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  1. Article ; Online: Commentary: The truth is out there.

    Barili, Fabio / Parolari, Alessandro

    The Journal of thoracic and cardiovascular surgery

    2021  Volume 164, Issue 6, Page(s) 1782–1783

    MeSH term(s) Humans ; Truth Disclosure
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2021.01.020
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  2. Article ; Online: The sounds of silence.

    Parolari, Alessandro / Almeida, Rui M S / Boden, William E

    European heart journal

    2022  Volume 43, Issue 31, Page(s) 2997

    Language English
    Publishing date 2022-07-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac333
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    Zs.A 1563: Show issues Location:
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  3. Article: Biology of mitral valve prolapse: from general mechanisms to advanced molecular patterns-a narrative review.

    Ronco, Daniele / Buttiglione, Gianpiero / Garatti, Andrea / Parolari, Alessandro

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1128195

    Abstract: Mitral valve prolapse (MVP) represents the most frequent cause of primary mitral regurgitation. For several years, biological mechanisms underlying this condition attracted the attention of investigators, trying to identify the pathways responsible for ... ...

    Abstract Mitral valve prolapse (MVP) represents the most frequent cause of primary mitral regurgitation. For several years, biological mechanisms underlying this condition attracted the attention of investigators, trying to identify the pathways responsible for such a peculiar condition. In the last ten years, cardiovascular research has moved from general biological mechanisms to altered molecular pathways activation. Overexpression of TGF-β signaling, for instance, was shown to play a key role in MVP, while angiotensin-II receptor blockade was found to limit MVP progression by acting on the same signaling pathway. Concerning extracellular matrix organization, the increased valvular interstitial cells density and dysregulated production of catalytic enzymes (matrix metalloproteinases above all) altering the homeostasis between collagen, elastin and proteoglycan components, have been shown to possibly provide a mechanistic basis contributing to the myxomatous MVP phenotype. Moreover, it has been observed that high levels of osteoprotegerin may contribute to the pathogenesis of MVP by increasing collagen deposition in degenerated mitral leaflets. Although MVP is believed to represent the result of multiple genetic pathways alterations, it is important to distinguish between syndromic and non-syndromic conditions. In the first case, such as in Marfan syndrome, the role of specific genes has been clearly identified, while in the latter a progressively increasing number of genetic loci have been thoroughly investigated. Moreover, genomics is gaining more interest as potential disease-causing genes and loci possibly associated with MVP progression and severity have been identified. Animal models could be of help in better understanding the molecular basis of MVP, possibly providing sufficient information to tackle specific mechanisms aimed at slowing down MVP progression, therefore developing non-surgical therapies impacting on the natural history of this condition. Although continuous progress has been made in this field, further translational studies are advocated to improve our knowledge of biological mechanisms underlying MVP development and progression.
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1128195
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  4. Article ; Online: Commentary: Looking for certainties, finding uncertainties.

    Barili, Fabio / Parolari, Alessandro

    The Journal of thoracic and cardiovascular surgery

    2020  Volume 163, Issue 2, Page(s) 763

    MeSH term(s) Humans ; Uncertainty
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2020.12.007
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  5. Article ; Online: Concerns Regarding the Report of 3-Year Outcomes of the Evolut Low Risk Trial.

    Barili, Fabio / Anselmi, Amedeo / Boden, William E / Sousa Uva, Miguel / Parolari, Alessandro

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 12, Page(s) e101

    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.05.071
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  6. Article ; Online: Biology of mitral valve prolapse

    Daniele Ronco / Gianpiero Buttiglione / Andrea Garatti / Alessandro Parolari

    Frontiers in Cardiovascular Medicine, Vol

    from general mechanisms to advanced molecular patterns—a narrative review

    2023  Volume 10

    Abstract: Mitral valve prolapse (MVP) represents the most frequent cause of primary mitral regurgitation. For several years, biological mechanisms underlying this condition attracted the attention of investigators, trying to identify the pathways responsible for ... ...

    Abstract Mitral valve prolapse (MVP) represents the most frequent cause of primary mitral regurgitation. For several years, biological mechanisms underlying this condition attracted the attention of investigators, trying to identify the pathways responsible for such a peculiar condition. In the last ten years, cardiovascular research has moved from general biological mechanisms to altered molecular pathways activation. Overexpression of TGF-β signaling, for instance, was shown to play a key role in MVP, while angiotensin-II receptor blockade was found to limit MVP progression by acting on the same signaling pathway. Concerning extracellular matrix organization, the increased valvular interstitial cells density and dysregulated production of catalytic enzymes (matrix metalloproteinases above all) altering the homeostasis between collagen, elastin and proteoglycan components, have been shown to possibly provide a mechanistic basis contributing to the myxomatous MVP phenotype. Moreover, it has been observed that high levels of osteoprotegerin may contribute to the pathogenesis of MVP by increasing collagen deposition in degenerated mitral leaflets. Although MVP is believed to represent the result of multiple genetic pathways alterations, it is important to distinguish between syndromic and non-syndromic conditions. In the first case, such as in Marfan syndrome, the role of specific genes has been clearly identified, while in the latter a progressively increasing number of genetic loci have been thoroughly investigated. Moreover, genomics is gaining more interest as potential disease-causing genes and loci possibly associated with MVP progression and severity have been identified. Animal models could be of help in better understanding the molecular basis of MVP, possibly providing sufficient information to tackle specific mechanisms aimed at slowing down MVP progression, therefore developing non-surgical therapies impacting on the natural history of this condition. Although continuous progress has been made in this field, ...
    Keywords mitral valve prolapse ; mitral regurgitation ; molecular biology ; fibroelastic deficiency ; Barlow disease ; Marfan syndrome ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Subject code 570
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Five-Year Outcomes with Transcatheter Aortic-Valve Replacement.

    Barili, Fabio / Freemantle, Nicholas / Parolari, Alessandro

    The New England journal of medicine

    2021  Volume 383, Issue 6, Page(s) 594

    MeSH term(s) Aortic Valve/surgery ; Heart Valve Prosthesis ; Transcatheter Aortic Valve Replacement
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2018853
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  8. Article ; Online: Linee guida europee sulla gestione delle valvulopatie: cosa c’è di nuovo dalla prospettiva del cardiochirurgo.

    Di Mauro, Michele / Barili, Fabio / Musumeci, Francesco / Parolari, Alessandro

    Giornale italiano di cardiologia (2006)

    2022  Volume 23, Issue 3, Page(s) 165–168

    Title translation ESC/EACTS Guidelines for the management of valvular heart disease: what's new from the cardiac surgeon's perspective.
    MeSH term(s) Heart ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis Implantation ; Humans
    Language Italian
    Publishing date 2022-03-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3751.37333
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    Zs.A 6738: Show issues Location:
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  9. Article ; Online: Commentary: Do not close a door that opens a window!

    Giambuzzi, Ilaria / Bonalumi, Giorgia / Parolari, Alessandro / Di Mauro, Michele

    JTCVS techniques

    2021  Volume 9, Page(s) 11–12

    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Editorial
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2021.06.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Legge Gelli-Bianco: bilancio a 5 anni dalla sua emanazione.

    Pagliaro, Marco / Cavalli, Giulio Giovanni / Oronzo, Egidio / Pacini, Davide / Parolari, Alessandro

    Giornale italiano di cardiologia (2006)

    2023  Volume 24, Issue 3, Page(s) 206–211

    Abstract: On April 1, 2017, the n. 24/2017 Gelli-Bianco law became effective, its aim being limiting the so-called "defensive medicine" phenomenon. The first bill was neither straightforward nor judicially flawless, thus complying evenly with the law was not ... ...

    Title translation The Gelli-Bianco Law: 5-year analysis since its emission.
    Abstract On April 1, 2017, the n. 24/2017 Gelli-Bianco law became effective, its aim being limiting the so-called "defensive medicine" phenomenon. The first bill was neither straightforward nor judicially flawless, thus complying evenly with the law was not obvious. As a consequence, since 2017 there were several attempts to better clarify it, yet its implementation still appears debatable. Ultimately, the Law has not been a real breakthrough in medical liability, as originally intended by the Legislator. The aim of this review is to outline "lights and shadows" of this Law 5 years after its emission.
    Language Italian
    Publishing date 2023-02-28
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3980.39623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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