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Article ; Online: Detection of TPSAB1 copy number variation for the diagnosis of hereditary alpha-tryptasemia by quantitative PCR.

Docquier, M / Nouspikel, T / Blouin, J L / Abramowicz, M / Seebach, J D / Spoerl, D

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2023 Volume 54, Issue 1, Page(s) 82–85

MeSH term(s)	Humans ; DNA Copy Number Variations ; Mast Cells ; Mastocytosis ; Polymerase Chain Reaction ; Tryptases ; Anaphylaxis ; Mast Cell Activation Syndrome
Chemical Substances	Tryptases (EC 3.4.21.59) ; TPSAB1 protein, human (EC 3.4.21.59)
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.14413
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Zs.A 767: Show issues

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Article ; Online: When mechanical engineering inspired from physiology improves postural-related somatosensory processes.

Sutter, Chloé / Fabre, Marie / Massi, Francesco / Blouin, Jean / Mouchnino, Laurence

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19495

Abstract: Despite numerous studies uncovering the neural signature of tactile processing, tactile afferent inputs relating to the contact surface has not been studied so far. Foot tactile receptors being the first stimulated by the relative movement of the foot ... ...

Abstract	Despite numerous studies uncovering the neural signature of tactile processing, tactile afferent inputs relating to the contact surface has not been studied so far. Foot tactile receptors being the first stimulated by the relative movement of the foot skin and the underneath moving support play an important role in the sensorimotor transformation giving rise to a postural reaction. A biomimetic surface, i.e., complying with the skin dermatoglyphs and tactile receptors characteristics should facilitate the cortical processes. Participants (n = 15) stood either on a biomimetic surface or on two control surfaces, when a sudden acceleration of the supporting surface was triggered (experiment 1). A larger intensity and shorter somatosensory response (i.e., SEP) was evoked by the biomimetic surface motion. This result and the associated decrease of theta activity (5-7 Hz) over the posterior parietal cortex suggest that increasing the amount of sensory input processing could make the balance task less challenging when standing on a biomimetic surface. This key point was confirmed by a second experiment (n = 21) where a cognitive task was added, hence decreasing the attentional resources devoted to the balance motor task. Greater efficiency of the postural reaction was observed while standing on the biomimetic than on the control surfaces.
MeSH term(s)	Humans ; Touch/physiology ; Movement/physiology ; Attention ; Postural Balance/physiology ; Somatosensory Cortex/physiology
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45381-z
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Article ; Online: Online corrective responses following target jump in altered gravitoinertial force field point to nested feedforward and feedback control.

Chomienne, L / Blouin, J / Bringoux, L

Journal of neurophysiology

2020 Volume 125, Issue 1, Page(s) 154–165

Abstract: Studies on goal-directed arm movements have shown a close link between feedforward and feedback control in protocols where both planning and online control processes faced a similar type of perturbation, either mechanical or visual. This particular ... ...

Abstract	Studies on goal-directed arm movements have shown a close link between feedforward and feedback control in protocols where both planning and online control processes faced a similar type of perturbation, either mechanical or visual. This particular context might have facilitated the use of an adapted internal model by feedforward and feedback control. Here, we considered this link in a context where, after feedforward control was adapted through proprioception-based processes, feedback control was tested under visual perturbation. We analyzed the response of the reaching hand to target displacements following adaptation to an altered force field induced by rotating participants at constant velocity. Reaching corrections were assessed through variables related to the accuracy (lateral and longitudinal end point errors) and kinematics (movement time, peak velocity) of the corrective movements. The electromyographic activity of different arm muscles (pectoralis, posterior deltoid, biceps brachii, and triceps brachii) was analyzed. Statistical analyses revealed that accuracy and kinematics of corrective movements were strikingly alike between normal and altered gravitoinertial force fields. However, pectoralis and biceps muscle activities recorded during corrective movements were significantly modified to counteract the effect of rotation-induced Coriolis and centrifugal forces on the arm. Remarkably, feedback control was functional from the very first time participants encountered a target jump in the altered force field. Overall, the present results demonstrate that feedforward control enables immediate functional feedback control even when applied to distinct sensorimotor processes.
MeSH term(s)	Adult ; Arm/physiology ; Biomechanical Phenomena ; Feedback, Physiological ; Female ; Gravitation ; Humans ; Male ; Movement ; Muscle, Skeletal/physiology ; Psychomotor Performance ; Rotation ; Sensorimotor Cortex/physiology
Language	English
Publishing date	2020-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00268.2020
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Article: Cortical facilitation of tactile afferents during the preparation of a body weight transfer when standing on a biomimetic surface.

Sutter, Chloé / Moinon, Alix / Felicetti, Livia / Massi, Francesco / Blouin, Jean / Mouchnino, Laurence

Frontiers in neurology

2023 Volume 14, Page(s) 1175667

Abstract: Self-generated movement shapes tactile perception, but few studies have investigated the brain mechanisms involved in the processing of the mechanical signals related to the static and transient skin deformations generated by forces and pressures exerted ...

Abstract	Self-generated movement shapes tactile perception, but few studies have investigated the brain mechanisms involved in the processing of the mechanical signals related to the static and transient skin deformations generated by forces and pressures exerted between the foot skin and the standing surface. We recently found that standing on a biomimetic surface (i.e., inspired by the characteristics of mechanoreceptors and skin dermatoglyphics), that magnified skin-surface interaction, increased the sensory flow to the somatosensory cortex and improved balance control compared to standing on control (e.g., smooth) surfaces. In this study, we tested whether the well-known sensory suppression that occurs during movements is alleviated when the tactile afferent signal becomes relevant with the use of a biomimetic surface. Eyes-closed participants
Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1175667
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Article ; Online: Research Methods Used in Evidence-Based Design: An Analysis of Five Years of Research Articles From the

Battisto, Dina / Li, Xiaowei / Dong, Jiaying / Hall, Luke / Blouin, Julia

HERD

2022 Volume 16, Issue 1, Page(s) 56–82

Abstract: Objective: This study aims to analyze research methodologies from 157 research articles published in this journal in the last five years (2016-2020).: Background: Health environments research is comprised of research covering many topics and from ... ...

Abstract	Objective: This study aims to analyze research methodologies from 157 research articles published in this journal in the last five years (2016-2020). Background: Health environments research is comprised of research covering many topics and from various disciplines worldwide. No systematic study exists to uncover themes in evidence-based design (EBD) research concerning the types of research published, people engaged in research, and the research methods employed. Understanding the nature of health environment research performed can help researchers, practitioners, and students situate their work within an EBD research structure. Methods: Case study research was used to analyze 157 articles published in the Results: Findings are reported on categories commonly found in empirical research articles: (i) key words, (ii) disciplines from authors, (iii) settings studied, (iv) populations studied or sampled, (v) research approach and study design, (vi) research strategies, (vii) data collection methods, (viii) data analysis procedures, (ix) design categories and variables, and (x) outcome categories and variables. Conclusions: The analyses highlighted the research methods most frequently used in health environments research. Findings revealed several inconsistencies across articles on key words and the framing of research methodologies. Results suggest that there should be a consistent and overarching research taxonomy with a set of acceptable terms for effective literature searches.
MeSH term(s)	Humans ; Research Design
Language	English
Publishing date	2022-11-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2525547-2
ISSN	2167-5112 ; 1937-5867
ISSN (online)	2167-5112
ISSN	1937-5867
DOI	10.1177/19375867221125940
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: On the Dynamics of Spatial Updating.

Blouin, Jean / Pialasse, Jean-Philippe / Mouchnino, Laurence / Simoneau, Martin

Frontiers in neuroscience

2022 Volume 16, Page(s) 780027

Abstract: Most of our knowledge on the human neural bases of spatial updating comes from functional magnetic resonance imaging (fMRI) studies in which recumbent participants moved in virtual environments. As a result, little is known about the dynamic of spatial ... ...

Abstract	Most of our knowledge on the human neural bases of spatial updating comes from functional magnetic resonance imaging (fMRI) studies in which recumbent participants moved in virtual environments. As a result, little is known about the dynamic of spatial updating during real body motion. Here, we exploited the high temporal resolution of electroencephalography (EEG) to investigate the dynamics of cortical activation in a spatial updating task where participants had to remember their initial orientation while they were passively rotated about their vertical axis in the dark. After the rotations, the participants pointed toward their initial orientation. We contrasted the EEG signals with those recorded in a control condition in which participants had no cognitive task to perform during body rotations. We found that the amplitude of the P
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.780027
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Article ; Online: Keeping in touch with our hidden side.

Mathieu, Benjamin / Abillama, Antonin / Martinez, Malvina / Mouchnino, Laurence / Blouin, Jean

Neuroscience letters

2022 Volume 782, Page(s) 136693

Abstract: Previous studies have shown that the sensory modality used to identify regions of the body hidden from sight, but frequently viewed, influences the type of the body representation employed for reaching them with the finger. The question then arises as to ...

Abstract	Previous studies have shown that the sensory modality used to identify regions of the body hidden from sight, but frequently viewed, influences the type of the body representation employed for reaching them with the finger. The question then arises as to whether this observation also applies to body regions which are rarely, if ever, viewed. We used an established technique for pinpointing the type of body representation used for the spatial encoding of targets which consisted of assessing the effect of peripheral gaze fixation on the pointing accuracy. More precisely, an exteroceptive, visually dependent, body representation is thought to be used if gaze deviation induces a deviation of the pointing movement. Three light-emitting diodes (LEDs) were positioned at the participants' eye level at -25 deg, 0 deg and +25 deg. Without moving the head, the participant fixated the lit LED before the experimenter indicated one of the three target head positions: topmost point of the head (vertex) and two other points located at the front and back of the head. These targets were either verbal-cued or tactile-cued and the participants had to reach them with their index finger. We analysed the accuracy of the movements directed to the topmost point of the head, which is a well-defined, yet out of view anatomical point. Based on the possibility of the brain to create visual representations of the body areas that remain out of view, we hypothesized that the position of the vertex is encoded using an exteroceptive body representation, both when verbally or tactile-cued. Results revealed that the pointing errors were biased in the opposite direction of gaze fixation for both verbal-cued and tactile-cued targets, suggesting the use of a vision-dependent exteroceptive body representation. The enhancement of the visual body representations by sensorimotor processes was suggested by the greater pointing accuracy when the vertex was identified by tactile stimulation compared to verbal instruction. Moreover, a control condition showed that participants were more accurate in indicating the position of their own vertex than the vertex of other people. Together, our results suggest that the position of rarely viewed body parts are spatially encoded by an exteroceptive body representation and that non-visual sensorimotor processes are involved in the constructing of this representation.
MeSH term(s)	Cues ; Fingers/physiology ; Fixation, Ocular ; Humans ; Movement/physiology ; Psychomotor Performance/physiology ; Touch Perception
Language	English
Publishing date	2022-05-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2022.136693
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Article: Using Neck Muscle Afferentation to Control an Ongoing Limb Movement? Individual Differences in the Influence of Brief Neck Vibration.

Alekhina, Maria / Perkic, Goran / Manson, Gerome Aleandro / Blouin, Jean / Tremblay, Luc

Brain sciences

2023 Volume 13, Issue 10

Abstract: When preparing and executing goal-directed actions, neck proprioceptive information is critical to determining the relative positions of the body and target in space. While the contribution of neck proprioception for upper-limb movements has been ... ...

Abstract	When preparing and executing goal-directed actions, neck proprioceptive information is critical to determining the relative positions of the body and target in space. While the contribution of neck proprioception for upper-limb movements has been previously investigated, we could not find evidence discerning its impact on the planning vs. online control of upper-limb trajectories. To investigate these distinct sensorimotor processes, participants performed discrete reaches towards a virtual target. On some trials, neck vibration was randomly applied before and/or during the movement, or not at all. The main dependent variable was the medio-lateral/directional bias of the reaching finger. The neck vibration conditions induced early leftward trajectory biases in some participants and late rightward trajectory biases in others. These different patterns of trajectory biases were explained by individual differences in the use of body-centered and head-centered frames of reference. Importantly, the current study provides direct evidence that sensory cues from the neck muscles contribute to the online control of goal-directed arm movements, likely accompanied by significant individual differences.
Language	English
Publishing date	2023-10-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13101407
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Article ; Online: Digital platforms to facilitate physical activities for people with physical or sensory disabilities: A scoping review.

Lapierre, N / Huet-Fiola, C / Labrie, D / Vincent-Blouin, E / Côté, C / Gagnon, M / Rhéaume, N / Laberge, J / Best, K L / Routhier, F

Disability and health journal

2024 , Page(s) 101626

Abstract: Background: People with disabilities (PWD) commonly experience difficulties in accessing their environments, which can lead to restricted participation in outdoor leisure-time physical activity. Participating in outdoor leisure-time physical activity ( ... ...

Abstract	Background: People with disabilities (PWD) commonly experience difficulties in accessing their environments, which can lead to restricted participation in outdoor leisure-time physical activity. Participating in outdoor leisure-time physical activity (OLTPA) provides health and social benefits to PWD and benefits to the communities in which they live. Objective: The aim of the study was to identify features existing in digital platforms that facilitate access to OLTPA for PWD. Methods: A scoping review was conducted in four library databases and in Google advance search to identify relevant scientific and grey literature, and websites. Each step of the review was independently conducted by two co-authors who confirmed consensus of results. Descriptive data analyses were performed. Results: Seven scientific studies and ten websites were included in the scoping review. Seven presented mobile apps, nine presented a website and one presented an online database. Sources reported five main obstacles to using digital platforms that support access to physical activities (e.g., lack of digital literacy, technical issues, unintuitive design), and 10 facilitators (e.g., possibility to personalize your online space, accessibility features of the navigation). Among these sources, a trend emerged in the most important factors and features to consider for the visuals and navigation of the platforms. Conclusion: The features of digital platforms that facilitate access to OLTPA include intuitive design compliant with accessibility guidelines and supported by navigation tools, personalization of the online space, and features for social interactions.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2414615-8
ISSN	1876-7583 ; 1936-6574
ISSN (online)	1876-7583
ISSN	1936-6574
DOI	10.1016/j.dhjo.2024.101626
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Article ; Online: Characterization of the novel HLA-A*36:12 allele by sequencing-based typing.

Cargou, Marine / Elsermans, Vincent / Top, Isabelle / Blouin, Laura / Visentin, Jonathan

HLA

2021 Volume 98, Issue 1, Page(s) 51–53

Abstract: HLA-A*36:12 differs from HLA-A*36:01:01:01 by one nucleotide substitution in codon 211 in exon 4. ...

Abstract	HLA-A36:12 differs from HLA-A36:01:01:01 by one nucleotide substitution in codon 211 in exon 4.
MeSH term(s)	Alleles ; Codon ; Exons/genetics ; HLA-A Antigens/genetics ; Humans ; Sequence Analysis, DNA
Chemical Substances	Codon ; HLA-A Antigens
Language	English
Publishing date	2021-05-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.14296
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