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  1. Article: Shen Shuai II Recipe Attenuates Renal Interstitial Fibrosis by Improving Hypoxia via the IL-1

    Yang, Liuyi / Wang, Meng / Zhou, Yuan / Yang, Jing / Ye, Chaoyang / Wang, Chen

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 5539584

    Abstract: ... of chronic kidney disease induced by various factors. Shen Shuai II Recipe (SSR) has been used in clinical practice for more ... Shuai II Recipe significantly reduced RIF and downregulated the expression of HIF-1: Conclusion ...

    Abstract Background: Renal interstitial fibrosis is a pathological manifestation of progression of chronic kidney disease induced by various factors. Shen Shuai II Recipe (SSR) has been used in clinical practice for more than 20 years, and clinical studies have confirmed that SSR significantly improves the renal function of patients with chronic kidney disease. However, the specific mechanisms underlying its efficacy require further research. This study aims to explore the influencing factors of renal interstitial fibrosis in the context of hypoxia via the IL-1
    Methods: A rat model of chronic renal failure was developed by performing 5/6 (ablation/infarction, A/I) surgery on randomly selected, male Sprague Dawley rats. Thirty-six successfully modeled rats were randomly divided into three groups: 5/6 (A/I), 5/6 (A/I) + SSR, and 5/6 (A/I) + losartan. Another 12 rats were used as the sham group. After 8 weeks of the corresponding intervention, renal function, liver function, and protein expression of renal-fibrosis-related factors, HIF-1
    Results: Shen Shuai II Recipe significantly reduced RIF and downregulated the expression of HIF-1
    Conclusion: The renoprotective effects of SSR in rats with chronic renal failure may be related to its inhibition of hypoxia via the IL-1
    Language English
    Publishing date 2021-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/5539584
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  2. Article ; Online: Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation.

    Wang, Meng / Wang, Lingchen / Zhou, Yuan / Feng, Xiaoxuan / Ye, Chaoyang / Wang, Chen

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 98, Page(s) 153947

    Abstract: Background: Shen Shuai Ⅱ Recipe (SSR) is an effective Chinese herbal formula for the treatment ...

    Abstract Background: Shen Shuai Ⅱ Recipe (SSR) is an effective Chinese herbal formula for the treatment of patients with chronic kidney disease (CKD) in the clinic and significantly improves 5/6 ablation and infarction (A/I) surgery-induced renal interstitial fibrosis (RIF) and intrarenal hypoxia in rats. However, the underlying molecular mechanisms need further elucidation.
    Purpose: This study aims to investigate the renoprotective mechanisms of SSR in vivo and in vitro.
    Methods: CKD model was induced in rats with 5/6 (A/I) surgery. 4 weeks later, rats were treated with vehicle or SSR or Fenofibrate by daily gavage. In vitro, HK2 cells exposed to hypoxia (1% O
    Results: The results showed that treatment with SSR significantly improved mitochondrial morphology and function, up-regulated the expression of PGC-1α protein, and inhibited the production of mtROS in 5/6 (A/I) kidneys and hypoxia-treated HK2 cells, which may be closely correlated with its anti-RIF effect. In addition, compared to wild-type HK2 cells, the roles of SSR in improving mitochondrial dynamics and energy metabolism were greatly diminished in HK2 cells of PGC-1α knockdown under hypoxic exposure. More importantly, compared to ZLN005 or SSR combined with ZLN005 treatment, MFN2-deficient HK2 cells exhibited the increased protein levels of FN, α-SMA, TGF-β1 and cleaved IL-1β in response to hypoxic stimulation.
    Conclusion: SSR exerted the renoprotective effects by improving mitochondrial dynamics under hypoxic condition via PGC-1α activation.
    Language English
    Publishing date 2022-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.153947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Shen Shuai II Recipe Attenuates Renal Interstitial Fibrosis by Improving Hypoxia via the IL-1β/c-Myc Pathway

    Liuyi Yang / Meng Wang / Yuan Zhou / Jing Yang / Chaoyang Ye / Chen Wang

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Volume 2021

    Abstract: ... of chronic kidney disease induced by various factors. Shen Shuai II Recipe (SSR) has been used in clinical practice for more ... factors after c-Myc gene silencing in IL-1β-stimulated NRK-49F treated with SSR. Results. Shen Shuai II ...

    Abstract Background. Renal interstitial fibrosis is a pathological manifestation of progression of chronic kidney disease induced by various factors. Shen Shuai II Recipe (SSR) has been used in clinical practice for more than 20 years, and clinical studies have confirmed that SSR significantly improves the renal function of patients with chronic kidney disease. However, the specific mechanisms underlying its efficacy require further research. This study aims to explore the influencing factors of renal interstitial fibrosis in the context of hypoxia via the IL-1β/c-Myc pathway and the potential molecular mechanisms of SSR intervention in vivo and in vitro. Methods. A rat model of chronic renal failure was developed by performing 5/6 (ablation/infarction, A/I) surgery on randomly selected, male Sprague Dawley rats. Thirty-six successfully modeled rats were randomly divided into three groups: 5/6 (A/I), 5/6 (A/I) + SSR, and 5/6 (A/I) + losartan. Another 12 rats were used as the sham group. After 8 weeks of the corresponding intervention, renal function, liver function, and protein expression of renal-fibrosis-related factors, HIF-1α, IL-1β, and c-Myc, were detected. In vitro analysis was performed using hypoxia-induced rat renal tubular epithelial cells (NRK-52E) and IL-1β-stimulated rat renal interstitial fibroblasts (NRK-49F). IL-1β concentration in the culture medium and IL-1β protein expression in hypoxic NRK-52E treated with different concentrations of SSR were investigated. Furthermore, we also studied the changes in protein expression of c-Myc and fibrosis-related factors after c-Myc gene silencing in IL-1β-stimulated NRK-49F treated with SSR. Results. Shen Shuai II Recipe significantly reduced RIF and downregulated the expression of HIF-1α, c-Myc, and IL-1β proteins in 5/6 (A/I) rats with chronic renal failure. It also inhibited IL-1β secretion from NRK-52E induced by hypoxia, which in turn inhibited fibroblast activation mediated by the IL-1β/c-Myc pathway, and finally reduced the overproduction of the ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation

    Wang, Meng / Wang, Lingchen / Zhou, Yuan / Feng, Xiaoxuan / Ye, Chaoyang / Wang, Chen

    Phytomedicine. 2022 Apr., v. 98

    2022  

    Abstract: Shen Shuai Ⅱ Recipe (SSR) is an effective Chinese herbal formula for the treatment of patients ...

    Abstract Shen Shuai Ⅱ Recipe (SSR) is an effective Chinese herbal formula for the treatment of patients with chronic kidney disease (CKD) in the clinic and significantly improves 5/6 ablation and infarction (A/I) surgery-induced renal interstitial fibrosis (RIF) and intrarenal hypoxia in rats. However, the underlying molecular mechanisms need further elucidation. This study aims to investigate the renoprotective mechanisms of SSR in vivo and in vitro. CKD model was induced in rats with 5/6 (A/I) surgery. 4 weeks later, rats were treated with vehicle or SSR or Fenofibrate by daily gavage. In vitro, HK2 cells exposed to hypoxia (1% O₂) were treated with SSR in the presence or absence of 100 μM MitoTEMPO or 10 μM Mitochondrial Fusion Promoter M1. The effects of SSR on RIF, mitochondrial dynamics, oxidative metabolism, and mitochondrial ROS (mtROS) were determined by immunoblotting, colorimetric, and fluorometric assays according to the experimental protocols. Furthermore, to explore the mechanisms of SSR against RIF, HK2 cells of PGC-1α or MFN2 knockdown under hypoxic stimulation were treated with 400 μg/ml of SSR and (or) 1 μM of ZLN005. The results showed that treatment with SSR significantly improved mitochondrial morphology and function, up-regulated the expression of PGC-1α protein, and inhibited the production of mtROS in 5/6 (A/I) kidneys and hypoxia-treated HK2 cells, which may be closely correlated with its anti-RIF effect. In addition, compared to wild-type HK2 cells, the roles of SSR in improving mitochondrial dynamics and energy metabolism were greatly diminished in HK2 cells of PGC-1α knockdown under hypoxic exposure. More importantly, compared to ZLN005 or SSR combined with ZLN005 treatment, MFN2-deficient HK2 cells exhibited the increased protein levels of FN, α-SMA, TGF-β1 and cleaved IL-1β in response to hypoxic stimulation. SSR exerted the renoprotective effects by improving mitochondrial dynamics under hypoxic condition via PGC-1α activation.
    Keywords aerobiosis ; colorimetry ; fenofibrate ; fibrosis ; fluorometry ; hypoxia ; immunoblotting ; infarction ; kidney diseases ; mitochondria ; models ; surgery
    Language English
    Dates of publication 2022-04
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.153947
    Database NAL-Catalogue (AGRICOLA)

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  5. Book ; Thesis: BCL-2 inhibition mitigates pouchitis in a preclinical rat model

    Yuan, Shuai

    2022  

    Author's details vorgelegt von Shuai Yuan
    Language English
    Size VI, 64 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    HBZ-ID HT030043541
    Database Catalogue ZB MED Medicine, Health

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  6. Article: [Clinical study on Shen Shuai Fang in treating chronic renal failure].

    Wu, Xin-Lin / Li, Zhi-Jian / Zhang, Wei-Jun / Ao, Qin-Xing / Xu, Yuan-Wen

    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

    2008  Volume 31, Issue 5, Page(s) 796–798

    Abstract: Objective: To explore the effect of Shen Shuai Fang in treating Chronic Renal Failure (CRF ... divided into two groups, 75 patients in treatment group were treated with Shen Shuai Fang adding western ... P < 0.05 or P < 0.01).: Conclusion: Shen Shuai Fang is effective to treat CRF of deficiency ...

    Abstract Objective: To explore the effect of Shen Shuai Fang in treating Chronic Renal Failure (CRF) of deficiency of spleen and kidney with turbid damp and blood stagnation symptom.
    Methods: 125 patients with CRF of deficiency of spleen and kidney with turbid damp and blood stagnation symptom were randomly divided into two groups, 75 patients in treatment group were treated with Shen Shuai Fang adding western medicine and the other patients in control group were treated only with western medicine. We observed the effect and indexes change including renal function, Hb, proteinuria, lipid before and after treatment.
    Results: After six months' treatment, the general effective rate in treatment group was 77.33%, which was higher than that in control group obviously (44.00%, P < 0.01). So treatment group was obviously better than control group on decreasing proteinuria, improving renal function, increasing Hb, ameliorating lipid metabolism (P < 0.05 or P < 0.01).
    Conclusion: Shen Shuai Fang is effective to treat CRF of deficiency of spleen and kidney with turbid damp and blood stagnation symptom.
    MeSH term(s) Adolescent ; Adult ; Aged ; Drug Combinations ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Kidney Failure, Chronic/drug therapy ; Kidney Failure, Chronic/pathology ; Kidney Function Tests ; Male ; Middle Aged ; Phytotherapy ; Plants, Medicinal/chemistry ; Ramipril/therapeutic use ; Treatment Outcome ; Yin Deficiency/drug therapy ; Young Adult
    Chemical Substances Drug Combinations ; Drugs, Chinese Herbal ; Ramipril (L35JN3I7SJ)
    Language Chinese
    Publishing date 2008-05
    Publishing country China
    Document type English Abstract ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1001-4454
    ISSN 1001-4454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: The role of Calpain2 in ZBTB18 regulation in Glioblastoma Multiforme

    Yuan, Shuai / Carro, Maria Stella / Niedermann, Gabriele

    2019  

    Abstract: Abstract: Glioblastoma multiforme (GBM) is the most common and aggressive form of primary human brain tumor. Despite the current comprehensive treatments, patients’ survival remains poor. Recent advances in molecular profiling reveal the distinct gene ... ...

    Institution Albert-Ludwigs-Universität Freiburg / Medizinische Fakultät
    Abstract Abstract: Glioblastoma multiforme (GBM) is the most common and aggressive form of primary human brain tumor. Despite the current comprehensive treatments, patients’ survival remains poor. Recent advances in molecular profiling reveal the distinct gene expression signatures that could further classify GBMs to prognosis-relevant subtypes, in which the Mesenchymal form represents the most lethal features.
    Previously, we have identified ZBTB18 (Zinc finger and BTB domain-containing protein 18) as a transcriptional repressor in Mesenchymal transformation and epithelial-mesenchymal transition (EMT) in GBMs. Interestingly, a truncated form of ZBTB18 is also tumor-specifically observed in brain tumor stem-like cells (BTSCs), indicating a hypothesis that GBM progression is promoted upon the loss of intactness of ZBTB18. The present study first validates the characteristics of the cleaved ZBTB18, including its abnormal localization and the loss of transcriptional regulation.
    By Microarray analysis for protease-encoding genes, we detect Calpain2 as the putative protease which is associated with cleaved ZBTB18 expression in BTSCs. By interfering with its activity or modulating its expression, we further identify the regulatory role of Calpain2 in ZBTB18 cleavage. In addition, one critical site for Calpain2 recognition is validated at Arg266-Ser267, while the cleavage site locates between Asn268 and Leu269 of ZBTB18. Therefore, it suggests that Calpain2 intervention could be developed as a potential therapeutic strategy for restoring ZBTB18 function in GBMs
    Keywords Glioblastoma multiforme
    Language English
    Size Online-Ressource
    Publisher Universität
    Publishing place Freiburg
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Freiburg, 2019
    HBZ-ID HT020456999
    DOI 10.6094/UNIFR/155345
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Improving the spatial resolution and signal-to-noise ratio of ultrasound switchable fluorescence imaging.

    Yu, Shuai / Yuan, Baohong

    Journal of biophotonics

    2024  , Page(s) e202300533

    Abstract: Ultrasound switchable fluorescence (USF) imaging, a hybrid imaging technology that combines the advantages of both fluorescence sensitivity and acoustic resolution in centimeter-deep tissue, has great potential for biomedical different applications. A ... ...

    Abstract Ultrasound switchable fluorescence (USF) imaging, a hybrid imaging technology that combines the advantages of both fluorescence sensitivity and acoustic resolution in centimeter-deep tissue, has great potential for biomedical different applications. A camera-based USF imaging system reveals its capability of capturing both spatial and temporal dynamics of the USF signal in tissue. In this study, various algorithms were explored to enhance the spatial resolution and signal-to-noise ratio (SNR) of USF images, utilizing temporal and spatial information from a camera-based time-domain USF imaging system. The correlation method proved effective in boosting SNR, while the ascending-slope-weighted method enhanced spatial resolution. Additionally, the spatially back-projection method significantly improved spatial resolution in silicone phantoms. The results underscore the advantages of incorporating temporal and spatial information from USF signals.
    Language English
    Publishing date 2024-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202300533
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  9. Article ; Online: Propofol induced seizure-like phenomena: A case report and literature review.

    Li, Yuan / Shuai, Bingxing / Liu, Jia / Wu, Lan

    Asian journal of surgery

    2023  Volume 46, Issue 9, Page(s) 3822–3824

    MeSH term(s) Humans ; Propofol ; Seizures
    Chemical Substances Propofol (YI7VU623SF)
    Language English
    Publishing date 2023-04-03
    Publishing country Netherlands
    Document type Review ; Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.03.127
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  10. Article ; Online: Morphology, Development, and Pigment Production of Talaromyces marneffei are Diversely Modulated Under Physiologically Relevant Growth Conditions.

    Nong, Yuan / Wang, Fang / Shuai, Feifei / Chen, Shi

    Current microbiology

    2024  Volume 81, Issue 5, Page(s) 119

    Abstract: Talaromyces marneffei is an opportunistic pathogenic fungus that mainly affects HIV-positive individuals endemic to Southeast Asia and China. Increasing efforts have been made in the pathogenic mechanism and host interactions understanding of this ... ...

    Abstract Talaromyces marneffei is an opportunistic pathogenic fungus that mainly affects HIV-positive individuals endemic to Southeast Asia and China. Increasing efforts have been made in the pathogenic mechanism and host interactions understanding of this pathogen in the last two decades; however, there are still no conclusions on how T. marneffei was transmitted from the donor bamboo rats to humans. A perception that the failure of fungus isolation from soil was attributed to the low salt tolerance of T. marneffei. Therefore, the effect of environmental fluctuations in fungal growth and development is fundamental for the characterization of its origin and fungal biology understanding. Herein, we characterized high osmolarity, pH, metal ions, nutrients, and oxidative stress have versatile effects on T. marneffei hyphal or yeast growth, conidia generation, and pigment production. Among these, high pH, low glucose amounts, and the inorganic nitrogen ammonium tartrate stimulated the red pigment production, whereas high osmolarity, high pH, and the inorganic nitrogen sodium nitrate could significantly accelerate the conidia generation. Specifically, zinc starvation repressed conidia generation and prevented the wrinkled yeast colony formation, indicating the function of zinc regulators in pathogenicity regulation. Since conidia are recognized as the infectious propagules, the effects characterization of different environmental factors in T. marneffei morphology in this work will not only expand the growth and pathogenic biology understanding of the fungus but also provide more clues for the T. marneffei infection transmission origin investigation.
    MeSH term(s) Humans ; Saccharomyces cerevisiae ; Talaromyces ; Nitrogen ; Zinc/pharmacology ; Mycoses
    Chemical Substances Nitrogen (N762921K75) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-024-03623-x
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