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  1. Book: The biology and treatment of cancer

    Pardee, Arthur B.

    understanding cancer

    2009  

    Author's details [ed. by] Arthur B. Pardee
    Language English
    Size IX, 287 S. : zahlr. Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    New title 2. Aufl. u.d.T. Cancer
    HBZ-ID HT015573511
    ISBN 0-470-00958-6 ; 978-0-470-00958-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2009 A 1079 order for loan Magazin

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  2. Article ; Online: Bioregulation.

    Pardee, Arthur B

    Journal of cellular physiology

    2015  Volume 230, Issue 12, Page(s) 2898–2902

    Abstract: During the 20th century great progress was made in genetics and biochemistry, and these were combined into a molecular biological understanding of functions of macromolecules. Further great discoveries will be made about bioregulations, applicable to ... ...

    Abstract During the 20th century great progress was made in genetics and biochemistry, and these were combined into a molecular biological understanding of functions of macromolecules. Further great discoveries will be made about bioregulations, applicable to scientific problems such as cell development and evolution, and to illnesses including heart disease through defective control of cholesterol production, and to neurological cell-based diseases. The "War Against Cancer" is still far from won. The present generation of scientists can develop clinical applications from recent basic science discoveries.
    MeSH term(s) Animals ; Biochemistry/methods ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation/genetics ; Early Detection of Cancer ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Genetic Therapy ; Genetics ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Signal Transduction/genetics ; Systems Biology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.25059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Two controls of cell proliferation underlie cancer relapse.

    Pardee, Arthur B / Li, Chiang J

    Journal of cellular physiology

    2018  Volume 233, Issue 11, Page(s) 8437–8440

    Abstract: Much progress has been made in understanding the basis of cancer. Current therapies can effectively shrink tumors. But they frequently relapse, metastasize to other locations, and are lethal. Effective therapies are very much needed for preventing this ... ...

    Abstract Much progress has been made in understanding the basis of cancer. Current therapies can effectively shrink tumors. But they frequently relapse, metastasize to other locations, and are lethal. Effective therapies are very much needed for preventing this relapse. Creation of a eukaryotic organism commences with one original stem cell, a fertilized egg, which multiplies and differentiates. Mutations of normal stem cells can produce cancer stem cells (CSC). These cells may resist chemotherapy, proliferate, and produce new tumors. Human chorionic gonadotrophin (hCG) is composed of two proteins (alpha and beta) that bind to the cell membrane and activate a number of intracellular pathways. hCG has been shown to activate the proliferation of cancer stem cells. Cyclin dependent regulation of the adult cells is created in normal differentiation and replaces the hCG regulation of stem cells. To selectively kill the cancer stem cells conventional cancer therapies could be followed with a therapy based on inactivating human chronic gonadotrophin (HCG). For example chemically modified prostaglandins like RU486 prevent binding of the unmodified steroid to hCG and inactivate hCG.
    MeSH term(s) Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Membrane/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Chorionic Gonadotropin/antagonists & inhibitors ; Chorionic Gonadotropin/genetics ; HeLa Cells ; Humans ; Mifepristone/pharmacology ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Prostaglandins/genetics ; Recurrence ; Signal Transduction/drug effects ; Stem Cells/metabolism ; Stem Cells/pathology ; Zygote/growth & development
    Chemical Substances Chorionic Gonadotropin ; Prostaglandins ; Mifepristone (320T6RNW1F)
    Language English
    Publishing date 2018-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.26597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Perspectives on cellular regulation

    Pardee, Arthur B. / Campisi, Judith

    from bacteria to cancer ; essays in honor of Arthur B. Pardee

    (MBL lectures in biology ; 11)

    1991  

    Author's details ed. Judith Campisi
    Series title MBL lectures in biology ; 11
    Collection
    Keywords Cell Division / essays ; Cell Differentiation / essays ; Cell Transformation, Neoplastic / essays ; Zelle ; Regulation ; Tumorzelle
    Size XVII, 355 S. : Ill., graph. Darst.
    Publisher Wiley-Liss
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003922987
    ISBN 0-471-56090-1 ; 978-0-471-56090-6
    Database Catalogue ZB MED Medicine, Health

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    1991 A 5270 order for loan Magazin

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  5. Article: Tumor progression--targets for differential therapy.

    Pardee, Arthur B

    Journal of cellular physiology

    2006  Volume 209, Issue 3, Page(s) 589–591

    Abstract: Differential killing of the patient's cancer cells versus normal cells is a necessity for chemotherapy. Advantage can be taken of close regulations of gene expression and of enzyme activity that are essential for normal cell functioning, and that are ... ...

    Abstract Differential killing of the patient's cancer cells versus normal cells is a necessity for chemotherapy. Advantage can be taken of close regulations of gene expression and of enzyme activity that are essential for normal cell functioning, and that are altered during tumor progression. Summarized here is our research on four such progression changes of cancer cells; some deregulate proliferation control and others decrease programmed death (apoptosis). These processes will be illustrated with examples of potential chemotherapies based on them. Methods for discovery of such changes include Differential Display and microarrays.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Caffeine/metabolism ; Cell Cycle/drug effects ; Cell Proliferation ; Disease Progression ; Drug Therapy/methods ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology
    Chemical Substances Antineoplastic Agents ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2006-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.20728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Regulatory molecular biology.

    Pardee, Arthur B

    Cell cycle (Georgetown, Tex.)

    2006  Volume 5, Issue 8, Page(s) 846–852

    Abstract: Close regulations of molecular biological processes are essential for life. Defective controls cause diseases such as cancer and neurological malfunctions. We now are provided with a plethora of regulatory mechanisms exerted at many levels. Prominent are ...

    Abstract Close regulations of molecular biological processes are essential for life. Defective controls cause diseases such as cancer and neurological malfunctions. We now are provided with a plethora of regulatory mechanisms exerted at many levels. Prominent are covalent protein modifications, non-covalent feedback inhibition that modifies enzyme activity, and enzyme induction. Non-covalent or covalent binding to them of either small molecules or proteins act on functional DNA, RNA, proteins and metabolites regulates their production and degradation rates, activities and intra-cell locations. Time frames differ greatly, from seconds to days or longer. A control at every level is balanced by an opposing mechanism: populations of organisms are balanced by birth vs. death, cell synthesis by apoptosis, mutation by DNA repair, macromolecular syntheses by their degradations, metabolite anabolism vs. catabolism, enzyme activation by inhibition, protein kinases by phosphatases. Any abnormal molecular condition is sensed when regulation is defective as in cancer, which leads to its rectification, to cell death, or to disease if this is not possible.
    MeSH term(s) Animals ; Cell Cycle ; Cell Death ; DNA/metabolism ; DNA Repair ; Feedback, Physiological ; Gene Expression Regulation, Neoplastic ; Humans ; Kinetics ; MAP Kinase Signaling System ; Models, Biological ; Mutation ; Neoplasms/pathology ; RNA/metabolism ; Systems Biology
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2)
    Language English
    Publishing date 2006-04-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.5.8.2634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Rambling thoughts about doing and thinking research.

    Pardee, Arthur B

    Cancer biology & therapy

    2004  Volume 3, Issue 6, Page(s) 573–577

    MeSH term(s) Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; Molecular Biology/history ; United States
    Language English
    Publishing date 2004-06-18
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 2146305-0
    ISSN 1538-4047
    ISSN 1538-4047
    DOI 10.4161/cbt.3.6.864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Normal cells arrest cancer cells in G2.

    Pardee, Arthur B

    Cell cycle (Georgetown, Tex.)

    2003  Volume 2, Issue 5, Page(s) 454

    MeSH term(s) 3T3 Cells ; Animals ; Antigens, Polyomavirus Transforming/metabolism ; Cell Adhesion/physiology ; Cell Cycle/physiology ; Extracellular Matrix/metabolism ; Mice ; Tumor Cells, Cultured
    Chemical Substances Antigens, Polyomavirus Transforming
    Language English
    Publishing date 2003-09-05
    Publishing country United States
    Document type Comment ; Journal Article ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Regulation, restriction, and reminiscences.

    Pardee, Arthur B

    The Journal of biological chemistry

    2002  Volume 277, Issue 30, Page(s) 26709–26716

    MeSH term(s) Biochemistry/history ; Gene Expression Regulation, Enzymologic ; History, 20th Century ; Neoplasms ; United States
    Language English
    Publishing date 2002-06-05
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.R200013200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Role reversal for anticancer agents.

    Pardee, Arthur B

    Cancer biology & therapy

    2002  Volume 1, Issue 4, Page(s) 426–427

    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Division/drug effects ; Doxorubicin/pharmacology ; Flavonoids/pharmacology ; G2 Phase/drug effects ; Humans ; Paclitaxel/pharmacology ; Piperidines/pharmacology ; Tumor Cells, Cultured
    Chemical Substances Antineoplastic Agents ; Antineoplastic Agents, Phytogenic ; Flavonoids ; Piperidines ; alvocidib (45AD6X575G) ; Doxorubicin (80168379AG) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2002-11-13
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2146305-0
    ISSN 1538-4047
    ISSN 1538-4047
    DOI 10.4161/cbt.1.4.22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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