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Article ; Online: Socioeconomic determinants of periodontitis.

Khajavi, Amin / Radvar, Mehrdad / Moeintaghavi, Amir

Periodontology 2000

2022 Volume 90, Issue 1, Page(s) 13–44

MeSH term(s)	Humans ; Periodontitis/epidemiology ; Socioeconomic Factors
Language	English
Publishing date	2022-08-11
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1200504-6
ISSN	1600-0757 ; 0906-6713
ISSN (online)	1600-0757
ISSN	0906-6713
DOI	10.1111/prd.12448
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Article ; Online: Monitoring Temperature in Children Under General Anesthesia

Farsad Imani / Khalilollah Aleamin / Mehrdad Goudarzi / Alireza Ebrahim Soltani / Fazeleh Majidi / Mohammad Reza Khajavi

Acta Medica Iranica, Vol 59, Iss

Nasopharynx Versus Carotid Artery Surface

2021 Volume 11

Abstract: Continuous body temperature monitoring during anesthesia in children is very important. Hypothermia in children may lead to higher morbidity and mortality. Measurement points to detect the temperature of core body are not simply accessible. In this study ...

Abstract	Continuous body temperature monitoring during anesthesia in children is very important. Hypothermia in children may lead to higher morbidity and mortality. Measurement points to detect the temperature of core body are not simply accessible. In this study we measured the skin temperature over the carotid artery and compared it with the nasopharynx. Totally, 84 children of 2-10 years undergoing elective surgery were selected. Temperature over the carotid artery and nasopharynx was measured during anesthesia. Mean temperature of these points was compared which each other, and the effects of age, sex, and weight change of temperature during anesthesia were evaluated. The mean age of patients was 5.4±2.6 years s. 37% of patients were female, and 63% were male. The mean weight was 20±7 kg. The mean duration of surgery was 60.45±6.65 min. The temperature of the skin and nasopharynx was decreased during surgery as after 60 min, the deference between skin over the carotid artery and the nasopharyngeal area was 1° C. The bodyweight has a significant effect on carotid skin temperature in regression model. Skin temperature over the carotid artery, with a simple correction factor of+1° C, provides a viable noninvasive estimate of nasopharyngeal temperature in children during elective surgery with a general anesthetic.
Keywords	Body temperature ; Intraoperative thermometry ; Skin temperature ; Pediatric thermal management ; Core temperature ; Medicine (General) ; R5-920
Subject code	541
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies.

Khajavi, Mehrdad / Zhou, Yi / Schiffer, Alex J / Bazinet, Lauren / Birsner, Amy E / Zon, Leonard / D'Amato, Robert J

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2021 Volume 35, Issue 5, Page(s) e21404

Abstract: We have previously used the genetic diversity available in common inbred mouse strains to identify quantitative trait loci (QTLs) responsible for the differences in angiogenic response using the corneal micropocket neovascularization (CoNV) assay. ... ...

Abstract	We have previously used the genetic diversity available in common inbred mouse strains to identify quantitative trait loci (QTLs) responsible for the differences in angiogenic response using the corneal micropocket neovascularization (CoNV) assay. Employing a mouse genome-wide association study (GWAS) approach, the region on chromosome 15 containing Basp1 was identified as being significantly associated with angiogenesis in inbred strains. Here, we developed a unique strategy to determine and verify the role of BASP1 in angiogenic pathways. Basp1 expression in cornea had a strong correlation with a haplotype shared by mouse strains with varied angiogenic phenotypes. In addition, inhibition of BASP1 demonstrated a dosage-dependent effect in both primary mouse brain endothelial and human microvascular endothelial cell (HMVEC) migration. To investigate its role in vivo, we knocked out basp1 in transgenic kdrl:zsGreen zebrafish embryos using a widely adopted CRISPR-Cas9 system. These embryos had severely disrupted vessel formation compared to control siblings. We further show that basp1 promotes angiogenesis by upregulating β-catenin gene and the Dll4/Notch1 signaling pathway. These results, to the best of our knowledge, provide the first in vivo evidence to indicate the role of Basp1 as an angiogenesis-regulating gene and opens the potential therapeutic avenues for a wide variety of systemic angiogenesis-dependent diseases.
MeSH term(s)	Animals ; Cell Movement ; Corneal Neovascularization/genetics ; Corneal Neovascularization/metabolism ; Corneal Neovascularization/pathology ; Genome-Wide Association Study ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Models, Biological ; Morphogenesis ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Wnt Signaling Pathway ; Zebrafish
Chemical Substances	BASP1 protein, human ; Membrane Proteins ; Nerve Tissue Proteins ; Repressor Proteins
Language	English
Publishing date	2021-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202001936RRR
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis.

Esa, Rawnaq / Steinberg, Eliana / Dror, Dvir / Schwob, Ouri / Khajavi, Mehrdad / Maoz, Miriam / Kinarty, Yael / Inbal, Adi / Zick, Aviad / Benny, Ofra

International journal of molecular sciences

2020 Volume 21, Issue 14

Abstract: During the metastasis process, tumor cells invade the blood circulatory system directly from venous capillaries or indirectly via lymphatic vessels. Understanding the relative contribution of each pathway and identifying the molecular targets that affect ...

Abstract	During the metastasis process, tumor cells invade the blood circulatory system directly from venous capillaries or indirectly via lymphatic vessels. Understanding the relative contribution of each pathway and identifying the molecular targets that affect both processes is critical for reducing cancer spread. Methionine aminopeptidase 2 (MetAp2) is an intracellular enzyme known to modulate angiogenesis. In this study, we investigated the additional role of MetAp2 in lymphangiogenesis. A histological staining of tumors from human breast-cancer donors was performed in order to detect the level and the localization of MetAp2 and lymphatic capillaries. The basal enzymatic level and activity in vascular and lymphatic endothelial cells were compared, followed by loss of function studies determining the role of MetAp2 in lymphangiogenesis in vitro and in vivo. The results from the histological analyses of the tumor tissues revealed a high MetAp2 expression, with detectable sites of co-localization with lymphatic capillaries. We showed slightly reduced levels of the MetAp2 enzyme and MetAp2 mRNA expression and activity in primary lymphatic cells when compared to the vascular endothelial cells. The genetic and biochemical manipulation of MetAp2 confirmed the dual activity of the enzyme in both vascular and lymphatic remodulation in cell function assays and in a zebrafish model. We found that cancer-related lymphangiogenesis is inhibited in murine models following MetAp2 inhibition treatment. Taken together, our study provides an indication that MetAp2 is a significant contributor to lymphangiogenesis and carries a dual role in both vascular and lymphatic capillary formation. Our data suggests that MetAp2 inhibitors can be effectively used as anti-metastatic broad-spectrum drugs.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Animals ; Animals, Genetically Modified ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Endothelial Cells/drug effects ; Endothelial Cells/enzymology ; Endothelial Cells/metabolism ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/enzymology ; Endothelium, Vascular/metabolism ; Humans ; Lymphangiogenesis/genetics ; Lymphatic Metastasis/genetics ; Lymphatic Metastasis/pathology ; Lymphatic Vessels/drug effects ; Lymphatic Vessels/metabolism ; Male ; Methionyl Aminopeptidases/antagonists & inhibitors ; Methionyl Aminopeptidases/genetics ; Methionyl Aminopeptidases/metabolism ; Mice ; Mice, Inbred C57BL ; Neovascularization, Pathologic/enzymology ; Neovascularization, Pathologic/metabolism ; O-(Chloroacetylcarbamoyl)fumagillol/pharmacology ; Xenograft Model Antitumor Assays ; Zebrafish
Chemical Substances	Angiogenesis Inhibitors ; METAP2 protein, human (EC 3.4.11.18) ; Methionyl Aminopeptidases (EC 3.4.11.18) ; O-(Chloroacetylcarbamoyl)fumagillol (X47GR46481)
Language	English
Publishing date	2020-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21145148
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Article ; Online: Programmed cell death 1 as prognostic marker and therapeutic target in upper gastrointestinal cancers.

Khoshghamat, Negar / Jafari, Niloufar / Moetamani-Ahmadi, Mehrdad / Khalili-Tanha, Ghazaleh / Khajavi Rad, Mohammad-Hossein / Sahebdel, Saeed / Khalili-Tanha, Nima / Soleimanpour, Saman / Khazaei, Majid / Hassanian, Seyed Mahdi / Ferns, Gordon A / Avan, Amir

Pathology, research and practice

2021 Volume 220, Page(s) 153390

Abstract: Gastrointestinal (GIs) cancers are among the most common causes of cancer related death, and hence the importance for the identification of novel prognostic/predictive biomarkers for detection of patients at an early stage, and for using these to ... ...

Abstract	Gastrointestinal (GIs) cancers are among the most common causes of cancer related death, and hence the importance for the identification of novel prognostic/predictive biomarkers for detection of patients at an early stage, and for using these to identify novel targeted therapies to improve the efficacy of existing chemotherapeutic regimens. Programmed cell death 1 has been reported as a potential target in several malignancies, and targeting agents are being developed, some already approved by FDA, such as: pembrolizumab, Atezolizumab, Nivolumab. Pembrolizumab that have been approved for the treatment of metastatic non-small cell lung cancer. Here we provide an overview of the mechanism of action PD-1/PD-L1, prognostic value and current progress in clinical trials using PD-1/PD-L1 inhibitors, and the resistant mechanisms at underlie the inhibitory effect of these agents in the treatment of gastrointestinal cancers.
MeSH term(s)	Animals ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Drug Resistance, Neoplasm ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/immunology ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Molecular Targeted Therapy ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Signal Transduction ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/immunology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Treatment Outcome
Chemical Substances	Antineoplastic Agents, Immunological ; B7-H1 Antigen ; CD274 protein, human ; Immune Checkpoint Inhibitors ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2021-02-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2021.153390
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Article ; Online: The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis

Rawnaq Esa / Eliana Steinberg / Dvir Dror / Ouri Schwob / Mehrdad Khajavi / Myriam Maoz / Yael Kinarty / Adi Inbal / Aviad Zick / Ofra Benny

International Journal of Molecular Sciences, Vol 21, Iss 5148, p

2020 Volume 5148

Abstract	During the metastasis process, tumor cells invade the blood circulatory system directly from venous capillaries or indirectly via lymphatic vessels. Understanding the relative contribution of each pathway and identifying the molecular targets that affect both processes is critical for reducing cancer spread. Methionine aminopeptidase 2 (MetAp2) is an intracellular enzyme known to modulate angiogenesis. In this study, we investigated the additional role of MetAp2 in lymphangiogenesis. A histological staining of tumors from human breast-cancer donors was performed in order to detect the level and the localization of MetAp2 and lymphatic capillaries. The basal enzymatic level and activity in vascular and lymphatic endothelial cells were compared, followed by loss of function studies determining the role of MetAp2 in lymphangiogenesis in vitro and in vivo. The results from the histological analyses of the tumor tissues revealed a high MetAp2 expression, with detectable sites of co-localization with lymphatic capillaries. We showed slightly reduced levels of the MetAp2 enzyme and MetAp2 mRNA expression and activity in primary lymphatic cells when compared to the vascular endothelial cells. The genetic and biochemical manipulation of MetAp2 confirmed the dual activity of the enzyme in both vascular and lymphatic remodulation in cell function assays and in a zebrafish model. We found that cancer-related lymphangiogenesis is inhibited in murine models following MetAp2 inhibition treatment. Taken together, our study provides an indication that MetAp2 is a significant contributor to lymphangiogenesis and carries a dual role in both vascular and lymphatic capillary formation. Our data suggests that MetAp2 inhibitors can be effectively used as anti-metastatic broad-spectrum drugs.
Keywords	MetAp2 ; angiogenesis ; lymphangiogenesis ; metastasis ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Balancing between adaptive and maladaptive cellular stress responses in peripheral neuropathy.

Khajavi, Mehrdad / Lupski, James R

Neuron

2008 Volume 57, Issue 3, Page(s) 329–330

Abstract: Point mutations in "myelin genes" result in a spectrum of inherited demyelinating neuropathies. The understanding of the pathomechanisms by which these mutations produce phenotypes remains limited. In this issue of Neuron, Wrabetz and colleagues report ... ...

Abstract	Point mutations in "myelin genes" result in a spectrum of inherited demyelinating neuropathies. The understanding of the pathomechanisms by which these mutations produce phenotypes remains limited. In this issue of Neuron, Wrabetz and colleagues report that the unfolded protein response (UPR) is responsible for demyelination in a Charcot-Marie-Tooth disease type 1B (CMT1B) mouse model. Deletion of the UPR mediator transcription factor CHOP completely rescues the motor deficit and ameliorates the neuropathy phenotype.
MeSH term(s)	Animals ; Demyelinating Diseases ; Disease Models, Animal ; Mice ; Myelin P0 Protein/physiology ; Peripheral Nervous System Diseases/genetics ; Peripheral Nervous System Diseases/physiopathology ; Protein Folding
Chemical Substances	Myelin P0 Protein
Language	English
Publishing date	2008-02-07
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2008.01.017
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article ; Online: Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes.

Bai, Jing / Khajavi, Mehrdad / Sui, Lufei / Fu, Haojie / Tarakkad Krishnaji, Subrahmanian / Birsner, Amy E / Bazinet, Lauren / Kamm, Roger D / D'Amato, Robert J

Angiogenesis

2020 Volume 24, Issue 1, Page(s) 111–127

Abstract: Angiogenesis plays a key role in the pathology of diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. Understanding the driving forces of endothelial cell migration and organization, as well as the time frame of these ... ...

Abstract	Angiogenesis plays a key role in the pathology of diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. Understanding the driving forces of endothelial cell migration and organization, as well as the time frame of these processes, can elucidate mechanisms of action of important pathological pathways. Herein, we have developed an organ-specific microfluidic platform recapitulating the in vivo angiogenic microenvironment by co-culturing mouse primary brain endothelial cells with brain pericytes in a three-dimensional (3D) collagen scaffold. As a proof of concept, we show that this model can be used for studying the angiogenic process and further comparing the angiogenic properties between two different common inbred mouse strains, C57BL/6J and 129S1/SvlmJ. We further show that the newly discovered angiogenesis-regulating gene Padi2 promotes angiogenesis through Dll4/Notch1 signaling by an on-chip mechanistic study. Analysis of the interplay between primary endothelial cells and pericytes in a 3D microfluidic environment assists in the elucidation of the angiogenic response.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Calcium-Binding Proteins/metabolism ; Cell Engineering ; Cell Separation ; Cells, Cultured ; Cellular Microenvironment ; Down-Regulation ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Imaging, Three-Dimensional ; Mice, Inbred C57BL ; Microfluidics ; Neovascularization, Pathologic/pathology ; Pericytes/metabolism ; Pericytes/pathology ; Protein-Arginine Deiminase Type 2/antagonists & inhibitors ; Protein-Arginine Deiminase Type 2/metabolism ; Receptors, Notch/metabolism ; Signal Transduction ; Mice
Chemical Substances	Adaptor Proteins, Signal Transducing ; Calcium-Binding Proteins ; DLL4 protein, mouse ; Receptors, Notch ; Padi2 protein, mouse (EC 3.5.3.15) ; Protein-Arginine Deiminase Type 2 (EC 3.5.3.15)
Language	English
Publishing date	2020-09-21
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1484717-6
ISSN	1573-7209 ; 0969-6970
ISSN (online)	1573-7209
ISSN	0969-6970
DOI	10.1007/s10456-020-09746-6
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Zs.A 5094: Show issues

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Article: A Burden Assessment of Occupational Exposures in Iran, 1990-2010: Findings from the Global Burden of Disease Study 2010.

NiakanKalhori, Sharareh R / Behzadi, Ali / Maharlou, Hamidreza / Rahimzadeh, Shadi / Khajavi, Alireza / Pouryaghoub, Gholamreza / Mehrdad, Ramin / Aminian, Omid / Jeddian, Alireza / Naderimagham, Shohreh

International journal of preventive medicine

2018 Volume 9, Page(s) 56

Abstract: Background: The present study describes the burden of occupational diseases in Iran based on the results of the Global Burden of Disease study conducted in 2010 (GBD 2010). This study aimed to determine the burden of occupational diseases in Iran based ... ...

Abstract	Background: The present study describes the burden of occupational diseases in Iran based on the results of the Global Burden of Disease study conducted in 2010 (GBD 2010). This study aimed to determine the burden of occupational diseases in Iran based on the results of GBD 2010. It is a cross-sectional study. Methods: Disability-adjusted life years (DALYs) of occupational diseases were calculated based on the prevalence rates obtained through model estimation, as well as GBD 2010 disability weights and mortality rates obtained from different data registry systems of Iran. Causal association criteria application to select risk outcome pairs, estimation of exposure to each risk factor in the population, estimation of etiological effect size, selection of a counterfactual exposure distribution, risk assessment, and identification of burden attributable to each risk factor were the main conducted statistical steps. Results: There was an increasing trend of DALYs (710.08/100,000 people in 1990 and 833.00/100,000 people in 2005) followed by a slight decrease (833.00/100,000 in 2005-784.55/100,000 people in 2010). A total of 50.4% and 36% of total DALYs per 100,000 people were due to the adverse effects of musculoskeletal disorders and work-related injuries, respectively. Conclusions: Musculoskeletal disorders and work-related injuries are the most important adverse consequences of work-related risks that require urgent interventions to be controlled. Male workers (15-25 years and over 60) with the highest DALYs and mortality rates need more training programs, safety regulations, and higher level of protection support. In spite the decreasing trend of occupational disease related DALYs and death rates in Iran in recent years, a long-term effort is required to maintain the currently decreasing trend.
Language	English
Publishing date	2018-06-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2574680-7
ISSN	2008-8213 ; 2008-7802
ISSN (online)	2008-8213
ISSN	2008-7802
DOI	10.4103/ijpvm.IJPVM_123_17
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Article: Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease.

Khajavi, Mehrdad / Inoue, Ken / Lupski, James R

European journal of human genetics : EJHG

2006 Volume 14, Issue 10, Page(s) 1074–1081

Abstract: The nonsense-mediated decay (NMD) pathway is an mRNA surveillance system that typically degrades transcripts containing premature termination codons (PTCs) in order to prevent translation of unnecessary or aberrant transcripts. Failure to eliminate these ...

Abstract	The nonsense-mediated decay (NMD) pathway is an mRNA surveillance system that typically degrades transcripts containing premature termination codons (PTCs) in order to prevent translation of unnecessary or aberrant transcripts. Failure to eliminate these mRNAs with PTCs may result in the synthesis of abnormal proteins that can be toxic to cells through dominant-negative or gain-of-function effects. Recent studies have expanded our understanding of the mechanism by which nonsense transcripts are recognized and targeted for decay. Here, we review the physiological role of this surveillance pathway, its implications for human diseases, and why knowledge of NMD is important to an understanding of genotype-phenotype correlations in various genetic disorders.
MeSH term(s)	Alleles ; Animals ; Codon, Nonsense/genetics ; Codon, Terminator ; Genes, Dominant ; Genes, Recessive ; Genetic Diseases, Inborn/genetics ; Humans ; Phenotype ; RNA, Messenger/genetics ; Trans-Activators/physiology
Chemical Substances	Codon, Nonsense ; Codon, Terminator ; NMD-F protein, human ; RNA, Messenger ; Trans-Activators ; UPF1 protein, human
Language	English
Publishing date	2006-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/sj.ejhg.5201649
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