, and follow-up. Previous studies have shown telepsychiatry to be feasible, accurate compared with in-person practice, ... ...

Abstract	Background: Telepsychiatry is the use of virtual communication, such as a video link, to deliver mental health assessment, treatment, and follow-up. Previous studies have shown telepsychiatry to be feasible, accurate compared with in-person practice, and satisfying for psychiatrists and patients. Telepsychiatry has also been associated with reduced waiting times for evaluation and, in some studies, lower admission rates. However, most previous studies focused on using telepsychiatry in community settings and not on involuntary admission. Objective: The aim of this study is to examine the effectiveness and implementation process of patient assessment for involuntary admissions in the psychiatric emergency department (ED) using a video link. Methods: This type 1 hybrid implementation study will examine telepsychiatry effectiveness and the implementation process, by comparing telepsychiatry (n=240) with historical controls who had a face-to-face evaluation (n=240) during the previous, usual care period in 5 psychiatric EDs in Israel. A temporary waiver of the standing policy requiring in-person evaluations only, for the purpose of research, was obtained from the Israeli Ministry of Health. During the telepsychiatry phase, clinical staff and patients will join a video call from the ED, while the attending physician will log in elsewhere. The Promoting Action on Research Implementation in Health Services (PARIHS) framework will guide the evaluation of the telepsychiatry implementation process in the ED. PARIHS has the following 3 constructs: (1) evidence: staff's opinions regarding the innovation's viability and practicality, their satisfaction levels with its use, and patients' perceptions of the change; (2) context: level of approval of new strategies in the ED, decision-making processes, and the manner in which clinical teams converse and work together; (3) facilitation: adequacy of the facilitation efforts using champions reports. Primary clinical outcomes include ED length of stay and violent incidents obtained from medical records. Results: This study received Helsinki approval from the Ethics Committee of Abarbanel Mental Health Center (174; March 13, 2023), Jerusalem Mental Health Center (22-21; November 6, 2022), Lev-Hasharon Mental Health Medical Center (LH12023; February 12, 2023), Tel-Aviv Medical Center (TLV-22-0656; January 3, 2023), and Sha'ar Menashe (1-4-23; April 18, 2023). Data collection began in July 2023 in 2 study sites and will begin soon at the others. Conclusions: Telepsychiatry could have significant benefits for patients in the psychiatric ED. Examining telepsychiatry effectiveness in the ED, in addition to identifying the facilitators and barriers of implementing it in different emergency settings, will facilitate better policy decisions regarding its implementation. Trial registration: ClinicalTrials.gov NCT05771545; https://clinicaltrials.gov/study/NCT05771545. International registered report identifier (irrid): DERR1-10.2196/49405.
Language	English
Publishing date	2023-10-17
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/49405
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