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  1. Article: Der besondere Fall. Noonan-Syndrom. Die zeitgerechte Diagnose ist bedeutsam, da eine Verzögerung nicht nur den Leidensweg für Kind und Familie verlängert, sondern auch diagnostisch-therapeutisch relevante Interventionen verzögert.

    Noordam, C. / Croonen, E. A. / Katschnig, C. K.

    Swiss medical forum

    2022  Volume 22, Issue 33/34, Page(s) 549

    Language German
    Document type Article
    ZDB-ID 2220114-2
    ISSN 1661-6138
    Database Current Contents Medicine

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  2. Article: An extremely rare case of pseudomelanosis of the urinary bladder.

    Duijn, M / Croonen, S L / Van der Zee, J A

    Urology case reports

    2022  Volume 45, Page(s) 102193

    Abstract: Pseudomelanosis (PM) is a rare, benign, condition that is characterized by deposition of melanin and/or melanin-like pigment in mucosal cells and macrophages and is best known as the entity pseudomelanosis coli. Pseudomelanosis primary of the urinary ... ...

    Abstract Pseudomelanosis (PM) is a rare, benign, condition that is characterized by deposition of melanin and/or melanin-like pigment in mucosal cells and macrophages and is best known as the entity pseudomelanosis coli. Pseudomelanosis primary of the urinary bladder has been reported only in a handful of cases worldwide. This article reports an extremely rare case of pseudomelanosis of the urinary bladder in a 79-year-old male with a history of macroscopic painless hematuria.
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2022.102193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A systematic review of reports of quality improvement for bronchopulmonary dysplasia.

    Healy, H / Croonen, L E E / Onland, W / van Kaam, A H / Gupta, M

    Seminars in fetal & neonatal medicine

    2021  Volume 26, Issue 1, Page(s) 101201

    Abstract: Bronchopulmonary dysplasia (BPD) is the most common morbidity of preterm infants, and its incidence has not responded to research and intervention efforts to the same degree as other major morbidities associated with prematurity. The complexity of ... ...

    Abstract Bronchopulmonary dysplasia (BPD) is the most common morbidity of preterm infants, and its incidence has not responded to research and intervention efforts to the same degree as other major morbidities associated with prematurity. The complexity of neonatal respiratory care as well as persistent inter-institutional variability in BPD rates suggest that BPD may be amenable to quality improvement (QI) efforts. We present a systematic review of QI for BPD in preterm infants. We identified 22 reports from single centers and seven from collaborative efforts published over the past two decades. In almost all of the reports, respiratory QI interventions successfully reduced BPD or other key respiratory measures, particularly for infants with birth weight over 1000 g. Several themes and lessons from existing reports may help inform future efforts in both research and QI to impact the burden of BPD.
    MeSH term(s) Bronchopulmonary Dysplasia/therapy ; Gestational Age ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Premature ; Quality Improvement
    Language English
    Publishing date 2021-01-30
    Publishing country Netherlands
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2021.101201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [No title information]

    Semmekrot, B A / Croonen, E A / Weijers, G / van Wieringen, P M V / Holl, R A / Hendriks, J C M / Gerrits, G P J M

    Tijdschrift voor kindergeneeskunde

    2020  Volume 76, Issue 1, Page(s) 2–8

    Abstract: Purpose: Evaluating the guideline 'Diagnosis and treatment of respiratory syncytial (RS) virus bronchiolitis' on the number of chest X-rays, C-reactive proteïn (CRP) counts, leukocyte counts, and antibiotic prescriptions in infants admitted to hospital ... ...

    Title translation Vermindering van diagnostiek en overbehandeling bij RS-virus-bronchiolitis na geprotocolleerde behandeling.
    Abstract Purpose: Evaluating the guideline 'Diagnosis and treatment of respiratory syncytial (RS) virus bronchiolitis' on the number of chest X-rays, C-reactive proteïn (CRP) counts, leukocyte counts, and antibiotic prescriptions in infants admitted to hospital with RS bronchiolitis.
    Design: Retrospective 'before-after' cohort study.
    Location: Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
    Patients: Infants admitted with proven RS virus infection.
    Methods: Guidelines, including sound restriction of performance of X-rays, CRP and leukocytes, were introduced in February 2003. Data from infants admitted with RS virus infection during 1997- 1999 (cohort A) were compared with those admitted from 2003- April 2006 (cohort B)Results: There were 155 infants in cohort A and 170 in cohort B. Implementation of guidelines led to significant reductions of CRP and leukocyte determinations: 49.0% and 48.2%, respectively (both p<0.001) and X-rays: 30.3% (p=0.020). Numbers of antibiotic prescriptions decreased with 55% (p<0.001). The chance of antibiotic prescription increased significantly when X-rays (OR=5.2), CRP (OR=5.4), or leukocytes (OR=4.2) were done. After implementation of the guidelines, the median stay in hospital decreased significantly from 8.0 to 6.0 days (p<0.001; ranges 1-13 days and 2-23 days, respectively). Performing X-ray, CRP or leukocytes, or antibiotic prescription did not significantly alter the total duration of hospital stay.
    Conclusion: Implementation of the guidelines led to significant decreases in numbers of X-rays, CRP and leukocytes determinations, and antibiotic prescriptions. Our data support the restrictive use of chest X-rays, CRP and leukocyte determinations in infants, admitted to hospital with RS virus bronchiolitis.
    Keywords covid19
    Language Dutch
    Publishing date 2020-02-21
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 197617-5
    ISSN 0376-7442
    ISSN 0376-7442
    DOI 10.1007/BF03078168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A pulmonary masquerade….

    Heidt, J / Croonen, S L / Huisman, P M / van Haarst, J M W

    The Netherlands journal of medicine

    2017  Volume 75, Issue 5, Page(s) 221

    Language English
    Publishing date 2017-06-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193149-0
    ISSN 1872-9061 ; 0300-2977
    ISSN (online) 1872-9061
    ISSN 0300-2977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: First-year growth in children with Noonan syndrome: Associated with feeding problems?

    Croonen, Ellen A / Draaisma, Jos M T / van der Burgt, Ineke / Roeleveld, Nel / Noordam, Cees

    American journal of medical genetics. Part A

    2018  Volume 176, Issue 4, Page(s) 951–958

    Abstract: Children with Noonan syndrome show rapid decline of growth in the first year of life and feeding problems are present in over 50%. The aim of this study was to explore whether growth decelerates because of feeding problems or other Noonan syndrome- ... ...

    Abstract Children with Noonan syndrome show rapid decline of growth in the first year of life and feeding problems are present in over 50%. The aim of this study was to explore whether growth decelerates because of feeding problems or other Noonan syndrome-related factors. We performed a retrospective, longitudinal cohort study of clinically and genetically diagnosed subjects with Noonan syndrome (n = 143). Questionnaires about the phenotypic-genotypic profile and reported feeding problems were sent to eligible subjects. Data on first-year growth was obtained from growth charts. Ninety-one participants were excluded because of different criteria. A total of 52 subjects with Noonan syndrome were included. The largest decline in weight and length standard deviation score (SDS) occurred in the first 2.5 months after birth (-1.93 and -1.15, respectively), with feeding problems causing a decline of 0.57 SDS in the remaining months. At 1 year, children with feeding problems were on average 290 g lighter and 0.8 cm shorter than children without feeding problems. Weight gain was also negatively influenced by having a PTPN11 mutation (n = 39) and a higher gestational age, whereas children of parents with Noonan syndrome and with a higher birth weight gained more weight. Growth in length was reduced by having cardiac surgery and a higher gestational age, but positively influenced by birth length and maternal height. Growth in children with Noonan syndrome is impaired right after birth and only partially associated with feeding problems. In addition, several specific Noonan syndrome-related factors seem to influence growth in the first year.
    MeSH term(s) Alleles ; Child ; Child, Preschool ; Feeding Behavior ; Female ; Genotype ; Growth Charts ; Humans ; Infant ; Longitudinal Studies ; Male ; Mutation ; Noonan Syndrome/diagnosis ; Noonan Syndrome/epidemiology ; Noonan Syndrome/genetics ; Odds Ratio ; Phenotype ; Retrospective Studies ; Surveys and Questionnaires ; Time Factors
    Language English
    Publishing date 2018-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1493479-6
    ISSN 1552-4833 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 1552-4825
    DOI 10.1002/ajmg.a.38649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: It Is Not Just the FEV1 That Matters, but the Personal Goals We Reach Along the Way: Qualitative, Multicenter, Prospective, Observational Study.

    Oppelaar, Martinus C / van den Wijngaart, Lara S / Merkus, Peter J F M / Croonen, Ellen A / Hugen, Cindy A C / Brouwer, Marianne L / Boehmer, Annemie L M / Roukema, Jolt

    Journal of medical Internet research

    2021  Volume 23, Issue 10, Page(s) e29218

    Abstract: Background: The COVID-19 pandemic has boosted the use of forced expiratory volume in 1 second (FEV: Objective: The aim of this study was to provide perspectives on how FEV: Methods: This is a qualitative, multicenter, prospective, observational ... ...

    Abstract Background: The COVID-19 pandemic has boosted the use of forced expiratory volume in 1 second (FEV
    Objective: The aim of this study was to provide perspectives on how FEV
    Methods: This is a qualitative, multicenter, prospective, observational study which included patients with asthma aged 6-16 and HCPs. Primary outcomes were results of 2 surveys that were sent to all participants at study start and after 3-4 months. Secondary outcomes consisted of FEV
    Results: A total of 39 participants (26 patients and 13 HCPs) were included in this study. Survey response rates were 97% (38/39) at the start and 87% (34/39) at the end of the study. Both patients and HCPs were receptive toward online FEV
    Conclusions: Patients and HCPs are receptive toward online FEV
    MeSH term(s) COVID-19 ; Child ; Forced Expiratory Volume ; Goals ; Humans ; Pandemics ; Prospective Studies ; Reproducibility of Results ; SARS-CoV-2
    Language English
    Publishing date 2021-10-20
    Publishing country Canada
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1439-4456
    ISSN (online) 1438-8871
    ISSN 1439-4456
    DOI 10.2196/29218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Managing machine learning in times of sudden disruption (COVID-19) in the insurance industry

    Lubina, Marko / van Lint, Jarno / Joosen, Nils / Wiercinska, Natalia / Croonen, Nick

    2020  

    Abstract: ... from 2019 (E. Hida, 2018) states that only approximately 40% of organizations utilize big data and make use ...

    Abstract As organizations struggle to manage the impact of COVID-19 on their operations and supply chains, even greater pressure is placed on insurers to provide support to their clients. Moreover, they have to bear in mind mitigating the downsides for their own business and processes. Simultaneously, markets are struggling while experiencing catastrophic losses like higher reinsurance costs. Already a long time before COVID-19 outbreak, insurance companies were striving to keep up with increasing asperity and uncertainty of natural disasters, terrorist attacks, epidemics and other risks emerging. Therefore, insurers were looking for the next generation technologies long before COVID-19. Long before industry was in need to compute adequate rates and come up with new premiums, while also thinking of securing their own profitability. However, now it is not prevention anymore, we need to take an action immediately and some models occur not suitable. In order to search for the solution we need to turn to Big Data Analytics. Deloitte’s survey from 2019 (E. Hida, 2018) states that only approximately 40% of organizations utilize big data and make use of big data analytics, despite the fact that over 60% of responders believe the emerging tech could drastically increase operational efficiency and improve risk analysis. Therefore, we need to push to increase those numbers.
    Keywords COVID-19 ; Insurance Industry ; sudden disruption ; disruptive events ; big data ; pandemics ; business process integration ; IT Governance ; Strategic Sourcing ; Cybersecuirity ; covid19
    Subject code 330
    Language English
    Publishing date 2020-11-01
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Motor performance in children with Noonan syndrome.

    Croonen, Ellen A / Essink, Marlou / van der Burgt, Ineke / Draaisma, Jos M / Noordam, Cees / Nijhuis-van der Sanden, Maria W G

    American journal of medical genetics. Part A

    2017  Volume 173, Issue 9, Page(s) 2335–2345

    Abstract: Although problems with motor performance in daily life are frequently mentioned in Noonan syndrome, the motor performance profile has never been systematically investigated. The aim of this study was to examine whether a specific profile in motor ... ...

    Abstract Although problems with motor performance in daily life are frequently mentioned in Noonan syndrome, the motor performance profile has never been systematically investigated. The aim of this study was to examine whether a specific profile in motor performance in children with Noonan syndrome was seen using valid norm-referenced tests. The study assessed motor performance in 19 children with Noonan syndrome (12 females, mean age 9 years 4 months, range 6 years 1 month to 11 years and 11 months, SDS 1 year and 11 months). More than 60% of the parents of the children reported pain, decreased muscle strength, reduced endurance, and/or clumsiness in daily functioning. The mean standard scores on the Visual Motor Integration (VMI) test and Movement Assessment Battery for Children 2, Dutch version (MABC-2-NL) items differed significantly from the reference scores. Grip strength, muscle force, and 6 min Walking Test (6 MWT) walking distance were significantly lower, and the presence of generalized hypermobility was significantly higher. All MABC-2-NL scores (except manual dexterity) correlated significantly with almost all muscle strength tests, VMI total score, and VMI visual perception score. The 6 MWT was only significantly correlated to grip strength. This is the first study that confirms that motor performance, strength, and endurance are significantly impaired in children with Noonan syndrome. Decreased functional motor performance seems to be related to decreased visual perception and reduced muscle strength. Research on causal relationships and the effectiveness of interventions is needed. Physical and/or occupational therapy guidance should be considered to enhance participation in daily life.
    MeSH term(s) Child ; Female ; Hand Strength/physiology ; Humans ; Male ; Motor Skills/physiology ; Muscle Strength/physiology ; Noonan Syndrome/epidemiology ; Noonan Syndrome/physiopathology ; Psychomotor Performance/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2017-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1493479-6
    ISSN 1552-4833 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 1552-4825
    DOI 10.1002/ajmg.a.38322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: How to choose the right real-time RT-PCR primer sets for the SARS-CoV-2 genome detection?

    Anantharajah, Ahalieyah / Helaers, Raphaël / Defour, Jean-Philippe / Olive, Nathalie / Kabera, Florence / Croonen, Luc / Deldime, Françoise / Vaerman, Jean-Luc / Barbée, Cindy / Bodéus, Monique / Scohy, Anais / Verroken, Alexia / Rodriguez-Villalobos, Hector / Kabamba-Mukadi, Benoît

    Journal of virological methods

    2021  Volume 295, Page(s) 114197

    Abstract: ... polymerase (RdRp), envelope (E) and nucleocapsid (N) coding region. However, it is currently unclear ...

    Abstract Objectives: The SARS-CoV-2 pandemic has created an unprecedented need for rapid large-scale diagnostic testing to prompt clinical and public health interventions. Currently, several quantitative reverse-transcription polymerase chain reaction (RT-qPCR) assays recommended by the World Health Organization are being used by clinical and public health laboratories and typically target regions of the RNA-dependent RNA polymerase (RdRp), envelope (E) and nucleocapsid (N) coding region. However, it is currently unclear if results from different tests are comparable. This study aimed to clarify the clinical performances of the primer/probe sets designed by US CDC and Charité/Berlin to help clinical laboratories in assay selection for SARS-CoV-2 routine detection.
    Methods: We compared the clinical performances of the recommended primer/probe sets using one hundred nasopharyngeal swab specimens from patients who were clinically diagnosed with COVID-19. An additional 30 "pre-intervention screening" samples from patients who were not suspected of COVID-19 were also included in this study. We also performed sequence alignment between 31064 European SARS-CoV-2 and variants of concern genomes and the recommended primer/probe sets.
    Results: The present study demonstrates substantial differences in SARS-CoV-2 RNA detection sensitivity among the primer/probe sets recommended by the World Health Organization especially for low-level viral loads. The alignment of thousands of SARS-CoV-2 sequences reveals that the genetic diversity remains relatively low at the primer/probe binding sites. However, multiple nucleotide mismatches might contribute to false negatives.
    Conclusion: An understanding of the limitations depending on the targeted genes and primer/probe sets may influence the selection of molecular detection assays by clinical laboratories.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Coronavirus/genetics ; DNA Primers/genetics ; Genome, Viral/genetics ; Humans ; RNA, Viral/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity ; Sequence Alignment ; Viral Load ; Viral Proteins/genetics
    Chemical Substances DNA Primers ; RNA, Viral ; Viral Proteins
    Language English
    Publishing date 2021-05-24
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2021.114197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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