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  1. Article ; Online: KRAS-Mutant Lung Cancer: Targeting Molecular and Immunologic Pathways, Therapeutic Advantages and Restrictions.

    Karimi, Nastaran / Moghaddam, Seyed Javad

    Cells

    2023  Volume 12, Issue 5

    Abstract: ... ...

    Abstract RAS
    MeSH term(s) Humans ; Lung Neoplasms/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Signal Transduction ; Immunotherapy
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; KRAS protein, human
    Language English
    Publishing date 2023-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12050749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: KRAS-Mutant Lung Cancer

    Nastaran Karimi / Seyed Javad Moghaddam

    Cells, Vol 12, Iss 749, p

    Targeting Molecular and Immunologic Pathways, Therapeutic Advantages and Restrictions

    2023  Volume 749

    Abstract: RAS mutations are among the most common oncogenic mutations in human cancers. Among RAS mutations, KRAS has the highest frequency and is present in almost 30% of non-small-cell lung cancer (NSCLC) patients. Lung cancer is the number one cause of ... ...

    Abstract RAS mutations are among the most common oncogenic mutations in human cancers. Among RAS mutations, KRAS has the highest frequency and is present in almost 30% of non-small-cell lung cancer (NSCLC) patients. Lung cancer is the number one cause of mortality among cancers as a consequence of outrageous aggressiveness and late diagnosis. High mortality rates have been the reason behind numerous investigations and clinical trials to discover proper therapeutic agents targeting KRAS. These approaches include the following: direct KRAS targeting; synthetic lethality partner inhibitors; targeting of KRAS membrane association and associated metabolic rewiring; autophagy inhibitors; downstream inhibitors; and immunotherapies and other immune-modalities such as modulating inflammatory signaling transcription factors (e.g., STAT3). The majority of these have unfortunately encountered limited therapeutic outcomes due to multiple restrictive mechanisms including the presence of co-mutations. In this review we plan to summarize the past and most recent therapies under investigation, along with their therapeutic success rate and potential restrictions. This will provide useful information to improve the design of novel agents for treatment of this deadly disease.
    Keywords lung cancer ; KRAS ; molecular pathways ; therapy ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma.

    Clowers, Michael J / Moghaddam, Seyed Javad

    Cancers

    2022  Volume 14, Issue 7

    Abstract: Worldwide, lung cancer, particularly K-ras mutant lung adenocarcinoma (KM-LUAD), is the leading cause of cancer mortality because of its high incidence and low cure rate. To treat and prevent KM-LUAD, there is an urgent unmet need for alternative ... ...

    Abstract Worldwide, lung cancer, particularly K-ras mutant lung adenocarcinoma (KM-LUAD), is the leading cause of cancer mortality because of its high incidence and low cure rate. To treat and prevent KM-LUAD, there is an urgent unmet need for alternative strategies targeting downstream effectors of K-ras and/or its cooperating pathways. Tumor-promoting inflammation, an enabling hallmark of cancer, strongly participates in the development and progression of KM-LUAD. However, our knowledge of the dynamic inflammatory mechanisms, immunomodulatory pathways, and cell-specific molecular signals mediating K-ras-induced lung tumorigenesis is substantially deficient. Nevertheless, within this signaling complexity, an inflammatory pathway is emerging as a druggable target: signal transducer and activator of transcription 3 (STAT3). Here, we review the cell type-specific functions of STAT3 in the pathogenesis and progression of KM-LUAD that could serve as a new target for personalized preventive and therapeutic intervention for this intractable form of lung cancer.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14071785
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  4. Article ; Online: Lung Cancer Murine Models and Methodology for Immunopreventive Study.

    Ramos-Castaneda, Marco / Moghaddam, Seyed Javad

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2435, Page(s) 203–214

    Abstract: Lung cancer is the second most common cancers in the world and remains as the cancer with the highest incidence of death (Siegel et al. CA Cancer J Clin 71(1):7-33, 2021). K-RAS mutation is one of the most common mutations in non-small-cell lung cancer ( ... ...

    Abstract Lung cancer is the second most common cancers in the world and remains as the cancer with the highest incidence of death (Siegel et al. CA Cancer J Clin 71(1):7-33, 2021). K-RAS mutation is one of the most common mutations in non-small-cell lung cancer (NSCLC), encompassing 15-30% of lung adenocarcinomas (Cancer Genome Atlas Research Network. Nature 511:543-550, 2014). In this chapter, we describe various murine models with the goal of studying the role of inflammation in development and promotion of lung cancer. Immunomodulatory strategies are described in detail as well as the protocols that follow the intervention for harvesting various tissue and fluids for immune-profiling.
    MeSH term(s) Adenocarcinoma/pathology ; Animals ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Disease Models, Animal ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mice ; Mutation
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2014-4_15
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  5. Article ; Online: Bromelain-loaded nanocomposites decrease inflammatory and cytotoxicity effects of gliadin on Caco-2 cells and peripheral blood mononuclear cells of celiac patients.

    Mousavi Maleki, Masoumeh Sadat / Ebrahimi Kiasari, Ramin / Seyed Mousavi, Seyed Javad / Hashemi-Moghaddam, Hamid / Shabani, Ali Akbar / Madanchi, Hamid / Sardari, Soroush

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 21180

    Abstract: Enzyme therapy can be an appropriate treatment option for celiac disease (CeD). Here, we developed Bromelain-Loaded Nanocomposites (BLNCs) to improve the stability and retention of bromelain enzyme activity. After the characterization of BLNCs, the ... ...

    Abstract Enzyme therapy can be an appropriate treatment option for celiac disease (CeD). Here, we developed Bromelain-Loaded Nanocomposites (BLNCs) to improve the stability and retention of bromelain enzyme activity. After the characterization of BLNCs, the cytotoxicity of BLNCs was determined on the Caco-2 cell line. The effect of BLNCs on gliadin degradation and the production of pro-inflammatory cytokines and anti-inflammatory molecules in peripheral blood mononuclear cells (PBMCs) obtained from celiac patients were assessed. Furthermore, the expression of CXCR3 and CCR5 genes was measured in CaCo-2 cells treated with gliadin, gliadin-digested with BLNCs, and bromelain. Our study demonstrated that the Bromelain entrapment efficiency in these nanoparticles was acceptable, and BLNCs have no toxic effect on cells. SDS-PAGE confirmed the digestion effect of bromelain released from nanocomposites. When Caco-2 cells were treated with gliadin digested by free bromelain and BLNCs, the expression of CXCR3 and CCR5 genes was significantly decreased. PBMCs of celiac patients treated with Bromelain and BLNCs decreased inflammatory cytokines (IL-1β, IL-6, TNF-α, and IFN-γ) production compared to untreated PBMCs. This treatment also increased IL-10 and CTLA-4 in PBMCs of CeD patients. According to the promising results of this study, we can hope for the therapeutic potential of BLNCs for CeD.
    MeSH term(s) Humans ; Caco-2 Cells ; Gliadin/metabolism ; Leukocytes, Mononuclear/metabolism ; Bromelains/pharmacology ; Cytokines/metabolism ; Celiac Disease/drug therapy ; Celiac Disease/metabolism
    Chemical Substances Gliadin (9007-90-3) ; Bromelains (9001-00-7) ; Cytokines
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48460-3
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  6. Article ; Online: Differential Expression of

    Saadat Akhtar, Mozhgan / Gholipour, Akram / Bagheri Moghaddam, Mahrokh / Oveisee, Maziar / Mowla, Seyed Javad / Malakootian, Mahshid

    Iranian journal of public health

    2023  Volume 52, Issue 2, Page(s) 427–435

    Abstract: Background: We investigated the expression pattern of a human stem cell-specific, large intergenic : Methods: qRT-PCR was used to investigate the expression alteration of a specific stem cell-related : Results: Expression was significantly ... ...

    Abstract Background: We investigated the expression pattern of a human stem cell-specific, large intergenic
    Methods: qRT-PCR was used to investigate the expression alteration of a specific stem cell-related
    Results: Expression was significantly upregulated in
    Conclusion: Aberrant expressions of
    Language English
    Publishing date 2023-04-15
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2240935-X
    ISSN 2251-6093 ; 2251-6093
    ISSN (online) 2251-6093
    ISSN 2251-6093
    DOI 10.18502/ijph.v52i2.11896
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  7. Article ; Online: Tannic Acid as a Green Cross-linker for Biomaterial Applications.

    Moghaddam, Seyed Yasaman Zolfaghari / Biazar, Esmaeil / Esmaeili, Javad / Kheilnezhad, Bahareh / Goleij, Fatemeh / Heidari, Samaneh

    Mini reviews in medicinal chemistry

    2022  Volume 23, Issue 13, Page(s) 1320–1340

    Abstract: Plant-derived tannic acid as a green material can play an important role in improving the mechanical and physical properties of biomaterials. Tannic acid can be used as an antioxidant, antimicrobial, and cross-linking agent in biomaterial products due to ...

    Abstract Plant-derived tannic acid as a green material can play an important role in improving the mechanical and physical properties of biomaterials. Tannic acid can be used as an antioxidant, antimicrobial, and cross-linking agent in biomaterial products due to its unique functional groups. Its active phenolic groups can react with biomaterial functional groups to form bonds that improve performance. In this review, the mechanism of effectiveness of tannic acid as a natural crosslinker in improving the properties of biomaterials for various applications, such as tissue engineering, tissue adhesives, drug delivery, wound healing, and toxicity studies, has been investigated. In general, tannic acid can be a suitable alternative to synthetic crosslinkers in biomaterial applications.
    MeSH term(s) Biocompatible Materials/pharmacology ; Biocompatible Materials/chemistry ; Tannins/pharmacology ; Tannins/chemistry ; Wound Healing ; Anti-Infective Agents/pharmacology
    Chemical Substances Biocompatible Materials ; Tannic Acid ; Tannins ; Anti-Infective Agents
    Language English
    Publishing date 2022-06-16
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/1389557522666220622112959
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5891: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Bromelain-loaded nanocomposites decrease inflammatory and cytotoxicity effects of gliadin on Caco-2 cells and peripheral blood mononuclear cells of celiac patients

    Masoumeh Sadat Mousavi Maleki / Ramin Ebrahimi kiasari / Seyed Javad Seyed Mousavi / Hamid Hashemi‐Moghaddam / Ali Akbar Shabani / Hamid Madanchi / Soroush Sardari

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract Enzyme therapy can be an appropriate treatment option for celiac disease (CeD). Here, we developed Bromelain-Loaded Nanocomposites (BLNCs) to improve the stability and retention of bromelain enzyme activity. After the characterization of BLNCs, ... ...

    Abstract Abstract Enzyme therapy can be an appropriate treatment option for celiac disease (CeD). Here, we developed Bromelain-Loaded Nanocomposites (BLNCs) to improve the stability and retention of bromelain enzyme activity. After the characterization of BLNCs, the cytotoxicity of BLNCs was determined on the Caco-2 cell line. The effect of BLNCs on gliadin degradation and the production of pro-inflammatory cytokines and anti-inflammatory molecules in peripheral blood mononuclear cells (PBMCs) obtained from celiac patients were assessed. Furthermore, the expression of CXCR3 and CCR5 genes was measured in CaCo-2 cells treated with gliadin, gliadin-digested with BLNCs, and bromelain. Our study demonstrated that the Bromelain entrapment efficiency in these nanoparticles was acceptable, and BLNCs have no toxic effect on cells. SDS-PAGE confirmed the digestion effect of bromelain released from nanocomposites. When Caco-2 cells were treated with gliadin digested by free bromelain and BLNCs, the expression of CXCR3 and CCR5 genes was significantly decreased. PBMCs of celiac patients treated with Bromelain and BLNCs decreased inflammatory cytokines (IL-1β, IL-6, TNF-α, and IFN-γ) production compared to untreated PBMCs. This treatment also increased IL-10 and CTLA-4 in PBMCs of CeD patients. According to the promising results of this study, we can hope for the therapeutic potential of BLNCs for CeD.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Cigarette smoke exposure accelerates AML progression in FLT3-ITD models.

    Figueroa, Mary / Ma, Huaxian / Alfayez, Mansour / Morales-Mantilla, Daniel Enrique / Wang, Fei / Lu, Yue / Estecio, Marcos R / King, Katherine Y / Kleinerman, Eugenie / Moghaddam, Seyed Javad / Daver, Naval / Andreeff, Michael / Konopleva, Marina / DiNardo, Courtney / Chandra, Joya

    Blood advances

    2023  Volume 7, Issue 21, Page(s) 6624–6629

    MeSH term(s) Humans ; Cigarette Smoking/adverse effects ; Leukemia, Myeloid, Acute/etiology ; Mutation ; fms-Like Tyrosine Kinase 3/genetics
    Chemical Substances fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; FLT3 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010111
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
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  10. Article: Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.

    Deng, Shanshan / Clowers, Michael J / Velasco, Walter V / Ramos-Castaneda, Marco / Moghaddam, Seyed Javad

    Frontiers in oncology

    2020  Volume 9, Page(s) 1556

    Abstract: Kirsten rat sarcoma viral oncogene (K-ras) is a well-documented, frequently mutated gene in lung cancer. Since K-ras regulates numerous signaling pathways related to cell survival and proliferation, mutations in this gene are powerful drivers of ... ...

    Abstract Kirsten rat sarcoma viral oncogene (K-ras) is a well-documented, frequently mutated gene in lung cancer. Since K-ras regulates numerous signaling pathways related to cell survival and proliferation, mutations in this gene are powerful drivers of tumorigenesis and confer prodigious survival advantages to developing tumors. These malignant cells dramatically alter their local tissue environment and in the process recruit a powerful ally: inflammation. Inflammation in the context of the tumor microenvironment can be described as either antitumor or protumor (i.e., aiding or restricting tumor progression, respectively). Many current treatments, like immune checkpoint blockade, seek to augment antitumor inflammation by alleviating inhibitory signaling in cytotoxic T cells; however, a burgeoning area of research is now focusing on ways to modulate and mitigate protumor inflammation. Here, we summarize the interplay of tumor-promoting inflammation and K-ras mutant lung cancer pathogenesis by exploring the cytokines, signaling pathways, and immune cells that mediate this process.
    Language English
    Publishing date 2020-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.01556
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